NF-kappaB-dependent genes induced by proteinuria and identified using DNA microarrays.

abstract：BACKGROUND:Children with nephrotic syndrome (NS) have hyperlipidemia, which may lead to endothelial dysfunction. This study evaluated endothelial function and structural atherosclerosis in NS children with disease duration more than 2 years, by assessment of brachial artery flow-mediated dilatation (FMD) and carotid in...

journal_title：Clinical and experimental nephrology

authors： Rahul I,Krishnamurthy S,Satheesh S,Biswal N,Bobby Z,Lakshminarayanan S

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:The present study was conducted to clarify the clinical risk factors related to the development of encapsulating peritoneal sclerosis (EPS), which is one of the most serious complications in patients undergoing peritoneal dialysis (PD). METHODS:The records of 78 patients with a history of PD treatment, incl...

journal_title：Clinical and experimental nephrology

authors： Yamamoto R,Otsuka Y,Nakayama M,Maruyama Y,Katoh N,Ikeda M,Yamamoto H,Yokoyama K,Kawaguchi Y,Matsushima M

更新日期：2005-06-01 00:00:00

abstract：:Endothelial dysfunction due to the reduced bioavailability of nitric oxide (NO) is involved in the course of atherosclerotic cardiovascular disease as well as chronic kidney disease (CKD). NO is synthesized from L-arginine via the action of NO synthase, which is blocked by endogenous L-arginine analogues such as asymm...

journal_title：Clinical and experimental nephrology

authors： Ueda S,Yamagishi SI,Matsumoto Y,Fukami K,Okuda S

更新日期：2007-06-01 00:00:00

abstract：:Lecithin:cholesterol acyltransferase (LCAT) is a key enzyme involved in reverse cholesterol transport from the peripheral tissues to the liver. LCAT deficiency, in which this enzyme is congenitally absent, is a genetic disease that impairs the esterification of free cholesterol in the plasma, leading to accumulation o...

journal_title：Clinical and experimental nephrology

authors： Hirashio S,Ueno T,Naito T,Masaki T

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:The definition of sepsis was updated to sepsis-3 in February 2016. Currently, direct hemoperfusion therapy using the polymyxin B-immobilized fiber cartridge (PMX-DHP) is widely performed to treat sepsis and septic shock. However, the prognostic factors of PMX-DHPs in patients with sepsis using the new defini...

journal_title：Clinical and experimental nephrology

authors： Okubo A,Nakashima A,Doi S,Ueno T,Sasaki K,Esaki T,Masaki T

更新日期：2018-10-01 00:00:00

abstract：:Idiopathic nephrotic syndrome is the most common chronic glomerular disease in children. At least 20 % of children with this syndrome show frequent relapses and/or steroid dependence during or after immunosuppressive therapies, a condition defined as complicated frequently relapsing/steroid-dependent nephrotic syndrom...

journal_title：Clinical and experimental nephrology

authors： Iijima K,Sako M,Nozu K

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Creatinine clearance (Ccr) overestimates glomerular filtration rate (GFR) due to the tubular secretion of creatinine. It is known that fractional excretion of creatinine (FE-Cr) increases with decreasing GFR. Association of serum albumin level with the tubular secretion of creatinine was also reported previo...

journal_title：Clinical and experimental nephrology

authors： Horio M,Imai E,Yasuda Y,Watanabe T,Matsuo S

更新日期：2014-06-01 00:00:00

abstract：:Waldenström's macroglobulinemia is rare lymphoproliferative disorder characterized by the presence of a monoclonal IgM paraproteinemia. Cryoglobulinemia is a common sequela of Waldenström's macroglobulinemia present in 8-18% of the patients. Cryoglobulinemia has also been described as occurring after treatment with ri...

journal_title：Clinical and experimental nephrology

authors： Shaikh A,Habermann TM,Fidler ME,Kumar S,Leung N

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:The herbicide paraquat (1, 1'-dimethyl-4, 4'-bipyridylium dichloride; PQ) is a poison well-known to cause delayed mortality due to acute kidney injuries (AKI). This study examines the changes in serum amino acids (AAs) metabolite profiles as surrogate markers of renal cell metabolism and function after paraq...

journal_title：Clinical and experimental nephrology

authors： Wan X,Li X,Wang Q,Zheng B,Zhou C,Kang X,Hu D,Bao H,Peng A

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Peritoneal dialysis (PD) exchange procedure is complex. Patients with cognitive impairment (CI) may require assistance. We studied the prevalence of CI among PD patients, its impact on PD-related peritonitis and the outcome of assisted PD. METHODS:Cantonese version of Mini-Mental State examination (CMMSE) w...

journal_title：Clinical and experimental nephrology

authors： Shea YF,Lam MF,Lee MS,Mok MY,Lui SL,Yip TP,Lo WK,Chu LW,Chan TM

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Injection of parathyroid hormone (PTH) rapidly stimulates renal Pi excretion, in part by downregulating NaPi-IIa (Npt2a/SLC34A1) and NaPi-IIc (Npt2c/SLC34A3) transporters. The mechanisms underlying the effects of PTH on NaPi-IIc are not fully elucidated. METHODS:We analyzed the effect of PTH on inorganic ph...

