Predictors of withdrawal from renal replacement therapy among patients with acute kidney injury requiring renal replacement therapy.

abstract：OBJECTIVES:Interleukin (IL)-33 plays an important role in host defense, immune regulation, and inflammation. This study assessed IL-33's role in the pathogenesis of severe hemolytic uremic syndrome (HUS) induced by enterohemorrhagic Escherichia coli (EHEC). We also investigated the clinical significance of IL-33 and so...

journal_title：Clinical and experimental nephrology

authors： Yamada S,Shimizu M,Kuroda M,Inoue N,Sugimoto N,Yachie A

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:In patients with IgA nephropathy (IgAN), recurrence after steroid pulse therapy is associated with reduced renal survival. However, the predictors of recurrence have not yet been clarified. METHODS:All patients who received 6-month steroid pulse therapy from 2004 to 2010 in our four affiliated hospitals and...

journal_title：Clinical and experimental nephrology

authors： Hirano K,Amano H,Kawamura T,Watanabe K,Koike K,Shimizu A,Endo S,Tsuboi N,Okonogi H,Miyazaki Y,Ikeda M,Hanaoka K,Ogura M,Komatsumoto S,Yokoo T

更新日期：2016-06-01 00:00:00

abstract：:Heavy chain deposition disease (HCDD) is one of three entities of monoclonal immunoglobulin deposition disease, characterized histopathologically by the presence of nodular glomerulosclerosis and glomerular and tubular deposition of monoclonal heavy chains without associated light chains. Although HCDD is an extremely...

journal_title：Clinical and experimental nephrology

authors： Oe Y,Soma J,Sato H,Ito S

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND/AIMS:Fibroblast growth factor 23 (FGF23) and soluble α-Klotho are emerging potential biomarkers of phosphorus and vitamin D metabolism which change in concentration in early chronic kidney disease (CKD) in order to maintain normal phosphorus levels. Tubular reabsorption of phosphate (TRP) has been commonly u...

journal_title：Clinical and experimental nephrology

authors： Hong YA,Lim JH,Kim MY,Kim Y,Yang KS,Chung BH,Chung S,Choi BS,Yang CW,Kim YS,Chang YS,Park CW

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Maxacalcitol (22-oxacalcitriol; OCT) is a novel vitamin D analogue. In previous clinical studies, OCT was administered three times a week to hemodialysis patients with refractory secondary hyperparathyroidism (2HPT), in whom it acted by inhibiting parathyroid hormone secretion, as well as causing mildly elev...

journal_title：Clinical and experimental nephrology

authors： Murakami K,Miyachi H,Watanabe A,Kawamura N,Fujii M,Koide S,Murase M,Kushimoto H,Hasegawa M,Tomita M,Hiki Y,Sugiyama S

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND:Mizoribine (MZR) therapy after cyclophosphamide (CPM) therapy may be an attractive option in patients with steroid-dependent nephrotic syndrome (SDNS) for the purpose of maintaining remission. This is because CPM is administered only once due to its severe side effects such as gonadal toxicity. However, the ...

journal_title：Clinical and experimental nephrology

authors： Mizutani A,Fujinaga S,Sakuraya K,Hirano D,Shimizu T

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:The current (2012) histological classification of immunoglobulin A nephropathy was established using a case-control study of 287 patients. However, the risk of progression to end-stage renal disease (ESRD) has not been validated for the previous (2002) classification. This study aimed to determine whether th...

journal_title：Clinical and experimental nephrology

authors： Miyazaki Y,Kawamura T,Joh K,Okonogi H,Koike K,Utsunomiya Y,Ogura M,Matsushima M,Yoshimura M,Horikoshi S,Suzuki Y,Furusu A,Yasuda T,Shirai S,Shibata T,Endoh M,Hattori M,Akioka Y,Katafuti R,Hashiguchi A,Kimura K,M

更新日期：2014-06-01 00:00:00

abstract：:A 69-year-old Caucasian man was admitted to our hospital because of myocardial infarction. A central venous catheter (CVC) for infusive therapy was inserted. After two weeks he developed fever, purpura, and knee arthralgia. Hemoculture yielded methicillin-sensitive Staphylococcus aureus. Subsequently, oliguric renal f...

journal_title：Clinical and experimental nephrology

authors： Uggeri S,Fabbian F,Catizone L

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:Autosomal dominant polycystic disease (ADPKD) often results in renal failure. Recently, allelic influences of PKD1 mutation types on renal survival were extensively investigated. Here, we analyzed integrated influences of PKD1 mutation types and positions on renal survival. METHODS:We included 338 (82 pedig...

journal_title：Clinical and experimental nephrology

authors： Higashihara E,Horie S,Kinoshita M,Harris PC,Okegawa T,Tanbo M,Hara H,Yamaguchi T,Shigemori K,Kawano H,Miyazaki I,Kaname S,Nutahara K

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Although it has been repeatedly shown that the oral carbonaceous absorbent AST-120 ameliorates the progression of chronic renal failure, the mechanisms remain unknown. METHODS:Male Sprague-Dawley rats (6 weeks old), weighing 180-210 g, were 4/5 nephrectomized, and were divided into two groups: one given AST...

