Abstract:
BACKGROUND:Previous studies reported that children with neural tube defects, but without any history of intrinsic renal diseases, have small kidneys when compared with age-matched standard renal growth. The aim of this study was to investigate the possible causes of small renal size in children with spina bifida by comparing growth hormone deficiency, physical limitations and hyperhomocysteinemia. METHODS:The sample included 187 newborns with spina bifida. Renal sizes in the patients were assessed by using maximum measurement of renal length and the measurements were compared by using the Sutherland monogram. According to the results, the sample was divided into two groups--a group of 120 patients with small kidneys (under the third percentile) and a control group of 67 newborns with normal kidney size. Plasma total homocysteine was investigated in mothers and in their children. Serum insulin-like growth factor-1 (IGF-1) levels were measured. RESULTS:Serum IGF-1 levels were normal in both groups. Children and mothers with homocysteine levels >10 μmol/l were more than twice as likely to have small kidneys and to give to birth children with small kidneys, respectively, compared with newborns and mothers with homocysteine levels <10 μmol/l. An inverse correlation was also found between the homocysteine levels of mothers and kidney sizes of children (r = - 0.6109 P ≤ 0.01). CONCLUSIONS:It is highly important for mothers with hyperhomocysteinemia to be educated about benefits of folate supplementation in order to reduce the risk of small renal size and lower renal function in children.
journal_name
Clin Exp Nephroljournal_title
Clinical and experimental nephrologyauthors
Montaldo P,Montaldo L,Iossa AC,Cennamo M,Caredda E,Del Gado Rdoi
10.1007/s10157-013-0802-zsubject
Has Abstractpub_date
2014-02-01 00:00:00pages
120-3issue
1eissn
1342-1751issn
1437-7799journal_volume
18pub_type
杂志文章abstract:BACKGROUND:Chronic kidney disease (CKD) eventually progresses to end-stage renal disease (ESRD). However, risk factors associated with CKD progression have not been well characterized in Japanese patients with CKD who are less affected with coronary disease than Westerners. METHODS:A large-scale, multicenter, prospect...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章,多中心研究
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更新日期:2017-06-01 00:00:00
abstract:BACKGROUND:Because of the well-established annual urinalysis screening system in Japan, the duration of nephropathy (DN) can be estimated in more than half of all patients with IgA nephropathy (IgAN). Treatment using a combination of tonsillectomy and steroid pulse (TSP) therapy has been reported as an effective method...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-011-0530-1
更新日期:2012-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2010-12-01 00:00:00
abstract:BACKGROUND:Recent studies have suggested that assessments of serum antibodies against M-type phospholipase A2 receptor (PLA2R) and the glomerular expression of PLA2R antigen in biopsy specimens are useful for the diagnosis of primary membranous nephropathy (MN). In this study, we assessed both of them and investigated ...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-014-1064-0
更新日期:2015-10-01 00:00:00
abstract::A 78-year old woman with complicating solitary kidney had nephrotic syndrome. Renal biopsy specimens showed focal segmental glomerulosclerosis (FSGS). First, the patient was treated with angiotensin receptor blocker (ARB) and angiotensin converting enzyme inhibitor (ACEI). Proteinuria decreased from 10 to 6 g/day, but...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
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更新日期:2009-02-01 00:00:00
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journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-009-0196-0
更新日期:2009-10-01 00:00:00
abstract:BACKGROUND:The number of elderly dialysis patients in Japan is dramatically increasing. Receiving therapy with better satisfaction through home care is one of the important factors in their daily lives. Thus, the quality of life of elderly patients on hemodialysis (HD) or peritoneal dialysis (PD) was evaluated. METHOD...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-016-1374-5
更新日期:2017-10-01 00:00:00
abstract::Recent studies on dendritic cells (DCs) and macrophages have greatly advanced our knowledge of glomerular immunopathology. This rapidly developing field most likely has considerable impact on our understanding of the major mediators of tissue injury and repair in kidney disease. The pivotal role of cytokine in the ini...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章,评审
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更新日期:2010-02-01 00:00:00
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journal_title:Clinical and experimental nephrology
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
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更新日期:2009-12-01 00:00:00
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journal_title:Clinical and experimental nephrology
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2018-04-01 00:00:00
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journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-011-0428-y