journal_title：Clinical and experimental nephrology

authors： Fujii T,Segawa H,Hanazaki A,Nishiguchi S,Minoshima S,Ohi A,Tominaga R,Sasaki S,Tanifuji K,Koike M,Arima Y,Shiozaki Y,Kaneko I,Ito M,Tatsumi S,Miyamoto KI

更新日期：2019-07-01 00:00:00

abstract：:A case of nephrotic syndrome (NS) and acute renal failure (ARF) associated with embryonal rhabdomyosarcoma (RMS) in a 10-year-old boy is reported. Ultrasound revealed irregular, echogenic, circumferential urinary bladder base mass, bilateral hydroureter and hydronephrosis. Histopathology of percutaneous renal and uret...

journal_title：Clinical and experimental nephrology

authors： Olowu WA,Salako AA,Adelusola KA,Sowande OA,Adetiloye VA,Adefehinti O,Osasan SA

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND:Stromal cell-derived factor-1α (SDF-1α) is an inflammatory chemokine that plays a critical role in cardiovascular disease. Although persistent inflammation causes renal dysfunction, it remains unclear whether SDF-1α is related to progression of chronic kidney disease. This study examined whether high levels ...

journal_title：Clinical and experimental nephrology

authors： Uematsu M,Nakamura T,Yoshizaki T,Watanabe Y,Deyama J,Watanabe K,Kobayashi T,Fujioka D,Saito Y,Nakamura K,Kawabata K,Obata JE,Kugiyama K

更新日期：2019-07-01 00:00:00

abstract：:The manifestation of diabetic nephropathy may be a consequence of the actions of certain cytokines and growth factors. Prominent among them is transforming growth factor-β (TGF-β), which promotes renal cell hypertrophy and stimulates extracellular matrix accumulation, the two hallmarks of diabetic renal disease. In ex...

journal_title：Clinical and experimental nephrology

authors： Ziyadeh FN,Isono M,Chen S

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:Although it has been repeatedly shown that the oral carbonaceous absorbent AST-120 ameliorates the progression of chronic renal failure, the mechanisms remain unknown. METHODS:Male Sprague-Dawley rats (6 weeks old), weighing 180-210 g, were 4/5 nephrectomized, and were divided into two groups: one given AST...

journal_title：Clinical and experimental nephrology

authors： Horike K,Usami T,Kamiya Y,Kamiya T,Yoshida A,Itoh S,Yamato H,Ise M,Kimura G

更新日期：2003-06-01 00:00:00

abstract：BACKGROUND:Autosomal dominant polycystic disease (ADPKD) often results in renal failure. Recently, allelic influences of PKD1 mutation types on renal survival were extensively investigated. Here, we analyzed integrated influences of PKD1 mutation types and positions on renal survival. METHODS:We included 338 (82 pedig...

journal_title：Clinical and experimental nephrology

authors： Higashihara E,Horie S,Kinoshita M,Harris PC,Okegawa T,Tanbo M,Hara H,Yamaguchi T,Shigemori K,Kawano H,Miyazaki I,Kaname S,Nutahara K

更新日期：2018-04-01 00:00:00

abstract：:Unique renal histopathological appearances, consisting of podocytic infolding and microstructures in the glomerular basement membrane (GBM) were identified in the renal biopsies from three patients with collagen diseases such as systemic lupus erythematosus (lupus nephritis, class II) and Sjögren's syndrome. In each c...

journal_title：Clinical and experimental nephrology

authors： Sugiyama H,Maruyama M,Morinaga H,Inoue T,Takiue K,Kikumoto Y,Kinomura M,Sada KE,Akagi S,Kitamura S,Maeshima Y,Makino H

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:Although several studies have investigated the relationship between dietary nutrient intake and microalbuminuria, no study of an Asian population has been reported. The present study investigates the relationship between dietary intake and microalbuminuria in a general Japanese population. METHODS:We analyz...

journal_title：Clinical and experimental nephrology

authors： Sato M,Hozawa A,Konta T,Shao L,Otani K,Narimatsu H,Sasaki S,Kato T,Kubota I,Yamashita H,Kayama T,Fukao A

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:Dotinurad, a novel selective urate reabsorption inhibitor, exerts a serum uric acid-lowering effect by selectively inhibiting urate transporter 1 (URAT1) in patients with hyperuricemia. It is generally known that the progression of renal dysfunction is associated with a reduction in the serum uric acid-lower...

journal_title：Clinical and experimental nephrology

authors： Fukase H,Okui D,Sasaki T,Fushimi M,Ohashi T,Hosoya T

更新日期：2020-03-01 00:00:00

abstract：:We report a 17-year-old male patient with tubulointerstitial nephritis and uveitis (TINU) associated with hyperthyroidism. He presented with a 2-month history of fatigue, loss of appetite, low-grade fever, and a 12-kg weight loss when he was admitted to our hospital. He had iritis, which was complicated by fibrin in t...

