Association between cystatin C and inflammation in patients with essential hypertension.

abstract：BACKGROUND:Mizoribine (MZR) was approved in 1984 in Japan for the suppression of rejection in renal transplantation with an approved administration dosage of 1-3 mg/kg/day. The action of MZR resembles that of mycophenolate mofetil (MMF), but MZR dosing is markedly lower than that of MMF. To examine whether higher dosin...

journal_title：Clinical and experimental nephrology

authors： Takahara S,Takahashi K,Akiyama T,Uchida K,Tanabe K,Amada N,Toma H

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Although acute kidney injury (AKI) is known as a potential complication of influenza infections, there is limited information concerning the association between influenza and AKI. The aim of this study is to evaluate the incidence, the mortality, and risk factors of AKI in hospitalized patients by seasonal i...

journal_title：Clinical and experimental nephrology

authors： Ishibuchi K,Fukasawa H,Kaneko M,Yasuda H,Furuya R

更新日期：2021-01-04 00:00:00

abstract：BACKGROUND:It has been recently reported that peroxisome proliferator-activated receptors (PPARs)gamma exist in various tissues and that they exibit anti-inflammatory effects. METHODS:We investigated the effects of PPARgamma activators on the development of crescentic glomerulonephritis. Crescentic glomerulonephritis ...

journal_title：Clinical and experimental nephrology

authors： Haraguchi K,Shimura H,Onaya T

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND:The Oxford Classification is utilized globally, but has not been fully validated. In this study, we conducted a comparative analysis between the Oxford Classification and Japanese Histologic Classification (JHC) to predict renal outcome in Japanese patients with IgA nephropathy (IgAN). METHODS:A retrospecti...

journal_title：Clinical and experimental nephrology

authors： Kaihan AB,Yasuda Y,Katsuno T,Kato S,Imaizumi T,Ozeki T,Hishida M,Nagata T,Ando M,Tsuboi N,Maruyama S

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Phosphodiesterase type IV (PDEIV) plays an important role in the immune response and inflammation. However, it is well known that classical PDEIV inhibitors have systemic side effects, so the clinical and chronic use of these agents as therapy for glomerulonephritis is difficult. This study was performed to ...

journal_title：Clinical and experimental nephrology

authors： Sadakane C,Kase Y,Koseki J,Hasegawa Y,Shindo S,Maruyama H,Takeda S,Takeda H,Hattori T

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:Dotinurad, a novel selective urate reabsorption inhibitor, exerts a serum uric acid-lowering effect by selectively inhibiting urate transporter 1 (URAT1) in patients with hyperuricemia. It is generally known that the progression of renal dysfunction is associated with a reduction in the serum uric acid-lower...

journal_title：Clinical and experimental nephrology

authors： Fukase H,Okui D,Sasaki T,Fushimi M,Ohashi T,Hosoya T

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA)-associated vasculitis frequently induces crescentic glomerulonephritis. However, a few cases have so far been reported to have only tubulointerstitial (TI) nephritis without any apparent glomerular lesions. We recently treated three similar cases...

journal_title：Clinical and experimental nephrology

authors： Nakabayashi K,Sumiishi A,Sano K,Fujioka Y,Yamada A,Karube M,Koji H,Arimura Y,Nagasawa T

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:Creatinine clearance (Ccr) overestimates glomerular filtration rate (GFR) due to the tubular secretion of creatinine. It is known that fractional excretion of creatinine (FE-Cr) increases with decreasing GFR. Association of serum albumin level with the tubular secretion of creatinine was also reported previo...

journal_title：Clinical and experimental nephrology

authors： Horio M,Imai E,Yasuda Y,Watanabe T,Matsuo S

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Acute renal infarction (ARI) is a rare disease with atrial fibrillation being its main cause. The possible laterality of ARI is controversial. This study aimed to evaluate the association between anatomical features of the renal arteries and ARI. METHODS:This was a single-center cross-sectional study that e...

journal_title：Clinical and experimental nephrology

authors： Kagaya S,Ojima Y,Aoki S,Sato H,Nagasawa T

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Data regarding renal disease in the elderly (age ≥65 years old) and very elderly (age ≥80 years old) Japanese are extremely limited. The aim of this study was to examine the causes of renal disease and their clinical presentations in elderly patients who underwent renal biopsy. DESIGN, SETTIN...

journal_title：Clinical and experimental nephrology

authors： Yokoyama H,Sugiyama H,Sato H,Taguchi T,Nagata M,Matsuo S,Makino H,Watanabe T,Saito T,Kiyohara Y,Nishi S,Iida H,Morozumi K,Fukatsu A,Sasaki T,Tsuruya K,Kohda Y,Higuchi M,Kiyomoto H,Goto S,Hattori M,Hataya H,Kag

