Risk of macrovascular disease stratified by stage of chronic kidney disease in type 2 diabetic patients: critical level of the estimated glomerular filtration rate and the significance of hyperuricemia.

Abstract:

BACKGROUND:Although a high prevalence of macrovascular disease (MVD) has been reported in patients with stage 3 chronic kidney disease (CKD), few studies have reported its risk with respect to the underlying cause of kidney disease. This study investigated the prevalence of MVD in type 2 diabetic patients with CKD stratified by CKD stage, as defined by estimated glomerular filtration rate (eGFR), as well as the risk factors for MVD. METHODS:1493 patients with diabetic CKD (1273 males, 220 females) were stratified by CKD stage (stage 1: 39, stage 2: 272, stage 3: 1052, stage 4: 101, stage 5: 29) based on eGFR calculated by the Japanese formula and averaged over 8 months. MVD was defined as one of the following: coronary heart disease (CHD), stroke or arteriosclerosis obliterans (ASO). RESULTS:The prevalence of MVD was 18.6%. A significant increasing trend in MVD prevalence was observed from stage 3 (17.78%) to 4 (52.48%). According to a receiver operating characteristic curve analysis on MVD prevalence in stage 3 patients, an eGFR of 46.4 ml/min/1.73 m(2) was determined to be a critical cut-off level. Proteinuria, eGFR <60 ml/min/1.73 m(2) and hyperuricemia were independent risk factors for MVD. CONCLUSIONS:In patients with diabetic CKD, a significant increase in MVD prevalence was observed from stage 3 to 4. An eGFR of 46.4 ml/min/1.73 m(2) is a critical level that affects MVD prevalence. From the perspective of cardiorenal association, CKD stage 3 should be divided into two substages. As hyperuricemia is related to an increased risk of MVD, uric acid control may be important in reducing MVD risk in diabetic CKD.

journal_name

Clin Exp Nephrol

authors

Tanaka K,Hara S,Kushiyama A,Ubara Y,Yoshida Y,Mizuiri S,Aikawa A,Kawatzu S

doi

10.1007/s10157-011-0420-6

subject

Has Abstract

pub_date

2011-06-01 00:00:00

pages

391-397

issue

3

eissn

1342-1751

issn

1437-7799

pii

10.1007/s10157-011-0420-6

journal_volume

15

pub_type

杂志文章
  • Heavy chain deposition disease: an overview.

    abstract::Heavy chain deposition disease (HCDD) is one of three entities of monoclonal immunoglobulin deposition disease, characterized histopathologically by the presence of nodular glomerulosclerosis and glomerular and tubular deposition of monoclonal heavy chains without associated light chains. Although HCDD is an extremely...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章,评审

    doi:10.1007/s10157-013-0812-x

    authors: Oe Y,Soma J,Sato H,Ito S

    更新日期:2013-12-01 00:00:00

  • Dendritic cells and macrophages in kidney disease.

    abstract::Recent studies on dendritic cells (DCs) and macrophages have greatly advanced our knowledge of glomerular immunopathology. This rapidly developing field most likely has considerable impact on our understanding of the major mediators of tissue injury and repair in kidney disease. The pivotal role of cytokine in the ini...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章,评审

    doi:10.1007/s10157-009-0218-y

    authors: Matsumoto K,Fukuda N,Abe M,Fujita T

    更新日期:2010-02-01 00:00:00

  • The relationship between neutrophil-to-lymphocyte ratio and the first occurrence of pneumonia in peritoneal dialysis patients.

    abstract:BACKGROUND:Although neutrophil-to-lymphocyte ratio (NLR) is closely associated with pneumonia in the general population, its relationship is unclear in peritoneal dialysis (PD) patients. METHODS:This is a cohort study consisting of 739 PD patients and dividing into two groups. Kaplan-Meier curves were applied to obser...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-020-01894-9

    authors: Zhang Y,Lai X,Chen Q,Zhan X,Long H,Peng F,Zhang F,Feng X,Zhou Q,Wu X,Liu L,Wang Z,ETNA.,Peng X,Hu K,Wang D,Guo G,Zeng Y,Wen Y,Liang J

    更新日期:2020-09-01 00:00:00

  • Spontaneous remission of persistent severe hematuria in an adolescent with nutcracker syndrome: seven years' observation.

