Unique microstructures and podocytic infolding in glomerular basement membrane associated with collagen diseases: a report of three cases.

abstract：:We describe here two sisters with nephronophthisis, which was not detected until the development of endstage renal failure. Twenty- and 15-year-old female siblings were admitted to our hospital for further examination of renal dysfunction. No urinalysis abnormalities had been found in yearly health checks in either pa...

journal_title：Clinical and experimental nephrology

authors： Ashizawa M,Miyazaki M,Furusu A,Abe K,Kanamoto Y,Iwanaga N,Ozono Y,Harada T,Taguchi T,Kohno S

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:Depression is common in chronic kidney disease (CKD) patients and associated with significant increase in morbidity and mortality. In recent years, a relationship between vitamin D deficiency and depression has been shown. The aim of this study is to investigate the relationship between 25-hydroxy (OH) vitam...

journal_title：Clinical and experimental nephrology

authors： Yavuz YC,Biyik Z,Ozkul D,Abusoglu S,Eryavuz D,Dag M,Korez MK,Guney I,Altintepe L

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Renin-angiotensin system blockers (RASBs) reduce end-stage kidney disease and cardiovascular event (CVE) development in chronic kidney disease. However, whether RASBs improve long-term prognosis in kidney transplant (KT) recipients remain unknown. METHOD:We investigated 900 kidney transplant patients in a m...

journal_title：Clinical and experimental nephrology

authors： Tsuchimoto A,Masutani K,Ueki K,Nakagawa K,Matsukuma Y,Tanaka S,Unagami K,Kakuta Y,Okumi M,Noguchi H,Kaku K,Okabe Y,Nakano T,Kitazono T,Nakamura M,Ishida H,Tanabe K,Japan Academic Consortium of Kidney Transplantation (JA

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:Aging is well known as one of the major causes of a reduced glomerular filtration rate (GFR). The resistive index (RI) measured by renal Doppler ultrasonography (RDU) is thought to be a good indicator of renal vascular resistance induced by arteriosclerosis. In this study, we investigated whether RI could be...

journal_title：Clinical and experimental nephrology

authors： Kawai T,Kamide K,Onishi M,Hongyo K,Yamamoto-Hanasaki H,Oguro R,Maekawa Y,Yamamoto K,Takeya Y,Sugimoto K,Ohishi M,Rakugi H

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:In Japan, systematic evaluation of the histologic parameters of anti-neutrophil cytoplasmic autoantibodies (ANCA)-related vasculitis has been performed according to the Japanese classification by Shigematsu et al. However, this classification is quite different from that of the European Vasculitis Study Grou...

journal_title：Clinical and experimental nephrology

authors： Joh K,Muso E,Shigematsu H,Nose M,Nagata M,Arimura Y,Yumura W,Wada T,Nitta K,Makino H,Taguma Y,Kaneoka H,Suzuki Y,Kobayashi M,Koyama A,Usui J,Hashimoto H,Ozaki S,Tomino Y,Yamagata K

更新日期：2008-08-01 00:00:00

abstract：:A 68-year-old man with a 30-year history of essential thrombocytosis developed nephrotic syndrome. Renal biopsy showed massive deposits of Congo red-negative periodic acid Schiff (PAS)-positive substance in the mesangium and capillary wall that was positive for IgG. Electron microscopic examination revealed 10- to 20-...

journal_title：Clinical and experimental nephrology

authors： Asaba K,Tojo A,Onozato ML,Mimura N,Kido M,Goto A,Endo H,Fujita T

更新日期：2003-12-01 00:00:00

abstract：BACKGROUND:Mizoribine (MZR) has been developed as an immunosuppressive agent, but has a less potent immunosuppressive effect up to 3 mg/kg/day MZR. Therefore, we investigated whether high-dose MZR, at 6 mg/kg/day, would be effective and safe for kidney transplant patients in conjunction with cyclosporine (CsA), basilix...

journal_title：Clinical and experimental nephrology

authors： Yoshimura N,Ushigome H,Akioka K,Nobori S,Suzuki T,Sakai K,Okamoto M

更新日期：2013-02-01 00:00:00

abstract：:Glomerular lipid deposition is sometimes associated with a particular kind of lipid metabolism disturbance. Ultrastructural analyses using electron microscopy often indicate a disease-specific aspect of intraglomerular lipid distribution. ...

journal_title：Clinical and experimental nephrology

authors： Sato H,Takahashi N,Sato E,Kisu K,Ito S,Saito T

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Although acute kidney injury (AKI) is known as a potential complication of influenza infections, there is limited information concerning the association between influenza and AKI. The aim of this study is to evaluate the incidence, the mortality, and risk factors of AKI in hospitalized patients by seasonal i...

journal_title：Clinical and experimental nephrology

authors： Ishibuchi K,Fukasawa H,Kaneko M,Yasuda H,Furuya R

更新日期：2021-01-04 00:00:00

abstract：BACKGROUND:Children with nephrotic syndrome (NS) have hyperlipidemia, which may lead to endothelial dysfunction. This study evaluated endothelial function and structural atherosclerosis in NS children with disease duration more than 2 years, by assessment of brachial artery flow-mediated dilatation (FMD) and carotid in...

