Creatinine-based equations to estimate glomerular filtration rate in Japanese children aged between 2 and 11 years old with chronic kidney disease.

abstract：BACKGROUND:Stromal cell-derived factor-1α (SDF-1α) is an inflammatory chemokine that plays a critical role in cardiovascular disease. Although persistent inflammation causes renal dysfunction, it remains unclear whether SDF-1α is related to progression of chronic kidney disease. This study examined whether high levels ...

journal_title：Clinical and experimental nephrology

authors： Uematsu M,Nakamura T,Yoshizaki T,Watanabe Y,Deyama J,Watanabe K,Kobayashi T,Fujioka D,Saito Y,Nakamura K,Kawabata K,Obata JE,Kugiyama K

更新日期：2019-07-01 00:00:00

abstract：:The clinical course of cryoglobulinemic glomerulonephritis (CGGN) is usually slowly progressive, and only a minority of these patients progress to end-stage renal failure. This report describes an atypical case of a patient with CGGN who demonstrated a rapidly progressive and irreversible renal deterioration. After pr...

journal_title：Clinical and experimental nephrology

authors： Tsuboi N,Ichinose M,Kawamura T,Joh K,Utsunomiya Y,Hosoya T

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:Chronic kidney disease is a predictor of end-stage renal disease (ESRD) and cardiovascular disease (CVD). Therefore, the medical expenses are higher with the decrease in glomerular filtration rate (GFR). However, few studies have examined the medical expenses according to the baseline GFR. METHODS:We invest...

journal_title：Clinical and experimental nephrology

authors： Iseki K,Iseki C,Kurahashi I,Watanabe T

更新日期：2013-06-01 00:00:00

abstract：:This report documents a case of metastatic papillary renal cell carcinoma (PRCC) which successfully responded to interleukin-2 (IL-2) therapy. A 59-year-old male presented with a left renal mass measuring 3.0 cm in diameter and a right adrenal mass measuring 5.0 cm in diameter. He underwent a left partial nephrectomy ...

journal_title：Clinical and experimental nephrology

authors： Kosaka T,Mikami S,Miyajima A,Oya M

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND:Darbepoetin alfa (DA) is an attractive alternative to recombinant human erythropoietin (rHuEPO) in managing renal anemia. Since DA has not been approved by the appropriate Japanese drug regulatory agencies for the indication of renal anemia in children in Japan, we have conducted a multicenter prospective st...

journal_title：Clinical and experimental nephrology

authors： Hattori M,Matsunaga A,Akioka Y,Fujinaga S,Nagai T,Uemura O,Nakakura H,Ashida A,Kamei K,Ito S,Yamada T,Goto Y,Ohta T,Hisano M,Komatsu Y,Itami N

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Renin-angiotensin system blockers (RASBs) reduce end-stage kidney disease and cardiovascular event (CVE) development in chronic kidney disease. However, whether RASBs improve long-term prognosis in kidney transplant (KT) recipients remain unknown. METHOD:We investigated 900 kidney transplant patients in a m...

journal_title：Clinical and experimental nephrology

authors： Tsuchimoto A,Masutani K,Ueki K,Nakagawa K,Matsukuma Y,Tanaka S,Unagami K,Kakuta Y,Okumi M,Noguchi H,Kaku K,Okabe Y,Nakano T,Kitazono T,Nakamura M,Ishida H,Tanabe K,Japan Academic Consortium of Kidney Transplantation (JA

更新日期：2020-04-01 00:00:00

abstract：:Endothelial dysfunction due to the reduced bioavailability of nitric oxide (NO) is involved in the course of atherosclerotic cardiovascular disease as well as chronic kidney disease (CKD). NO is synthesized from L-arginine via the action of NO synthase, which is blocked by endogenous L-arginine analogues such as asymm...

journal_title：Clinical and experimental nephrology

authors： Ueda S,Yamagishi SI,Matsumoto Y,Fukami K,Okuda S

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND:Data about the clinical outcomes of ACS patients with advanced renal dysfunction (estimated glomerular filtration rate < 30 mL/min/1.73 m2) following percutaneous coronary intervention (PCI) are limited. METHODS:We examined the data obtained from 194 ACS patients with non-dialysis advanced renal dysfunction...

journal_title：Clinical and experimental nephrology

authors： Uemura Y,Ishikawa S,Takemoto K,Negishi Y,Tanaka A,Takagi K,Yoshioka N,Umemoto N,Inoue Y,Morishima I,Shibata N,Asano H,Ishii H,Watarai M,Murohara T,N-registry investigators.

