Pre-operative and post-operative estimated glomerular filtration rate in Japanese patients with urological malignancies.

abstract：:Unique renal histopathological appearances, consisting of podocytic infolding and microstructures in the glomerular basement membrane (GBM) were identified in the renal biopsies from three patients with collagen diseases such as systemic lupus erythematosus (lupus nephritis, class II) and Sjögren's syndrome. In each c...

journal_title：Clinical and experimental nephrology

authors： Sugiyama H,Maruyama M,Morinaga H,Inoue T,Takiue K,Kikumoto Y,Kinomura M,Sada KE,Akagi S,Kitamura S,Maeshima Y,Makino H

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:Depression is common in chronic kidney disease (CKD) patients and associated with significant increase in morbidity and mortality. In recent years, a relationship between vitamin D deficiency and depression has been shown. The aim of this study is to investigate the relationship between 25-hydroxy (OH) vitam...

journal_title：Clinical and experimental nephrology

authors： Yavuz YC,Biyik Z,Ozkul D,Abusoglu S,Eryavuz D,Dag M,Korez MK,Guney I,Altintepe L

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Although it has been repeatedly shown that the oral carbonaceous absorbent AST-120 ameliorates the progression of chronic renal failure, the mechanisms remain unknown. METHODS:Male Sprague-Dawley rats (6 weeks old), weighing 180-210 g, were 4/5 nephrectomized, and were divided into two groups: one given AST...

journal_title：Clinical and experimental nephrology

authors： Horike K,Usami T,Kamiya Y,Kamiya T,Yoshida A,Itoh S,Yamato H,Ise M,Kimura G

更新日期：2003-06-01 00:00:00

abstract：BACKGROUND:Vascular endothelial cells (VECs) play crucial roles in physiological and pathologic conditions in tissues and organs. Most of these roles are related to VEC plasma membrane proteins. In the kidney, VECs are closely associated with structures and functions; however, plasma membrane proteins in kidney VECs re...

journal_title：Clinical and experimental nephrology

authors： Liu Z,Xu B,Nameta M,Zhang Y,Magdeldin S,Yoshida Y,Yamamoto K,Fujinaka H,Yaoita E,Tasaki M,Nakagawa Y,Saito K,Takahashi K,Yamamoto T

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Proteinuria caused by glomerular disease is characterized by podocyte injury. Vasopressin V2 receptor antagonists are effective in reducing albuminuria, although their actions on glomerular podocytes have not been explored. The objective of this study was to evaluate the effects of tolvaptan, a selective ora...

journal_title：Clinical and experimental nephrology

authors： Okada T,Sakaguchi T,Hatamura I,Saji F,Negi S,Otani H,Muragaki Y,Kawachi H,Shigematsu T

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:The Determinants of the prescribed dialysis dose have not been well studied in a large patient population. Few studies have examined survival rates after adjusting for dose determinants. METHODS:Data were obtained from a cohort of chronic hemodialysis patients for the period January 1991 through December 20...

journal_title：Clinical and experimental nephrology

authors： Iseki K,Tozawa M,Takishita S

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND:The aim of this study was to evaluate the renal preservation effect of ubiquinol, the reduced form of coenzyme Q10 (CoQ10). METHODS:Three-week-old heminephrectomized male Sprague-Dawley rats were divided into three groups (10 animals each): diet with normal (0.3%) salt, high (8%) salt, and high salt plus 60...

journal_title：Clinical and experimental nephrology

authors： Ishikawa A,Kawarazaki H,Ando K,Fujita M,Fujita T,Homma Y

更新日期：2011-02-01 00:00:00

abstract：:A 61-year-old man infected with hepatitis C virus developed urinary protein. Two-dimensional electrophoresis and immunoblotting of sera revealed no monoclonal proteins. Light microscopy and immunofluorescence of a kidney biopsy specimen demonstrated bubbling appearance and formation of spikes, associated with predomin...

journal_title：Clinical and experimental nephrology

authors： Miura N,Uemura Y,Suzuki N,Suga N,Maeda K,Yamaguchi S,Kitagawa W,Yamada H,Nishikawa K,Imai H

更新日期：2010-02-01 00:00:00

abstract：:The manifestation of diabetic nephropathy may be a consequence of the actions of certain cytokines and growth factors. Prominent among them is transforming growth factor-β (TGF-β), which promotes renal cell hypertrophy and stimulates extracellular matrix accumulation, the two hallmarks of diabetic renal disease. In ex...

journal_title：Clinical and experimental nephrology

authors： Ziyadeh FN,Isono M,Chen S

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:In the tubular cells of patients with polycystic kidney disease (PKD), a reduced intracellular Ca(2+) level accelerates cell proliferation, resulting in cyst formation. Thus, whether calcium channel blockers (CCB) are useful for the treatment of hypertension in patients with PKD is questionable. METHODS:Thi...

journal_title：Clinical and experimental nephrology

authors： Mitobe M,Yoshida T,Sugiura H,Shiohira S,Shimada K,Nitta K,Tsuchiya K

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Data regarding renal disease in the elderly (age ≥65 years old) and very elderly (age ≥80 years old) Japanese are extremely limited. The aim of this study was to examine the causes of renal disease and their clinical presentations in elderly patients who underwent renal biopsy. DESIGN, SETTIN...

