Pseudoaldosteronism due to the concurrent use of two herbal medicines containing glycyrrhizin: interaction of glycyrrhizin with angiotensin-converting enzyme inhibitor.

abstract：BACKGROUND:Chronic kidney disease (CKD) is a significant public health problem. Strategy for its early detection is still controversial. This study aims to assess the cost-effectiveness of population strategy, i.e. mass screening, and Japan's health checkup reform. METHODS:Cost-effectiveness analysis was carried out t...

journal_title：Clinical and experimental nephrology

authors： Kondo M,Yamagata K,Hoshi SL,Saito C,Asahi K,Moriyama T,Tsuruya K,Yoshida H,Iseki K,Watanabe T

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:Erythropoiesis-stimulating agent (ESA) responsiveness is related to the nutritional status of patients on hemodialysis (HD). Serum butyrylcholinesterase (BChE), an alpha-glycoprotein, may decrease in case of malnutrition. We investigated whether BChE was independently related to ESA resistance in patients on...

journal_title：Clinical and experimental nephrology

authors： Okamoto T,Hatakeyama S,Tanaka Y,Imanishi K,Takashima T,Saitoh F,Koie T,Suzuki T,Ohyama C

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Although it has been repeatedly shown that the oral carbonaceous absorbent AST-120 ameliorates the progression of chronic renal failure, the mechanisms remain unknown. METHODS:Male Sprague-Dawley rats (6 weeks old), weighing 180-210 g, were 4/5 nephrectomized, and were divided into two groups: one given AST...

journal_title：Clinical and experimental nephrology

authors： Horike K,Usami T,Kamiya Y,Kamiya T,Yoshida A,Itoh S,Yamato H,Ise M,Kimura G

更新日期：2003-06-01 00:00:00

abstract：BACKGROUND:Liposomal amphotericin B (L-AMB), a broad-spectrum antifungicidal drug, is often used to treat fungal infections. However, clinical evidence of its use in patients with renal dysfunction, especially those receiving renal replacement therapy (RRT), is limited. Therefore, we evaluated the usage and occurrence ...

journal_title：Clinical and experimental nephrology

authors： Obata Y,Takazono T,Tashiro M,Ota Y,Wakamura T,Takahashi A,Sato K,Miyazaki T,Nishino T,Izumikawa K

更新日期：2020-11-11 00:00:00

abstract：BACKGROUND:Sirt1, a mammalian homolog of silent information regulator 2 (Sir2), is the founding member of class III histone deacetylase (HDAC). METHODS:In this study, we examined whether Sirt1 is involved in the modification of acetylated histone H3, acetylated p53 and Werner syndrome protein (WRN), which is stabilize...

journal_title：Clinical and experimental nephrology

authors： Sakao Y,Kato A,Tsuji T,Yasuda H,Togawa A,Fujigaki Y,Kahyo T,Setou M,Hishida A

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:The Oxford Classification is utilized globally, but has not been fully validated. In this study, we conducted a comparative analysis between the Oxford Classification and Japanese Histologic Classification (JHC) to predict renal outcome in Japanese patients with IgA nephropathy (IgAN). METHODS:A retrospecti...

journal_title：Clinical and experimental nephrology

authors： Kaihan AB,Yasuda Y,Katsuno T,Kato S,Imaizumi T,Ozeki T,Hishida M,Nagata T,Ando M,Tsuboi N,Maruyama S

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Adrenomedullin (AM) has antiproliferative and proapoptotic effects on mesangial cells in culture, but the regulation of AM and its receptors in glomeruli with glomerulonephritis have not been clarified. METHODS:We examined sequential changes in the mRNA expression of AM and its receptors (receptor-activity-...

journal_title：Clinical and experimental nephrology

authors： Matsumoto M,Fujimoto S,Iwatsubo S,Sato Y,Hara S,Kitamura K,Eto T

更新日期：2004-12-01 00:00:00

abstract：BACKGROUND:Stromal cell-derived factor-1α (SDF-1α) is an inflammatory chemokine that plays a critical role in cardiovascular disease. Although persistent inflammation causes renal dysfunction, it remains unclear whether SDF-1α is related to progression of chronic kidney disease. This study examined whether high levels ...

journal_title：Clinical and experimental nephrology

authors： Uematsu M,Nakamura T,Yoshizaki T,Watanabe Y,Deyama J,Watanabe K,Kobayashi T,Fujioka D,Saito Y,Nakamura K,Kawabata K,Obata JE,Kugiyama K

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Dotinurad, a novel selective urate reabsorption inhibitor (SURI), increases urinary uric acid excretion. The aim of this study is to examine the pharmacokinetics, pharmacodynamics, and safety of dotinurad according to the type of hyperuricemia, with or without concomitant use of xanthine oxidase inhibitor, i...

journal_title：Clinical and experimental nephrology

authors： Okui D,Sasaki T,Fushimi M,Ohashi T

更新日期：2020-03-01 00:00:00

abstract：:Lecithin:cholesterol acyltransferase (LCAT) is a key enzyme involved in reverse cholesterol transport from the peripheral tissues to the liver. LCAT deficiency, in which this enzyme is congenitally absent, is a genetic disease that impairs the esterification of free cholesterol in the plasma, leading to accumulation o...