更新日期：2020-04-01 00:00:00

abstract：:Chronic kidney disease (CKD), as defined by reduced glomerular filtration rate (<60 ml/min/1.73 m(2)) and/or the presence of renal damage for >3 months, is a significant threat for public health in modern societies. Recent epidemiological studies have demonstrated that CKD is a significant risk for cardiovascular even...

journal_title：Clinical and experimental nephrology

authors： Ito S

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:The present study aimed to clarify the beneficial effect of allopurinol on cardiovascular morbidity and mortality in a cohort of hypertensive nephropathy patients with impaired kidney function. METHODS:One hundred and seventy-eight patients diagnosed with hypertensive nephropathy and presenting with impaire...

journal_title：Clinical and experimental nephrology

authors： Terawaki H,Nakayama M,Miyazawa E,Murata Y,Nakayama K,Matsushima M,Miyazaki M,Sato H,Sato M,Sato T,Taguma Y,Ito S

更新日期：2013-08-01 00:00:00

abstract：:A 33-year-old woman was transferred to our hospital with a 5-month history of taking Chinese herbal medicine containing aristolochic acid. She presented with metabolic acidosis, severe anemia, hypophosphatemia and uric aciduria, and generalized aminoaciduria and glycosuria, features which were consistent with the clin...

journal_title：Clinical and experimental nephrology

authors： Kazama I,Matsubara M,Michimata M,Suzuki M,Hatano R,Sato H,Ito S

更新日期：2004-09-01 00:00:00

abstract：:We report a case of a 59-year-old woman who had severe metabolic acidosis and hypokalemia due to an enterovesical fistula. The patient came to our hospital complaining of systemic weakness and numbness of the fingers. She was found to have hyperchloremic metabolic acidosis (arterial bicarbonate, 2.8 mEq/l) and hypokal...

journal_title：Clinical and experimental nephrology

authors： Murakami K,Tomita M,Kawamura N,Hasegawa M,Nabeshima K,Hiki Y,Sugiyama S

更新日期：2007-09-01 00:00:00

abstract：:A 34-year-old man who had been on dialysis for about 6 years, and had acquired renal cystic disease, received a renal transplantation. However, in spite of the success of the transplantation, one area without cyst regression was observed in the original kidney. Therefore, carcinoma was suspected and nephrectomy was pe...

journal_title：Clinical and experimental nephrology

authors： Ishikawa I,Saito A,Chikazawa Y,Asaka M,Tomosugi N,Yuri T,Suzuki K,Ueda Y,Ozaki M

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND:Proteinuria caused by glomerular disease is characterized by podocyte injury. Vasopressin V2 receptor antagonists are effective in reducing albuminuria, although their actions on glomerular podocytes have not been explored. The objective of this study was to evaluate the effects of tolvaptan, a selective ora...

journal_title：Clinical and experimental nephrology

authors： Okada T,Sakaguchi T,Hatamura I,Saji F,Negi S,Otani H,Muragaki Y,Kawachi H,Shigematsu T

更新日期：2009-10-01 00:00:00

abstract：:Acute kidney injury (AKI) is a threatening medical condition associated with poor outcomes at different settings. The development of standardized diagnostic criteria and new biomarkers addressed significant clinical impacts of AKI and the need for an early AKI detection, respectively. There have been some breakthrough...

journal_title：Clinical and experimental nephrology

authors： Doi K

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Hypertriglyceridemia (hTG) is a risk factor for progression of chronic kidney disease (CKD); however, it remains unknown whether the adipocytokine complement component 3 (C3) is involved in the association between hTG and CKD. METHODS:The study included 138 patients (54 % male) with non-nephrotic (serum alb...

journal_title：Clinical and experimental nephrology

authors： Kohagura K,Kochi M,Miyagi T,Kinjyo T,Maehara Y,Kinjyo K,Nagahama K,Sakima A,Iseki K,Ohya Y

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:In 2013, eculizumab was approved for treatment of the atypical hemolytic-uremic syndrome (aHUS) in Japan, which was defined as a thrombotic microangiopathy (TMA) excluding Shiga toxin-producing Escherichia coli-HUS and thrombotic thrombocytopenic purpura. Simultaneously, post-marketing surveillance was start...

journal_title：Clinical and experimental nephrology

authors： Ito S,Hidaka Y,Inoue N,Kaname S,Kato H,Matsumoto M,Miyakawa Y,Mizuno M,Okada H,Shimono A,Matsuda T,Maruyama S,Fujimura Y,Nangaku M,Kagami S

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Autosomal dominant polycystic kidney disease (ADPKD), one of the most common hereditary kidney diseases, causes gradual growth of cysts in the kidneys, leading to renal failure. Owing to the advanced technology of next-generation sequencing (NGS), genetic analyses of the causative genes PKD1 and PKD2 have be...

journal_title：Clinical and experimental nephrology

authors： Mochizuki T,Teraoka A,Akagawa H,Makabe S,Akihisa T,Sato M,Kataoka H,Mitobe M,Furukawa T,Tsuchiya K,Nitta K

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Although neutrophil-to-lymphocyte ratio (NLR) is closely associated with pneumonia in the general population, its relationship is unclear in peritoneal dialysis (PD) patients. METHODS:This is a cohort study consisting of 739 PD patients and dividing into two groups. Kaplan-Meier curves were applied to obser...

journal_title：Clinical and experimental nephrology

authors： Zhang Y,Lai X,Chen Q,Zhan X,Long H,Peng F,Zhang F,Feng X,Zhou Q,Wu X,Liu L,Wang Z,ETNA.,Peng X,Hu K,Wang D,Guo G,Zeng Y,Wen Y,Liang J

