Abstract:
BACKGROUND:Achieving a normal final adult height (FH) remains a challenge in the field of pediatric kidney transplantation (KTx). To examine the optimal approach to assuring normal FH following KTx, we retrospectively examined the post-transplant growth and FH of pediatric KTx recipients. METHODS:Since the relevant factors affecting the FH of children following KTx are multifactorial and notably complex, KTx recipients with persistent good graft function and successful steroid minimization until FH attainment were selected for this study. RESULTS:Thirteen patients were enrolled in this study. The mean estimated glomerular filtration rate was 72.1 ± 15.3 ml/min/1.73 m(2), and the mean corticosteroid dose was 0.05 ± 0.05 mg/kg on alternate days at the time of FH attainment. Despite highly successful KTx, four (30.8 %) patients (one who underwent KTx before puberty and three during puberty) showed a decrease in the height standard deviation score (hSDS) from the time of KTx until FH attainment. Moreover, of these, two male patients had an FH with an SD <-2. CONCLUSION:FH remained suboptimal despite highly successful KTx. Not only highly successful KTx but also further treatment such as steroid avoidance, early steroid withdrawal or using rhGH might be necessary to assure a normal FH in some pubertal patients.
journal_name
Clin Exp Nephroljournal_title
Clinical and experimental nephrologyauthors
Fujii H,Chikamoto H,Akioka Y,Hattori Mdoi
10.1007/s10157-013-0842-4subject
Has Abstractpub_date
2014-06-01 00:00:00pages
515-20issue
3eissn
1342-1751issn
1437-7799journal_volume
18pub_type
杂志文章abstract:BACKGROUND:The incidence of childhood nephrotic syndrome (NS) in Germany is not well known. METHODS:An ESPED-based nationwide collection of epidemiological data of children in 2005 and 2006. RESULT:The mean age of NS at onset was 5.5 ± 3.7 years. The gender ratio of boys to girls was 1.8:1. The average length of stay...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-017-1433-6
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:Renal dysfunction is recognized with increasing frequency among the noninfectious comorbidities associated with human immunodeficiency virus (HIV) infection. Urinary liver-type fatty acid-binding protein (L-FABP) has been shown to be a new biomarker to screen for not only tubulointerstitial damage but also k...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-016-1347-8
更新日期:2017-12-01 00:00:00
abstract::Heavy chain deposition disease (HCDD) is one of three entities of monoclonal immunoglobulin deposition disease, characterized histopathologically by the presence of nodular glomerulosclerosis and glomerular and tubular deposition of monoclonal heavy chains without associated light chains. Although HCDD is an extremely...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章,评审
doi:10.1007/s10157-013-0812-x
更新日期:2013-12-01 00:00:00
abstract::Glomerular lipid deposition is sometimes associated with a particular kind of lipid metabolism disturbance. Ultrastructural analyses using electron microscopy often indicate a disease-specific aspect of intraglomerular lipid distribution. ...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章,评审
doi:10.1007/s10157-013-0882-9
更新日期:2014-04-01 00:00:00
abstract::We present a case of proliferative glomerulonephritis with peculiar IgM deposition associated with sarcoidosis. A 62-year-old woman, who had been diagnosed with sarcoidosis 3 years previously because of abnormalities on chest X-ray radiophotographs and lymph node pathology, was admitted to our hospital for the evaluat...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-005-0390-7
更新日期:2006-03-01 00:00:00
abstract::IgA nephropathy (IgAN) associated with leukemia and lymphoma has not, to our knowledge, been reported in children. Two children suffering from these diseases are described here. One patient developed IgAN at the end of 5 years' chemotherapy for acute lymphocytic leukemia. The other had microscopic hematuria 3 years be...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-007-0009-2
更新日期:2008-04-01 00:00:00
abstract::Waldenström's macroglobulinemia is rare lymphoproliferative disorder characterized by the presence of a monoclonal IgM paraproteinemia. Cryoglobulinemia is a common sequela of Waldenström's macroglobulinemia present in 8-18% of the patients. Cryoglobulinemia has also been described as occurring after treatment with ri...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-008-0042-9
更新日期:2008-08-01 00:00:00
abstract:BACKGROUND AND AIM:The infusion of chronic angiotensin II (Ang II) has been shown to promote renal interstitial fibrosis. To evaluate the pathophysiological significance of the natriuretic peptide-GC-A system, we infused Ang II (1.0 mg/kg/day) in GC-A-deficient mice (GC-A-KO). METHODS:We used 5 groups (Wild-Saline n =...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-014-0982-1