journal_title：Clinical and experimental nephrology

authors： Hirashio S,Ueno T,Naito T,Masaki T

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Adenosine monophosphate (AMP)-activated protein kinase (AMPK), as a sensor of cellular energy status, has been known to play an important role in the pathophysiology of diabetes and its complications. As AMPK is also expressed in podocytes, it is possible that podocyte AMPK would be an important contributing...

journal_title：Clinical and experimental nephrology

authors： Choi JY,Ha TS,Park HY,Ahn HY

更新日期：2013-02-01 00:00:00

abstract：:This report documents a case of metastatic papillary renal cell carcinoma (PRCC) which successfully responded to interleukin-2 (IL-2) therapy. A 59-year-old male presented with a left renal mass measuring 3.0 cm in diameter and a right adrenal mass measuring 5.0 cm in diameter. He underwent a left partial nephrectomy ...

journal_title：Clinical and experimental nephrology

authors： Kosaka T,Mikami S,Miyajima A,Oya M

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND:In patients with IgA nephropathy (IgAN), recurrence after steroid pulse therapy is associated with reduced renal survival. However, the predictors of recurrence have not yet been clarified. METHODS:All patients who received 6-month steroid pulse therapy from 2004 to 2010 in our four affiliated hospitals and...

journal_title：Clinical and experimental nephrology

authors： Hirano K,Amano H,Kawamura T,Watanabe K,Koike K,Shimizu A,Endo S,Tsuboi N,Okonogi H,Miyazaki Y,Ikeda M,Hanaoka K,Ogura M,Komatsumoto S,Yokoo T

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Chronic kidney disease is a predictor of end-stage renal disease (ESRD) and cardiovascular disease (CVD). Therefore, the medical expenses are higher with the decrease in glomerular filtration rate (GFR). However, few studies have examined the medical expenses according to the baseline GFR. METHODS:We invest...

journal_title：Clinical and experimental nephrology

authors： Iseki K,Iseki C,Kurahashi I,Watanabe T

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Acute kidney injury (AKI) is a common complication in critically ill patients. Urinary excretion of liver-type fatty acid-binding protein (L-FABP), which is expressed in the proximal tubules, reflects the presence of tubular injury. Urinary excretion of podocalyxin (PCX), a glycoprotein prominently expressed...

journal_title：Clinical and experimental nephrology

authors： Matsui K,Kamijo-Ikemori A,Hara M,Sugaya T,Kodama T,Fujitani S,Taira Y,Yasuda T,Kimura K

更新日期：2011-04-01 00:00:00

abstract：:Idiopathic nephrotic syndrome is the most common chronic glomerular disease in children. At least 20 % of children with this syndrome show frequent relapses and/or steroid dependence during or after immunosuppressive therapies, a condition defined as complicated frequently relapsing/steroid-dependent nephrotic syndrom...

journal_title：Clinical and experimental nephrology

authors： Iijima K,Sako M,Nozu K

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Aquaporin-2 (AQP2) is a key water channel protein which determines the water permeability of the collecting duct. Multiple phosphorylation sites are present at the C-terminal of AQP2 including S256 (serine at 256 residue), S261, S264 and S/T269, which are regulated by vasopressin (VP) to modulate AQP2 traffi...

journal_title：Clinical and experimental nephrology

authors： Sakai M,Yamamoto K,Mizumura H,Matsumoto T,Tanaka Y,Noda Y,Ishibashi K,Yamamoto T,Sasaki S

更新日期：2020-09-01 00:00:00

abstract：:We report a case of acute kidney injury (AKI) caused by a novel direct renin inhibitor, aliskiren. A 43-year-old Japanese man with dilated cardiomyopathy on cardiac resynchronization therapy with defibrillator and chronic kidney disease (CKD) was started on aliskiren in addition to enalapril, carvedilol, furosemide, a...

journal_title：Clinical and experimental nephrology

authors： Yamauchi J,Shibagaki Y,Uehara K,Yasuda T,Kimura K

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:Achieving a normal final adult height (FH) remains a challenge in the field of pediatric kidney transplantation (KTx). To examine the optimal approach to assuring normal FH following KTx, we retrospectively examined the post-transplant growth and FH of pediatric KTx recipients. METHODS:Since the relevant fa...

journal_title：Clinical and experimental nephrology

authors： Fujii H,Chikamoto H,Akioka Y,Hattori M

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Although congenital anomalies of the kidney and urinary tract (CAKUT) are the most common cause of pediatric end-stage renal disease (ESRD), little is known about the characteristics exhibited in the infantile period by CAKUT patients who develop ESRD. Further, an efficient screening method for CAKUT diagnos...

journal_title：Clinical and experimental nephrology

authors： Yoshino A,Honda M,Sasaki N,Hataya H,Ishikura K,Sakazume S,Tanaka Y,Nagai T