journal_title：Clinical and experimental nephrology

authors： Horike K,Usami T,Kamiya Y,Kamiya T,Yoshida A,Itoh S,Yamato H,Ise M,Kimura G

更新日期：2003-06-01 00:00:00

abstract：:A 57-year-old woman presented with fever and cellulitis of the right leg. Urinalysis and kidney function were normal on admission. Cellulitis remitted but fever persisted for six weeks. X-ray imaging, cultures, serological assays for viruses and autoimmunity did not reveal the cause of fever. Unexpectedly anti-Scl 70 ...

journal_title：Clinical and experimental nephrology

authors： Vega Stieb J,Goecke Saavedra H,Méndez Olivieri G

更新日期：2008-10-01 00:00:00

abstract：:Acute kidney injury (AKI) is a threatening medical condition associated with poor outcomes at different settings. The development of standardized diagnostic criteria and new biomarkers addressed significant clinical impacts of AKI and the need for an early AKI detection, respectively. There have been some breakthrough...

journal_title：Clinical and experimental nephrology

authors： Doi K

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Adenosine monophosphate (AMP)-activated protein kinase (AMPK), as a sensor of cellular energy status, has been known to play an important role in the pathophysiology of diabetes and its complications. As AMPK is also expressed in podocytes, it is possible that podocyte AMPK would be an important contributing...

journal_title：Clinical and experimental nephrology

authors： Choi JY,Ha TS,Park HY,Ahn HY

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:Pulmonary-renal syndrome is characterized by pulmonary hemorrhage and rapidly progressive glomerulonephritis in various immunological states. Histopathological analysis of pulmonary-renal syndrome is not yet complete. METHODS:Wistar-Kyoto (WKY) rats were sensitized using the noncollagenous (NC1) domain of t...

journal_title：Clinical and experimental nephrology

authors： Aoyagi D,Nakazawa K,Kaneyama T,Masumoto J,Otani M,Shigematsu H

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:Hematuria is the first manifestation of urinary abnormality in immunoglobulin A nephropathy (IgAN). Hematuria has recently been reported as a risk factor for deterioration of renal function; however, its cause remains unknown. METHODS:We analyzed the surface marker of peripheral blood mononuclear cells befo...

journal_title：Clinical and experimental nephrology

authors： Iwatani H,Nagasawa Y,Yamamoto R,Iio K,Mizui M,Horii A,Kitahara T,Inohara H,Kumanogoh A,Imai E,Rakugi H,Isaka Y

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Mizoribine (MZR) was approved in 1984 in Japan for the suppression of rejection in renal transplantation with an approved administration dosage of 1-3 mg/kg/day. The action of MZR resembles that of mycophenolate mofetil (MMF), but MZR dosing is markedly lower than that of MMF. To examine whether higher dosin...

journal_title：Clinical and experimental nephrology

authors： Takahara S,Takahashi K,Akiyama T,Uchida K,Tanabe K,Amada N,Toma H

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Proteinuria caused by glomerular disease is characterized by podocyte injury. Vasopressin V2 receptor antagonists are effective in reducing albuminuria, although their actions on glomerular podocytes have not been explored. The objective of this study was to evaluate the effects of tolvaptan, a selective ora...

journal_title：Clinical and experimental nephrology

authors： Okada T,Sakaguchi T,Hatamura I,Saji F,Negi S,Otani H,Muragaki Y,Kawachi H,Shigematsu T

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:Renin-angiotensin system blockers (RASBs) reduce end-stage kidney disease and cardiovascular event (CVE) development in chronic kidney disease. However, whether RASBs improve long-term prognosis in kidney transplant (KT) recipients remain unknown. METHOD:We investigated 900 kidney transplant patients in a m...

journal_title：Clinical and experimental nephrology

authors： Tsuchimoto A,Masutani K,Ueki K,Nakagawa K,Matsukuma Y,Tanaka S,Unagami K,Kakuta Y,Okumi M,Noguchi H,Kaku K,Okabe Y,Nakano T,Kitazono T,Nakamura M,Ishida H,Tanabe K,Japan Academic Consortium of Kidney Transplantation (JA

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:Recently, preemptive kidney transplantation (PKT) has increased in Japan; however, the effects of PKT on calcium (Ca) and phosphorus (Pi) metabolism are poorly understood. METHODS:Thirty-two consecutive patients were enrolled in this study at Nagoya Daini Red Cross Hospital. Fifteen patients were in the PKT...

journal_title：Clinical and experimental nephrology

authors： Tsujita M,Inaguma D,Goto N,Yamamoto T,Hiramitsu T,Katayama A,Takeda A,Kobayashi T,Morozumi K,Uchida K,Narumi S,Watarai Y,Tominaga Y

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Both myeloperoxidase-associated antineutrophil cytoplasmic antibody (MPO-ANCA) and antiglomerular basement membrane antibody (anti-GBM Ab) positivity have been demonstrated in patients with rapidly progressive glomerulonephritis (RPGN), either with or without pulmonary hemorrhage; however, the implications o...

