当前位置： SCI文献检索 > Clinical and Experimental Nephrology期刊下所有文献 > Suppression of parathyroid hormone secretion in CAPD patients by intraperitoneal administration of Maxacalcitol.

Suppression of parathyroid hormone secretion in CAPD patients by intraperitoneal administration of Maxacalcitol.

Abstract：

BACKGROUND:Maxacalcitol (22-oxacalcitriol; OCT) is a novel vitamin D analogue. In previous clinical studies, OCT was administered three times a week to hemodialysis patients with refractory secondary hyperparathyroidism (2HPT), in whom it acted by inhibiting parathyroid hormone secretion, as well as causing mildly elevated serum calcium. However, intravenous injection of OCT, which requires frequent visits to the outpatient clinic, degrades the quality of life of patients with continuous ambulatory peritoneal dialysis (CAPD) who otherwise visit the clinic only once or twice per month. In the present study, we investigated whether transperitoneal absorption of OCT inhibited intact parathyroid hormone (i-PTH) in CAPD patients when the OCT was added to the peritoneal dialysis fluid. METHODS:Peritoneal dialysis fluid containing 20 micro g of OCT was injected into the peritoneal cavity of five CAPD patients. The serum and peritoneal fluid levels of OCT, i-PTH, calcium, and phosphate were measured before and after treatment. RESULTS:The mean concentration of OCT in peritoneal dialysis fluid rapidly decreased, from 25268.0 pg/ml at 0 h to 1694.0 pg/ml at 2 h and 44.9 pg/ml at 4 h. In contrast, the mean serum OCT level increased from the pretreatment level, which was below the detection limit of the assay, to 656.0 pg/ml at 0.5 h and a peak of 759.0 pg/ml at 1 h, and thereafter gradually decreased, to 713.8 pg/ml at 2 h and 555.8 pg/ml at 4 h. Mean i-PTH significantly decreased, to 83.9% of the baseline level, at 1 h (P < 0.05) and thereafter stayed at around 90%. No consistent trends in calcium and phosphate levels were observed in the five patients. CONCLUSIONS:By injecting OCT into the peritoneal cavity, i-PTH levels could be significantly decreased. These findings indicate the therapeutic efficacy of intraperitoneal administration of OCT for CAPD patients.

journal_name

Clin Exp Nephrol

journal_title

Clinical and experimental nephrology

authors

Murakami K,Miyachi H,Watanabe A,Kawamura N,Fujii M,Koide S,Murase M,Kushimoto H,Hasegawa M,Tomita M,Hiki Y,Sugiyama S

doi

10.1007/s10157-004-0283-1

subject

Has Abstract

pub_date

2004-06-01 00:00:00

pages

134-8

issue

eissn

1342-1751

issn

1437-7799

journal_volume

pub_type

临床试验,杂志文章

在线工具

Suppression of parathyroid hormone secretion in CAPD patients by intraperitoneal administration of Maxacalcitol.