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:Recent studies have suggested that assessments of serum antibodies against M-type phospholipase A2 receptor (PLA2R) and the glomerular expression of PLA2R antigen in biopsy specimens are useful for the diagnosis of primary membranous nephropathy (MN). In this study, we assessed both of them and investigated ...

journal_title：Clinical and experimental nephrology

authors： Hayashi N,Akiyama S,Okuyama H,Matsui Y,Adachi H,Yamaya H,Maruyama S,Imai E,Matsuo S,Yokoyama H

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:In patients with IgA nephropathy (IgAN), recurrence after steroid pulse therapy is associated with reduced renal survival. However, the predictors of recurrence have not yet been clarified. METHODS:All patients who received 6-month steroid pulse therapy from 2004 to 2010 in our four affiliated hospitals and...

journal_title：Clinical and experimental nephrology

authors： Hirano K,Amano H,Kawamura T,Watanabe K,Koike K,Shimizu A,Endo S,Tsuboi N,Okonogi H,Miyazaki Y,Ikeda M,Hanaoka K,Ogura M,Komatsumoto S,Yokoo T

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Cardiovascular disease is the leading cause of morbidity and mortality in patients with kidney failure. Nocturnal home hemodialysis (NHD) is a form of kidney replacement therapy whereby hemodialysis is performed for at least 6-h overnight, at least 4 days per week. Little is known about the effects of NHD on...

journal_title：Clinical and experimental nephrology

authors： Friesen T,Jassal DS,Zhu M,Eng F,Rigatto C,Tangri N,Sood MM,Karlstedt E,Premecz S,Komenda P

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Dotinurad is a novel, selective urate reabsorption inhibitor (SURI), which reduces serum uric acid levels by selective inhibition of the urate transporter 1 (URAT1). The Japanese guideline for the management of hyperuricemia and gout recommends that drug selection should be based on classification of hyperur...

journal_title：Clinical and experimental nephrology

authors： Hosoya T,Furuno K,Kanda S

更新日期：2020-03-01 00:00:00

abstract：:A case of nephrotic syndrome (NS) and acute renal failure (ARF) associated with embryonal rhabdomyosarcoma (RMS) in a 10-year-old boy is reported. Ultrasound revealed irregular, echogenic, circumferential urinary bladder base mass, bilateral hydroureter and hydronephrosis. Histopathology of percutaneous renal and uret...

journal_title：Clinical and experimental nephrology

authors： Olowu WA,Salako AA,Adelusola KA,Sowande OA,Adetiloye VA,Adefehinti O,Osasan SA

更新日期：2008-04-01 00:00:00

abstract：:Lipoprotein glomerulopathy (LPG) is a rare hereditary disease characterized by the accumulation of much thrombi material consisting of lipoproteins at the glomerular capillary lumen. Most patients show nephrotic syndrome; nearly half progress to chronic renal failure. Intensive therapy with lipid-lowering agents repor...

journal_title：Clinical and experimental nephrology

authors： Matsunaga A,Furuyama M,Hashimoto T,Toyoda K,Ogino D,Hayasaka K

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:IgG4-related disease has attracted wide attention recently. It is characterized by a high level of serum IgG4 and dense infiltration of IgG4-positive plasma cells into multiple organs, with the kidney being one representative target. Although several sets of diagnostic criteria for autoimmune pancreatitis (A...

journal_title：Clinical and experimental nephrology

authors： Kawano M,Saeki T,Nakashima H,Nishi S,Yamaguchi Y,Hisano S,Yamanaka N,Inoue D,Yamamoto M,Takahashi H,Nomura H,Taguchi T,Umehara H,Makino H,Saito T

更新日期：2011-10-01 00:00:00

abstract：:Both thin basement membrane nephropathy (TBMN) and autosomal dominant Alport syndrome (ADAS) are types of hereditary nephritis resulting from heterozygous mutations in COL4A3 or COL4A4 genes. Although TBMN is characterized by hematuria and thinning of the glomerular basement membrane (GBM) with excellent renal prognos...

journal_title：Clinical and experimental nephrology

authors： Imafuku A,Nozu K,Sawa N,Nakanishi K,Ubara Y

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Low-energy extracorporeal shock wave (SW) improves ventricular function in ischemic cardiomyopathy through the upregulation of vascular endothelial growth factor (VEGF). VEGF is known to play important roles in acute kidney injury (AKI), and the present study investigates the efficacy of SW for AKI by renal ...

journal_title：Clinical and experimental nephrology

authors： Yoshida M,Nakamichi T,Mori T,Ito K,Shimokawa H,Ito S

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Equations for the creatinine-based estimated glomerular filtration rate (eGFR) were recently established for Japanese adults (>18 years old) and children (2-11 years old), respectively, but it is unclear whether eGFR can be as useful as 24-h creatinine clearance (CCr) for assessing renal function in patients...