更新日期:2015-04-01 00:00:00
abstract:OBJECTIVE:Myeloid-derived suppressor cells (MDSCs) have been identified as immunosuppressive cells in tumor-related inflammation. However, the pathogenesis of MDSCs for autoimmune disease has not been investigated as yet. The aim of this study was to address whether MDSCs contribute to autoimmune organ injury in lupus-...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-010-0309-9
更新日期:2010-10-01 00:00:00
abstract::Chronic kidney disease (CKD), as defined by reduced glomerular filtration rate (<60 ml/min/1.73 m(2)) and/or the presence of renal damage for >3 months, is a significant threat for public health in modern societies. Recent epidemiological studies have demonstrated that CKD is a significant risk for cardiovascular even...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章,评审
doi:10.1007/s10157-011-0493-2
更新日期:2012-02-01 00:00:00
abstract:BACKGROUND:Equations for the creatinine-based estimated glomerular filtration rate (eGFR) were recently established for Japanese adults (>18 years old) and children (2-11 years old), respectively, but it is unclear whether eGFR can be as useful as 24-h creatinine clearance (CCr) for assessing renal function in patients...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-014-0976-z
更新日期:2015-04-01 00:00:00
abstract::The case of a 63-year-old woman with a relatively rapidly growing angiomyolipoma (AML) originating from the right renal sinus is presented. The tumor had enlarged to more than fivefold in volume (7.4 × 6.7 × 10.1 cm) in the 7 years following its detection (5.6 × 3.4 × 4.6 cm) and had significantly pushed aside the duo...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-011-0519-9
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:Residual cardiovascular risk factors, such as triglyceride (TG), can cause cardiovascular disease. The role of TG metabolism in kidney transplantation remains unclear. METHODS:Sixty-three consecutive stable recipients at 1 year after their kidney transplants were included in the study from January to Septem...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-017-1462-1
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:The number of elderly dialysis patients in Japan is dramatically increasing. Receiving therapy with better satisfaction through home care is one of the important factors in their daily lives. Thus, the quality of life of elderly patients on hemodialysis (HD) or peritoneal dialysis (PD) was evaluated. METHOD...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-016-1374-5
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:Ambulatory blood pressure (ABP) monitoring and carotid-femoral pulse wave velocity (cfPWV) provide important cardiovascular risk information for dialysis patients. This study aims to evaluate the risk factors of cfPWV and the associations between ambulatory blood pressure, especially night-time blood pressur...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-017-1464-z
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:Microalbuminuria, a marker of vascular damage, is associated with increased risk of progressive renal deterioration, cardiovascular disease and mortality. However, the relationship between antinuclear antibody (ANA) and microalbuminuria in the general population is unknown. Thus, we conducted a cross-section...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-008-0030-0
更新日期:2008-06-01 00:00:00
abstract::Unique renal histopathological appearances, consisting of podocytic infolding and microstructures in the glomerular basement membrane (GBM) were identified in the renal biopsies from three patients with collagen diseases such as systemic lupus erythematosus (lupus nephritis, class II) and Sjögren's syndrome. In each c...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-008-0098-6
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND:In patients with IgA nephropathy (IgAN), recurrence after steroid pulse therapy is associated with reduced renal survival. However, the predictors of recurrence have not yet been clarified. METHODS:All patients who received 6-month steroid pulse therapy from 2004 to 2010 in our four affiliated hospitals and...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章,多中心研究
doi:10.1007/s10157-015-1170-7
更新日期:2016-06-01 00:00:00
abstract::A 77-year-old man with a history of hypertension and hyperuricemia was admitted to our hospital complaining of limb weakness, persistent constipation, and worsening hypertension. He had been taking a Chinese herbal remedy for allergic rhinitis for the past 10 years, together with an angiotensin-converting enzyme inhib...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-006-0415-x
