Severe metabolic acidosis and hypokalemia in a patient with enterovesical fistula.

abstract：BACKGROUND:Tolvaptan slowed the rates of total kidney volume (TKV) growth and renal function decline over a 3-year period in patients with autosomal dominant polycystic kidney disease (ADPKD) enrolled in the Tolvaptan Efficacy and Safety in Management of Autosomal Dominant Polycystic Kidney Disease and Its Outcomes (TE...

journal_title：Clinical and experimental nephrology

authors： Horie S,Muto S,Kawano H,Okada T,Shibasaki Y,Nakajima K,Ibuki T

更新日期：2021-01-20 00:00:00

abstract：BACKGROUND AND AIM:The infusion of chronic angiotensin II (Ang II) has been shown to promote renal interstitial fibrosis. To evaluate the pathophysiological significance of the natriuretic peptide-GC-A system, we infused Ang II (1.0 mg/kg/day) in GC-A-deficient mice (GC-A-KO). METHODS:We used 5 groups (Wild-Saline n =...

journal_title：Clinical and experimental nephrology

authors： Yoshihara F,Tokudome T,Kishimoto I,Otani K,Kuwabara A,Horio T,Kawano Y,Kangawa K

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Cardiovascular disease is the leading cause of morbidity and mortality in patients with kidney failure. Nocturnal home hemodialysis (NHD) is a form of kidney replacement therapy whereby hemodialysis is performed for at least 6-h overnight, at least 4 days per week. Little is known about the effects of NHD on...

journal_title：Clinical and experimental nephrology

authors： Friesen T,Jassal DS,Zhu M,Eng F,Rigatto C,Tangri N,Sood MM,Karlstedt E,Premecz S,Komenda P

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Acute renal infarction (ARI) is a rare disease with atrial fibrillation being its main cause. The possible laterality of ARI is controversial. This study aimed to evaluate the association between anatomical features of the renal arteries and ARI. METHODS:This was a single-center cross-sectional study that e...

journal_title：Clinical and experimental nephrology

authors： Kagaya S,Ojima Y,Aoki S,Sato H,Nagasawa T

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Hypertension is a risk factor common to both chronic kidney disease and cardiovascular disease. Nicorandil is widely used for the treatment of angina. We investigated the benefits of nicorandil with respect to renal dysfunction in Dahl salt-sensitive hypertensive (DS) rats. METHOD:DS rats were fed a high-sa...

journal_title：Clinical and experimental nephrology

authors： Tashiro Y,Yogo K,Serizawa K,Endo K

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:It has been recently reported that peroxisome proliferator-activated receptors (PPARs)gamma exist in various tissues and that they exibit anti-inflammatory effects. METHODS:We investigated the effects of PPARgamma activators on the development of crescentic glomerulonephritis. Crescentic glomerulonephritis ...

journal_title：Clinical and experimental nephrology

authors： Haraguchi K,Shimura H,Onaya T

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND:X-linked Alport syndrome (XLAS) is a progressive hereditary nephropathy caused by mutations in the type IV collagen alpha chain 5 gene (COL4A5). Although many COL4A5 mutations have previously been identified, pathogenic synonymous mutations have not yet been described. METHODS:A family with XLAS underwent m...

journal_title：Clinical and experimental nephrology

authors： Fu XJ,Nozu K,Eguchi A,Nozu Y,Morisada N,Shono A,Taniguchi-Ikeda M,Shima Y,Nakanishi K,Vorechovsky I,Iijima K

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Chronic kidney disease (CKD) is a significant public health problem. Strategy for its early detection is still controversial. This study aims to assess the cost-effectiveness of population strategy, i.e. mass screening, and Japan's health checkup reform. METHODS:Cost-effectiveness analysis was carried out t...

journal_title：Clinical and experimental nephrology

authors： Kondo M,Yamagata K,Hoshi SL,Saito C,Asahi K,Moriyama T,Tsuruya K,Yoshida H,Iseki K,Watanabe T

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:Renal dysfunction is recognized with increasing frequency among the noninfectious comorbidities associated with human immunodeficiency virus (HIV) infection. Urinary liver-type fatty acid-binding protein (L-FABP) has been shown to be a new biomarker to screen for not only tubulointerstitial damage but also k...

journal_title：Clinical and experimental nephrology

authors： Hikasa S,Yasuda M,Hideta K,Kawakami M,Higasa S,Sawada A,Tokugawa T,Kimura T

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND/AIMS:Fibroblast growth factor 23 (FGF23) and soluble α-Klotho are emerging potential biomarkers of phosphorus and vitamin D metabolism which change in concentration in early chronic kidney disease (CKD) in order to maintain normal phosphorus levels. Tubular reabsorption of phosphate (TRP) has been commonly u...

