Metastatic type-2 papillary renal cell carcinoma responded to interleukin-2 therapy: case report.

abstract：BACKGROUND:Intravascular administration of iodinated contrast media continues to be a common cause of hospital-acquired acute kidney injury. Accumulating evidence suggests that radiocontrast agent-induced nephrotoxicity is associated with increased oxidative stress, which leads to renal tissue damage with DNA fragmenta...

journal_title：Clinical and experimental nephrology

authors： Ludwig U,Connemann J,Keller F

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:In patients with IgA nephropathy (IgAN), recurrence after steroid pulse therapy is associated with reduced renal survival. However, the predictors of recurrence have not yet been clarified. METHODS:All patients who received 6-month steroid pulse therapy from 2004 to 2010 in our four affiliated hospitals and...

journal_title：Clinical and experimental nephrology

authors： Hirano K,Amano H,Kawamura T,Watanabe K,Koike K,Shimizu A,Endo S,Tsuboi N,Okonogi H,Miyazaki Y,Ikeda M,Hanaoka K,Ogura M,Komatsumoto S,Yokoo T

更新日期：2016-06-01 00:00:00

abstract：:We report a case of a 59-year-old woman who had severe metabolic acidosis and hypokalemia due to an enterovesical fistula. The patient came to our hospital complaining of systemic weakness and numbness of the fingers. She was found to have hyperchloremic metabolic acidosis (arterial bicarbonate, 2.8 mEq/l) and hypokal...

journal_title：Clinical and experimental nephrology

authors： Murakami K,Tomita M,Kawamura N,Hasegawa M,Nabeshima K,Hiki Y,Sugiyama S

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:Several comorbidity scoring systems have been developed and validated, mostly in western hemodialysis patients with a high risk of cardiovascular disease. The performance of comorbidity scoring, however, depends on the patient population. In this study, we determine the optimal comorbidity scoring system for...

journal_title：Clinical and experimental nephrology

authors： Ma TK,Chow KM,Kwan BC,Ng JK,Pang WF,Leung CB,Li PK,Szeto CC

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Mizoribine (MZR) therapy after cyclophosphamide (CPM) therapy may be an attractive option in patients with steroid-dependent nephrotic syndrome (SDNS) for the purpose of maintaining remission. This is because CPM is administered only once due to its severe side effects such as gonadal toxicity. However, the ...

journal_title：Clinical and experimental nephrology

authors： Mizutani A,Fujinaga S,Sakuraya K,Hirano D,Shimizu T

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Recent studies have suggested that assessments of serum antibodies against M-type phospholipase A2 receptor (PLA2R) and the glomerular expression of PLA2R antigen in biopsy specimens are useful for the diagnosis of primary membranous nephropathy (MN). In this study, we assessed both of them and investigated ...

journal_title：Clinical and experimental nephrology

authors： Hayashi N,Akiyama S,Okuyama H,Matsui Y,Adachi H,Yamaya H,Maruyama S,Imai E,Matsuo S,Yokoyama H

更新日期：2015-10-01 00:00:00

abstract：:Endothelial dysfunction due to the reduced bioavailability of nitric oxide (NO) is involved in the course of atherosclerotic cardiovascular disease as well as chronic kidney disease (CKD). NO is synthesized from L-arginine via the action of NO synthase, which is blocked by endogenous L-arginine analogues such as asymm...

journal_title：Clinical and experimental nephrology

authors： Ueda S,Yamagishi SI,Matsumoto Y,Fukami K,Okuda S

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND:The appropriate blood pressure target to prevent end-stage renal disease (ESRD) is controversial. METHODS:We examined the association between systolic blood pressure (SBP) changes and ESRD incidence in 69,575 participants from the Okinawa general population aged ≥ 20 years who underwent health check-ups in ...

journal_title：Clinical and experimental nephrology

authors： Usui T,Iseki C,Iseki K,Kawakami K,Nangaku M

更新日期：2019-11-01 00:00:00

abstract：:In the original publication of the article, the second sentence under the heading, Case presentation appears incorrectly as A computed tomographic (CT) scan demonstrated left-sided hydronephrosis (Fig. 1). ...

journal_title：Clinical and experimental nephrology

authors： Wu BS,Ho Y,Yang CY

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:In patients with autosomal dominant polycystic kidney disease (ADPKD), renal cysts grow exponentially. Since remaining renal parenchyma has a capacity to compensate for the loss of glomerular filtration, the glomerular filtration rate (GFR) may be sustained until the disease progresses. The purpose of this s...

journal_title：Clinical and experimental nephrology

authors： Tokiwa S,Muto S,China T,Horie S

更新日期：2011-08-01 00:00:00

abstract：:The clinical course of cryoglobulinemic glomerulonephritis (CGGN) is usually slowly progressive, and only a minority of these patients progress to end-stage renal failure. This report describes an atypical case of a patient with CGGN who demonstrated a rapidly progressive and irreversible renal deterioration. After pr...

