Low-energy extracorporeal shock wave ameliorates ischemic acute kidney injury in rats.

abstract：BACKGROUND:The present study aimed to clarify the beneficial effect of allopurinol on cardiovascular morbidity and mortality in a cohort of hypertensive nephropathy patients with impaired kidney function. METHODS:One hundred and seventy-eight patients diagnosed with hypertensive nephropathy and presenting with impaire...

journal_title：Clinical and experimental nephrology

authors： Terawaki H,Nakayama M,Miyazawa E,Murata Y,Nakayama K,Matsushima M,Miyazaki M,Sato H,Sato M,Sato T,Taguma Y,Ito S

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Acute renal infarction (ARI) is a rare disease with atrial fibrillation being its main cause. The possible laterality of ARI is controversial. This study aimed to evaluate the association between anatomical features of the renal arteries and ARI. METHODS:This was a single-center cross-sectional study that e...

journal_title：Clinical and experimental nephrology

authors： Kagaya S,Ojima Y,Aoki S,Sato H,Nagasawa T

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA)-associated vasculitis frequently induces crescentic glomerulonephritis. However, a few cases have so far been reported to have only tubulointerstitial (TI) nephritis without any apparent glomerular lesions. We recently treated three similar cases...

journal_title：Clinical and experimental nephrology

authors： Nakabayashi K,Sumiishi A,Sano K,Fujioka Y,Yamada A,Karube M,Koji H,Arimura Y,Nagasawa T

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:Hypertension is a risk factor common to both chronic kidney disease and cardiovascular disease. Nicorandil is widely used for the treatment of angina. We investigated the benefits of nicorandil with respect to renal dysfunction in Dahl salt-sensitive hypertensive (DS) rats. METHOD:DS rats were fed a high-sa...

journal_title：Clinical and experimental nephrology

authors： Tashiro Y,Yogo K,Serizawa K,Endo K

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Hyperuricemia is an established risk factor for cardiovascular events and mortality. This study investigated the association between serum uric acid and the incidence of nonfatal stroke in a Japanese community-based population. METHODS:We used a nationwide database of 155,322 subjects (aged 40-73, male 39 %...

journal_title：Clinical and experimental nephrology

authors： Kamei K,Konta T,Hirayama A,Ichikawa K,Kubota I,Fujimoto S,Iseki K,Moriyama T,Yamagata K,Tsuruya K,Narita I,Kondo M,Shibagaki Y,Kasahara M,Asahi K,Watanabe T

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:Mortality in the first year of maintenance dialysis is higher than in subsequent years and, within this first year, the risk of death is highest in the first 90 days. Some studies have shown that pre-dialysis education reduces early mortality. Limited data have been published from South Africa regarding earl...

journal_title：Clinical and experimental nephrology

authors： Fabian J,Van Jaarsveld K,Maher HA,Gaylard P

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:The renoprotection achieved by angiotensin II blockade in the treatment of diabetic nephropathy is well established in both the clinical and the experimental settings. In contrast, the therapeutic efficacy of calcium channel blockers (CCBs) in the treatment of diabetic nephropathy still remains controversial...

journal_title：Clinical and experimental nephrology

authors： Moriyama T,Oka K,Ueda H,Imai E

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND:Although acute kidney injury (AKI) is known as a potential complication of influenza infections, there is limited information concerning the association between influenza and AKI. The aim of this study is to evaluate the incidence, the mortality, and risk factors of AKI in hospitalized patients by seasonal i...

journal_title：Clinical and experimental nephrology

authors： Ishibuchi K,Fukasawa H,Kaneko M,Yasuda H,Furuya R

更新日期：2021-01-04 00:00:00

abstract：BACKGROUND:X-linked Alport syndrome (XLAS) is a progressive hereditary nephropathy caused by mutations in the type IV collagen alpha chain 5 gene (COL4A5). Although many COL4A5 mutations have previously been identified, pathogenic synonymous mutations have not yet been described. METHODS:A family with XLAS underwent m...

journal_title：Clinical and experimental nephrology

authors： Fu XJ,Nozu K,Eguchi A,Nozu Y,Morisada N,Shono A,Taniguchi-Ikeda M,Shima Y,Nakanishi K,Vorechovsky I,Iijima K

更新日期：2016-10-01 00:00:00

abstract：:A case of nephrotic syndrome (NS) and acute renal failure (ARF) associated with embryonal rhabdomyosarcoma (RMS) in a 10-year-old boy is reported. Ultrasound revealed irregular, echogenic, circumferential urinary bladder base mass, bilateral hydroureter and hydronephrosis. Histopathology of percutaneous renal and uret...

journal_title：Clinical and experimental nephrology

authors： Olowu WA,Salako AA,Adelusola KA,Sowande OA,Adetiloye VA,Adefehinti O,Osasan SA

