Suppression of experimental crescentic glomerulonephritis by peroxisome proliferator-activated receptor (PPAR)gamma activators.

abstract：BACKGROUND:The incidence of hypocomplementemia detected in the school urinary screening program in Kanagawa Prefecture, Japan, and the number of new patients with membranoproliferative glomerulonephritis (MPGN) diagnosed in our institution were decreasing during the period between 1974 and 1997. Follow-up of this study...

journal_title：Clinical and experimental nephrology

authors： Iitaka K,Nakamura S,Moriya S,Koshino H,Iwanami N,Sakai T,Motoyama O

更新日期：2005-03-01 00:00:00

abstract：:We report a 58-year-old Japanese man with primary systemic AL amyloidosis who achieved disappearance of proteinuria including Bence-Jones protein (lambda-type) after two courses of VAD therapy (vincristine, doxorubicin, and dexamethasone) and subsequent high-dose melphalan, followed by autologous peripheral blood stem...

journal_title：Clinical and experimental nephrology

authors： Yamazaki O,Ubara Y,Suwabe T,Nakanishi S,Hoshino J,Sawa N,Hayami N,Yamanouchi M,Takemoto F,Kenmei T,Masuoka K,Oohashi K

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:Phosphodiesterase type IV (PDEIV) plays an important role in the immune response and inflammation. However, it is well known that classical PDEIV inhibitors have systemic side effects, so the clinical and chronic use of these agents as therapy for glomerulonephritis is difficult. This study was performed to ...

journal_title：Clinical and experimental nephrology

authors： Sadakane C,Kase Y,Koseki J,Hasegawa Y,Shindo S,Maruyama H,Takeda S,Takeda H,Hattori T

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:Renin-angiotensin system blockers (RASBs) reduce end-stage kidney disease and cardiovascular event (CVE) development in chronic kidney disease. However, whether RASBs improve long-term prognosis in kidney transplant (KT) recipients remain unknown. METHOD:We investigated 900 kidney transplant patients in a m...

journal_title：Clinical and experimental nephrology

authors： Tsuchimoto A,Masutani K,Ueki K,Nakagawa K,Matsukuma Y,Tanaka S,Unagami K,Kakuta Y,Okumi M,Noguchi H,Kaku K,Okabe Y,Nakano T,Kitazono T,Nakamura M,Ishida H,Tanabe K,Japan Academic Consortium of Kidney Transplantation (JA

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:Acute kidney injury (AKI) is a common complication in critically ill patients. Urinary excretion of liver-type fatty acid-binding protein (L-FABP), which is expressed in the proximal tubules, reflects the presence of tubular injury. Urinary excretion of podocalyxin (PCX), a glycoprotein prominently expressed...

journal_title：Clinical and experimental nephrology

authors： Matsui K,Kamijo-Ikemori A,Hara M,Sugaya T,Kodama T,Fujitani S,Taira Y,Yasuda T,Kimura K

更新日期：2011-04-01 00:00:00

abstract：:Increasing attention has been paid to the relationship of autoantibodies to ribosomal P proteins (anti-P) with lupus nephritis. Several mechanisms of involvement of anti-P in lupus nephritis have been proposed, including cross-reactivity with anti-dsDNA and anti-endothelial cell antibodies (AECA). In addition, it is a...

journal_title：Clinical and experimental nephrology

authors： Hirohata S

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:The kidney is a major organ involved in calcium (Ca(2+)) metabolism. Ca(2+) is transported through renal tubular epithelial cells. The intracellular free calcium concentration ([Ca(2+)](i)) is tightly controlled at a low concentration, but transient increases and oscillations in [Ca(2+)](i) are induced by va...

journal_title：Clinical and experimental nephrology

authors： Udagawa T,Hanaoka K,Kawamura M,Hosoya T

更新日期：2012-06-01 00:00:00

abstract：:A 52-year-old Japanese female was admitted to our hospital for microhematuria, proteinuria and progressive renal dysfunction. Two years prior to admission, she was diagnosed with lung adenocarcinoma and multiple bone and brain metastases, and was treated with gefitinib (250 mg/day). Treatment for 6 months induced part...

journal_title：Clinical and experimental nephrology

authors： Masutani K,Fujisaki K,Maeda H,Toyonaga J,Inoshima I,Takayama K,Katafuchi R,Hirakata H,Tsuruya K,Iida M

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:Although a high prevalence of macrovascular disease (MVD) has been reported in patients with stage 3 chronic kidney disease (CKD), few studies have reported its risk with respect to the underlying cause of kidney disease. This study investigated the prevalence of MVD in type 2 diabetic patients with CKD stra...

journal_title：Clinical and experimental nephrology

authors： Tanaka K,Hara S,Kushiyama A,Ubara Y,Yoshida Y,Mizuiri S,Aikawa A,Kawatzu S

更新日期：2011-06-01 00:00:00

abstract：:Lecithin:cholesterol acyltransferase (LCAT) is a key enzyme involved in reverse cholesterol transport from the peripheral tissues to the liver. LCAT deficiency, in which this enzyme is congenitally absent, is a genetic disease that impairs the esterification of free cholesterol in the plasma, leading to accumulation o...

