Abstract:
BACKGROUND:Edaravone, a drug for treating acute ischemic stroke, has been reported to provoke acute renal disorders. In the previous study, the author evaluated the role of edaravone in the development of renal disorders in 207 patients reported as having developed them in the post-marketing survey of the drug. The overall recovery rate of renal function in the survey was 43%. Risk factors that affect the recovery rate of renal function and mortality remain to be clarified. METHODS:The recovery rate of renal function and mortality rate were examined according to the extent of edaravone involvement in renal disorder onset, which was defined by the concurrence of other risk factors for renal disorders, in previously reported 207 patients. Risk factors for the nonrecovery of renal function and death were determined by using a stepwise logistic regression analysis. RESULTS:The recovery rate of renal function was low and mortality rate was high in the group where the above extent of edaravone involvement was slight. The above analysis showed that risk factors for the nonrecovery of renal function were the complication of severe infection and the implementation of blood purification, and that risk factors for death were advanced age (> or =80 years) and the complication of severe infection. CONCLUSIONS:The nonrecovery rate of renal function and mortality rate were high in the cases of patients that were complicated with factors that affected renal function other than edaravone. The complication of severe infection was a risk factor for the nonrecovery of renal function and for death.
journal_name
Clin Exp Nephroljournal_title
Clinical and experimental nephrologyauthors
Hishida Adoi
10.1007/s10157-008-0108-8subject
Has Abstractpub_date
2009-04-01 00:00:00pages
118-122issue
2eissn
1342-1751issn
1437-7799pii
10.1007/s10157-008-0108-8journal_volume
13pub_type
杂志文章abstract:BACKGROUND:Accurate glomerular filtration rate (GFR) evaluation is significant for drug dosing of carboplatin, anticancer drug excreted mainly from kidney. Serum cystatin-C (sCys-C) is a GFR marker with little affected by body muscle mass volume. And GFR equations based on serum creatinine (eGFRcreat) and sCys-C (eGFRc...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-015-1115-1
更新日期:2015-12-01 00:00:00
abstract::The manifestation of diabetic nephropathy may be a consequence of the actions of certain cytokines and growth factors. Prominent among them is transforming growth factor-β (TGF-β), which promotes renal cell hypertrophy and stimulates extracellular matrix accumulation, the two hallmarks of diabetic renal disease. In ex...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s101570200021
更新日期:2002-09-01 00:00:00
abstract:BACKGROUND:Mizoribine (MZR) therapy after cyclophosphamide (CPM) therapy may be an attractive option in patients with steroid-dependent nephrotic syndrome (SDNS) for the purpose of maintaining remission. This is because CPM is administered only once due to its severe side effects such as gonadal toxicity. However, the ...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-018-1628-5
更新日期:2019-02-01 00:00:00
abstract::A 52-year-old Japanese female was admitted to our hospital for microhematuria, proteinuria and progressive renal dysfunction. Two years prior to admission, she was diagnosed with lung adenocarcinoma and multiple bone and brain metastases, and was treated with gefitinib (250 mg/day). Treatment for 6 months induced part...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-008-0066-1
更新日期:2008-10-01 00:00:00
abstract::Lipoprotein glomerulopathy (LPG) is a rare hereditary disease characterized by the accumulation of much thrombi material consisting of lipoproteins at the glomerular capillary lumen. Most patients show nephrotic syndrome; nearly half progress to chronic renal failure. Intensive therapy with lipid-lowering agents repor...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-009-0207-1
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND:Genetic susceptibility to atypical hemolytic uremic syndrome (aHUS) may lie within genes regulating or activating the alternate complement and related pathways converging on endothelial cell activation. METHODS:We tested 32 Indian patients of aHUS negative for antibodies to complement factor H for genetic v...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-017-1478-6
更新日期:2018-06-01 00:00:00
abstract::Distal renal tubular acidosis (dRTA) results from impaired urinary acidification by the renal collecting duct. Acquired dRTA can be secondary to diverse pathological processes, including diabetic, ischemic, fibrosing, or immunological processes; less frequently it presents as a familial disorder with either an autosom...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章,评审
doi:10.1007/s10157-003-0271-x
更新日期:2004-03-01 00:00:00