journal_title：Clinical and experimental nephrology

authors： Hong YA,Lim JH,Kim MY,Kim Y,Yang KS,Chung BH,Chung S,Choi BS,Yang CW,Kim YS,Chang YS,Park CW

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Maxacalcitol (22-oxacalcitriol; OCT) is a novel vitamin D analogue. In previous clinical studies, OCT was administered three times a week to hemodialysis patients with refractory secondary hyperparathyroidism (2HPT), in whom it acted by inhibiting parathyroid hormone secretion, as well as causing mildly elev...

journal_title：Clinical and experimental nephrology

authors： Murakami K,Miyachi H,Watanabe A,Kawamura N,Fujii M,Koide S,Murase M,Kushimoto H,Hasegawa M,Tomita M,Hiki Y,Sugiyama S

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND:Dotinurad is a novel selective urate reabsorption inhibitor (SURI) that selectively inhibits the reabsorption of uric acid in renal tubules and promotes the excretion of uric acid into urine. In this study, the effects of age and gender on the pharmacokinetics (PK), pharmacodynamics (PD), and safety of dotin...

journal_title：Clinical and experimental nephrology

authors： Nakatani H,Fushimi M,Sasaki T,Okui D,Ohashi T

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Although a high prevalence of macrovascular disease (MVD) has been reported in patients with stage 3 chronic kidney disease (CKD), few studies have reported its risk with respect to the underlying cause of kidney disease. This study investigated the prevalence of MVD in type 2 diabetic patients with CKD stra...

journal_title：Clinical and experimental nephrology

authors： Tanaka K,Hara S,Kushiyama A,Ubara Y,Yoshida Y,Mizuiri S,Aikawa A,Kawatzu S

更新日期：2011-06-01 00:00:00

abstract：:The manifestation of diabetic nephropathy may be a consequence of the actions of certain cytokines and growth factors. Prominent among them is transforming growth factor-β (TGF-β), which promotes renal cell hypertrophy and stimulates extracellular matrix accumulation, the two hallmarks of diabetic renal disease. In ex...

journal_title：Clinical and experimental nephrology

authors： Ziyadeh FN,Isono M,Chen S

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:Analyses of selected cases suggest that immunosuppressive treatment could reduce proteinuria and delay the progression of immunoglobulin A nephropathy (IgAN). The aim of this study was to examine the long-term effectiveness of this therapy on the clinical course of IgAN. We also examined the relationship bet...

journal_title：Clinical and experimental nephrology

authors： Oshima S,Kawamura O

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:The suitable methods evaluating glomerular filtration rate (GFR) have not been established in patients undergoing radical nephrectomy (RN) or radical nephroureterectomy (RNU) due to urological malignancies in Japan as well as worldwide. METHODS:We examined the relationship between creatinine clearance-based...

journal_title：Clinical and experimental nephrology

authors： Niwa N,Yoshida T,Mizuno R,Kikuchi E,Miyajima A,Hayashi M,Oya M

更新日期：2018-10-01 00:00:00

abstract：:A Japanese boy aged 14 years presented with gross hematuria associated with mild proteinuria and was diagnosed as having nutcracker syndrome. Magnetic resonance angiography (MRA) revealed significant compression of the left renal vein between the aorta and the superior mesenteric artery with collaterals. A percutaneou...

journal_title：Clinical and experimental nephrology

authors： Tanaka H,Waga S

更新日期：2004-03-01 00:00:00

abstract：:Unique renal histopathological appearances, consisting of podocytic infolding and microstructures in the glomerular basement membrane (GBM) were identified in the renal biopsies from three patients with collagen diseases such as systemic lupus erythematosus (lupus nephritis, class II) and Sjögren's syndrome. In each c...

journal_title：Clinical and experimental nephrology

authors： Sugiyama H,Maruyama M,Morinaga H,Inoue T,Takiue K,Kikumoto Y,Kinomura M,Sada KE,Akagi S,Kitamura S,Maeshima Y,Makino H

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:The post-marketing surveillance of edaravone has reported serious adverse reactions, including renal and hepatic disorders. Renal disorders were the most frequently reported serious/important adverse reactions, which led to the evaluation of their causation by edaravone, their severity, and the recovery of r...

journal_title：Clinical and experimental nephrology

authors： Hishida A

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:Contrast media (CM)-induced nephropathy (CIN) is an acute deterioration of renal function following administration of CM mediated to a large extent by the increased production of ROS within the kidney. Aim of this study was to evaluate whether a novel isoform of a recombinant Manganese SOD (rMnSOD) could pro...

journal_title：Clinical and experimental nephrology

authors： Pisani A,Sabbatini M,Riccio E,Rossano R,Andreucci M,Capasso C,De Luca V,Carginale V,Bizzarri M,Borrelli A,Schiattarella A,Santangelo M,Mancini A

