Abstract:
BACKGROUND:The herbicide paraquat (1, 1'-dimethyl-4, 4'-bipyridylium dichloride; PQ) is a poison well-known to cause delayed mortality due to acute kidney injuries (AKI). This study examines the changes in serum amino acids (AAs) metabolite profiles as surrogate markers of renal cell metabolism and function after paraquat poisoning. METHODS:To identify the metabolic profiling of free serum AAs and its metabolites, serum from 40 paraquat-poisoned patients with or without AKI is collected. LC-MS/GC-MS is performed to analyze AA molecules. A Cox proportional hazard model was used to assess for incidence of AKI. Receiver operating characteristic (ROC) curve is applied to evaluate AKI occurrence and prognosis. RESULTS:A total of 102 serum AAs and its metabolites were identified. Compared with non-AKI patients, 37 varied significantly in AKI patients. The univariate Cox proportional hazard model analysis revealed that the estimated PQ amount, plasma PQ concentration, urine PQ concentration, APACHE, SOFA scores and 16 amino acids correlated with the incidence of AKI. Further analyses revealed that 3-methylglutarylcarnitine, 1-methylimidazoleacetate, and urea showed higher cumulative hazard ratios for the occurrence of AKI during follow-up (P < 0.05). The area under the curve (AUC) of 3-methylglutarylcarnitine, 1-methylimidazoleacetate and urea were 0.917, 0.857, 0.872, respectively. CONCLUSION:3-methylglutarylcarnitine, 1-methylimidazoleacetate and urea were associated with AKI in patients with paraquat intoxication.
journal_name
Clin Exp Nephroljournal_title
Clinical and experimental nephrologyauthors
Wan X,Li X,Wang Q,Zheng B,Zhou C,Kang X,Hu D,Bao H,Peng Adoi
10.1007/s10157-019-01702-zsubject
Has Abstractpub_date
2019-04-01 00:00:00pages
474-483issue
4eissn
1342-1751issn
1437-7799pii
10.1007/s10157-019-01702-zjournal_volume
23pub_type
杂志文章abstract:BACKGROUND:The appropriate blood pressure target to prevent end-stage renal disease (ESRD) is controversial. METHODS:We examined the association between systolic blood pressure (SBP) changes and ESRD incidence in 69,575 participants from the Okinawa general population aged ≥ 20 years who underwent health check-ups in ...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-019-01771-0
更新日期:2019-11-01 00:00:00
abstract::Because of the increasing incidence of cardiac failure and chronic renal failure due to the progressive aging of the population, the extensive application of cardiac interventional techniques, the rising rates of obesity and diabetes mellitus, coexistence of heart failure and renal failure in the same patient are freq...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章,评审
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abstract:BACKGROUND:Children with nephrotic syndrome (NS) have hyperlipidemia, which may lead to endothelial dysfunction. This study evaluated endothelial function and structural atherosclerosis in NS children with disease duration more than 2 years, by assessment of brachial artery flow-mediated dilatation (FMD) and carotid in...
journal_title:Clinical and experimental nephrology
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abstract::Posterior reversible encephalopathy syndrome (PRES) is a rare complication of nephrotic syndrome and corticosteroid therapy. Here, we discuss an 18 year old man with type 1 membranoproliferative glomerulonephritis (MPGN) secondary to hepatitis B infection who developed posterior leukoencephalopathy while on therapy wi...
journal_title:Clinical and experimental nephrology
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journal_title:Clinical and experimental nephrology
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journal_title:Clinical and experimental nephrology
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Clinical and experimental nephrology
pub_type: 杂志文章,评审
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journal_title:Clinical and experimental nephrology
pub_type: 临床试验,杂志文章,多中心研究
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journal_title:Clinical and experimental nephrology
pub_type: 杂志文章,评审
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更新日期:2009-02-01 00:00:00
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journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-014-1064-0
更新日期:2015-10-01 00:00:00
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journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-007-0475-6
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abstract::Glomerular lipid deposition is sometimes associated with a particular kind of lipid metabolism disturbance. Ultrastructural analyses using electron microscopy often indicate a disease-specific aspect of intraglomerular lipid distribution. ...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章,评审
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journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-018-1666-z
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journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
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journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-014-0998-6
更新日期:2015-06-01 00:00:00
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journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-019-01722-9
更新日期:2019-07-01 00:00:00
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journal_title:Clinical and experimental nephrology
pub_type: 临床试验,杂志文章,多中心研究
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journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2011-08-01 00:00:00
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journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
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abstract:BACKGROUND:The Determinants of the prescribed dialysis dose have not been well studied in a large patient population. Few studies have examined survival rates after adjusting for dose determinants. METHODS:Data were obtained from a cohort of chronic hemodialysis patients for the period January 1991 through December 20...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
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journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-014-1058-y
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