    abstract::A Japanese boy aged 14 years presented with gross hematuria associated with mild proteinuria and was diagnosed as having nutcracker syndrome. Magnetic resonance angiography (MRA) revealed significant compression of the left renal vein between the aorta and the superior mesenteric artery with collaterals. A percutaneou...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-003-0267-6

    authors: Tanaka H,Waga S

    更新日期:2004-03-01 00:00:00

  • Focal segmental glomerulosclerosis and nephrotic syndrome in a child with embryonal rhabdomyosarcoma.

    abstract::A case of nephrotic syndrome (NS) and acute renal failure (ARF) associated with embryonal rhabdomyosarcoma (RMS) in a 10-year-old boy is reported. Ultrasound revealed irregular, echogenic, circumferential urinary bladder base mass, bilateral hydroureter and hydronephrosis. Histopathology of percutaneous renal and uret...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-007-0015-4

    authors: Olowu WA,Salako AA,Adelusola KA,Sowande OA,Adetiloye VA,Adefehinti O,Osasan SA

    更新日期:2008-04-01 00:00:00

  • Are the equations for the creatinine-based estimated glomerular filtration rate applicable to the evaluation of renal function in Japanese children and adult patients receiving chemotherapy?

    abstract:BACKGROUND:Equations for the creatinine-based estimated glomerular filtration rate (eGFR) were recently established for Japanese adults (>18 years old) and children (2-11 years old), respectively, but it is unclear whether eGFR can be as useful as 24-h creatinine clearance (CCr) for assessing renal function in patients...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-014-0976-z

    authors: Inoue N,Watanabe H,Okamura K,Kondo S,Kagami S

    更新日期:2015-04-01 00:00:00

  • Night-time blood pressure and pulse wave velocity in dialysis patients.

    abstract:BACKGROUND:Ambulatory blood pressure (ABP) monitoring and carotid-femoral pulse wave velocity (cfPWV) provide important cardiovascular risk information for dialysis patients. This study aims to evaluate the risk factors of cfPWV and the associations between ambulatory blood pressure, especially night-time blood pressur...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-017-1464-z

    authors: Li X,Jiang Q,Wu W,Xu X,Miao L,Jin L,Xue L,Huang T,Di J,Liu J,He X

    更新日期:2018-02-01 00:00:00

  • Risk factors for CKD progression in Japanese patients: findings from the Chronic Kidney Disease Japan Cohort (CKD-JAC) study.

    abstract:BACKGROUND:Chronic kidney disease (CKD) eventually progresses to end-stage renal disease (ESRD). However, risk factors associated with CKD progression have not been well characterized in Japanese patients with CKD who are less affected with coronary disease than Westerners. METHODS:A large-scale, multicenter, prospect...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s10157-016-1309-1

    authors: Inaguma D,Imai E,Takeuchi A,Ohashi Y,Watanabe T,Nitta K,Akizawa T,Matsuo S,Makino H,Hishida A,Chronic Kidney Disease Japan Cohort Study Group.

    更新日期:2017-06-01 00:00:00

  • Tonsillectomy reduces recurrence of IgA nephropathy in mesangial hypercellularity type categorized by the Oxford classification.

    abstract:BACKGROUND:In patients with IgA nephropathy (IgAN), recurrence after steroid pulse therapy is associated with reduced renal survival. However, the predictors of recurrence have not yet been clarified. METHODS:All patients who received 6-month steroid pulse therapy from 2004 to 2010 in our four affiliated hospitals and...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s10157-015-1170-7

    authors: Hirano K,Amano H,Kawamura T,Watanabe K,Koike K,Shimizu A,Endo S,Tsuboi N,Okonogi H,Miyazaki Y,Ikeda M,Hanaoka K,Ogura M,Komatsumoto S,Yokoo T

    更新日期:2016-06-01 00:00:00

  • The beneficial effect of high-dose mizoribine combined with cyclosporine, basiliximab, and corticosteroids on CMV infection in renal transplant recipients.

    abstract:BACKGROUND:Mizoribine (MZR) has been developed as an immunosuppressive agent, but has a less potent immunosuppressive effect up to 3 mg/kg/day MZR. Therefore, we investigated whether high-dose MZR, at 6 mg/kg/day, would be effective and safe for kidney transplant patients in conjunction with cyclosporine (CsA), basilix...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-012-0669-4

    authors: Yoshimura N,Ushigome H,Akioka K,Nobori S,Suzuki T,Sakai K,Okamoto M

    更新日期:2013-02-01 00:00:00

  • IgM-immune complex glomerulonephritis associated with sarcoidosis.

