Health-related quality of life and prognosis in patients with chronic kidney disease: a 3-year follow-up study.

abstract：BACKGROUND:The renoprotection achieved by angiotensin II blockade in the treatment of diabetic nephropathy is well established in both the clinical and the experimental settings. In contrast, the therapeutic efficacy of calcium channel blockers (CCBs) in the treatment of diabetic nephropathy still remains controversial...

journal_title：Clinical and experimental nephrology

authors： Moriyama T,Oka K,Ueda H,Imai E

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND:Sirt1, a mammalian homolog of silent information regulator 2 (Sir2), is the founding member of class III histone deacetylase (HDAC). METHODS:In this study, we examined whether Sirt1 is involved in the modification of acetylated histone H3, acetylated p53 and Werner syndrome protein (WRN), which is stabilize...

journal_title：Clinical and experimental nephrology

authors： Sakao Y,Kato A,Tsuji T,Yasuda H,Togawa A,Fujigaki Y,Kahyo T,Setou M,Hishida A

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:Acute renal infarction (ARI) is a rare disease. ARI causes decline in renal function in both the acute and chronic phases. However, the correlation between the volume of the infarction and degree of renal function decline has not been fully investigated. Therefore, we aimed to examine the relationship betwee...

journal_title：Clinical and experimental nephrology

authors： Kagaya S,Yoshie O,Fukami H,Sato H,Saito A,Takeuchi Y,Matsuda K,Nagasawa T

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Proteinuria caused by glomerular disease is characterized by podocyte injury. Vasopressin V2 receptor antagonists are effective in reducing albuminuria, although their actions on glomerular podocytes have not been explored. The objective of this study was to evaluate the effects of tolvaptan, a selective ora...

journal_title：Clinical and experimental nephrology

authors： Okada T,Sakaguchi T,Hatamura I,Saji F,Negi S,Otani H,Muragaki Y,Kawachi H,Shigematsu T

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:In 2013, eculizumab was approved for treatment of the atypical hemolytic-uremic syndrome (aHUS) in Japan, which was defined as a thrombotic microangiopathy (TMA) excluding Shiga toxin-producing Escherichia coli-HUS and thrombotic thrombocytopenic purpura. Simultaneously, post-marketing surveillance was start...

journal_title：Clinical and experimental nephrology

authors： Ito S,Hidaka Y,Inoue N,Kaname S,Kato H,Matsumoto M,Miyakawa Y,Mizuno M,Okada H,Shimono A,Matsuda T,Maruyama S,Fujimura Y,Nangaku M,Kagami S

更新日期：2019-01-01 00:00:00

abstract：:We report a 58-year-old Japanese man with primary systemic AL amyloidosis who achieved disappearance of proteinuria including Bence-Jones protein (lambda-type) after two courses of VAD therapy (vincristine, doxorubicin, and dexamethasone) and subsequent high-dose melphalan, followed by autologous peripheral blood stem...

journal_title：Clinical and experimental nephrology

authors： Yamazaki O,Ubara Y,Suwabe T,Nakanishi S,Hoshino J,Sawa N,Hayami N,Yamanouchi M,Takemoto F,Kenmei T,Masuoka K,Oohashi K

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:Hyperuricemia is an established risk factor for cardiovascular events and mortality. This study investigated the association between serum uric acid and the incidence of nonfatal stroke in a Japanese community-based population. METHODS:We used a nationwide database of 155,322 subjects (aged 40-73, male 39 %...

journal_title：Clinical and experimental nephrology

authors： Kamei K,Konta T,Hirayama A,Ichikawa K,Kubota I,Fujimoto S,Iseki K,Moriyama T,Yamagata K,Tsuruya K,Narita I,Kondo M,Shibagaki Y,Kasahara M,Asahi K,Watanabe T

更新日期：2017-06-01 00:00:00

abstract：:We report a 17-year-old male patient with tubulointerstitial nephritis and uveitis (TINU) associated with hyperthyroidism. He presented with a 2-month history of fatigue, loss of appetite, low-grade fever, and a 12-kg weight loss when he was admitted to our hospital. He had iritis, which was complicated by fibrin in t...

journal_title：Clinical and experimental nephrology

authors： Ebihara I,Hirayama K,Usui J,Seki M,Higuchi F,Oteki T,Kobayashi M,Yamagata K

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:Mizoribine (MZR) therapy after cyclophosphamide (CPM) therapy may be an attractive option in patients with steroid-dependent nephrotic syndrome (SDNS) for the purpose of maintaining remission. This is because CPM is administered only once due to its severe side effects such as gonadal toxicity. However, the ...

journal_title：Clinical and experimental nephrology

authors： Mizutani A,Fujinaga S,Sakuraya K,Hirano D,Shimizu T

更新日期：2019-02-01 00:00:00

abstract：:We describe here two sisters with nephronophthisis, which was not detected until the development of endstage renal failure. Twenty- and 15-year-old female siblings were admitted to our hospital for further examination of renal dysfunction. No urinalysis abnormalities had been found in yearly health checks in either pa...

