Abstract:
:We report a case of acute kidney injury (AKI) caused by a novel direct renin inhibitor, aliskiren. A 43-year-old Japanese man with dilated cardiomyopathy on cardiac resynchronization therapy with defibrillator and chronic kidney disease (CKD) was started on aliskiren in addition to enalapril, carvedilol, furosemide, and spironolactone for worsening cardiac function suggested by the elevation of serum brain natriuretic peptide. After 1 month, he noticed general malaise, loss of appetite and his serum creatinine level increased from 2.0 to 7.24 mg/dL. He had no evidence of exacerbation of hemodynamic instability (heart failure or hypotension) or post-renal cause of AKI. Although a cessation of aliskiren did not ameliorate AKI, renal function returned to baseline after withholding enalapril. Careful monitoring is necessary when aliskiren is used in patients with CKD and/or significant systolic dysfunction since it can cause normotensive ischemic AKI, especially when there is a concomitant use of other renin-angiotensin-aldosterone system inhibitors.
journal_name
Clin Exp Nephroljournal_title
Clinical and experimental nephrologyauthors
Yamauchi J,Shibagaki Y,Uehara K,Yasuda T,Kimura Kdoi
10.1007/s10157-011-0566-2subject
Has Abstractpub_date
2012-04-01 00:00:00pages
333-6issue
2eissn
1342-1751issn
1437-7799journal_volume
16pub_type
杂志文章abstract:BACKGROUND:Dotinurad, a novel selective urate reabsorption inhibitor (SURI), increases urinary uric acid excretion. The aim of this study is to examine the pharmacokinetics, pharmacodynamics, and safety of dotinurad according to the type of hyperuricemia, with or without concomitant use of xanthine oxidase inhibitor, i...
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,多中心研究,随机对照试验
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