听力与言语-语言病理学

行为科学

医学伦理学

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  • Preservation of kidney function irrelevant of total kidney volume growth rate with tolvaptan treatment in patients with autosomal dominant polycystic kidney disease.

    abstract:BACKGROUND:Tolvaptan slowed the rates of total kidney volume (TKV) growth and renal function decline over a 3-year period in patients with autosomal dominant polycystic kidney disease (ADPKD) enrolled in the Tolvaptan Efficacy and Safety in Management of Autosomal Dominant Polycystic Kidney Disease and Its Outcomes (TE...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-020-02009-0

    authors: Horie S,Muto S,Kawano H,Okada T,Shibasaki Y,Nakajima K,Ibuki T

    更新日期:2021-01-20 00:00:00

  • Elevation of creatine kinase is associated with acute kidney injury in hospitalized patients infected with seasonal influenza virus.

    abstract:BACKGROUND:Although acute kidney injury (AKI) is known as a potential complication of influenza infections, there is limited information concerning the association between influenza and AKI. The aim of this study is to evaluate the incidence, the mortality, and risk factors of AKI in hospitalized patients by seasonal i...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-020-02006-3

    authors: Ishibuchi K,Fukasawa H,Kaneko M,Yasuda H,Furuya R

    更新日期:2021-01-04 00:00:00

  • The clinical usage of liposomal amphotericin B in patients receiving renal replacement therapy in Japan: a nationwide observational study.

    abstract:BACKGROUND:Liposomal amphotericin B (L-AMB), a broad-spectrum antifungicidal drug, is often used to treat fungal infections. However, clinical evidence of its use in patients with renal dysfunction, especially those receiving renal replacement therapy (RRT), is limited. Therefore, we evaluated the usage and occurrence ...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-020-01989-3

    authors: Obata Y,Takazono T,Tashiro M,Ota Y,Wakamura T,Takahashi A,Sato K,Miyazaki T,Nishino T,Izumikawa K

    更新日期:2020-11-11 00:00:00

  • The need for disruptive innovation in acute kidney injury.

    abstract::Acute kidney injury (AKI) is a threatening medical condition associated with poor outcomes at different settings. The development of standardized diagnostic criteria and new biomarkers addressed significant clinical impacts of AKI and the need for an early AKI detection, respectively. There have been some breakthrough...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章,评审

    doi:10.1007/s10157-020-01920-w

    authors: Doi K

    更新日期:2020-11-01 00:00:00

  • Fact-finding survey on health literacy among Japanese predialysis chronic kidney disease patients: a multi-institutional cross-sectional study.

    abstract:BACKGROUND:Low health literacy (HL) has been associated with poor chronic disease management and adverse outcomes. However, reports on HL in predialysis chronic kidney disease (CKD) patients are limited in Japan. METHODS:From August 2019 to February 2020, the European Health Literacy Survey (Japanese version) and a pa...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-020-01982-w

    authors: Kita Y,Machida S,Shibagaki Y,Sakurada T

    更新日期:2020-10-15 00:00:00

  • Correction to: A Nautilus kidney.

    abstract::In the original publication of the article, the second sentence under the heading, Case presentation appears incorrectly as A computed tomographic (CT) scan demonstrated left-sided hydronephrosis (Fig. 1). ...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章,已发布勘误

    doi:10.1007/s10157-020-01934-4

    authors: Wu BS,Ho Y,Yang CY

    更新日期:2020-10-01 00:00:00

  • Pre-dialysis serum creatinine as an independent predictor of responsiveness to zinc supplementation among patients on hemodialysis.

    abstract:BACKGROUND:To investigate whether pre-dialysis level of serum creatinine (SCre) could indicate the responsiveness to zinc supplementation of patients on maintenance hemodialysis (MHD). METHODS:We retrospectively reviewed the results of our previous randomized study of 91 patients who had been on MHD and received zinc ...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-020-01911-x

    authors: Okamoto T,Hatakeyama S,Togashi K,Hamaya T,Tanaka Y,Imanishi K,Takashima T,Saitoh F,Suzuki T,Ohyama C

    更新日期:2020-10-01 00:00:00

  • The relationship between neutrophil-to-lymphocyte ratio and the first occurrence of pneumonia in peritoneal dialysis patients.