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND:Mizoribine (MZR) has been developed as an immunosuppressive agent, but has a less potent immunosuppressive effect up to 3 mg/kg/day MZR. Therefore, we investigated whether high-dose MZR, at 6 mg/kg/day, would be effective and safe for kidney transplant patients in conjunction with cyclosporine (CsA), basilix...

journal_title：Clinical and experimental nephrology

authors： Yoshimura N,Ushigome H,Akioka K,Nobori S,Suzuki T,Sakai K,Okamoto M

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:Although a high prevalence of macrovascular disease (MVD) has been reported in patients with stage 3 chronic kidney disease (CKD), few studies have reported its risk with respect to the underlying cause of kidney disease. This study investigated the prevalence of MVD in type 2 diabetic patients with CKD stra...

journal_title：Clinical and experimental nephrology

authors： Tanaka K,Hara S,Kushiyama A,Ubara Y,Yoshida Y,Mizuiri S,Aikawa A,Kawatzu S

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:Renin-angiotensin system blockers (RASBs) reduce end-stage kidney disease and cardiovascular event (CVE) development in chronic kidney disease. However, whether RASBs improve long-term prognosis in kidney transplant (KT) recipients remain unknown. METHOD:We investigated 900 kidney transplant patients in a m...

journal_title：Clinical and experimental nephrology

authors： Tsuchimoto A,Masutani K,Ueki K,Nakagawa K,Matsukuma Y,Tanaka S,Unagami K,Kakuta Y,Okumi M,Noguchi H,Kaku K,Okabe Y,Nakano T,Kitazono T,Nakamura M,Ishida H,Tanabe K,Japan Academic Consortium of Kidney Transplantation (JA

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND/AIMS:Fibroblast growth factor 23 (FGF23) and soluble α-Klotho are emerging potential biomarkers of phosphorus and vitamin D metabolism which change in concentration in early chronic kidney disease (CKD) in order to maintain normal phosphorus levels. Tubular reabsorption of phosphate (TRP) has been commonly u...

journal_title：Clinical and experimental nephrology

authors： Hong YA,Lim JH,Kim MY,Kim Y,Yang KS,Chung BH,Chung S,Choi BS,Yang CW,Kim YS,Chang YS,Park CW

更新日期：2015-04-01 00:00:00

abstract：:We report a 17-year-old male patient with tubulointerstitial nephritis and uveitis (TINU) associated with hyperthyroidism. He presented with a 2-month history of fatigue, loss of appetite, low-grade fever, and a 12-kg weight loss when he was admitted to our hospital. He had iritis, which was complicated by fibrin in t...

journal_title：Clinical and experimental nephrology

authors： Ebihara I,Hirayama K,Usui J,Seki M,Higuchi F,Oteki T,Kobayashi M,Yamagata K

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:Dotinurad, a novel selective urate reabsorption inhibitor, exerts a serum uric acid-lowering effect by selectively inhibiting urate transporter 1 (URAT1) in patients with hyperuricemia. It is generally known that the progression of renal dysfunction is associated with a reduction in the serum uric acid-lower...

journal_title：Clinical and experimental nephrology

authors： Fukase H,Okui D,Sasaki T,Fushimi M,Ohashi T,Hosoya T

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:In order to clarify the interaction between cardiac dysfunction and sodium homeostasis in the kidney, we used a murine model of cardiac dysfunction and investigated the effect on sodium transporters in renal tubular cells. METHODS:Cardiac function was deteriorated by abdominal aortic banding, and the gene e...

journal_title：Clinical and experimental nephrology

authors： Tsuchida Y,Kaneko Y,Otsuka T,Goto K,Saito A,Yamamoto K,Yamamoto T,Narita I

更新日期：2014-02-01 00:00:00

abstract：:C1q nephropathy, first proposed by Jennette and Hipp [Am J Clin Pathol 83:415-420, 1985; Am J Kidney Dis 6:103-110, 1985], was described as a distinct glomerular disease entity characterized by extensive mesangial deposition of C1q, with associated mesangial immune complexes, and the absence of any clinical and labora...

journal_title：Clinical and experimental nephrology

authors： Mii A,Shimizu A,Masuda Y,Fujita E,Aki K,Ishizaki M,Sato S,Griesemer A,Fukuda Y

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND:Chronic kidney disease (CKD) eventually progresses to end-stage renal disease (ESRD). However, risk factors associated with CKD progression have not been well characterized in Japanese patients with CKD who are less affected with coronary disease than Westerners. METHODS:A large-scale, multicenter, prospect...

journal_title：Clinical and experimental nephrology

authors： Inaguma D,Imai E,Takeuchi A,Ohashi Y,Watanabe T,Nitta K,Akizawa T,Matsuo S,Makino H,Hishida A,Chronic Kidney Disease Japan Cohort Study Group.

