Abstract:
BACKGROUND:Mizoribine (MZR) therapy after cyclophosphamide (CPM) therapy may be an attractive option in patients with steroid-dependent nephrotic syndrome (SDNS) for the purpose of maintaining remission. This is because CPM is administered only once due to its severe side effects such as gonadal toxicity. However, the long-term prognosis after the treatment regimen remains unknown. METHODS:We retrospectively analyzed the clinical course (median follow-up, 5.9 years) of 54 young children with SDNS (43 boys; age < 10 years) who had undergone 12-week CPM therapy. The patients were classified into two groups: group A, undergoing MZR therapy for > 12 months for maintaining remission after CPM therapy (N = 36), and group B, undergoing CPM monotherapy (N = 18). RESULTS:For 2 years after CPM therapy, 21 of the 36 group A patients were in sustained remission, whereas only 4 of the 18 group B patients had maintained remission (58% vs. 22%, p < 0.05). Furthermore, the rate of regression to SDNS after CPM was significantly lower in group A than in group B (6% vs. 39%, p < 0.05). At the last follow-up (mean age, 10.9 years), 27 of the 36 group A patients (75%) had not received any steroid-sparing agent after the treatment regimen. CONCLUSIONS:Single daily high-dose MZR therapy after CPM therapy may have positive outcomes in young children with SDNS in the long term.
journal_name
Clin Exp Nephroljournal_title
Clinical and experimental nephrologyauthors
Mizutani A,Fujinaga S,Sakuraya K,Hirano D,Shimizu Tdoi
10.1007/s10157-018-1628-5subject
Has Abstractpub_date
2019-02-01 00:00:00pages
244-250issue
2eissn
1342-1751issn
1437-7799pii
10.1007/s10157-018-1628-5journal_volume
23pub_type
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