    abstract:BACKGROUND:Although neutrophil-to-lymphocyte ratio (NLR) is closely associated with pneumonia in the general population, its relationship is unclear in peritoneal dialysis (PD) patients. METHODS:This is a cohort study consisting of 739 PD patients and dividing into two groups. Kaplan-Meier curves were applied to obser...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-020-01894-9

    authors: Zhang Y,Lai X,Chen Q,Zhan X,Long H,Peng F,Zhang F,Feng X,Zhou Q,Wu X,Liu L,Wang Z,ETNA.,Peng X,Hu K,Wang D,Guo G,Zeng Y,Wen Y,Liang J

    更新日期:2020-09-01 00:00:00

  • Phosphorylation profile of human AQP2 in urinary exosomes by LC-MS/MS phosphoproteomic analysis.

    abstract:BACKGROUND:Aquaporin-2 (AQP2) is a key water channel protein which determines the water permeability of the collecting duct. Multiple phosphorylation sites are present at the C-terminal of AQP2 including S256 (serine at 256 residue), S261, S264 and S/T269, which are regulated by vasopressin (VP) to modulate AQP2 traffi...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-020-01899-4

    authors: Sakai M,Yamamoto K,Mizumura H,Matsumoto T,Tanaka Y,Noda Y,Ishibashi K,Yamamoto T,Sasaki S

    更新日期:2020-09-01 00:00:00

  • The clinical characteristic and outcome of skin and soft tissue infection in immunosuppressive patients with nephrotic syndrome.

    abstract:OBJECTIVE:Skin and soft tissue infection (SSTI) is the most common of infectious diseases with high morbidity and mortality. However, the clinical characteristics of SSTI in patients with nephrotic syndrome (NS), especially in those patients who received immunosuppressive therapy, are still lacking. The present study w...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-020-01893-w

    authors: Hu T,Wang M,Chen W,Zhao J,Xiong J

    更新日期:2020-09-01 00:00:00

  • How to resolve confusion in the clinical setting for the diagnosis of heterozygous COL4A3 or COL4A4 gene variants? Discussion and suggestions from nephrologists.

    abstract::Both thin basement membrane nephropathy (TBMN) and autosomal dominant Alport syndrome (ADAS) are types of hereditary nephritis resulting from heterozygous mutations in COL4A3 or COL4A4 genes. Although TBMN is characterized by hematuria and thinning of the glomerular basement membrane (GBM) with excellent renal prognos...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章,评审

    doi:10.1007/s10157-020-01880-1

    authors: Imafuku A,Nozu K,Sawa N,Nakanishi K,Ubara Y

    更新日期:2020-08-01 00:00:00

  • Identification of children with chronic kidney disease through school urinary screening using urinary protein/creatinine ratio measurement: an observational study.

    abstract:BACKGROUND:School urinary screening has been performed in Japan. METHODS:Ikeda City and Toyono Town introduced, in 2012 and 2013, urinary protein/creatinine (Cr) ratio measurement into the urine-screening protocols designed for students aged between 4 and 15 years. For each student whose urinary protein/Cr ratio was ≥...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-020-01852-5

    authors: Kajiwara N,Hayashi K,Fujiwara M,Nakayama H,Ozaki Y

    更新日期:2020-05-01 00:00:00

  • Anion gap predicts early mortality after starting hemodialysis in the elderly.

    abstract:BACKGROUND:Serum anion gap (AG) has recently been proven to represent a biomarker for predicting prognosis in patients with end-stage renal disease (ESRD). However, whether change in AG (ΔAG) at the time of starting hemodialysis predicts mortality after starting hemodialysis in elderly patients with ESRD remains unknow...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-019-01844-0

    authors: Arai Y,Tanaka H,Shioji S,Sakamoto E,Kondo I,Suzuki M,Katagiri D,Tada M,Hinoshita F

    更新日期:2020-05-01 00:00:00

  • Clinical outcomes after percutaneous coronary intervention in non-dialysis patients with acute coronary syndrome and advanced renal dysfunction.

    abstract:BACKGROUND:Data about the clinical outcomes of ACS patients with advanced renal dysfunction (estimated glomerular filtration rate < 30 mL/min/1.73 m2) following percutaneous coronary intervention (PCI) are limited. METHODS:We examined the data obtained from 194 ACS patients with non-dialysis advanced renal dysfunction...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s10157-019-01839-x

    authors: Uemura Y,Ishikawa S,Takemoto K,Negishi Y,Tanaka A,Takagi K,Yoshioka N,Umemoto N,Inoue Y,Morishima I,Shibata N,Asano H,Ishii H,Watarai M,Murohara T,N-registry investigators.