    abstract::We present a case of proliferative glomerulonephritis with peculiar IgM deposition associated with sarcoidosis. A 62-year-old woman, who had been diagnosed with sarcoidosis 3 years previously because of abnormalities on chest X-ray radiophotographs and lymph node pathology, was admitted to our hospital for the evaluat...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-005-0390-7

    authors: Kanamori H,Ota M,Takeoka H,Osafune K,Yonezu S,Fukatsu A,Kanatsu K

    更新日期:2006-03-01 00:00:00

  • Acid-base disturbances in nephrotic syndrome: analysis using the CO2/HCO3 method (traditional Boston model) and the physicochemical method (Stewart model).

    abstract:BACKGROUND:The Stewart model for analyzing acid-base disturbances emphasizes serum albumin levels, which are ignored in the traditional Boston model. We compared data derived using the Stewart model to those using the Boston model in patients with nephrotic syndrome. METHODS:Twenty-nine patients with nephrotic syndrom...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-017-1387-8

    authors: Kasagi T,Imai H,Miura N,Suzuki K,Yoshino M,Nobata H,Nagai T,Banno S

    更新日期:2017-10-01 00:00:00

  • High plasma pentosidine level is accompanied with cardiovascular events in hemodialysis patients.

    abstract:BACKGROUND:Cardiovascular disease is a major complication in patients with end-stage renal disease (ESRD). The accumulation of advanced glycation end products (AGEs) is facilitated in these patients. The aim of this study was to investigate the relationship between circulating AGEs and cardiovascular events in hemodial...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-011-0573-3

    authors: Furuya R,Kumagai H,Miyata T,Fukasawa H,Isobe S,Kinoshita N,Hishida A

    更新日期:2012-06-01 00:00:00

  • Relationship between antinuclear antibody and microalbuminuria in the general population: the Takahata study.

    abstract:BACKGROUND:Microalbuminuria, a marker of vascular damage, is associated with increased risk of progressive renal deterioration, cardiovascular disease and mortality. However, the relationship between antinuclear antibody (ANA) and microalbuminuria in the general population is unknown. Thus, we conducted a cross-section...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-008-0030-0

    authors: Ishikawa M,Konta T,Hao Z,Takasaki S,Abiko H,Takahashi T,Ikeda A,Ichikawa K,Shibata Y,Takeishi Y,Kato T,Kawata S,Kubota I

    更新日期:2008-06-01 00:00:00

  • Predictors of withdrawal from renal replacement therapy among patients with acute kidney injury requiring renal replacement therapy.

    abstract:BACKGROUND:Although recovery of renal function after an episode of acute kidney injury (AKI) is an important clinical measure of morbidity, predictors of withdrawal from renal replacement therapy (RRT) among AKI patients remain unclear. METHODS:In this single-center retrospective cohort study, we examined the clinical...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-019-01711-y

    authors: Ihara K,Ishigami J,Inoshita S

    更新日期:2019-06-01 00:00:00

  • Unusual glomerulopathy with aggregated subepithelial microspheric particles resembling membranous nephropathy: a variant of glomerulopathy associated with podocytic infolding?

    abstract::A 69-year-old woman presented with unusual electron microscopic findings. The patient was admitted to ascertain the cause of her persistent proteinuria, and kidney biopsy was performed. While light microscopic findings and immunofluorescence study suggested membranous nephropathy, electron microscopic study showed mic...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-008-0089-7

    authors: Nomura S,Inoue-Kiyohara M,Oosugi K,Ishikawa E,Obe T,Horiki T,Ito M

    更新日期:2008-12-01 00:00:00

  • Pathology of glomerular lipidosis.

    abstract::Glomerular lipid deposition is sometimes associated with a particular kind of lipid metabolism disturbance. Ultrastructural analyses using electron microscopy often indicate a disease-specific aspect of intraglomerular lipid distribution. ...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章,评审

    doi:10.1007/s10157-013-0882-9

    authors: Sato H,Takahashi N,Sato E,Kisu K,Ito S,Saito T

    更新日期:2014-04-01 00:00:00

  • Clinicopathological characteristics of M-type phospholipase A2 receptor (PLA2R)-related membranous nephropathy in Japanese.