abstract:BACKGROUND:Chronic kidney disease (CKD) is a significant public health problem. Strategy for its early detection is still controversial. This study aims to assess the cost-effectiveness of population strategy, i.e. mass screening, and Japan's health checkup reform. METHODS:Cost-effectiveness analysis was carried out t...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-011-0567-1
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND:Depending on the etiology and pathophysiology of hematuria, urinary bleeding is classified as glomerular hematuria or nonglomerular hematuria. Nephritis is usually detected by the presence of proteinuria, especially elevated albumin excretion. In this study, we report on the use of the urinary albumin-to-tot...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-006-0451-6
更新日期:2007-03-01 00:00:00
abstract:BACKGROUND:Guidelines for treatment of hypertension are not available for chronic hemodialysis (HD) population, despite the high mortality rate due to cardiovascular disease (CVD). Survival is much better among hypertensive patients than normal to hypotensive patients. Target levels of blood pressure and the class of a...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s10157-008-0116-8
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:The number of elderly dialysis patients in Japan is dramatically increasing. Receiving therapy with better satisfaction through home care is one of the important factors in their daily lives. Thus, the quality of life of elderly patients on hemodialysis (HD) or peritoneal dialysis (PD) was evaluated. METHOD...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-016-1374-5
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:IgG4-related disease has attracted wide attention recently. It is characterized by a high level of serum IgG4 and dense infiltration of IgG4-positive plasma cells into multiple organs, with the kidney being one representative target. Although several sets of diagnostic criteria for autoimmune pancreatitis (A...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-011-0521-2
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND:Dotinurad is a novel, selective urate reabsorption inhibitor, which reduces serum uric acid levels by inhibiting the urate transporter 1 (URAT1). We compared the pharmacokinetics (PK), pharmacodynamics (PD), and safety of dotinurad in subjects with hepatic impairment and normal hepatic function. METHODS:Thi...
journal_title:Clinical and experimental nephrology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1007/s10157-019-01816-4
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND:It has been recently reported that peroxisome proliferator-activated receptors (PPARs)gamma exist in various tissues and that they exibit anti-inflammatory effects. METHODS:We investigated the effects of PPARgamma activators on the development of crescentic glomerulonephritis. Crescentic glomerulonephritis ...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s101570300003
更新日期:2003-03-01 00:00:00
abstract::Both thin basement membrane nephropathy (TBMN) and autosomal dominant Alport syndrome (ADAS) are types of hereditary nephritis resulting from heterozygous mutations in COL4A3 or COL4A4 genes. Although TBMN is characterized by hematuria and thinning of the glomerular basement membrane (GBM) with excellent renal prognos...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章,评审
doi:10.1007/s10157-020-01880-1
更新日期:2020-08-01 00:00:00
abstract::Lecithin:cholesterol acyltransferase (LCAT) is a key enzyme involved in reverse cholesterol transport from the peripheral tissues to the liver. LCAT deficiency, in which this enzyme is congenitally absent, is a genetic disease that impairs the esterification of free cholesterol in the plasma, leading to accumulation o...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章,评审
doi:10.1007/s10157-013-0895-4
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:Previous studies reported that children with neural tube defects, but without any history of intrinsic renal diseases, have small kidneys when compared with age-matched standard renal growth. The aim of this study was to investigate the possible causes of small renal size in children with spina bifida by com...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-013-0802-z
更新日期:2014-02-01 00:00:00
abstract::Posterior reversible encephalopathy syndrome (PRES) is a rare complication of nephrotic syndrome and corticosteroid therapy. Here, we discuss an 18 year old man with type 1 membranoproliferative glomerulonephritis (MPGN) secondary to hepatitis B infection who developed posterior leukoencephalopathy while on therapy wi...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-010-0331-y
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND:Intravascular administration of iodinated contrast media continues to be a common cause of hospital-acquired acute kidney injury. Accumulating evidence suggests that radiocontrast agent-induced nephrotoxicity is associated with increased oxidative stress, which leads to renal tissue damage with DNA fragmenta...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-013-0774-z