journal_title：Clinical and experimental nephrology

authors： Tsuboi N,Ichinose M,Kawamura T,Joh K,Utsunomiya Y,Hosoya T

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:The definition of sepsis was updated to sepsis-3 in February 2016. Currently, direct hemoperfusion therapy using the polymyxin B-immobilized fiber cartridge (PMX-DHP) is widely performed to treat sepsis and septic shock. However, the prognostic factors of PMX-DHPs in patients with sepsis using the new defini...

journal_title：Clinical and experimental nephrology

authors： Okubo A,Nakashima A,Doi S,Ueno T,Sasaki K,Esaki T,Masaki T

更新日期：2018-10-01 00:00:00

abstract：:C1q nephropathy, first proposed by Jennette and Hipp [Am J Clin Pathol 83:415-420, 1985; Am J Kidney Dis 6:103-110, 1985], was described as a distinct glomerular disease entity characterized by extensive mesangial deposition of C1q, with associated mesangial immune complexes, and the absence of any clinical and labora...

journal_title：Clinical and experimental nephrology

authors： Mii A,Shimizu A,Masuda Y,Fujita E,Aki K,Ishizaki M,Sato S,Griesemer A,Fukuda Y

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND:Equations for the creatinine-based estimated glomerular filtration rate (eGFR) were recently established for Japanese adults (>18 years old) and children (2-11 years old), respectively, but it is unclear whether eGFR can be as useful as 24-h creatinine clearance (CCr) for assessing renal function in patients...

journal_title：Clinical and experimental nephrology

authors： Inoue N,Watanabe H,Okamura K,Kondo S,Kagami S

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Dotinurad is a novel, selective urate reabsorption inhibitor (SURI), which reduces serum uric acid levels by selective inhibition of the urate transporter 1 (URAT1). The Japanese guideline for the management of hyperuricemia and gout recommends that drug selection should be based on classification of hyperur...

journal_title：Clinical and experimental nephrology

authors： Hosoya T,Furuno K,Kanda S

更新日期：2020-03-01 00:00:00

abstract：:We herein report two cases of patients with chronic kidney disease who developed hypertensive encephalopathy, which occurred after a sudden discontinuance of antihypertensive agents. Both patients underwent care at our hospital after experiencing neurological abnormalities. In both patients, magnetic resonance imaging...

journal_title：Clinical and experimental nephrology

authors： Nakabou M,Kai T,Maeshima T,Kanamasa K

更新日期：2010-06-01 00:00:00

abstract：:A 68-year-old man with a 30-year history of essential thrombocytosis developed nephrotic syndrome. Renal biopsy showed massive deposits of Congo red-negative periodic acid Schiff (PAS)-positive substance in the mesangium and capillary wall that was positive for IgG. Electron microscopic examination revealed 10- to 20-...

journal_title：Clinical and experimental nephrology

authors： Asaba K,Tojo A,Onozato ML,Mimura N,Kido M,Goto A,Endo H,Fujita T

更新日期：2003-12-01 00:00:00

abstract：BACKGROUND:Chronic kidney disease (CKD) is a significant public health problem. Strategy for its early detection is still controversial. This study aims to assess the cost-effectiveness of population strategy, i.e. mass screening, and Japan's health checkup reform. METHODS:Cost-effectiveness analysis was carried out t...

journal_title：Clinical and experimental nephrology

authors： Kondo M,Yamagata K,Hoshi SL,Saito C,Asahi K,Moriyama T,Tsuruya K,Yoshida H,Iseki K,Watanabe T

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:Stromal cell-derived factor-1α (SDF-1α) is an inflammatory chemokine that plays a critical role in cardiovascular disease. Although persistent inflammation causes renal dysfunction, it remains unclear whether SDF-1α is related to progression of chronic kidney disease. This study examined whether high levels ...

journal_title：Clinical and experimental nephrology

authors： Uematsu M,Nakamura T,Yoshizaki T,Watanabe Y,Deyama J,Watanabe K,Kobayashi T,Fujioka D,Saito Y,Nakamura K,Kawabata K,Obata JE,Kugiyama K

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Cinacalcet markedly reduces the serum intact parathyroid hormone (PTH) level of hemodialysis (HD) patients with secondary hyperparathyroidism. Parathyroidectomy also reduces the serum intact PTH level of HD patients and it increases their bone mineral density (BMD). However, there is little information about...

journal_title：Clinical and experimental nephrology

authors： Tsuruta Y,Okano K,Kikuchi K,Tsuruta Y,Akiba T,Nitta K

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:Chronic kidney disease (CKD) is a major global problem and is also associated with a decreased health-related quality of life (HRQOL). The aim of this study was to evaluate measured HRQOL based on the new CKD classification including proteinuria stage, and the effect of measured HRQOL on CKD progression and ...