更新日期:2006-06-01 00:00:00
abstract:BACKGROUND:The current (2012) histological classification of immunoglobulin A nephropathy was established using a case-control study of 287 patients. However, the risk of progression to end-stage renal disease (ESRD) has not been validated for the previous (2002) classification. This study aimed to determine whether th...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-013-0848-y
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND:Mizoribine (MZR) was approved in 1984 in Japan for the suppression of rejection in renal transplantation with an approved administration dosage of 1-3 mg/kg/day. The action of MZR resembles that of mycophenolate mofetil (MMF), but MZR dosing is markedly lower than that of MMF. To examine whether higher dosin...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s10157-013-0780-1
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:Chronic kidney disease (CKD) eventually progresses to end-stage renal disease (ESRD). However, risk factors associated with CKD progression have not been well characterized in Japanese patients with CKD who are less affected with coronary disease than Westerners. METHODS:A large-scale, multicenter, prospect...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章,多中心研究
doi:10.1007/s10157-016-1309-1
更新日期:2017-06-01 00:00:00
abstract:BACKGROUND:Peritoneal dialysis (PD) exchange procedure is complex. Patients with cognitive impairment (CI) may require assistance. We studied the prevalence of CI among PD patients, its impact on PD-related peritonitis and the outcome of assisted PD. METHODS:Cantonese version of Mini-Mental State examination (CMMSE) w...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-015-1127-x
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:Cinacalcet markedly reduces the serum intact parathyroid hormone (PTH) level of hemodialysis (HD) patients with secondary hyperparathyroidism. Parathyroidectomy also reduces the serum intact PTH level of HD patients and it increases their bone mineral density (BMD). However, there is little information about...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-012-0665-8
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:Vascular endothelial cells (VECs) play crucial roles in physiological and pathologic conditions in tissues and organs. Most of these roles are related to VEC plasma membrane proteins. In the kidney, VECs are closely associated with structures and functions; however, plasma membrane proteins in kidney VECs re...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-012-0708-1
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:Although acute kidney injury (AKI) is known as a potential complication of influenza infections, there is limited information concerning the association between influenza and AKI. The aim of this study is to evaluate the incidence, the mortality, and risk factors of AKI in hospitalized patients by seasonal i...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-020-02006-3
更新日期:2021-01-04 00:00:00
abstract:BACKGROUND:Chronic kidney disease (CKD) is a major global problem and is also associated with a decreased health-related quality of life (HRQOL). The aim of this study was to evaluate measured HRQOL based on the new CKD classification including proteinuria stage, and the effect of measured HRQOL on CKD progression and ...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-013-0901-x
更新日期:2014-10-01 00:00:00
abstract::Acute kidney injury (AKI) is a threatening medical condition associated with poor outcomes at different settings. The development of standardized diagnostic criteria and new biomarkers addressed significant clinical impacts of AKI and the need for an early AKI detection, respectively. There have been some breakthrough...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章,评审
doi:10.1007/s10157-020-01920-w
更新日期:2020-11-01 00:00:00
abstract:OBJECTIVE:Skin and soft tissue infection (SSTI) is the most common of infectious diseases with high morbidity and mortality. However, the clinical characteristics of SSTI in patients with nephrotic syndrome (NS), especially in those patients who received immunosuppressive therapy, are still lacking. The present study w...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-020-01893-w
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:Bone disease is caused not only by increased bone turnover accompanying secondary hyperparathyroidism but also by factors such as bone metabolic disorder accompanying kidney disease and postmenopausal or age-related osteoporosis in hemodialysis patients. In this study, we investigated the effects of raloxife...
journal_title:Clinical and experimental nephrology
pub_type: 杂志文章
doi:10.1007/s10157-010-0366-0
更新日期:2011-02-01 00:00:00