journal_title：Clinical and experimental nephrology

authors： Ashizawa M,Miyazaki M,Furusu A,Abe K,Kanamoto Y,Iwanaga N,Ozono Y,Harada T,Taguchi T,Kohno S

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:Several comorbidity scoring systems have been developed and validated, mostly in western hemodialysis patients with a high risk of cardiovascular disease. The performance of comorbidity scoring, however, depends on the patient population. In this study, we determine the optimal comorbidity scoring system for...

journal_title：Clinical and experimental nephrology

authors： Ma TK,Chow KM,Kwan BC,Ng JK,Pang WF,Leung CB,Li PK,Szeto CC

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Hematuria is the first manifestation of urinary abnormality in immunoglobulin A nephropathy (IgAN). Hematuria has recently been reported as a risk factor for deterioration of renal function; however, its cause remains unknown. METHODS:We analyzed the surface marker of peripheral blood mononuclear cells befo...

journal_title：Clinical and experimental nephrology

authors： Iwatani H,Nagasawa Y,Yamamoto R,Iio K,Mizui M,Horii A,Kitahara T,Inohara H,Kumanogoh A,Imai E,Rakugi H,Isaka Y

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Accurate glomerular filtration rate (GFR) evaluation is significant for drug dosing of carboplatin, anticancer drug excreted mainly from kidney. Serum cystatin-C (sCys-C) is a GFR marker with little affected by body muscle mass volume. And GFR equations based on serum creatinine (eGFRcreat) and sCys-C (eGFRc...

journal_title：Clinical and experimental nephrology

authors： Shibata K,Yasuda Y,Kobayashi R,Ando Y,Shimokata T,Kamiya H,Hayashi M,Maruyama S,Matsuo S,Nakao M,Tsuchiya T,Teramachi H

更新日期：2015-12-01 00:00:00

abstract：OBJECTIVES:Interleukin (IL)-33 plays an important role in host defense, immune regulation, and inflammation. This study assessed IL-33's role in the pathogenesis of severe hemolytic uremic syndrome (HUS) induced by enterohemorrhagic Escherichia coli (EHEC). We also investigated the clinical significance of IL-33 and so...

journal_title：Clinical and experimental nephrology

authors： Yamada S,Shimizu M,Kuroda M,Inoue N,Sugimoto N,Yachie A

更新日期：2019-04-01 00:00:00

abstract：:Recent studies on dendritic cells (DCs) and macrophages have greatly advanced our knowledge of glomerular immunopathology. This rapidly developing field most likely has considerable impact on our understanding of the major mediators of tissue injury and repair in kidney disease. The pivotal role of cytokine in the ini...

journal_title：Clinical and experimental nephrology

authors： Matsumoto K,Fukuda N,Abe M,Fujita T

更新日期：2010-02-01 00:00:00

abstract：:We report a case of acute kidney injury (AKI) caused by a novel direct renin inhibitor, aliskiren. A 43-year-old Japanese man with dilated cardiomyopathy on cardiac resynchronization therapy with defibrillator and chronic kidney disease (CKD) was started on aliskiren in addition to enalapril, carvedilol, furosemide, a...

journal_title：Clinical and experimental nephrology

authors： Yamauchi J,Shibagaki Y,Uehara K,Yasuda T,Kimura K

更新日期：2012-04-01 00:00:00

abstract：:We present a case of proliferative glomerulonephritis with peculiar IgM deposition associated with sarcoidosis. A 62-year-old woman, who had been diagnosed with sarcoidosis 3 years previously because of abnormalities on chest X-ray radiophotographs and lymph node pathology, was admitted to our hospital for the evaluat...

journal_title：Clinical and experimental nephrology

authors： Kanamori H,Ota M,Takeoka H,Osafune K,Yonezu S,Fukatsu A,Kanatsu K

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:Injection of parathyroid hormone (PTH) rapidly stimulates renal Pi excretion, in part by downregulating NaPi-IIa (Npt2a/SLC34A1) and NaPi-IIc (Npt2c/SLC34A3) transporters. The mechanisms underlying the effects of PTH on NaPi-IIc are not fully elucidated. METHODS:We analyzed the effect of PTH on inorganic ph...

journal_title：Clinical and experimental nephrology

authors： Fujii T,Segawa H,Hanazaki A,Nishiguchi S,Minoshima S,Ohi A,Tominaga R,Sasaki S,Tanifuji K,Koike M,Arima Y,Shiozaki Y,Kaneko I,Ito M,Tatsumi S,Miyamoto KI

更新日期：2019-07-01 00:00:00

abstract：:Chronic kidney disease (CKD), as defined by reduced glomerular filtration rate (<60 ml/min/1.73 m(2)) and/or the presence of renal damage for >3 months, is a significant threat for public health in modern societies. Recent epidemiological studies have demonstrated that CKD is a significant risk for cardiovascular even...

journal_title：Clinical and experimental nephrology

authors： Ito S

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:Aquaporin-2 (AQP2) is a key water channel protein which determines the water permeability of the collecting duct. Multiple phosphorylation sites are present at the C-terminal of AQP2 including S256 (serine at 256 residue), S261, S264 and S/T269, which are regulated by vasopressin (VP) to modulate AQP2 traffi...