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:Several comorbidity scoring systems have been developed and validated, mostly in western hemodialysis patients with a high risk of cardiovascular disease. The performance of comorbidity scoring, however, depends on the patient population. In this study, we determine the optimal comorbidity scoring system for...

journal_title：Clinical and experimental nephrology

authors： Ma TK,Chow KM,Kwan BC,Ng JK,Pang WF,Leung CB,Li PK,Szeto CC

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Stromal cell-derived factor-1α (SDF-1α) is an inflammatory chemokine that plays a critical role in cardiovascular disease. Although persistent inflammation causes renal dysfunction, it remains unclear whether SDF-1α is related to progression of chronic kidney disease. This study examined whether high levels ...

journal_title：Clinical and experimental nephrology

authors： Uematsu M,Nakamura T,Yoshizaki T,Watanabe Y,Deyama J,Watanabe K,Kobayashi T,Fujioka D,Saito Y,Nakamura K,Kawabata K,Obata JE,Kugiyama K

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:The activation of the nuclear factor-κB (NF-κB) signaling pathway gives rise to inflammation in the pathogenesis of lupus nephritis (LN), with A20 serving as a negative feedback regulator and ubiquitin C‑terminal hydrolase L1 (UCH-L1) acting as a downstream target protein. However, their roles in the mechani...

journal_title：Clinical and experimental nephrology

authors： Sun L,Zou LX,Han YC,Zhu DD,Chen T,Wang J

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Dotinurad is a novel selective urate reabsorption inhibitor (SURI) that selectively inhibits the reabsorption of uric acid in renal tubules and promotes the excretion of uric acid into urine. In this study, the effects of age and gender on the pharmacokinetics (PK), pharmacodynamics (PD), and safety of dotin...

journal_title：Clinical and experimental nephrology

authors： Nakatani H,Fushimi M,Sasaki T,Okui D,Ohashi T

更新日期：2020-03-01 00:00:00

abstract：:Both thin basement membrane nephropathy (TBMN) and autosomal dominant Alport syndrome (ADAS) are types of hereditary nephritis resulting from heterozygous mutations in COL4A3 or COL4A4 genes. Although TBMN is characterized by hematuria and thinning of the glomerular basement membrane (GBM) with excellent renal prognos...

journal_title：Clinical and experimental nephrology

authors： Imafuku A,Nozu K,Sawa N,Nakanishi K,Ubara Y

更新日期：2020-08-01 00:00:00

abstract：:A 77-year-old Japanese female developed Churg-Strauss syndrome (CSS), showing fever and numbness in bilateral hands. She was being treated for bronchial asthma with combination inhalant of corticosteroid with beta(2)-agonist, and an oral leukotriene receptor antagonist (LTRA), montelukast, for 15 months. She presented...

journal_title：Clinical and experimental nephrology

authors： Kanda T,Tanio H,Wu C,Nishihara H,Nogaki F,Ono T

更新日期：2010-12-01 00:00:00

abstract：:Recent studies on dendritic cells (DCs) and macrophages have greatly advanced our knowledge of glomerular immunopathology. This rapidly developing field most likely has considerable impact on our understanding of the major mediators of tissue injury and repair in kidney disease. The pivotal role of cytokine in the ini...

journal_title：Clinical and experimental nephrology

authors： Matsumoto K,Fukuda N,Abe M,Fujita T

更新日期：2010-02-01 00:00:00

abstract：:Waldenström's macroglobulinemia is rare lymphoproliferative disorder characterized by the presence of a monoclonal IgM paraproteinemia. Cryoglobulinemia is a common sequela of Waldenström's macroglobulinemia present in 8-18% of the patients. Cryoglobulinemia has also been described as occurring after treatment with ri...

journal_title：Clinical and experimental nephrology

authors： Shaikh A,Habermann TM,Fidler ME,Kumar S,Leung N

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:The appropriate blood pressure target to prevent end-stage renal disease (ESRD) is controversial. METHODS:We examined the association between systolic blood pressure (SBP) changes and ESRD incidence in 69,575 participants from the Okinawa general population aged ≥ 20 years who underwent health check-ups in ...

journal_title：Clinical and experimental nephrology

authors： Usui T,Iseki C,Iseki K,Kawakami K,Nangaku M

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Acute renal infarction (ARI) is a rare disease. ARI causes decline in renal function in both the acute and chronic phases. However, the correlation between the volume of the infarction and degree of renal function decline has not been fully investigated. Therefore, we aimed to examine the relationship betwee...

journal_title：Clinical and experimental nephrology

authors： Kagaya S,Yoshie O,Fukami H,Sato H,Saito A,Takeuchi Y,Matsuda K,Nagasawa T

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Genetic susceptibility to atypical hemolytic uremic syndrome (aHUS) may lie within genes regulating or activating the alternate complement and related pathways converging on endothelial cell activation. METHODS:We tested 32 Indian patients of aHUS negative for antibodies to complement factor H for genetic v...

journal_title：Clinical and experimental nephrology

authors： Thergaonkar RW,Narang A,Gurjar BS,Tiwari P,Puraswani M,Saini H,Sinha A,Varma B,Mukerji M,Hari P,Bagga A

更新日期：2018-06-01 00:00:00