    更新日期:2020-04-01 00:00:00

  • Effect of renin-angiotensin system blockade on graft survival and cardiovascular disease in kidney transplant recipients: retrospective multicenter study in Japan.

    abstract:BACKGROUND:Renin-angiotensin system blockers (RASBs) reduce end-stage kidney disease and cardiovascular event (CVE) development in chronic kidney disease. However, whether RASBs improve long-term prognosis in kidney transplant (KT) recipients remain unknown. METHOD:We investigated 900 kidney transplant patients in a m...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s10157-019-01827-1

    authors: Tsuchimoto A,Masutani K,Ueki K,Nakagawa K,Matsukuma Y,Tanaka S,Unagami K,Kakuta Y,Okumi M,Noguchi H,Kaku K,Okabe Y,Nakano T,Kitazono T,Nakamura M,Ishida H,Tanabe K,Japan Academic Consortium of Kidney Transplantation (JA

    更新日期:2020-04-01 00:00:00

  • A clinical pharmacology study of the novel, selective urate reabsorption inhibitor dotinurad in outpatients.

    abstract:BACKGROUND:Dotinurad is a novel, selective urate reabsorption inhibitor (SURI), which reduces serum uric acid levels by selective inhibition of the urate transporter 1 (URAT1). The Japanese guideline for the management of hyperuricemia and gout recommends that drug selection should be based on classification of hyperur...

    journal_title:Clinical and experimental nephrology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1007/s10157-020-01857-0

    authors: Hosoya T,Furuno K,Kanda S

    更新日期:2020-03-01 00:00:00

  • Effects of mild and moderate renal dysfunction on pharmacokinetics, pharmacodynamics, and safety of dotinurad: a novel selective urate reabsorption inhibitor.

    abstract:BACKGROUND:Dotinurad, a novel selective urate reabsorption inhibitor, exerts a serum uric acid-lowering effect by selectively inhibiting urate transporter 1 (URAT1) in patients with hyperuricemia. It is generally known that the progression of renal dysfunction is associated with a reduction in the serum uric acid-lower...

    journal_title:Clinical and experimental nephrology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s10157-019-01825-3

    authors: Fukase H,Okui D,Sasaki T,Fushimi M,Ohashi T,Hosoya T

    更新日期:2020-03-01 00:00:00

  • Clinical efficacy and safety of dotinurad, a novel selective urate reabsorption inhibitor, in Japanese hyperuricemic patients with or without gout: randomized, multicenter, double-blind, placebo-controlled, parallel-group, confirmatory phase 2 study.

    abstract:BACKGROUND:Dotinurad, a novel selective urate reabsorption inhibitor (SURI), reduces serum uric acid levels by selectively inhibiting urate transporter 1 (URAT1) for the treatment of hyperuricemia with or without gout. We confirmed the serum uric acid lowering effect and safety of dotinurad. METHODS:This was a confirm...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1007/s10157-019-01818-2

    authors: Hosoya T,Sano T,Sasaki T,Fushimi M,Ohashi T

    更新日期:2020-03-01 00:00:00

  • The effect for hyperuricemia inpatient of uric acid overproduction type or in combination with topiroxostat on the pharmacokinetics, pharmacodynamics and safety of dotinurad, a selective urate reabsorption inhibitor.

    abstract:BACKGROUND:Dotinurad, a novel selective urate reabsorption inhibitor (SURI), increases urinary uric acid excretion. The aim of this study is to examine the pharmacokinetics, pharmacodynamics, and safety of dotinurad according to the type of hyperuricemia, with or without concomitant use of xanthine oxidase inhibitor, i...

    journal_title:Clinical and experimental nephrology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s10157-019-01817-3

    authors: Okui D,Sasaki T,Fushimi M,Ohashi T

    更新日期:2020-03-01 00:00:00

  • Dotinurad: a clinical pharmacokinetic study of a novel, selective urate reabsorption inhibitor in subjects with hepatic impairment.

    abstract:BACKGROUND:Dotinurad is a novel, selective urate reabsorption inhibitor, which reduces serum uric acid levels by inhibiting the urate transporter 1 (URAT1). We compared the pharmacokinetics (PK), pharmacodynamics (PD), and safety of dotinurad in subjects with hepatic impairment and normal hepatic function. METHODS:Thi...