journal_title：Clinical and experimental nephrology

authors： Yokoyama H,Sugiyama H,Sato H,Taguchi T,Nagata M,Matsuo S,Makino H,Watanabe T,Saito T,Kiyohara Y,Nishi S,Iida H,Morozumi K,Fukatsu A,Sasaki T,Tsuruya K,Kohda Y,Higuchi M,Kiyomoto H,Goto S,Hattori M,Hataya H,Kag

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:Low-energy extracorporeal shock wave (SW) improves ventricular function in ischemic cardiomyopathy through the upregulation of vascular endothelial growth factor (VEGF). VEGF is known to play important roles in acute kidney injury (AKI), and the present study investigates the efficacy of SW for AKI by renal ...

journal_title：Clinical and experimental nephrology

authors： Yoshida M,Nakamichi T,Mori T,Ito K,Shimokawa H,Ito S

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Intravascular administration of iodinated contrast media continues to be a common cause of hospital-acquired acute kidney injury. Accumulating evidence suggests that radiocontrast agent-induced nephrotoxicity is associated with increased oxidative stress, which leads to renal tissue damage with DNA fragmenta...

journal_title：Clinical and experimental nephrology

authors： Ludwig U,Connemann J,Keller F

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Microalbuminuria, a marker of vascular damage, is associated with increased risk of progressive renal deterioration, cardiovascular disease and mortality. However, the relationship between antinuclear antibody (ANA) and microalbuminuria in the general population is unknown. Thus, we conducted a cross-section...

journal_title：Clinical and experimental nephrology

authors： Ishikawa M,Konta T,Hao Z,Takasaki S,Abiko H,Takahashi T,Ikeda A,Ichikawa K,Shibata Y,Takeishi Y,Kato T,Kawata S,Kubota I

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:Creatinine clearance (Ccr) overestimates glomerular filtration rate (GFR) due to the tubular secretion of creatinine. It is known that fractional excretion of creatinine (FE-Cr) increases with decreasing GFR. Association of serum albumin level with the tubular secretion of creatinine was also reported previo...

journal_title：Clinical and experimental nephrology

authors： Horio M,Imai E,Yasuda Y,Watanabe T,Matsuo S

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Aging is well known as one of the major causes of a reduced glomerular filtration rate (GFR). The resistive index (RI) measured by renal Doppler ultrasonography (RDU) is thought to be a good indicator of renal vascular resistance induced by arteriosclerosis. In this study, we investigated whether RI could be...

journal_title：Clinical and experimental nephrology

authors： Kawai T,Kamide K,Onishi M,Hongyo K,Yamamoto-Hanasaki H,Oguro R,Maekawa Y,Yamamoto K,Takeya Y,Sugimoto K,Ohishi M,Rakugi H

更新日期：2012-10-01 00:00:00

abstract：:We report a 58-year-old Japanese man with primary systemic AL amyloidosis who achieved disappearance of proteinuria including Bence-Jones protein (lambda-type) after two courses of VAD therapy (vincristine, doxorubicin, and dexamethasone) and subsequent high-dose melphalan, followed by autologous peripheral blood stem...

journal_title：Clinical and experimental nephrology

authors： Yamazaki O,Ubara Y,Suwabe T,Nakanishi S,Hoshino J,Sawa N,Hayami N,Yamanouchi M,Takemoto F,Kenmei T,Masuoka K,Oohashi K

更新日期：2009-10-01 00:00:00

abstract：:Idiopathic nephrotic syndrome is the most common chronic glomerular disease in children. At least 20 % of children with this syndrome show frequent relapses and/or steroid dependence during or after immunosuppressive therapies, a condition defined as complicated frequently relapsing/steroid-dependent nephrotic syndrom...

journal_title：Clinical and experimental nephrology

authors： Iijima K,Sako M,Nozu K

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:The present study was conducted to clarify the clinical risk factors related to the development of encapsulating peritoneal sclerosis (EPS), which is one of the most serious complications in patients undergoing peritoneal dialysis (PD). METHODS:The records of 78 patients with a history of PD treatment, incl...

journal_title：Clinical and experimental nephrology

authors： Yamamoto R,Otsuka Y,Nakayama M,Maruyama Y,Katoh N,Ikeda M,Yamamoto H,Yokoyama K,Kawaguchi Y,Matsushima M

更新日期：2005-06-01 00:00:00

abstract：BACKGROUND:Liposomal amphotericin B (L-AMB), a broad-spectrum antifungicidal drug, is often used to treat fungal infections. However, clinical evidence of its use in patients with renal dysfunction, especially those receiving renal replacement therapy (RRT), is limited. Therefore, we evaluated the usage and occurrence ...

journal_title：Clinical and experimental nephrology

authors： Obata Y,Takazono T,Tashiro M,Ota Y,Wakamura T,Takahashi A,Sato K,Miyazaki T,Nishino T,Izumikawa K