    abstract:BACKGROUND:Recent studies have suggested that assessments of serum antibodies against M-type phospholipase A2 receptor (PLA2R) and the glomerular expression of PLA2R antigen in biopsy specimens are useful for the diagnosis of primary membranous nephropathy (MN). In this study, we assessed both of them and investigated ...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-014-1064-0

    authors: Hayashi N,Akiyama S,Okuyama H,Matsui Y,Adachi H,Yamaya H,Maruyama S,Imai E,Matsuo S,Yokoyama H

    更新日期:2015-10-01 00:00:00

  • Phosphorylation profile of human AQP2 in urinary exosomes by LC-MS/MS phosphoproteomic analysis.

    abstract:BACKGROUND:Aquaporin-2 (AQP2) is a key water channel protein which determines the water permeability of the collecting duct. Multiple phosphorylation sites are present at the C-terminal of AQP2 including S256 (serine at 256 residue), S261, S264 and S/T269, which are regulated by vasopressin (VP) to modulate AQP2 traffi...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-020-01899-4

    authors: Sakai M,Yamamoto K,Mizumura H,Matsumoto T,Tanaka Y,Noda Y,Ishibashi K,Yamamoto T,Sasaki S

    更新日期:2020-09-01 00:00:00

  • An IgA1-lambda-type monoclonal immunoglobulin deposition disease associated with membranous features in a patient with chronic hepatitis C viral infection and rectal cancer.

    abstract::A 61-year-old man infected with hepatitis C virus developed urinary protein. Two-dimensional electrophoresis and immunoblotting of sera revealed no monoclonal proteins. Light microscopy and immunofluorescence of a kidney biopsy specimen demonstrated bubbling appearance and formation of spikes, associated with predomin...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-009-0227-x

    authors: Miura N,Uemura Y,Suzuki N,Suga N,Maeda K,Yamaguchi S,Kitagawa W,Yamada H,Nishikawa K,Imai H

    更新日期:2010-02-01 00:00:00

  • Effects of cinacalcet on bone mineral density and bone markers in hemodialysis patients with secondary hyperparathyroidism.

    abstract:BACKGROUND:Cinacalcet markedly reduces the serum intact parathyroid hormone (PTH) level of hemodialysis (HD) patients with secondary hyperparathyroidism. Parathyroidectomy also reduces the serum intact PTH level of HD patients and it increases their bone mineral density (BMD). However, there is little information about...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-012-0665-8

    authors: Tsuruta Y,Okano K,Kikuchi K,Tsuruta Y,Akiba T,Nitta K

    更新日期:2013-02-01 00:00:00

  • Clinical significance of tubular and podocyte biomarkers in acute kidney injury.

    abstract:BACKGROUND:Acute kidney injury (AKI) is a common complication in critically ill patients. Urinary excretion of liver-type fatty acid-binding protein (L-FABP), which is expressed in the proximal tubules, reflects the presence of tubular injury. Urinary excretion of podocalyxin (PCX), a glycoprotein prominently expressed...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-010-0384-y

    authors: Matsui K,Kamijo-Ikemori A,Hara M,Sugaya T,Kodama T,Fujitani S,Taira Y,Yasuda T,Kimura K

    更新日期:2011-04-01 00:00:00

  • Anti-MPO small-vessel vasculitis causing prostatis and nephritis.

    abstract::Microscopic polyangiitis is a necrotizing angiitis involving capillaries, venules, and arterioles. The vascular beds of various organs may be involved, causing varying presentations. To our knowledge, this is the first case of anti-myeloperoxidase (anti-MPO) antibody small-vessel vasculitis causing prostatic vasculiti...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-007-0473-8

    authors: Lamarche JA,Peguero AM,Rosario JO,Patel A,Courville C

    更新日期:2007-06-01 00:00:00

  • The incidence of the nephrotic syndrome in childhood in Germany.