    journal_title:Clinical and experimental nephrology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1007/s10157-019-01816-4

    authors: Kumagai Y,Sakaki M,Furihata K,Ito T,Inoue K,Yoshida T,Matsumoto S,Furuno K,Hagino A

    更新日期:2020-03-01 00:00:00

  • Clinical pharmacological study of dotinurad administered to male and female elderly or young subjects.

    abstract:BACKGROUND:Dotinurad is a novel selective urate reabsorption inhibitor (SURI) that selectively inhibits the reabsorption of uric acid in renal tubules and promotes the excretion of uric acid into urine. In this study, the effects of age and gender on the pharmacokinetics (PK), pharmacodynamics (PD), and safety of dotin...

    journal_title:Clinical and experimental nephrology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s10157-019-01836-0

    authors: Nakatani H,Fushimi M,Sasaki T,Okui D,Ohashi T

    更新日期:2020-03-01 00:00:00

  • Role of A20/TNFAIP3 deficiency in lupus nephritis in MRL/lpr mice.

    abstract:BACKGROUND:The activation of the nuclear factor-κB (NF-κB) signaling pathway gives rise to inflammation in the pathogenesis of lupus nephritis (LN), with A20 serving as a negative feedback regulator and ubiquitin C‑terminal hydrolase L1 (UCH-L1) acting as a downstream target protein. However, their roles in the mechani...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-019-01826-2

    authors: Sun L,Zou LX,Han YC,Zhu DD,Chen T,Wang J

    更新日期:2020-02-01 00:00:00

  • Association of depressive symptoms with 25(OH) vitamin D in hemodialysis patients and effect of gender.

    abstract:BACKGROUND:Depression is common in chronic kidney disease (CKD) patients and associated with significant increase in morbidity and mortality. In recent years, a relationship between vitamin D deficiency and depression has been shown. The aim of this study is to investigate the relationship between 25-hydroxy (OH) vitam...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-019-01794-7

    authors: Yavuz YC,Biyik Z,Ozkul D,Abusoglu S,Eryavuz D,Dag M,Korez MK,Guney I,Altintepe L

    更新日期:2020-01-01 00:00:00

  • Longitudinal change in blood pressure and risk of end-stage renal disease in a community-based cohort in Okinawa.

    abstract:BACKGROUND:The appropriate blood pressure target to prevent end-stage renal disease (ESRD) is controversial. METHODS:We examined the association between systolic blood pressure (SBP) changes and ESRD incidence in 69,575 participants from the Okinawa general population aged ≥ 20 years who underwent health check-ups in ...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-019-01771-0

    authors: Usui T,Iseki C,Iseki K,Kawakami K,Nangaku M

    更新日期:2019-11-01 00:00:00

  • Mutation analyses by next-generation sequencing and multiplex ligation-dependent probe amplification in Japanese autosomal dominant polycystic kidney disease patients.

    abstract:BACKGROUND:Autosomal dominant polycystic kidney disease (ADPKD), one of the most common hereditary kidney diseases, causes gradual growth of cysts in the kidneys, leading to renal failure. Owing to the advanced technology of next-generation sequencing (NGS), genetic analyses of the causative genes PKD1 and PKD2 have be...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-019-01736-3

    authors: Mochizuki T,Teraoka A,Akagawa H,Makabe S,Akihisa T,Sato M,Kataoka H,Mitobe M,Furukawa T,Tsuchiya K,Nitta K

    更新日期:2019-08-01 00:00:00

  • Genetic risk score raises the risk of incidence of chronic kidney disease in Korean general population-based cohort.

    abstract:BACKGROUND:Chronic kidney disease (CKD) is a common disease, affecting about 10% of the general population. The genetic component about CKD incidence in Asian population is not well known. The aim of the study is to find the genetic loci associated with incident CKD and to figure out the effect of genetic variation on ...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s10157-019-01731-8

    authors: Yun S,Han M,Kim HJ,Kim H,Kang E,Kim S,Ahn C,Oh KH

    更新日期:2019-08-01 00:00:00

  • High levels of stromal cell-derived factor-1α predict short-term progression of renal dysfunction in patients with coronary artery disease.