journal_title：Clinical and experimental nephrology

authors： Okubo R,Kai H,Kondo M,Saito C,Yoh K,Morito N,Usui J,Yamagata K

更新日期：2014-10-01 00:00:00

abstract：:A 69-year-old Caucasian man was admitted to our hospital because of myocardial infarction. A central venous catheter (CVC) for infusive therapy was inserted. After two weeks he developed fever, purpura, and knee arthralgia. Hemoculture yielded methicillin-sensitive Staphylococcus aureus. Subsequently, oliguric renal f...

journal_title：Clinical and experimental nephrology

authors： Uggeri S,Fabbian F,Catizone L

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:Dotinurad is a novel selective urate reabsorption inhibitor (SURI) that selectively inhibits the reabsorption of uric acid in renal tubules and promotes the excretion of uric acid into urine. In this study, the effects of age and gender on the pharmacokinetics (PK), pharmacodynamics (PD), and safety of dotin...

journal_title：Clinical and experimental nephrology

authors： Nakatani H,Fushimi M,Sasaki T,Okui D,Ohashi T

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:The present study aimed to clarify the beneficial effect of allopurinol on cardiovascular morbidity and mortality in a cohort of hypertensive nephropathy patients with impaired kidney function. METHODS:One hundred and seventy-eight patients diagnosed with hypertensive nephropathy and presenting with impaire...

journal_title：Clinical and experimental nephrology

authors： Terawaki H,Nakayama M,Miyazawa E,Murata Y,Nakayama K,Matsushima M,Miyazaki M,Sato H,Sato M,Sato T,Taguma Y,Ito S

更新日期：2013-08-01 00:00:00

abstract：:We present a case of proliferative glomerulonephritis with peculiar IgM deposition associated with sarcoidosis. A 62-year-old woman, who had been diagnosed with sarcoidosis 3 years previously because of abnormalities on chest X-ray radiophotographs and lymph node pathology, was admitted to our hospital for the evaluat...

journal_title：Clinical and experimental nephrology

authors： Kanamori H,Ota M,Takeoka H,Osafune K,Yonezu S,Fukatsu A,Kanatsu K

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:Residual cardiovascular risk factors, such as triglyceride (TG), can cause cardiovascular disease. The role of TG metabolism in kidney transplantation remains unclear. METHODS:Sixty-three consecutive stable recipients at 1 year after their kidney transplants were included in the study from January to Septem...

journal_title：Clinical and experimental nephrology

authors： Tsujita M,Goto N,Futamura K,Okada M,Hiramitsu T,Narumi S,Watarai Y

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:The Oxford Classification is utilized globally, but has not been fully validated. In this study, we conducted a comparative analysis between the Oxford Classification and Japanese Histologic Classification (JHC) to predict renal outcome in Japanese patients with IgA nephropathy (IgAN). METHODS:A retrospecti...

journal_title：Clinical and experimental nephrology

authors： Kaihan AB,Yasuda Y,Katsuno T,Kato S,Imaizumi T,Ozeki T,Hishida M,Nagata T,Ando M,Tsuboi N,Maruyama S

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Low-energy extracorporeal shock wave (SW) improves ventricular function in ischemic cardiomyopathy through the upregulation of vascular endothelial growth factor (VEGF). VEGF is known to play important roles in acute kidney injury (AKI), and the present study investigates the efficacy of SW for AKI by renal ...

journal_title：Clinical and experimental nephrology

authors： Yoshida M,Nakamichi T,Mori T,Ito K,Shimokawa H,Ito S

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Aquaporin-2 (AQP2) is a key water channel protein which determines the water permeability of the collecting duct. Multiple phosphorylation sites are present at the C-terminal of AQP2 including S256 (serine at 256 residue), S261, S264 and S/T269, which are regulated by vasopressin (VP) to modulate AQP2 traffi...

journal_title：Clinical and experimental nephrology

authors： Sakai M,Yamamoto K,Mizumura H,Matsumoto T,Tanaka Y,Noda Y,Ishibashi K,Yamamoto T,Sasaki S

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Thallium-201 washout rate of stress myocardial perfusion imaging (MPI) has been reported to correlate with coronary flow reserve which is a parameter of myocardial microcirculation. However, the evidence for its use in diabetic kidney disease (DKD) has been lacking, and the association between thallium-201 w...

journal_title：Clinical and experimental nephrology

authors： Hayashi T,Joki N,Tanaka Y,Iwasaki M,Kubo S,Matsukane A,Takahashi Y,Imamura Y,Hirahata K,Hase H

更新日期：2018-02-01 00:00:00