An IgA1-lambda-type monoclonal immunoglobulin deposition disease associated with membranous features in a patient with chronic hepatitis C viral infection and rectal cancer.

Abstract:

:A 61-year-old man infected with hepatitis C virus developed urinary protein. Two-dimensional electrophoresis and immunoblotting of sera revealed no monoclonal proteins. Light microscopy and immunofluorescence of a kidney biopsy specimen demonstrated bubbling appearance and formation of spikes, associated with predominantly IgA1-lambda deposition, but not IgG, along glomerular capillary walls. Electron microscopy showed electron-dense deposits without any fibrillary structure located in the glomerular basement membrane. Seven months after the kidney biopsy, the patient had a surgical operation for rectal cancer. One year later, the urinary protein was still present. The present case is the first report of an IgA1-lambda-type monoclonal immunoglobulin deposition disease associated with membranous features.

journal_name

Clin Exp Nephrol

authors

Miura N,Uemura Y,Suzuki N,Suga N,Maeda K,Yamaguchi S,Kitagawa W,Yamada H,Nishikawa K,Imai H

doi

10.1007/s10157-009-0227-x

subject

Has Abstract

pub_date

2010-02-01 00:00:00

pages

90-3

issue

1

eissn

1342-1751

issn

1437-7799

journal_volume

14

pub_type

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