    abstract:BACKGROUND:Stromal cell-derived factor-1α (SDF-1α) is an inflammatory chemokine that plays a critical role in cardiovascular disease. Although persistent inflammation causes renal dysfunction, it remains unclear whether SDF-1α is related to progression of chronic kidney disease. This study examined whether high levels ...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-019-01722-9

    authors: Uematsu M,Nakamura T,Yoshizaki T,Watanabe Y,Deyama J,Watanabe K,Kobayashi T,Fujioka D,Saito Y,Nakamura K,Kawabata K,Obata JE,Kugiyama K

    更新日期:2019-07-01 00:00:00

  • Role of the putative PKC phosphorylation sites of the type IIc sodium-dependent phosphate transporter in parathyroid hormone regulation.

    abstract:BACKGROUND:Injection of parathyroid hormone (PTH) rapidly stimulates renal Pi excretion, in part by downregulating NaPi-IIa (Npt2a/SLC34A1) and NaPi-IIc (Npt2c/SLC34A3) transporters. The mechanisms underlying the effects of PTH on NaPi-IIc are not fully elucidated. METHODS:We analyzed the effect of PTH on inorganic ph...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-019-01725-6

    authors: Fujii T,Segawa H,Hanazaki A,Nishiguchi S,Minoshima S,Ohi A,Tominaga R,Sasaki S,Tanifuji K,Koike M,Arima Y,Shiozaki Y,Kaneko I,Ito M,Tatsumi S,Miyamoto KI

    更新日期:2019-07-01 00:00:00

  • Predictors of withdrawal from renal replacement therapy among patients with acute kidney injury requiring renal replacement therapy.

    abstract:BACKGROUND:Although recovery of renal function after an episode of acute kidney injury (AKI) is an important clinical measure of morbidity, predictors of withdrawal from renal replacement therapy (RRT) among AKI patients remain unclear. METHODS:In this single-center retrospective cohort study, we examined the clinical...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-019-01711-y

    authors: Ihara K,Ishigami J,Inoshita S

    更新日期:2019-06-01 00:00:00

  • Low-energy extracorporeal shock wave ameliorates ischemic acute kidney injury in rats.

    abstract:BACKGROUND:Low-energy extracorporeal shock wave (SW) improves ventricular function in ischemic cardiomyopathy through the upregulation of vascular endothelial growth factor (VEGF). VEGF is known to play important roles in acute kidney injury (AKI), and the present study investigates the efficacy of SW for AKI by renal ...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-019-01689-7

    authors: Yoshida M,Nakamichi T,Mori T,Ito K,Shimokawa H,Ito S

    更新日期:2019-05-01 00:00:00

  • Interleukin-33/ST2 signaling contributes to the severity of hemolytic uremic syndrome induced by enterohemorrhagic Escherichia coli.

    abstract:OBJECTIVES:Interleukin (IL)-33 plays an important role in host defense, immune regulation, and inflammation. This study assessed IL-33's role in the pathogenesis of severe hemolytic uremic syndrome (HUS) induced by enterohemorrhagic Escherichia coli (EHEC). We also investigated the clinical significance of IL-33 and so...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-018-1675-y

    authors: Yamada S,Shimizu M,Kuroda M,Inoue N,Sugimoto N,Yachie A

    更新日期:2019-04-01 00:00:00

  • JAK2/STAT3/BMP-2 axis and NF-κB pathway are involved in erythropoietin-induced calcification in rat vascular smooth muscle cells.

    abstract:BACKGROUND:Vascular calcification is common in chronic kidney disease (CKD) patients, while erythropoietin (EPO) is widely used in the treatment of renal anemia in CKD patients, whether there is a link between the two is still not clear. METHODS:The primary rat vascular smooth muscle cells (VSMCs) and CKD rats were tr...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-018-1666-z

    authors: He J,Zhong X,Zhao L,Gan H

    更新日期:2019-04-01 00:00:00

  • Metabolitic profiling of amino acids in paraquat-induced acute kidney injury.

    abstract:BACKGROUND:The herbicide paraquat (1, 1'-dimethyl-4, 4'-bipyridylium dichloride; PQ) is a poison well-known to cause delayed mortality due to acute kidney injuries (AKI). This study examines the changes in serum amino acids (AAs) metabolite profiles as surrogate markers of renal cell metabolism and function after paraq...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-019-01702-z

    authors: Wan X,Li X,Wang Q,Zheng B,Zhou C,Kang X,Hu D,Bao H,Peng A

    更新日期:2019-04-01 00:00:00

  • Biological variation of procalcitonin levels in hemodialysis patients.