更新日期：2020-11-11 00:00:00

abstract：:Endothelial dysfunction due to the reduced bioavailability of nitric oxide (NO) is involved in the course of atherosclerotic cardiovascular disease as well as chronic kidney disease (CKD). NO is synthesized from L-arginine via the action of NO synthase, which is blocked by endogenous L-arginine analogues such as asymm...

journal_title：Clinical and experimental nephrology

authors： Ueda S,Yamagishi SI,Matsumoto Y,Fukami K,Okuda S

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND:The incidence of childhood nephrotic syndrome (NS) in Germany is not well known. METHODS:An ESPED-based nationwide collection of epidemiological data of children in 2005 and 2006. RESULT:The mean age of NS at onset was 5.5 ± 3.7 years. The gender ratio of boys to girls was 1.8:1. The average length of stay...

journal_title：Clinical and experimental nephrology

authors： Franke I,Aydin M,Llamas Lopez CE,Kurylowicz L,Ganschow R,Lentze M,Born M

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Cardiovascular disease is the leading cause of morbidity and mortality in patients with kidney failure. Nocturnal home hemodialysis (NHD) is a form of kidney replacement therapy whereby hemodialysis is performed for at least 6-h overnight, at least 4 days per week. Little is known about the effects of NHD on...

journal_title：Clinical and experimental nephrology

authors： Friesen T,Jassal DS,Zhu M,Eng F,Rigatto C,Tangri N,Sood MM,Karlstedt E,Premecz S,Komenda P

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Several comorbidity scoring systems have been developed and validated, mostly in western hemodialysis patients with a high risk of cardiovascular disease. The performance of comorbidity scoring, however, depends on the patient population. In this study, we determine the optimal comorbidity scoring system for...

journal_title：Clinical and experimental nephrology

authors： Ma TK,Chow KM,Kwan BC,Ng JK,Pang WF,Leung CB,Li PK,Szeto CC

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Previous studies have shown that GFR estimated from serum creatinine (eGFRcr) is higher in smokers although the implications remain unclear. We aimed to clarify the associations of smoking with eGFRcys (GFR estimated from serum cystatin C) and eGFRcr, cys (the surmised most precise GFR estimate based on seru...

journal_title：Clinical and experimental nephrology

authors： Yamada Y,Noborisaka Y,Ishizaki M,Yamazaki M,Honda R,Yokoyama H,Kakuma T

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:Cirrhosis of the liver is often associated with an impairment of renal function that is usually not associated with consistent structural abnormalities of the renal parenchyma, but is thought to be the functional consequence of arterial underfilling and reduced arterial blood pressure. METHOD:We have used t...

journal_title：Clinical and experimental nephrology

authors： Maoka T,Kawata T,Koike T,Mochizuki T,Schnermann J,Hashimoto S

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Renin-angiotensin system blockers (RASBs) reduce end-stage kidney disease and cardiovascular event (CVE) development in chronic kidney disease. However, whether RASBs improve long-term prognosis in kidney transplant (KT) recipients remain unknown. METHOD:We investigated 900 kidney transplant patients in a m...

journal_title：Clinical and experimental nephrology

authors： Tsuchimoto A,Masutani K,Ueki K,Nakagawa K,Matsukuma Y,Tanaka S,Unagami K,Kakuta Y,Okumi M,Noguchi H,Kaku K,Okabe Y,Nakano T,Kitazono T,Nakamura M,Ishida H,Tanabe K,Japan Academic Consortium of Kidney Transplantation (JA

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:Mizoribine (MZR) has been developed as an immunosuppressive agent, but has a less potent immunosuppressive effect up to 3 mg/kg/day MZR. Therefore, we investigated whether high-dose MZR, at 6 mg/kg/day, would be effective and safe for kidney transplant patients in conjunction with cyclosporine (CsA), basilix...

journal_title：Clinical and experimental nephrology

authors： Yoshimura N,Ushigome H,Akioka K,Nobori S,Suzuki T,Sakai K,Okamoto M

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:Sirt1, a mammalian homolog of silent information regulator 2 (Sir2), is the founding member of class III histone deacetylase (HDAC). METHODS:In this study, we examined whether Sirt1 is involved in the modification of acetylated histone H3, acetylated p53 and Werner syndrome protein (WRN), which is stabilize...

journal_title：Clinical and experimental nephrology

authors： Sakao Y,Kato A,Tsuji T,Yasuda H,Togawa A,Fujigaki Y,Kahyo T,Setou M,Hishida A

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:Dotinurad is a novel, selective urate reabsorption inhibitor, which reduces serum uric acid levels by inhibiting the urate transporter 1 (URAT1). We compared the pharmacokinetics (PK), pharmacodynamics (PD), and safety of dotinurad in subjects with hepatic impairment and normal hepatic function. METHODS:Thi...

journal_title：Clinical and experimental nephrology

authors： Kumagai Y,Sakaki M,Furihata K,Ito T,Inoue K,Yoshida T,Matsumoto S,Furuno K,Hagino A

更新日期：2020-03-01 00:00:00