journal_title：Clinical and experimental nephrology

authors： Hirashio S,Ueno T,Naito T,Masaki T

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Although congenital anomalies of the kidney and urinary tract (CAKUT) are the most common cause of pediatric end-stage renal disease (ESRD), little is known about the characteristics exhibited in the infantile period by CAKUT patients who develop ESRD. Further, an efficient screening method for CAKUT diagnos...

journal_title：Clinical and experimental nephrology

authors： Yoshino A,Honda M,Sasaki N,Hataya H,Ishikura K,Sakazume S,Tanaka Y,Nagai T

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:Renal dysfunction is recognized with increasing frequency among the noninfectious comorbidities associated with human immunodeficiency virus (HIV) infection. Urinary liver-type fatty acid-binding protein (L-FABP) has been shown to be a new biomarker to screen for not only tubulointerstitial damage but also k...

journal_title：Clinical and experimental nephrology

authors： Hikasa S,Yasuda M,Hideta K,Kawakami M,Higasa S,Sawada A,Tokugawa T,Kimura T

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA)-associated vasculitis frequently induces crescentic glomerulonephritis. However, a few cases have so far been reported to have only tubulointerstitial (TI) nephritis without any apparent glomerular lesions. We recently treated three similar cases...

journal_title：Clinical and experimental nephrology

authors： Nakabayashi K,Sumiishi A,Sano K,Fujioka Y,Yamada A,Karube M,Koji H,Arimura Y,Nagasawa T

更新日期：2009-12-01 00:00:00

abstract：OBJECTIVE:Myeloid-derived suppressor cells (MDSCs) have been identified as immunosuppressive cells in tumor-related inflammation. However, the pathogenesis of MDSCs for autoimmune disease has not been investigated as yet. The aim of this study was to address whether MDSCs contribute to autoimmune organ injury in lupus-...

journal_title：Clinical and experimental nephrology

authors： Iwata Y,Furuichi K,Kitagawa K,Hara A,Okumura T,Kokubo S,Shimizu K,Sakai N,Sagara A,Kurokawa Y,Ueha S,Matsushima K,Kaneko S,Wada T

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:The Stewart model for analyzing acid-base disturbances emphasizes serum albumin levels, which are ignored in the traditional Boston model. We compared data derived using the Stewart model to those using the Boston model in patients with nephrotic syndrome. METHODS:Twenty-nine patients with nephrotic syndrom...

journal_title：Clinical and experimental nephrology

authors： Kasagi T,Imai H,Miura N,Suzuki K,Yoshino M,Nobata H,Nagai T,Banno S

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:Dotinurad is a novel, selective urate reabsorption inhibitor, which reduces serum uric acid levels by inhibiting the urate transporter 1 (URAT1). We compared the pharmacokinetics (PK), pharmacodynamics (PD), and safety of dotinurad in subjects with hepatic impairment and normal hepatic function. METHODS:Thi...

journal_title：Clinical and experimental nephrology

authors： Kumagai Y,Sakaki M,Furihata K,Ito T,Inoue K,Yoshida T,Matsumoto S,Furuno K,Hagino A

更新日期：2020-03-01 00:00:00

abstract：:A Japanese boy aged 14 years presented with gross hematuria associated with mild proteinuria and was diagnosed as having nutcracker syndrome. Magnetic resonance angiography (MRA) revealed significant compression of the left renal vein between the aorta and the superior mesenteric artery with collaterals. A percutaneou...

journal_title：Clinical and experimental nephrology

authors： Tanaka H,Waga S

更新日期：2004-03-01 00:00:00

abstract：:Because of the increasing incidence of cardiac failure and chronic renal failure due to the progressive aging of the population, the extensive application of cardiac interventional techniques, the rising rates of obesity and diabetes mellitus, coexistence of heart failure and renal failure in the same patient are freq...

journal_title：Clinical and experimental nephrology

authors： Longhini C,Molino C,Fabbian F

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:Equations for the creatinine-based estimated glomerular filtration rate (eGFR) were recently established for Japanese adults (>18 years old) and children (2-11 years old), respectively, but it is unclear whether eGFR can be as useful as 24-h creatinine clearance (CCr) for assessing renal function in patients...

journal_title：Clinical and experimental nephrology

authors： Inoue N,Watanabe H,Okamura K,Kondo S,Kagami S

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Thallium-201 washout rate of stress myocardial perfusion imaging (MPI) has been reported to correlate with coronary flow reserve which is a parameter of myocardial microcirculation. However, the evidence for its use in diabetic kidney disease (DKD) has been lacking, and the association between thallium-201 w...

journal_title：Clinical and experimental nephrology

authors： Hayashi T,Joki N,Tanaka Y,Iwasaki M,Kubo S,Matsukane A,Takahashi Y,Imamura Y,Hirahata K,Hase H