journal_title：Clinical and experimental nephrology

authors： Rahul I,Krishnamurthy S,Satheesh S,Biswal N,Bobby Z,Lakshminarayanan S

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:Contrast media (CM)-induced nephropathy (CIN) is an acute deterioration of renal function following administration of CM mediated to a large extent by the increased production of ROS within the kidney. Aim of this study was to evaluate whether a novel isoform of a recombinant Manganese SOD (rMnSOD) could pro...

journal_title：Clinical and experimental nephrology

authors： Pisani A,Sabbatini M,Riccio E,Rossano R,Andreucci M,Capasso C,De Luca V,Carginale V,Bizzarri M,Borrelli A,Schiattarella A,Santangelo M,Mancini A

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Tolvaptan slowed the rates of total kidney volume (TKV) growth and renal function decline over a 3-year period in patients with autosomal dominant polycystic kidney disease (ADPKD) enrolled in the Tolvaptan Efficacy and Safety in Management of Autosomal Dominant Polycystic Kidney Disease and Its Outcomes (TE...

journal_title：Clinical and experimental nephrology

authors： Horie S,Muto S,Kawano H,Okada T,Shibasaki Y,Nakajima K,Ibuki T

更新日期：2021-01-20 00:00:00

abstract：BACKGROUND:Aquaporin-2 (AQP2) is a key water channel protein which determines the water permeability of the collecting duct. Multiple phosphorylation sites are present at the C-terminal of AQP2 including S256 (serine at 256 residue), S261, S264 and S/T269, which are regulated by vasopressin (VP) to modulate AQP2 traffi...

journal_title：Clinical and experimental nephrology

authors： Sakai M,Yamamoto K,Mizumura H,Matsumoto T,Tanaka Y,Noda Y,Ishibashi K,Yamamoto T,Sasaki S

更新日期：2020-09-01 00:00:00

abstract：:Chronic kidney disease (CKD), as defined by reduced glomerular filtration rate (<60 ml/min/1.73 m(2)) and/or the presence of renal damage for >3 months, is a significant threat for public health in modern societies. Recent epidemiological studies have demonstrated that CKD is a significant risk for cardiovascular even...

journal_title：Clinical and experimental nephrology

authors： Ito S

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:Although it has been repeatedly shown that the oral carbonaceous absorbent AST-120 ameliorates the progression of chronic renal failure, the mechanisms remain unknown. METHODS:Male Sprague-Dawley rats (6 weeks old), weighing 180-210 g, were 4/5 nephrectomized, and were divided into two groups: one given AST...

journal_title：Clinical and experimental nephrology

authors： Horike K,Usami T,Kamiya Y,Kamiya T,Yoshida A,Itoh S,Yamato H,Ise M,Kimura G

更新日期：2003-06-01 00:00:00

abstract：BACKGROUND:The herbicide paraquat (1, 1'-dimethyl-4, 4'-bipyridylium dichloride; PQ) is a poison well-known to cause delayed mortality due to acute kidney injuries (AKI). This study examines the changes in serum amino acids (AAs) metabolite profiles as surrogate markers of renal cell metabolism and function after paraq...

journal_title：Clinical and experimental nephrology

authors： Wan X,Li X,Wang Q,Zheng B,Zhou C,Kang X,Hu D,Bao H,Peng A

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:The Oxford Classification is utilized globally, but has not been fully validated. In this study, we conducted a comparative analysis between the Oxford Classification and Japanese Histologic Classification (JHC) to predict renal outcome in Japanese patients with IgA nephropathy (IgAN). METHODS:A retrospecti...

journal_title：Clinical and experimental nephrology

authors： Kaihan AB,Yasuda Y,Katsuno T,Kato S,Imaizumi T,Ozeki T,Hishida M,Nagata T,Ando M,Tsuboi N,Maruyama S

更新日期：2017-12-01 00:00:00

abstract：:Recently, there has been a paradigm shift away from an emphasis on the role of the endocrine (circulating) renin-angiotensin system (RAS) in the regulation of the sodium and extracellular fluid balance, blood pressure, and the pathophysiology of hypertensive organ damage toward a focus on the role of tissue RAS found ...

journal_title：Clinical and experimental nephrology

authors： Kagami S

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:Chronic kidney disease (CKD) is a significant public health problem. Strategy for its early detection is still controversial. This study aims to assess the cost-effectiveness of population strategy, i.e. mass screening, and Japan's health checkup reform. METHODS:Cost-effectiveness analysis was carried out t...

journal_title：Clinical and experimental nephrology

authors： Kondo M,Yamagata K,Hoshi SL,Saito C,Asahi K,Moriyama T,Tsuruya K,Yoshida H,Iseki K,Watanabe T

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:To investigate whether pre-dialysis level of serum creatinine (SCre) could indicate the responsiveness to zinc supplementation of patients on maintenance hemodialysis (MHD). METHODS:We retrospectively reviewed the results of our previous randomized study of 91 patients who had been on MHD and received zinc ...