    abstract:BACKGROUND:There is no obvious evidence regarding biological variation of procalcitonin (PCT) levels in hemodialysis (HD) patients without infections. The aim of this study was to determine the within- and between-person biological variation of PCT levels in HD patients without infections. METHODS:A multicenter, prosp...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s10157-018-1639-2

    authors: Kubo S,Iwasaki M,Horie M,Matsukane A,Hayashi T,Tanaka Y,Hase H,Joki N

    更新日期:2019-03-01 00:00:00

  • Positive effects of single-daily high-dose mizoribine therapy after cyclophosphamide in young children with steroid-dependent nephrotic syndrome.

    abstract:BACKGROUND:Mizoribine (MZR) therapy after cyclophosphamide (CPM) therapy may be an attractive option in patients with steroid-dependent nephrotic syndrome (SDNS) for the purpose of maintaining remission. This is because CPM is administered only once due to its severe side effects such as gonadal toxicity. However, the ...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-018-1628-5

    authors: Mizutani A,Fujinaga S,Sakuraya K,Hirano D,Shimizu T

    更新日期:2019-02-01 00:00:00

  • Safety and effectiveness of eculizumab for pediatric patients with atypical hemolytic-uremic syndrome in Japan: interim analysis of post-marketing surveillance.

    abstract:BACKGROUND:In 2013, eculizumab was approved for treatment of the atypical hemolytic-uremic syndrome (aHUS) in Japan, which was defined as a thrombotic microangiopathy (TMA) excluding Shiga toxin-producing Escherichia coli-HUS and thrombotic thrombocytopenic purpura. Simultaneously, post-marketing surveillance was start...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-018-1610-2

    authors: Ito S,Hidaka Y,Inoue N,Kaname S,Kato H,Matsumoto M,Miyakawa Y,Mizuno M,Okada H,Shimono A,Matsuda T,Maruyama S,Fujimura Y,Nangaku M,Kagami S

    更新日期:2019-01-01 00:00:00

  • Defective renal autoregulation in the chronic bile duct ligation model of liver failure.

    abstract:BACKGROUND:Cirrhosis of the liver is often associated with an impairment of renal function that is usually not associated with consistent structural abnormalities of the renal parenchyma, but is thought to be the functional consequence of arterial underfilling and reduced arterial blood pressure. METHOD:We have used t...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-018-1551-9

    authors: Maoka T,Kawata T,Koike T,Mochizuki T,Schnermann J,Hashimoto S

    更新日期:2018-10-01 00:00:00

  • pH after the first session of direct hemoperfusion with polymyxin B-immobilized fibers predicts mortality in patients with sepsis and septic shock.

    abstract:BACKGROUND:The definition of sepsis was updated to sepsis-3 in February 2016. Currently, direct hemoperfusion therapy using the polymyxin B-immobilized fiber cartridge (PMX-DHP) is widely performed to treat sepsis and septic shock. However, the prognostic factors of PMX-DHPs in patients with sepsis using the new defini...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-018-1548-4

    authors: Okubo A,Nakashima A,Doi S,Ueno T,Sasaki K,Esaki T,Masaki T

    更新日期:2018-10-01 00:00:00

  • Pre-operative and post-operative estimated glomerular filtration rate in Japanese patients with urological malignancies.

    abstract:BACKGROUND:The suitable methods evaluating glomerular filtration rate (GFR) have not been established in patients undergoing radical nephrectomy (RN) or radical nephroureterectomy (RNU) due to urological malignancies in Japan as well as worldwide. METHODS:We examined the relationship between creatinine clearance-based...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-017-1509-3

    authors: Niwa N,Yoshida T,Mizuno R,Kikuchi E,Miyajima A,Hayashi M,Oya M

    更新日期:2018-10-01 00:00:00

  • The size of the renal artery orifice contributes to laterality of acute renal infarction.

    abstract:BACKGROUND:Acute renal infarction (ARI) is a rare disease with atrial fibrillation being its main cause. The possible laterality of ARI is controversial. This study aimed to evaluate the association between anatomical features of the renal arteries and ARI. METHODS:This was a single-center cross-sectional study that e...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-018-1566-2

    authors: Kagaya S,Ojima Y,Aoki S,Sato H,Nagasawa T

    更新日期:2018-10-01 00:00:00

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