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Hematuria is the first manifestation of urinary abnormality in immunoglobulin A nephropathy (IgAN). Hematuria has recently been reported as a risk factor for deterioration of renal function; however, its cause remains unknown. METHODS:We analyzed the surface marker of peripheral blood mononuclear cells befo...

journal_title：Clinical and experimental nephrology

authors： Iwatani H,Nagasawa Y,Yamamoto R,Iio K,Mizui M,Horii A,Kitahara T,Inohara H,Kumanogoh A,Imai E,Rakugi H,Isaka Y

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Injection of parathyroid hormone (PTH) rapidly stimulates renal Pi excretion, in part by downregulating NaPi-IIa (Npt2a/SLC34A1) and NaPi-IIc (Npt2c/SLC34A3) transporters. The mechanisms underlying the effects of PTH on NaPi-IIc are not fully elucidated. METHODS:We analyzed the effect of PTH on inorganic ph...

journal_title：Clinical and experimental nephrology

authors： Fujii T,Segawa H,Hanazaki A,Nishiguchi S,Minoshima S,Ohi A,Tominaga R,Sasaki S,Tanifuji K,Koike M,Arima Y,Shiozaki Y,Kaneko I,Ito M,Tatsumi S,Miyamoto KI

更新日期：2019-07-01 00:00:00

abstract：:Recently, there has been a paradigm shift away from an emphasis on the role of the endocrine (circulating) renin-angiotensin system (RAS) in the regulation of the sodium and extracellular fluid balance, blood pressure, and the pathophysiology of hypertensive organ damage toward a focus on the role of tissue RAS found ...

journal_title：Clinical and experimental nephrology

authors： Kagami S

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:IgG4-related disease has attracted wide attention recently. It is characterized by a high level of serum IgG4 and dense infiltration of IgG4-positive plasma cells into multiple organs, with the kidney being one representative target. Although several sets of diagnostic criteria for autoimmune pancreatitis (A...

journal_title：Clinical and experimental nephrology

authors： Kawano M,Saeki T,Nakashima H,Nishi S,Yamaguchi Y,Hisano S,Yamanaka N,Inoue D,Yamamoto M,Takahashi H,Nomura H,Taguchi T,Umehara H,Makino H,Saito T

更新日期：2011-10-01 00:00:00

abstract：:Waldenström's macroglobulinemia is rare lymphoproliferative disorder characterized by the presence of a monoclonal IgM paraproteinemia. Cryoglobulinemia is a common sequela of Waldenström's macroglobulinemia present in 8-18% of the patients. Cryoglobulinemia has also been described as occurring after treatment with ri...

journal_title：Clinical and experimental nephrology

authors： Shaikh A,Habermann TM,Fidler ME,Kumar S,Leung N

更新日期：2008-08-01 00:00:00

abstract：:IgA nephropathy (IgAN) associated with leukemia and lymphoma has not, to our knowledge, been reported in children. Two children suffering from these diseases are described here. One patient developed IgAN at the end of 5 years' chemotherapy for acute lymphocytic leukemia. The other had microscopic hematuria 3 years be...

journal_title：Clinical and experimental nephrology

authors： Motoyama O,Kojima Y,Ohara A,Tsukimoto I,Ishikawa Y,Iitaka K

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND:Hypertension is a risk factor common to both chronic kidney disease and cardiovascular disease. Nicorandil is widely used for the treatment of angina. We investigated the benefits of nicorandil with respect to renal dysfunction in Dahl salt-sensitive hypertensive (DS) rats. METHOD:DS rats were fed a high-sa...

journal_title：Clinical and experimental nephrology

authors： Tashiro Y,Yogo K,Serizawa K,Endo K

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Dotinurad, a novel selective urate reabsorption inhibitor, exerts a serum uric acid-lowering effect by selectively inhibiting urate transporter 1 (URAT1) in patients with hyperuricemia. It is generally known that the progression of renal dysfunction is associated with a reduction in the serum uric acid-lower...

journal_title：Clinical and experimental nephrology

authors： Fukase H,Okui D,Sasaki T,Fushimi M,Ohashi T,Hosoya T

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Two randomized, double-blind, placebo-controlled trials (EPPIC-1 and EPPIC-2) investigated the efficacy and safety of AST-120, an oral spherical carbon adsorbent, in adults with chronic kidney disease (CKD). While the benefit of adding AST-120 to standard therapy was not supported by these trials, we perform...

journal_title：Clinical and experimental nephrology

authors： Schulman G,Berl T,Beck GJ,Remuzzi G,Ritz E,Shimizu M,Kikuchi M,Shobu Y

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:The number of elderly dialysis patients in Japan is dramatically increasing. Receiving therapy with better satisfaction through home care is one of the important factors in their daily lives. Thus, the quality of life of elderly patients on hemodialysis (HD) or peritoneal dialysis (PD) was evaluated. METHOD...

journal_title：Clinical and experimental nephrology

authors： Saka Y,Naruse T,Tawada N,Tokomoto M,Noda Y,Taniguchi Y,Nagahara Y,Yamashita R,Karasawa M,Watanabe Y,Ito Y

更新日期：2017-10-01 00:00:00