journal_title：Clinical and experimental nephrology

authors： Sakai M,Yamamoto K,Mizumura H,Matsumoto T,Tanaka Y,Noda Y,Ishibashi K,Yamamoto T,Sasaki S

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA)-associated vasculitis frequently induces crescentic glomerulonephritis. However, a few cases have so far been reported to have only tubulointerstitial (TI) nephritis without any apparent glomerular lesions. We recently treated three similar cases...

journal_title：Clinical and experimental nephrology

authors： Nakabayashi K,Sumiishi A,Sano K,Fujioka Y,Yamada A,Karube M,Koji H,Arimura Y,Nagasawa T

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:Renal inulin clearance is the gold standard for glomerular filtration rate (GFR), but is compromised by problems of collecting urine samples in children, especially those <6 years of age or with a bladder dysfunction. Therefore, we should utilize the serum creatinine (Cr)-based estimated GFR (eGFR), measurin...

journal_title：Clinical and experimental nephrology

authors： Nagai T,Uemura O,Ishikura K,Ito S,Hataya H,Gotoh Y,Fujita N,Akioka Y,Kaneko T,Honda M

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:The aim of this study was to evaluate the renal preservation effect of ubiquinol, the reduced form of coenzyme Q10 (CoQ10). METHODS:Three-week-old heminephrectomized male Sprague-Dawley rats were divided into three groups (10 animals each): diet with normal (0.3%) salt, high (8%) salt, and high salt plus 60...

journal_title：Clinical and experimental nephrology

authors： Ishikawa A,Kawarazaki H,Ando K,Fujita M,Fujita T,Homma Y

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:Although several studies have investigated the relationship between dietary nutrient intake and microalbuminuria, no study of an Asian population has been reported. The present study investigates the relationship between dietary intake and microalbuminuria in a general Japanese population. METHODS:We analyz...

journal_title：Clinical and experimental nephrology

authors： Sato M,Hozawa A,Konta T,Shao L,Otani K,Narimatsu H,Sasaki S,Kato T,Kubota I,Yamashita H,Kayama T,Fukao A

更新日期：2012-02-01 00:00:00

abstract：:Recently, there has been a paradigm shift away from an emphasis on the role of the endocrine (circulating) renin-angiotensin system (RAS) in the regulation of the sodium and extracellular fluid balance, blood pressure, and the pathophysiology of hypertensive organ damage toward a focus on the role of tissue RAS found ...

journal_title：Clinical and experimental nephrology

authors： Kagami S

更新日期：2012-04-01 00:00:00

abstract：:C1q nephropathy, first proposed by Jennette and Hipp [Am J Clin Pathol 83:415-420, 1985; Am J Kidney Dis 6:103-110, 1985], was described as a distinct glomerular disease entity characterized by extensive mesangial deposition of C1q, with associated mesangial immune complexes, and the absence of any clinical and labora...

journal_title：Clinical and experimental nephrology

authors： Mii A,Shimizu A,Masuda Y,Fujita E,Aki K,Ishizaki M,Sato S,Griesemer A,Fukuda Y

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND:Little is known concerning the risk of hospitalization and the risk of death before receiving dialysis by the stage of chronic kidney disease (CKD) in Japan. METHODS:The subjects comprised a total of 13,911 Japanese men (mean age 49.2 ± 9.9 years). Based on the results of a health checkup performed in 2006,...

journal_title：Clinical and experimental nephrology

authors： Nishikawa K,Takahashi K,Yamada R,Kinaga T,Masato M,Yamamoto M

更新日期：2017-04-01 00:00:00

abstract：:Heavy chain deposition disease (HCDD) is one of three entities of monoclonal immunoglobulin deposition disease, characterized histopathologically by the presence of nodular glomerulosclerosis and glomerular and tubular deposition of monoclonal heavy chains without associated light chains. Although HCDD is an extremely...

journal_title：Clinical and experimental nephrology

authors： Oe Y,Soma J,Sato H,Ito S

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND/AIMS:Vascular access dysfunction caused by stenosis is a major complication for hemodialysis (HD) patients. However, physiopathology of late arteriovenous fistula (AVF) stenosis is still under investigation. The aim of the present study was to evaluate the association between plasma soluble EPCR (sEPCR) with...

journal_title：Clinical and experimental nephrology

authors： Bilgic MA,Yilmaz H,Bozkurt A,Celik HT,Bilgic IC,Gurel OM,Kirbas I,Bavbek N,Akcay A

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:Recent studies have suggested that assessments of serum antibodies against M-type phospholipase A2 receptor (PLA2R) and the glomerular expression of PLA2R antigen in biopsy specimens are useful for the diagnosis of primary membranous nephropathy (MN). In this study, we assessed both of them and investigated ...

journal_title：Clinical and experimental nephrology

authors： Hayashi N,Akiyama S,Okuyama H,Matsui Y,Adachi H,Yamaya H,Maruyama S,Imai E,Matsuo S,Yokoyama H

更新日期：2015-10-01 00:00:00