Risk of macrovascular disease stratified by stage of chronic kidney disease in type 2 diabetic patients: critical level of the estimated glomerular filtration rate and the significance of hyperuricemia.

abstract：BACKGROUND:The risk of developing CKD is increased in HIV-infected patients; however, the relationship between renal function decline and lipid abnormalities currently remains unclear in these patients. METHODS:A retrospective cohort study was conducted on 661 HIV-infected patients, whose estimated glomerular filtrati...

journal_title：Clinical and experimental nephrology

authors： Hara M,Yanagisawa N,Ohta A,Momoki K,Tsuchiya K,Nitta K,Ando M

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND AND AIM:The infusion of chronic angiotensin II (Ang II) has been shown to promote renal interstitial fibrosis. To evaluate the pathophysiological significance of the natriuretic peptide-GC-A system, we infused Ang II (1.0 mg/kg/day) in GC-A-deficient mice (GC-A-KO). METHODS:We used 5 groups (Wild-Saline n =...

journal_title：Clinical and experimental nephrology

authors： Yoshihara F,Tokudome T,Kishimoto I,Otani K,Kuwabara A,Horio T,Kawano Y,Kangawa K

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Edaravone, a drug for treating acute ischemic stroke, has been reported to provoke acute renal disorders. In the previous study, the author evaluated the role of edaravone in the development of renal disorders in 207 patients reported as having developed them in the post-marketing survey of the drug. The ove...

journal_title：Clinical and experimental nephrology

authors： Hishida A

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:Mortality in the first year of maintenance dialysis is higher than in subsequent years and, within this first year, the risk of death is highest in the first 90 days. Some studies have shown that pre-dialysis education reduces early mortality. Limited data have been published from South Africa regarding earl...

journal_title：Clinical and experimental nephrology

authors： Fabian J,Van Jaarsveld K,Maher HA,Gaylard P

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Dotinurad, a novel selective urate reabsorption inhibitor (SURI), reduces serum uric acid levels by selectively inhibiting urate transporter 1 (URAT1) for the treatment of hyperuricemia with or without gout. We confirmed the serum uric acid lowering effect and safety of dotinurad. METHODS:This was a confirm...

journal_title：Clinical and experimental nephrology

authors： Hosoya T,Sano T,Sasaki T,Fushimi M,Ohashi T

更新日期：2020-03-01 00:00:00

abstract：:Heavy chain deposition disease (HCDD) is one of three entities of monoclonal immunoglobulin deposition disease, characterized histopathologically by the presence of nodular glomerulosclerosis and glomerular and tubular deposition of monoclonal heavy chains without associated light chains. Although HCDD is an extremely...

journal_title：Clinical and experimental nephrology

authors： Oe Y,Soma J,Sato H,Ito S

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Cirrhosis of the liver is often associated with an impairment of renal function that is usually not associated with consistent structural abnormalities of the renal parenchyma, but is thought to be the functional consequence of arterial underfilling and reduced arterial blood pressure. METHOD:We have used t...

journal_title：Clinical and experimental nephrology

authors： Maoka T,Kawata T,Koike T,Mochizuki T,Schnermann J,Hashimoto S

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Low-energy extracorporeal shock wave (SW) improves ventricular function in ischemic cardiomyopathy through the upregulation of vascular endothelial growth factor (VEGF). VEGF is known to play important roles in acute kidney injury (AKI), and the present study investigates the efficacy of SW for AKI by renal ...

journal_title：Clinical and experimental nephrology

authors： Yoshida M,Nakamichi T,Mori T,Ito K,Shimokawa H,Ito S

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:In 2013, eculizumab was approved for treatment of the atypical hemolytic-uremic syndrome (aHUS) in Japan, which was defined as a thrombotic microangiopathy (TMA) excluding Shiga toxin-producing Escherichia coli-HUS and thrombotic thrombocytopenic purpura. Simultaneously, post-marketing surveillance was start...

journal_title：Clinical and experimental nephrology

authors： Ito S,Hidaka Y,Inoue N,Kaname S,Kato H,Matsumoto M,Miyakawa Y,Mizuno M,Okada H,Shimono A,Matsuda T,Maruyama S,Fujimura Y,Nangaku M,Kagami S

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:The incidence of childhood nephrotic syndrome (NS) in Germany is not well known. METHODS:An ESPED-based nationwide collection of epidemiological data of children in 2005 and 2006. RESULT:The mean age of NS at onset was 5.5 ± 3.7 years. The gender ratio of boys to girls was 1.8:1. The average length of stay...

journal_title：Clinical and experimental nephrology

authors： Franke I,Aydin M,Llamas Lopez CE,Kurylowicz L,Ganschow R,Lentze M,Born M