更新日期:2011-08-01 00:00:00
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journal_title:Clinical and experimental nephrology
pub_type: 杂志文章,多中心研究
doi:10.1007/s10157-015-1170-7
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Data regarding renal disease in the elderly (age ≥65 years old) and very elderly (age ≥80 years old) Japanese are extremely limited. The aim of this study was to examine the causes of renal disease and their clinical presentations in elderly patients who underwent renal biopsy. DESIGN, SETTIN...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-012-0673-8
更新日期:2012-12-01 00:00:00
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journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-016-1311-7
更新日期:2017-06-01 00:00:00
abstract:OBJECTIVES:Interleukin (IL)-33 plays an important role in host defense, immune regulation, and inflammation. This study assessed IL-33's role in the pathogenesis of severe hemolytic uremic syndrome (HUS) induced by enterohemorrhagic Escherichia coli (EHEC). We also investigated the clinical significance of IL-33 and so...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-018-1675-y
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:Dotinurad is a novel selective urate reabsorption inhibitor (SURI) that selectively inhibits the reabsorption of uric acid in renal tubules and promotes the excretion of uric acid into urine. In this study, the effects of age and gender on the pharmacokinetics (PK), pharmacodynamics (PD), and safety of dotin...
journal_title:Clinical and experimental nephrology
pub_type: 临床试验,杂志文章
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更新日期:2020-03-01 00:00:00
abstract::A case of nephrotic syndrome (NS) and acute renal failure (ARF) associated with embryonal rhabdomyosarcoma (RMS) in a 10-year-old boy is reported. Ultrasound revealed irregular, echogenic, circumferential urinary bladder base mass, bilateral hydroureter and hydronephrosis. Histopathology of percutaneous renal and uret...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-007-0015-4
更新日期:2008-04-01 00:00:00
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journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
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更新日期:2019-02-01 00:00:00
abstract::In encapsulating peritoneal sclerosis (EPS), matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases are involved in the remodeling of peritoneal tissue. We measured the MMP-2 concentration in the peritoneal effluents of a patient with EPS who discontinued continuous ambulatory peritoneal dialysis ...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-004-0328-5
更新日期:2005-03-01 00:00:00
abstract::A 34-year-old man who had been on dialysis for about 6 years, and had acquired renal cystic disease, received a renal transplantation. However, in spite of the success of the transplantation, one area without cyst regression was observed in the original kidney. Therefore, carcinoma was suspected and nephrectomy was pe...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
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更新日期:2003-03-01 00:00:00
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journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-020-02006-3
更新日期:2021-01-04 00:00:00
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pub_type: 杂志文章
doi:10.1007/s10157-011-0566-2
更新日期:2012-04-01 00:00:00
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journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-014-0976-z
更新日期:2015-04-01 00:00:00
abstract:OBJECTIVE:Myeloid-derived suppressor cells (MDSCs) have been identified as immunosuppressive cells in tumor-related inflammation. However, the pathogenesis of MDSCs for autoimmune disease has not been investigated as yet. The aim of this study was to address whether MDSCs contribute to autoimmune organ injury in lupus-...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-010-0309-9
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND:School urinary screening has been performed in Japan. METHODS:Ikeda City and Toyono Town introduced, in 2012 and 2013, urinary protein/creatinine (Cr) ratio measurement into the urine-screening protocols designed for students aged between 4 and 15 years. For each student whose urinary protein/Cr ratio was ≥...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-020-01852-5
更新日期:2020-05-01 00:00:00
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journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-018-1566-2
更新日期:2018-10-01 00:00:00
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journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-006-0423-x
更新日期:2006-09-01 00:00:00
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journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-017-1464-z
更新日期:2018-02-01 00:00:00
abstract::Both thin basement membrane nephropathy (TBMN) and autosomal dominant Alport syndrome (ADAS) are types of hereditary nephritis resulting from heterozygous mutations in COL4A3 or COL4A4 genes. Although TBMN is characterized by hematuria and thinning of the glomerular basement membrane (GBM) with excellent renal prognos...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章,评审
doi:10.1007/s10157-020-01880-1
更新日期:2020-08-01 00:00:00