    abstract:BACKGROUND:The incidence of childhood nephrotic syndrome (NS) in Germany is not well known. METHODS:An ESPED-based nationwide collection of epidemiological data of children in 2005 and 2006. RESULT:The mean age of NS at onset was 5.5 ± 3.7 years. The gender ratio of boys to girls was 1.8:1. The average length of stay...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-017-1433-6

    authors: Franke I,Aydin M,Llamas Lopez CE,Kurylowicz L,Ganschow R,Lentze M,Born M

    更新日期:2018-02-01 00:00:00

  • Association of depressive symptoms with 25(OH) vitamin D in hemodialysis patients and effect of gender.

    abstract:BACKGROUND:Depression is common in chronic kidney disease (CKD) patients and associated with significant increase in morbidity and mortality. In recent years, a relationship between vitamin D deficiency and depression has been shown. The aim of this study is to investigate the relationship between 25-hydroxy (OH) vitam...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-019-01794-7

    authors: Yavuz YC,Biyik Z,Ozkul D,Abusoglu S,Eryavuz D,Dag M,Korez MK,Guney I,Altintepe L

    更新日期:2020-01-01 00:00:00

  • Identification of children with chronic kidney disease through school urinary screening using urinary protein/creatinine ratio measurement: an observational study.

    abstract:BACKGROUND:School urinary screening has been performed in Japan. METHODS:Ikeda City and Toyono Town introduced, in 2012 and 2013, urinary protein/creatinine (Cr) ratio measurement into the urine-screening protocols designed for students aged between 4 and 15 years. For each student whose urinary protein/Cr ratio was ≥...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-020-01852-5

    authors: Kajiwara N,Hayashi K,Fujiwara M,Nakayama H,Ozaki Y

    更新日期:2020-05-01 00:00:00

  • Quality of life of elderly patients on peritoneal dialysis versus hemodialysis: a single-center study.

    abstract:BACKGROUND:The number of elderly dialysis patients in Japan is dramatically increasing. Receiving therapy with better satisfaction through home care is one of the important factors in their daily lives. Thus, the quality of life of elderly patients on hemodialysis (HD) or peritoneal dialysis (PD) was evaluated. METHOD...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-016-1374-5

    authors: Saka Y,Naruse T,Tawada N,Tokomoto M,Noda Y,Taniguchi Y,Nagahara Y,Yamashita R,Karasawa M,Watanabe Y,Ito Y

    更新日期:2017-10-01 00:00:00

  • Beneficial effects of preemptive kidney transplantation on calcium and phosphorus disorders in early post-transplant recipients.

    abstract:BACKGROUND:Recently, preemptive kidney transplantation (PKT) has increased in Japan; however, the effects of PKT on calcium (Ca) and phosphorus (Pi) metabolism are poorly understood. METHODS:Thirty-two consecutive patients were enrolled in this study at Nagoya Daini Red Cross Hospital. Fifteen patients were in the PKT...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-014-0967-0

    authors: Tsujita M,Inaguma D,Goto N,Yamamoto T,Hiramitsu T,Katayama A,Takeda A,Kobayashi T,Morozumi K,Uchida K,Narumi S,Watarai Y,Tominaga Y

    更新日期:2015-04-01 00:00:00

  • Nicorandil suppresses urinary protein excretion and activates eNOS in Dahl salt-sensitive hypertensive rats.

    abstract:BACKGROUND:Hypertension is a risk factor common to both chronic kidney disease and cardiovascular disease. Nicorandil is widely used for the treatment of angina. We investigated the benefits of nicorandil with respect to renal dysfunction in Dahl salt-sensitive hypertensive (DS) rats. METHOD:DS rats were fed a high-sa...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-014-0998-6

    authors: Tashiro Y,Yogo K,Serizawa K,Endo K

    更新日期:2015-06-01 00:00:00

  • Angiotensin II suppresses adenosine monophosphate-activated protein kinase of podocytes via angiotensin II type 1 receptor and mitogen-activated protein kinase signaling.

    abstract:BACKGROUND:Adenosine monophosphate (AMP)-activated protein kinase (AMPK), as a sensor of cellular energy status, has been known to play an important role in the pathophysiology of diabetes and its complications. As AMPK is also expressed in podocytes, it is possible that podocyte AMPK would be an important contributing...

    journal_title:Clinical and experimental nephrology

    pub_type: 杂志文章

    doi:10.1007/s10157-012-0649-8

    authors: Choi JY,Ha TS,Park HY,Ahn HY

    更新日期:2013-02-01 00:00:00