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:Contrast media (CM)-induced nephropathy (CIN) is an acute deterioration of renal function following administration of CM mediated to a large extent by the increased production of ROS within the kidney. Aim of this study was to evaluate whether a novel isoform of a recombinant Manganese SOD (rMnSOD) could pro...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-013-0828-2
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND:The appropriate blood pressure target to prevent end-stage renal disease (ESRD) is controversial. METHODS:We examined the association between systolic blood pressure (SBP) changes and ESRD incidence in 69,575 participants from the Okinawa general population aged ≥ 20 years who underwent health check-ups in ...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-019-01771-0
更新日期:2019-11-01 00:00:00
abstract:BACKGROUND:Liposomal amphotericin B (L-AMB), a broad-spectrum antifungicidal drug, is often used to treat fungal infections. However, clinical evidence of its use in patients with renal dysfunction, especially those receiving renal replacement therapy (RRT), is limited. Therefore, we evaluated the usage and occurrence ...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-020-01989-3
更新日期:2020-11-11 00:00:00
abstract::We report a 58-year-old Japanese man with primary systemic AL amyloidosis who achieved disappearance of proteinuria including Bence-Jones protein (lambda-type) after two courses of VAD therapy (vincristine, doxorubicin, and dexamethasone) and subsequent high-dose melphalan, followed by autologous peripheral blood stem...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-009-0198-y
更新日期:2009-10-01 00:00:00
abstract:BACKGROUND:Peritoneal dialysis (PD) exchange procedure is complex. Patients with cognitive impairment (CI) may require assistance. We studied the prevalence of CI among PD patients, its impact on PD-related peritonitis and the outcome of assisted PD. METHODS:Cantonese version of Mini-Mental State examination (CMMSE) w...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-015-1127-x
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:In the tubular cells of patients with polycystic kidney disease (PKD), a reduced intracellular Ca(2+) level accelerates cell proliferation, resulting in cyst formation. Thus, whether calcium channel blockers (CCB) are useful for the treatment of hypertension in patients with PKD is questionable. METHODS:Thi...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-010-0329-5
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND:The definition of sepsis was updated to sepsis-3 in February 2016. Currently, direct hemoperfusion therapy using the polymyxin B-immobilized fiber cartridge (PMX-DHP) is widely performed to treat sepsis and septic shock. However, the prognostic factors of PMX-DHPs in patients with sepsis using the new defini...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-018-1548-4
更新日期:2018-10-01 00:00:00
abstract::A case of nephrotic syndrome (NS) and acute renal failure (ARF) associated with embryonal rhabdomyosarcoma (RMS) in a 10-year-old boy is reported. Ultrasound revealed irregular, echogenic, circumferential urinary bladder base mass, bilateral hydroureter and hydronephrosis. Histopathology of percutaneous renal and uret...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-007-0015-4
更新日期:2008-04-01 00:00:00
abstract:BACKGROUND:We previously reported a significant increase in plasma TGF-beta1 in patients with chronic renal failure (CRF). Progression of CRF may be caused by persistent renal production of TGF-beta1. In CRF rat models, an oral carbonic absorbent (AST-120) reduces the expression of the TGF-beta1 gene in the kidney, and...
journal_title:Clinical and experimental nephrology
pub_type: 临床试验,杂志文章
doi:10.1007/s10157-006-0441-8
更新日期:2006-12-01 00:00:00
abstract::We describe here two sisters with nephronophthisis, which was not detected until the development of endstage renal failure. Twenty- and 15-year-old female siblings were admitted to our hospital for further examination of renal dysfunction. No urinalysis abnormalities had been found in yearly health checks in either pa...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-005-0377-4
更新日期:2005-12-01 00:00:00
abstract:BACKGROUND:The Japanese classification of diabetic nephropathy reflects the risks of mortality, cardiovascular events and kidney prognosis and is clinically useful. Furthermore, pathological findings of diabetic nephropathy are useful for predicting prognoses. In this study, we evaluated the characteristics of patholog...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章,多中心研究
doi:10.1007/s10157-017-1485-7
更新日期:2018-06-01 00:00:00