journal_title：Clinical and experimental nephrology

authors： Nakabayashi K,Fujioka Y,Nagasawa T,Kimura T,Kojima K,Arimura Y,Yamada A

更新日期：2011-04-01 00:00:00

abstract：:Recent studies on dendritic cells (DCs) and macrophages have greatly advanced our knowledge of glomerular immunopathology. This rapidly developing field most likely has considerable impact on our understanding of the major mediators of tissue injury and repair in kidney disease. The pivotal role of cytokine in the ini...

journal_title：Clinical and experimental nephrology

authors： Matsumoto K,Fukuda N,Abe M,Fujita T

更新日期：2010-02-01 00:00:00

abstract：:Glomerular lipid deposition is sometimes associated with a particular kind of lipid metabolism disturbance. Ultrastructural analyses using electron microscopy often indicate a disease-specific aspect of intraglomerular lipid distribution. ...

journal_title：Clinical and experimental nephrology

authors： Sato H,Takahashi N,Sato E,Kisu K,Ito S,Saito T

更新日期：2014-04-01 00:00:00

abstract：:The manifestation of diabetic nephropathy may be a consequence of the actions of certain cytokines and growth factors. Prominent among them is transforming growth factor-β (TGF-β), which promotes renal cell hypertrophy and stimulates extracellular matrix accumulation, the two hallmarks of diabetic renal disease. In ex...

journal_title：Clinical and experimental nephrology

authors： Ziyadeh FN,Isono M,Chen S

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:Serum cystatin C is not only a marker of renal function but also acts as an independent risk factor for cardiovascular damage, heart failure, and death. It is known that the initiation and progression of these cardiovascular events contributes to renal dysfunction and chronic inflammation. In this study, we ...

journal_title：Clinical and experimental nephrology

authors： Okura T,Jotoku M,Irita J,Enomoto D,Nagao T,Desilva VR,Yamane S,Pei Z,Kojima S,Hamano Y,Mashiba S,Kurata M,Miyoshi K,Higaki J

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:The aim of this study was to evaluate the renal preservation effect of ubiquinol, the reduced form of coenzyme Q10 (CoQ10). METHODS:Three-week-old heminephrectomized male Sprague-Dawley rats were divided into three groups (10 animals each): diet with normal (0.3%) salt, high (8%) salt, and high salt plus 60...

journal_title：Clinical and experimental nephrology

authors： Ishikawa A,Kawarazaki H,Ando K,Fujita M,Fujita T,Homma Y

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:Chronic kidney disease (CKD) is a major global problem and is also associated with a decreased health-related quality of life (HRQOL). The aim of this study was to evaluate measured HRQOL based on the new CKD classification including proteinuria stage, and the effect of measured HRQOL on CKD progression and ...

journal_title：Clinical and experimental nephrology

authors： Okubo R,Kai H,Kondo M,Saito C,Yoh K,Morito N,Usui J,Yamagata K

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:Data about the clinical outcomes of ACS patients with advanced renal dysfunction (estimated glomerular filtration rate < 30 mL/min/1.73 m2) following percutaneous coronary intervention (PCI) are limited. METHODS:We examined the data obtained from 194 ACS patients with non-dialysis advanced renal dysfunction...

journal_title：Clinical and experimental nephrology

authors： Uemura Y,Ishikawa S,Takemoto K,Negishi Y,Tanaka A,Takagi K,Yoshioka N,Umemoto N,Inoue Y,Morishima I,Shibata N,Asano H,Ishii H,Watarai M,Murohara T,N-registry investigators.

更新日期：2020-04-01 00:00:00

abstract：:Dyslipidemia is an established risk factor for atherosclerotic disease, such as stroke and ischemic heart disease, and is often detected in patients with chronic kidney disease (CKD). The role of dyslipidemia in CKD progression, however, is not well understood. CKD patients are heterogeneous and may include those who ...

journal_title：Clinical and experimental nephrology

authors： Iseki K

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:The present study was conducted to clarify the clinical risk factors related to the development of encapsulating peritoneal sclerosis (EPS), which is one of the most serious complications in patients undergoing peritoneal dialysis (PD). METHODS:The records of 78 patients with a history of PD treatment, incl...

journal_title：Clinical and experimental nephrology

authors： Yamamoto R,Otsuka Y,Nakayama M,Maruyama Y,Katoh N,Ikeda M,Yamamoto H,Yokoyama K,Kawaguchi Y,Matsushima M

更新日期：2005-06-01 00:00:00

abstract：:We report a 17-year-old male patient with tubulointerstitial nephritis and uveitis (TINU) associated with hyperthyroidism. He presented with a 2-month history of fatigue, loss of appetite, low-grade fever, and a 12-kg weight loss when he was admitted to our hospital. He had iritis, which was complicated by fibrin in t...

journal_title：Clinical and experimental nephrology

authors： Ebihara I,Hirayama K,Usui J,Seki M,Higuchi F,Oteki T,Kobayashi M,Yamagata K

更新日期：2006-09-01 00:00:00