journal_title：Clinical and experimental nephrology

authors： Inoue N,Watanabe H,Okamura K,Kondo S,Kagami S

更新日期：2015-04-01 00:00:00

abstract：:Recent studies on dendritic cells (DCs) and macrophages have greatly advanced our knowledge of glomerular immunopathology. This rapidly developing field most likely has considerable impact on our understanding of the major mediators of tissue injury and repair in kidney disease. The pivotal role of cytokine in the ini...

journal_title：Clinical and experimental nephrology

authors： Matsumoto K,Fukuda N,Abe M,Fujita T

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:The renoprotection achieved by angiotensin II blockade in the treatment of diabetic nephropathy is well established in both the clinical and the experimental settings. In contrast, the therapeutic efficacy of calcium channel blockers (CCBs) in the treatment of diabetic nephropathy still remains controversial...

journal_title：Clinical and experimental nephrology

authors： Moriyama T,Oka K,Ueda H,Imai E

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND:The risk of developing CKD is increased in HIV-infected patients; however, the relationship between renal function decline and lipid abnormalities currently remains unclear in these patients. METHODS:A retrospective cohort study was conducted on 661 HIV-infected patients, whose estimated glomerular filtrati...

journal_title：Clinical and experimental nephrology

authors： Hara M,Yanagisawa N,Ohta A,Momoki K,Tsuchiya K,Nitta K,Ando M

更新日期：2017-04-01 00:00:00

abstract：:Sarcoidosis is a systemic granulomatous disease of unknown etiology and is associated with a wide variety of renal disorders including nephrolithiasis, hypercalciuria, hypercalcemia, nephrocalcinosis, tubular defect, glomerulonephritis, and granulomatous interstitial nephritis. We report a case of renal sarcoidosis in...

journal_title：Clinical and experimental nephrology

authors： Mitome J,Kawaguchi Y,Arase S,Horino T,Okada H,Osaka N,Hanaoka K,Shimada T,Kawamura T,Hosoya T,Yamaguchi Y,Hano H

更新日期：2004-12-01 00:00:00

abstract：:A 34-year-old man who had been on dialysis for about 6 years, and had acquired renal cystic disease, received a renal transplantation. However, in spite of the success of the transplantation, one area without cyst regression was observed in the original kidney. Therefore, carcinoma was suspected and nephrectomy was pe...

journal_title：Clinical and experimental nephrology

authors： Ishikawa I,Saito A,Chikazawa Y,Asaka M,Tomosugi N,Yuri T,Suzuki K,Ueda Y,Ozaki M

更新日期：2003-03-01 00:00:00

abstract：:Endothelial dysfunction due to the reduced bioavailability of nitric oxide (NO) is involved in the course of atherosclerotic cardiovascular disease as well as chronic kidney disease (CKD). NO is synthesized from L-arginine via the action of NO synthase, which is blocked by endogenous L-arginine analogues such as asymm...

journal_title：Clinical and experimental nephrology

authors： Ueda S,Yamagishi SI,Matsumoto Y,Fukami K,Okuda S

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND:Cirrhosis of the liver is often associated with an impairment of renal function that is usually not associated with consistent structural abnormalities of the renal parenchyma, but is thought to be the functional consequence of arterial underfilling and reduced arterial blood pressure. METHOD:We have used t...

journal_title：Clinical and experimental nephrology

authors： Maoka T,Kawata T,Koike T,Mochizuki T,Schnermann J,Hashimoto S

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Aquaporin-2 (AQP2) is a key water channel protein which determines the water permeability of the collecting duct. Multiple phosphorylation sites are present at the C-terminal of AQP2 including S256 (serine at 256 residue), S261, S264 and S/T269, which are regulated by vasopressin (VP) to modulate AQP2 traffi...

journal_title：Clinical and experimental nephrology

authors： Sakai M,Yamamoto K,Mizumura H,Matsumoto T,Tanaka Y,Noda Y,Ishibashi K,Yamamoto T,Sasaki S

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:The etiology of hemodialysis (HD)-induced hypotension and hypertension remains speculative. There is mounting evidence that endothelin-1 (ET-1) may play a vital role in these hemodynamic changes. We examined the possible role of intradialytic changes of ET-1 in the pathogenesis of hypotension and rebound hyp...

journal_title：Clinical and experimental nephrology

authors： El-Shafey EM,El-Nagar GF,Selim MF,El-Sorogy HA,Sabry AA

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:Peritoneal injury is an important cause of technical failure of long-term peritoneal dialysis (PD). Encapsulating peritoneal sclerosis (EPS) is a severe complication of long-term PD with potentially life threatening consequences. CD147 is a glycoprotein with diverse functions including modulation of extracel...

journal_title：Clinical and experimental nephrology

authors： Seeger H,Latus J,Kitterer D,Alscher MD,Biegger D,Chen J,Edenhofer I,Wüthrich RP,Segerer S

更新日期：2017-12-01 00:00:00