journal_title：Clinical and experimental nephrology

authors： Okamoto T,Hatakeyama S,Togashi K,Hamaya T,Tanaka Y,Imanishi K,Takashima T,Saitoh F,Suzuki T,Ohyama C

更新日期：2020-10-01 00:00:00

abstract：:A 52-year-old Japanese female was admitted to our hospital for microhematuria, proteinuria and progressive renal dysfunction. Two years prior to admission, she was diagnosed with lung adenocarcinoma and multiple bone and brain metastases, and was treated with gefitinib (250 mg/day). Treatment for 6 months induced part...

journal_title：Clinical and experimental nephrology

authors： Masutani K,Fujisaki K,Maeda H,Toyonaga J,Inoshima I,Takayama K,Katafuchi R,Hirakata H,Tsuruya K,Iida M

更新日期：2008-10-01 00:00:00

abstract：:A 62-year-old female dialysis patient with chronic glomerulonephritis had been receiving hemodialysis therapy for 32 years. In 1985 she underwent a parathyroidectomy for secondary hyperparathyroidism (HPT); however, her parathyroid hormone (PTH) levels gradually increased. Her serum calcium level ranged from 9.0 to 10...

journal_title：Clinical and experimental nephrology

authors： Oshiro Y,Tanaka H,Okimoto N

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Peritoneal injury is an important cause of technical failure of long-term peritoneal dialysis (PD). Encapsulating peritoneal sclerosis (EPS) is a severe complication of long-term PD with potentially life threatening consequences. CD147 is a glycoprotein with diverse functions including modulation of extracel...

journal_title：Clinical and experimental nephrology

authors： Seeger H,Latus J,Kitterer D,Alscher MD,Biegger D,Chen J,Edenhofer I,Wüthrich RP,Segerer S

更新日期：2017-12-01 00:00:00

abstract：:Distal renal tubular acidosis (dRTA) results from impaired urinary acidification by the renal collecting duct. Acquired dRTA can be secondary to diverse pathological processes, including diabetic, ischemic, fibrosing, or immunological processes; less frequently it presents as a familial disorder with either an autosom...

journal_title：Clinical and experimental nephrology

authors： Shayakul C,Alper SL

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND:The etiology of hemodialysis (HD)-induced hypotension and hypertension remains speculative. There is mounting evidence that endothelin-1 (ET-1) may play a vital role in these hemodynamic changes. We examined the possible role of intradialytic changes of ET-1 in the pathogenesis of hypotension and rebound hyp...

journal_title：Clinical and experimental nephrology

authors： El-Shafey EM,El-Nagar GF,Selim MF,El-Sorogy HA,Sabry AA

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:Creatinine clearance (Ccr) overestimates glomerular filtration rate (GFR) due to the tubular secretion of creatinine. It is known that fractional excretion of creatinine (FE-Cr) increases with decreasing GFR. Association of serum albumin level with the tubular secretion of creatinine was also reported previo...

journal_title：Clinical and experimental nephrology

authors： Horio M,Imai E,Yasuda Y,Watanabe T,Matsuo S

更新日期：2014-06-01 00:00:00

abstract：:A 78-year old woman with complicating solitary kidney had nephrotic syndrome. Renal biopsy specimens showed focal segmental glomerulosclerosis (FSGS). First, the patient was treated with angiotensin receptor blocker (ARB) and angiotensin converting enzyme inhibitor (ACEI). Proteinuria decreased from 10 to 6 g/day, but...

journal_title：Clinical and experimental nephrology

authors： Oshiro Y,Umena S,Noda M

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND:Cirrhosis of the liver is often associated with an impairment of renal function that is usually not associated with consistent structural abnormalities of the renal parenchyma, but is thought to be the functional consequence of arterial underfilling and reduced arterial blood pressure. METHOD:We have used t...

journal_title：Clinical and experimental nephrology

authors： Maoka T,Kawata T,Koike T,Mochizuki T,Schnermann J,Hashimoto S

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Recently, preemptive kidney transplantation (PKT) has increased in Japan; however, the effects of PKT on calcium (Ca) and phosphorus (Pi) metabolism are poorly understood. METHODS:Thirty-two consecutive patients were enrolled in this study at Nagoya Daini Red Cross Hospital. Fifteen patients were in the PKT...

journal_title：Clinical and experimental nephrology

authors： Tsujita M,Inaguma D,Goto N,Yamamoto T,Hiramitsu T,Katayama A,Takeda A,Kobayashi T,Morozumi K,Uchida K,Narumi S,Watarai Y,Tominaga Y

更新日期：2015-04-01 00:00:00

abstract：:We report a case of a 59-year-old woman who had severe metabolic acidosis and hypokalemia due to an enterovesical fistula. The patient came to our hospital complaining of systemic weakness and numbness of the fingers. She was found to have hyperchloremic metabolic acidosis (arterial bicarbonate, 2.8 mEq/l) and hypokal...

journal_title：Clinical and experimental nephrology

authors： Murakami K,Tomita M,Kawamura N,Hasegawa M,Nabeshima K,Hiki Y,Sugiyama S

更新日期：2007-09-01 00:00:00