更新日期：2018-02-01 00:00:00

abstract：:A case of nephrotic syndrome (NS) and acute renal failure (ARF) associated with embryonal rhabdomyosarcoma (RMS) in a 10-year-old boy is reported. Ultrasound revealed irregular, echogenic, circumferential urinary bladder base mass, bilateral hydroureter and hydronephrosis. Histopathology of percutaneous renal and uret...

journal_title：Clinical and experimental nephrology

authors： Olowu WA,Salako AA,Adelusola KA,Sowande OA,Adetiloye VA,Adefehinti O,Osasan SA

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND:Vascular endothelial cells (VECs) play crucial roles in physiological and pathologic conditions in tissues and organs. Most of these roles are related to VEC plasma membrane proteins. In the kidney, VECs are closely associated with structures and functions; however, plasma membrane proteins in kidney VECs re...

journal_title：Clinical and experimental nephrology

authors： Liu Z,Xu B,Nameta M,Zhang Y,Magdeldin S,Yoshida Y,Yamamoto K,Fujinaka H,Yaoita E,Tasaki M,Nakagawa Y,Saito K,Takahashi K,Yamamoto T

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Dotinurad is a novel selective urate reabsorption inhibitor (SURI) that selectively inhibits the reabsorption of uric acid in renal tubules and promotes the excretion of uric acid into urine. In this study, the effects of age and gender on the pharmacokinetics (PK), pharmacodynamics (PD), and safety of dotin...

journal_title：Clinical and experimental nephrology

authors： Nakatani H,Fushimi M,Sasaki T,Okui D,Ohashi T

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:The appropriate blood pressure target to prevent end-stage renal disease (ESRD) is controversial. METHODS:We examined the association between systolic blood pressure (SBP) changes and ESRD incidence in 69,575 participants from the Okinawa general population aged ≥ 20 years who underwent health check-ups in ...

journal_title：Clinical and experimental nephrology

authors： Usui T,Iseki C,Iseki K,Kawakami K,Nangaku M

更新日期：2019-11-01 00:00:00

abstract：:We report a case of a 59-year-old woman who had severe metabolic acidosis and hypokalemia due to an enterovesical fistula. The patient came to our hospital complaining of systemic weakness and numbness of the fingers. She was found to have hyperchloremic metabolic acidosis (arterial bicarbonate, 2.8 mEq/l) and hypokal...

journal_title：Clinical and experimental nephrology

authors： Murakami K,Tomita M,Kawamura N,Hasegawa M,Nabeshima K,Hiki Y,Sugiyama S

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:Ambulatory blood pressure (ABP) monitoring and carotid-femoral pulse wave velocity (cfPWV) provide important cardiovascular risk information for dialysis patients. This study aims to evaluate the risk factors of cfPWV and the associations between ambulatory blood pressure, especially night-time blood pressur...

journal_title：Clinical and experimental nephrology

authors： Li X,Jiang Q,Wu W,Xu X,Miao L,Jin L,Xue L,Huang T,Di J,Liu J,He X

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:The present study was conducted to clarify the clinical risk factors related to the development of encapsulating peritoneal sclerosis (EPS), which is one of the most serious complications in patients undergoing peritoneal dialysis (PD). METHODS:The records of 78 patients with a history of PD treatment, incl...

journal_title：Clinical and experimental nephrology

authors： Yamamoto R,Otsuka Y,Nakayama M,Maruyama Y,Katoh N,Ikeda M,Yamamoto H,Yokoyama K,Kawaguchi Y,Matsushima M

更新日期：2005-06-01 00:00:00

abstract：AIM:IgA nephropathy (IgAN) is a very common glomerulonephritis among young adults, but the best therapeutic approach has not been fully elucidated. This study evaluated the effect of two different treatment regimes in IgAN, steroids alone or in combination with azathioprine. METHODS:Among 122 patients with primary IgA...

journal_title：Clinical and experimental nephrology

authors： Stangou M,Ekonomidou D,Giamalis P,Liakou H,Tsiantoulas A,Pantzaki A,Papagianni A,Efstratiadis G,Alexopoulos E,Memmos D

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:In Japan, systematic evaluation of the histologic parameters of anti-neutrophil cytoplasmic autoantibodies (ANCA)-related vasculitis has been performed according to the Japanese classification by Shigematsu et al. However, this classification is quite different from that of the European Vasculitis Study Grou...

journal_title：Clinical and experimental nephrology

authors： Joh K,Muso E,Shigematsu H,Nose M,Nagata M,Arimura Y,Yumura W,Wada T,Nitta K,Makino H,Taguma Y,Kaneoka H,Suzuki Y,Kobayashi M,Koyama A,Usui J,Hashimoto H,Ozaki S,Tomino Y,Yamagata K

更新日期：2008-08-01 00:00:00

abstract：:Ischemia-reperfusion injury is a main cause of acute kidney injury. Tubular necrosis and interstitial inflammatory cell infiltration are characteristic pathologic changes of acute kidney injury. The main necrotic area should be repaired with new tubular epithelial cells after the injury. On the other hand, some parts ...