journal_title：Clinical and experimental nephrology

authors： Ebihara I,Hirayama K,Usui J,Seki M,Higuchi F,Oteki T,Kobayashi M,Yamagata K

更新日期：2006-09-01 00:00:00

abstract：:Acute kidney injury (AKI) is a threatening medical condition associated with poor outcomes at different settings. The development of standardized diagnostic criteria and new biomarkers addressed significant clinical impacts of AKI and the need for an early AKI detection, respectively. There have been some breakthrough...

journal_title：Clinical and experimental nephrology

authors： Doi K

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Chronic kidney disease (CKD) is a common disease, affecting about 10% of the general population. The genetic component about CKD incidence in Asian population is not well known. The aim of the study is to find the genetic loci associated with incident CKD and to figure out the effect of genetic variation on ...

journal_title：Clinical and experimental nephrology

authors： Yun S,Han M,Kim HJ,Kim H,Kang E,Kim S,Ahn C,Oh KH

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Ambulatory blood pressure (ABP) monitoring and carotid-femoral pulse wave velocity (cfPWV) provide important cardiovascular risk information for dialysis patients. This study aims to evaluate the risk factors of cfPWV and the associations between ambulatory blood pressure, especially night-time blood pressur...

journal_title：Clinical and experimental nephrology

authors： Li X,Jiang Q,Wu W,Xu X,Miao L,Jin L,Xue L,Huang T,Di J,Liu J,He X

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Microalbuminuria, a marker of vascular damage, is associated with increased risk of progressive renal deterioration, cardiovascular disease and mortality. However, the relationship between antinuclear antibody (ANA) and microalbuminuria in the general population is unknown. Thus, we conducted a cross-section...

journal_title：Clinical and experimental nephrology

authors： Ishikawa M,Konta T,Hao Z,Takasaki S,Abiko H,Takahashi T,Ikeda A,Ichikawa K,Shibata Y,Takeishi Y,Kato T,Kawata S,Kubota I

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:Proteinuria caused by glomerular disease is characterized by podocyte injury. Vasopressin V2 receptor antagonists are effective in reducing albuminuria, although their actions on glomerular podocytes have not been explored. The objective of this study was to evaluate the effects of tolvaptan, a selective ora...

journal_title：Clinical and experimental nephrology

authors： Okada T,Sakaguchi T,Hatamura I,Saji F,Negi S,Otani H,Muragaki Y,Kawachi H,Shigematsu T

更新日期：2009-10-01 00:00:00

abstract：:A 57-year-old woman presented with fever and cellulitis of the right leg. Urinalysis and kidney function were normal on admission. Cellulitis remitted but fever persisted for six weeks. X-ray imaging, cultures, serological assays for viruses and autoimmunity did not reveal the cause of fever. Unexpectedly anti-Scl 70 ...

journal_title：Clinical and experimental nephrology

authors： Vega Stieb J,Goecke Saavedra H,Méndez Olivieri G

更新日期：2008-10-01 00:00:00

abstract：:A 77-year-old Japanese female developed Churg-Strauss syndrome (CSS), showing fever and numbness in bilateral hands. She was being treated for bronchial asthma with combination inhalant of corticosteroid with beta(2)-agonist, and an oral leukotriene receptor antagonist (LTRA), montelukast, for 15 months. She presented...

journal_title：Clinical and experimental nephrology

authors： Kanda T,Tanio H,Wu C,Nishihara H,Nogaki F,Ono T

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Hypertriglyceridemia (hTG) is a risk factor for progression of chronic kidney disease (CKD); however, it remains unknown whether the adipocytokine complement component 3 (C3) is involved in the association between hTG and CKD. METHODS:The study included 138 patients (54 % male) with non-nephrotic (serum alb...

journal_title：Clinical and experimental nephrology

authors： Kohagura K,Kochi M,Miyagi T,Kinjyo T,Maehara Y,Kinjyo K,Nagahama K,Sakima A,Iseki K,Ohya Y

更新日期：2014-06-01 00:00:00

abstract：:A 69-year-old Caucasian man was admitted to our hospital because of myocardial infarction. A central venous catheter (CVC) for infusive therapy was inserted. After two weeks he developed fever, purpura, and knee arthralgia. Hemoculture yielded methicillin-sensitive Staphylococcus aureus. Subsequently, oliguric renal f...

journal_title：Clinical and experimental nephrology

authors： Uggeri S,Fabbian F,Catizone L

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:In Japan, systematic evaluation of the histologic parameters of anti-neutrophil cytoplasmic autoantibodies (ANCA)-related vasculitis has been performed according to the Japanese classification by Shigematsu et al. However, this classification is quite different from that of the European Vasculitis Study Grou...

journal_title：Clinical and experimental nephrology

authors： Joh K,Muso E,Shigematsu H,Nose M,Nagata M,Arimura Y,Yumura W,Wada T,Nitta K,Makino H,Taguma Y,Kaneoka H,Suzuki Y,Kobayashi M,Koyama A,Usui J,Hashimoto H,Ozaki S,Tomino Y,Yamagata K

更新日期：2008-08-01 00:00:00