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Serum cystatin C is not only a marker of renal function but also acts as an independent risk factor for cardiovascular damage, heart failure, and death. It is known that the initiation and progression of these cardiovascular events contributes to renal dysfunction and chronic inflammation. In this study, we ...

journal_title：Clinical and experimental nephrology

authors： Okura T,Jotoku M,Irita J,Enomoto D,Nagao T,Desilva VR,Yamane S,Pei Z,Kojima S,Hamano Y,Mashiba S,Kurata M,Miyoshi K,Higaki J

更新日期：2010-12-01 00:00:00

abstract：:C1q nephropathy, first proposed by Jennette and Hipp [Am J Clin Pathol 83:415-420, 1985; Am J Kidney Dis 6:103-110, 1985], was described as a distinct glomerular disease entity characterized by extensive mesangial deposition of C1q, with associated mesangial immune complexes, and the absence of any clinical and labora...

journal_title：Clinical and experimental nephrology

authors： Mii A,Shimizu A,Masuda Y,Fujita E,Aki K,Ishizaki M,Sato S,Griesemer A,Fukuda Y

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND:Thallium-201 washout rate of stress myocardial perfusion imaging (MPI) has been reported to correlate with coronary flow reserve which is a parameter of myocardial microcirculation. However, the evidence for its use in diabetic kidney disease (DKD) has been lacking, and the association between thallium-201 w...

journal_title：Clinical and experimental nephrology

authors： Hayashi T,Joki N,Tanaka Y,Iwasaki M,Kubo S,Matsukane A,Takahashi Y,Imamura Y,Hirahata K,Hase H

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:The Stewart model for analyzing acid-base disturbances emphasizes serum albumin levels, which are ignored in the traditional Boston model. We compared data derived using the Stewart model to those using the Boston model in patients with nephrotic syndrome. METHODS:Twenty-nine patients with nephrotic syndrom...

journal_title：Clinical and experimental nephrology

authors： Kasagi T,Imai H,Miura N,Suzuki K,Yoshino M,Nobata H,Nagai T,Banno S

更新日期：2017-10-01 00:00:00

abstract：:In the original publication of the article, the second sentence under the heading, Case presentation appears incorrectly as A computed tomographic (CT) scan demonstrated left-sided hydronephrosis (Fig. 1). ...

journal_title：Clinical and experimental nephrology

authors： Wu BS,Ho Y,Yang CY

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:Microalbuminuria, a marker of vascular damage, is associated with increased risk of progressive renal deterioration, cardiovascular disease and mortality. However, the relationship between antinuclear antibody (ANA) and microalbuminuria in the general population is unknown. Thus, we conducted a cross-section...

journal_title：Clinical and experimental nephrology

authors： Ishikawa M,Konta T,Hao Z,Takasaki S,Abiko H,Takahashi T,Ikeda A,Ichikawa K,Shibata Y,Takeishi Y,Kato T,Kawata S,Kubota I

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:Edaravone, a drug for treating acute ischemic stroke, has been reported to provoke acute renal disorders. In the previous study, the author evaluated the role of edaravone in the development of renal disorders in 207 patients reported as having developed them in the post-marketing survey of the drug. The ove...

journal_title：Clinical and experimental nephrology

authors： Hishida A

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:Chronic kidney disease is a predictor of end-stage renal disease (ESRD) and cardiovascular disease (CVD). Therefore, the medical expenses are higher with the decrease in glomerular filtration rate (GFR). However, few studies have examined the medical expenses according to the baseline GFR. METHODS:We invest...

journal_title：Clinical and experimental nephrology

authors： Iseki K,Iseki C,Kurahashi I,Watanabe T

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Both myeloperoxidase-associated antineutrophil cytoplasmic antibody (MPO-ANCA) and antiglomerular basement membrane antibody (anti-GBM Ab) positivity have been demonstrated in patients with rapidly progressive glomerulonephritis (RPGN), either with or without pulmonary hemorrhage; however, the implications o...

journal_title：Clinical and experimental nephrology

authors： Nakabayashi K,Fujioka Y,Nagasawa T,Kimura T,Kojima K,Arimura Y,Yamada A

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:Renal inulin clearance is the gold standard for glomerular filtration rate (GFR), but is compromised by problems of collecting urine samples in children, especially those <6 years of age or with a bladder dysfunction. Therefore, we should utilize the serum creatinine (Cr)-based estimated GFR (eGFR), measurin...

journal_title：Clinical and experimental nephrology

authors： Nagai T,Uemura O,Ishikura K,Ito S,Hataya H,Gotoh Y,Fujita N,Akioka Y,Kaneko T,Honda M

更新日期：2013-12-01 00:00:00