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Analyses of selected cases suggest that immunosuppressive treatment could reduce proteinuria and delay the progression of immunoglobulin A nephropathy (IgAN). The aim of this study was to examine the long-term effectiveness of this therapy on the clinical course of IgAN. We also examined the relationship bet...

journal_title：Clinical and experimental nephrology

authors： Oshima S,Kawamura O

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:In patients with autosomal dominant polycystic kidney disease (ADPKD), renal cysts grow exponentially. Since remaining renal parenchyma has a capacity to compensate for the loss of glomerular filtration, the glomerular filtration rate (GFR) may be sustained until the disease progresses. The purpose of this s...

journal_title：Clinical and experimental nephrology

authors： Tokiwa S,Muto S,China T,Horie S

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Maxacalcitol (22-oxacalcitriol; OCT) is a novel vitamin D analogue. In previous clinical studies, OCT was administered three times a week to hemodialysis patients with refractory secondary hyperparathyroidism (2HPT), in whom it acted by inhibiting parathyroid hormone secretion, as well as causing mildly elev...

journal_title：Clinical and experimental nephrology

authors： Murakami K,Miyachi H,Watanabe A,Kawamura N,Fujii M,Koide S,Murase M,Kushimoto H,Hasegawa M,Tomita M,Hiki Y,Sugiyama S

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND:Low-energy extracorporeal shock wave (SW) improves ventricular function in ischemic cardiomyopathy through the upregulation of vascular endothelial growth factor (VEGF). VEGF is known to play important roles in acute kidney injury (AKI), and the present study investigates the efficacy of SW for AKI by renal ...

journal_title：Clinical and experimental nephrology

authors： Yoshida M,Nakamichi T,Mori T,Ito K,Shimokawa H,Ito S

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Autosomal dominant polycystic disease (ADPKD) often results in renal failure. Recently, allelic influences of PKD1 mutation types on renal survival were extensively investigated. Here, we analyzed integrated influences of PKD1 mutation types and positions on renal survival. METHODS:We included 338 (82 pedig...

journal_title：Clinical and experimental nephrology

authors： Higashihara E,Horie S,Kinoshita M,Harris PC,Okegawa T,Tanbo M,Hara H,Yamaguchi T,Shigemori K,Kawano H,Miyazaki I,Kaname S,Nutahara K

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Genetic susceptibility to atypical hemolytic uremic syndrome (aHUS) may lie within genes regulating or activating the alternate complement and related pathways converging on endothelial cell activation. METHODS:We tested 32 Indian patients of aHUS negative for antibodies to complement factor H for genetic v...

journal_title：Clinical and experimental nephrology

authors： Thergaonkar RW,Narang A,Gurjar BS,Tiwari P,Puraswani M,Saini H,Sinha A,Varma B,Mukerji M,Hari P,Bagga A

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Guidelines for treatment of hypertension are not available for chronic hemodialysis (HD) population, despite the high mortality rate due to cardiovascular disease (CVD). Survival is much better among hypertensive patients than normal to hypotensive patients. Target levels of blood pressure and the class of a...

journal_title：Clinical and experimental nephrology

authors： Iseki K,Tokuyama K,Shiohira Y,Higa A,Hirano H,Toma S,Kohagura K,Ueda S

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:Vascular endothelial cells (VECs) play crucial roles in physiological and pathologic conditions in tissues and organs. Most of these roles are related to VEC plasma membrane proteins. In the kidney, VECs are closely associated with structures and functions; however, plasma membrane proteins in kidney VECs re...

journal_title：Clinical and experimental nephrology

authors： Liu Z,Xu B,Nameta M,Zhang Y,Magdeldin S,Yoshida Y,Yamamoto K,Fujinaka H,Yaoita E,Tasaki M,Nakagawa Y,Saito K,Takahashi K,Yamamoto T

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:The aim of this study was to evaluate the renal preservation effect of ubiquinol, the reduced form of coenzyme Q10 (CoQ10). METHODS:Three-week-old heminephrectomized male Sprague-Dawley rats were divided into three groups (10 animals each): diet with normal (0.3%) salt, high (8%) salt, and high salt plus 60...

journal_title：Clinical and experimental nephrology

authors： Ishikawa A,Kawarazaki H,Ando K,Fujita M,Fujita T,Homma Y

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:The post-marketing surveillance of edaravone has reported serious adverse reactions, including renal and hepatic disorders. Renal disorders were the most frequently reported serious/important adverse reactions, which led to the evaluation of their causation by edaravone, their severity, and the recovery of r...

journal_title：Clinical and experimental nephrology

authors： Hishida A

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:Myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA)-associated vasculitis frequently induces crescentic glomerulonephritis. However, a few cases have so far been reported to have only tubulointerstitial (TI) nephritis without any apparent glomerular lesions. We recently treated three similar cases...

journal_title：Clinical and experimental nephrology

authors： Nakabayashi K,Sumiishi A,Sano K,Fujioka Y,Yamada A,Karube M,Koji H,Arimura Y,Nagasawa T

更新日期：2009-12-01 00:00:00