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:Recent evidence indicates that both ambulatory blood pressure monitoring (ABPM) and home blood pressure monitoring (HBPM) are more useful than the measurement of office blood pressure for evaluating cardiovascular risks in subjects with hypertension. The major advantage of ABPM over HBPM is the ability to me...

journal_title：Clinical and experimental nephrology

authors： Ushio H,Ishigami T,Araki N,Minegishi S,Tamura K,Okano Y,Uchino K,Tochikubo O,Umemura S

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:A close correlation has been shown between tubulointerstitial (TI) injury and the outcome of renal dysfunction, and nuclear factor-kappaB (NFkappaB) has been shown to play a key role in proteinuria-induced TI injury. To explore the molecular mechanisms of the proteinuria-induced TI injury further, we have an...

journal_title：Clinical and experimental nephrology

authors： Takase O,Marumo T,Hishikawa K,Fujita T,Quigg RJ,Hayashi M

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:Recent studies have suggested that assessments of serum antibodies against M-type phospholipase A2 receptor (PLA2R) and the glomerular expression of PLA2R antigen in biopsy specimens are useful for the diagnosis of primary membranous nephropathy (MN). In this study, we assessed both of them and investigated ...

journal_title：Clinical and experimental nephrology

authors： Hayashi N,Akiyama S,Okuyama H,Matsui Y,Adachi H,Yamaya H,Maruyama S,Imai E,Matsuo S,Yokoyama H

更新日期：2015-10-01 00:00:00

abstract：:A 33-year-old woman was transferred to our hospital with a 5-month history of taking Chinese herbal medicine containing aristolochic acid. She presented with metabolic acidosis, severe anemia, hypophosphatemia and uric aciduria, and generalized aminoaciduria and glycosuria, features which were consistent with the clin...

journal_title：Clinical and experimental nephrology

authors： Kazama I,Matsubara M,Michimata M,Suzuki M,Hatano R,Sato H,Ito S

更新日期：2004-09-01 00:00:00

abstract：:Waldenström's macroglobulinemia is rare lymphoproliferative disorder characterized by the presence of a monoclonal IgM paraproteinemia. Cryoglobulinemia is a common sequela of Waldenström's macroglobulinemia present in 8-18% of the patients. Cryoglobulinemia has also been described as occurring after treatment with ri...

journal_title：Clinical and experimental nephrology

authors： Shaikh A,Habermann TM,Fidler ME,Kumar S,Leung N

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:Darbepoetin alfa (DA) is an attractive alternative to recombinant human erythropoietin (rHuEPO) in managing renal anemia. Since DA has not been approved by the appropriate Japanese drug regulatory agencies for the indication of renal anemia in children in Japan, we have conducted a multicenter prospective st...

journal_title：Clinical and experimental nephrology

authors： Hattori M,Matsunaga A,Akioka Y,Fujinaga S,Nagai T,Uemura O,Nakakura H,Ashida A,Kamei K,Ito S,Yamada T,Goto Y,Ohta T,Hisano M,Komatsu Y,Itami N

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Cardiovascular disease is the leading cause of morbidity and mortality in patients with kidney failure. Nocturnal home hemodialysis (NHD) is a form of kidney replacement therapy whereby hemodialysis is performed for at least 6-h overnight, at least 4 days per week. Little is known about the effects of NHD on...

journal_title：Clinical and experimental nephrology

authors： Friesen T,Jassal DS,Zhu M,Eng F,Rigatto C,Tangri N,Sood MM,Karlstedt E,Premecz S,Komenda P

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Intravascular administration of iodinated contrast media continues to be a common cause of hospital-acquired acute kidney injury. Accumulating evidence suggests that radiocontrast agent-induced nephrotoxicity is associated with increased oxidative stress, which leads to renal tissue damage with DNA fragmenta...

journal_title：Clinical and experimental nephrology

authors： Ludwig U,Connemann J,Keller F

更新日期：2013-12-01 00:00:00

abstract：:Posterior reversible encephalopathy syndrome (PRES) is a rare complication of nephrotic syndrome and corticosteroid therapy. Here, we discuss an 18 year old man with type 1 membranoproliferative glomerulonephritis (MPGN) secondary to hepatitis B infection who developed posterior leukoencephalopathy while on therapy wi...

journal_title：Clinical and experimental nephrology

authors： Sathyanarayanan V,Razak A,Narayan G,Prabhu M,Ramachandran B,Ranjini K,Vidya M,Joshi K

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:The current (2012) histological classification of immunoglobulin A nephropathy was established using a case-control study of 287 patients. However, the risk of progression to end-stage renal disease (ESRD) has not been validated for the previous (2002) classification. This study aimed to determine whether th...

journal_title：Clinical and experimental nephrology

authors： Miyazaki Y,Kawamura T,Joh K,Okonogi H,Koike K,Utsunomiya Y,Ogura M,Matsushima M,Yoshimura M,Horikoshi S,Suzuki Y,Furusu A,Yasuda T,Shirai S,Shibata T,Endoh M,Hattori M,Akioka Y,Katafuti R,Hashiguchi A,Kimura K,M

更新日期：2014-06-01 00:00:00