journal_title：Clinical and experimental nephrology

authors： Furuichi K,Kaneko S,Wada T

更新日期：2009-02-01 00:00:00

abstract：:In encapsulating peritoneal sclerosis (EPS), matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases are involved in the remodeling of peritoneal tissue. We measured the MMP-2 concentration in the peritoneal effluents of a patient with EPS who discontinued continuous ambulatory peritoneal dialysis ...

journal_title：Clinical and experimental nephrology

authors： Masunaga Y,Hirahara I,Shimano Y,Kurosu M,Iimura O,Miyata Y,Amemiya M,Homma S,Kusano E,Asano Y

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:Aquaporin-2 (AQP2) is a key water channel protein which determines the water permeability of the collecting duct. Multiple phosphorylation sites are present at the C-terminal of AQP2 including S256 (serine at 256 residue), S261, S264 and S/T269, which are regulated by vasopressin (VP) to modulate AQP2 traffi...

journal_title：Clinical and experimental nephrology

authors： Sakai M,Yamamoto K,Mizumura H,Matsumoto T,Tanaka Y,Noda Y,Ishibashi K,Yamamoto T,Sasaki S

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Hematuria is the first manifestation of urinary abnormality in immunoglobulin A nephropathy (IgAN). Hematuria has recently been reported as a risk factor for deterioration of renal function; however, its cause remains unknown. METHODS:We analyzed the surface marker of peripheral blood mononuclear cells befo...

journal_title：Clinical and experimental nephrology

authors： Iwatani H,Nagasawa Y,Yamamoto R,Iio K,Mizui M,Horii A,Kitahara T,Inohara H,Kumanogoh A,Imai E,Rakugi H,Isaka Y

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:The post-marketing surveillance of edaravone has reported serious adverse reactions, including renal and hepatic disorders. Renal disorders were the most frequently reported serious/important adverse reactions, which led to the evaluation of their causation by edaravone, their severity, and the recovery of r...

journal_title：Clinical and experimental nephrology

authors： Hishida A

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:Achieving a normal final adult height (FH) remains a challenge in the field of pediatric kidney transplantation (KTx). To examine the optimal approach to assuring normal FH following KTx, we retrospectively examined the post-transplant growth and FH of pediatric KTx recipients. METHODS:Since the relevant fa...

journal_title：Clinical and experimental nephrology

authors： Fujii H,Chikamoto H,Akioka Y,Hattori M

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:The incidence of hypocomplementemia detected in the school urinary screening program in Kanagawa Prefecture, Japan, and the number of new patients with membranoproliferative glomerulonephritis (MPGN) diagnosed in our institution were decreasing during the period between 1974 and 1997. Follow-up of this study...

journal_title：Clinical and experimental nephrology

authors： Iitaka K,Nakamura S,Moriya S,Koshino H,Iwanami N,Sakai T,Motoyama O

更新日期：2005-03-01 00:00:00

abstract：:The manifestation of diabetic nephropathy may be a consequence of the actions of certain cytokines and growth factors. Prominent among them is transforming growth factor-β (TGF-β), which promotes renal cell hypertrophy and stimulates extracellular matrix accumulation, the two hallmarks of diabetic renal disease. In ex...

journal_title：Clinical and experimental nephrology

authors： Ziyadeh FN,Isono M,Chen S

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND/AIMS:Vascular access dysfunction caused by stenosis is a major complication for hemodialysis (HD) patients. However, physiopathology of late arteriovenous fistula (AVF) stenosis is still under investigation. The aim of the present study was to evaluate the association between plasma soluble EPCR (sEPCR) with...

journal_title：Clinical and experimental nephrology

authors： Bilgic MA,Yilmaz H,Bozkurt A,Celik HT,Bilgic IC,Gurel OM,Kirbas I,Bavbek N,Akcay A

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:The definition of sepsis was updated to sepsis-3 in February 2016. Currently, direct hemoperfusion therapy using the polymyxin B-immobilized fiber cartridge (PMX-DHP) is widely performed to treat sepsis and septic shock. However, the prognostic factors of PMX-DHPs in patients with sepsis using the new defini...

journal_title：Clinical and experimental nephrology

authors： Okubo A,Nakashima A,Doi S,Ueno T,Sasaki K,Esaki T,Masaki T

更新日期：2018-10-01 00:00:00

abstract：:A 52-year-old Japanese female was admitted to our hospital for microhematuria, proteinuria and progressive renal dysfunction. Two years prior to admission, she was diagnosed with lung adenocarcinoma and multiple bone and brain metastases, and was treated with gefitinib (250 mg/day). Treatment for 6 months induced part...

journal_title：Clinical and experimental nephrology

authors： Masutani K,Fujisaki K,Maeda H,Toyonaga J,Inoshima I,Takayama K,Katafuchi R,Hirakata H,Tsuruya K,Iida M

更新日期：2008-10-01 00:00:00