Abstract:
:A 33-year-old woman was transferred to our hospital with a 5-month history of taking Chinese herbal medicine containing aristolochic acid. She presented with metabolic acidosis, severe anemia, hypophosphatemia and uric aciduria, and generalized aminoaciduria and glycosuria, features which were consistent with the clinical manifestations of Fanconi syndrome. Renal biopsy was performed when her plasma creatinine was 0.7 mg/dl and creatinine clearance was 46 ml/min per 1.73 m(2). The renal specimen showed extensive interstitial edema with focal fibrosis, tubular atrophy, and focal glomerulopathy, which suggested the presence of glomerular endothelial damage or glomerular ischemia. Although steroid therapy ameliorated the plasma electrolyte levels, renal failure progressed, and hemodialysis therapy was initiated approximately 18 months after the time of renal biopsy. This patient demonstrated the early renal lesions of Chinese herbs nephropathy in association with various clinical manifestations. The characteristic glomerulopathy found in the present patient is considered to be an additional renal lesion, leading to the renal failure.
journal_name
Clin Exp Nephroljournal_title
Clinical and experimental nephrologyauthors
Kazama I,Matsubara M,Michimata M,Suzuki M,Hatano R,Sato H,Ito Sdoi
10.1007/s10157-004-0296-9subject
Has Abstractpub_date
2004-09-01 00:00:00pages
283-7issue
3eissn
1342-1751issn
1437-7799journal_volume
8pub_type
杂志文章abstract:BACKGROUND:Cardiovascular disease is the leading cause of morbidity and mortality in patients with kidney failure. Nocturnal home hemodialysis (NHD) is a form of kidney replacement therapy whereby hemodialysis is performed for at least 6-h overnight, at least 4 days per week. Little is known about the effects of NHD on...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
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journal_title:Clinical and experimental nephrology
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pub_type: 杂志文章
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pub_type: 临床试验,杂志文章,多中心研究
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更新日期:2013-06-01 00:00:00
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更新日期:2007-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s10157-014-0967-0
更新日期:2015-04-01 00:00:00
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更新日期:2014-02-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2018-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s10157-005-0358-7
更新日期:2005-09-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-013-0774-z
更新日期:2013-12-01 00:00:00
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journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-004-0309-8
更新日期:2004-12-01 00:00:00