Abstract:
BACKGROUND:Renal dysfunction is recognized with increasing frequency among the noninfectious comorbidities associated with human immunodeficiency virus (HIV) infection. Urinary liver-type fatty acid-binding protein (L-FABP) has been shown to be a new biomarker to screen for not only tubulointerstitial damage but also kidney dysfunction. METHODS:We performed a cross-sectional study to determine the association between the urinary L-FABP and chronic kidney disease (CKD) among 77 HIV-infected Japanese patients by backward-stepwise multivariable logistic regression. RESULTS:The prevalence of individuals in the low risk was 80 %. Urinary L-FABP level was not associated with antiretroviral therapy and tenofovir disoproxil fumarate. On the other hand, urinary L-FABP level was independently associated with the CKD classification. CONCLUSION:Urinary L-FABP may be used as an adjunct to diagnose the CKD stage.
journal_name
Clin Exp Nephroljournal_title
Clinical and experimental nephrologyauthors
Hikasa S,Yasuda M,Hideta K,Kawakami M,Higasa S,Sawada A,Tokugawa T,Kimura Tdoi
10.1007/s10157-016-1347-8subject
Has Abstractpub_date
2017-12-01 00:00:00pages
971-977issue
6eissn
1342-1751issn
1437-7799pii
10.1007/s10157-016-1347-8journal_volume
21pub_type
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