Oxaliplatin Alters Expression of T1R2 Receptor and Sensitivity to Sweet Taste in Rats.

abstract：:Mucus on the nasal mucosa is translocated to the pharynx by ciliary beating, which is an important nonspecific defense mechanism called mucociliary clearance (MC). MC is one of the important factors determining the rate and extent of drug absorption after nasal application. The purpose of this study is to evaluate MC ...

journal_title：Biological & pharmaceutical bulletin

authors： Inoue D,Furubayashi T,Ogawara K,Kimura T,Higaki K,Katsumi H,Sakane T,Yamamoto A,Higashi Y

更新日期：2012-01-01 00:00:00

abstract：:The onset of oral candidiasis is accompanied by inflammatory symptoms such as pain in the tongue, edema or tissue damage and lowers the quality of life (QOL) of the patient. In a murine oral candidiasis model, the effects were studied of terpinen-4-ol (T-4-ol), one of the main constituents of tea tree oil, Melaleuca a...

journal_title：Biological & pharmaceutical bulletin

authors： Ninomiya K,Hayama K,Ishijima SA,Maruyama N,Irie H,Kurihara J,Abe S

更新日期：2013-01-01 00:00:00

abstract：:Collagen-induced arthritis (CIA) is an experimental model of rheumatoid arthritis (RA) used for studying the clinical, immunological and genetic factors of the disease. Many studies of genetic susceptibility to CIA have been performed, usually with two strains of mice, DBA/1 and B10.RIII, since they are highly suscept...

journal_title：Biological & pharmaceutical bulletin

authors： Hida S,Nagi-Miura N,Adachi Y,Ohno N

更新日期：2006-06-01 00:00:00

abstract：:Dopamine agonists have neuroprotective properties in addition to their original pharmacologic function. We examined the effects of pergolide mesilate (PM) on the levels of metallothionein mRNA expression and lipid peroxidation in the corpus striata of 1-methyl 4-phenyl 1,2,3,6-tetrahydropyridine (MPTP)-induced Parkins...

journal_title：Biological & pharmaceutical bulletin

authors： Ono S,Hirai K,Tokuda E

更新日期：2009-10-01 00:00:00

abstract：:A novel tricyclic 21-amino-acid peptide, FR901724, was isolated from the cultured broth of Streptomyces sp. No. 73264. This peptide appears to possess potent anti-human immunodeficiency virus (HIV) activity in vitro and might represent a lead to a new class of anti-HIV agents; it qualifies as an HIV-cell fusion inhibi...

journal_title：Biological & pharmaceutical bulletin

authors： Nakashima H,Ichiyama K,Inazawa K,Ito M,Hayashi H,Nishihara Y,Tsujii E,Kino T

更新日期：1996-03-01 00:00:00

abstract：:Duloxetine is a widely used antidepressant worldwide. In the present report, we evaluated its capacity to induce micronucleated polychromatic erythrocytes (MNPEs) and micronucleated normochromatic erythrocytes (MNNEs) in mice. Two assays were performed, one with a single chemical administration and the other with dail...

journal_title：Biological & pharmaceutical bulletin

authors： Madrigal-Bujaidar E,Álvarez-González I,Madrigal-Santillán EO,Morales-González JA

更新日期：2015-01-01 00:00:00

abstract：:In an acute treatment experiment, metformin (150, 300 mg/kg, per os (p.o.)) markedly reduced the consumption of a high-fat diet (HFD) (45 kcal% fat-containing diet) for 2 h after the HFD was given to the fasted male C57BL/6J (B6) mice. In addition, metformin at a higher dose increased plasma active glucagon-like pepti...

journal_title：Biological & pharmaceutical bulletin

authors： Matsui Y,Hirasawa Y,Sugiura T,Toyoshi T,Kyuki K,Ito M

更新日期：2010-01-01 00:00:00

abstract：:Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are associated with Parkinson's disease. LRRK2 is a large protein with multiple functional domains, including a guanosine 5'-triphosphate (GTP)-binding domain and a protein kinase domain. Recent studies indicated that the members of the Rab GTPase family, Rab8...

journal_title：Biological & pharmaceutical bulletin

authors： Imai M,Kawakami F,Kubo M,Kanzaki M,Maruyama H,Kawashima R,Maekawa T,Kurosaki Y,Kojima F,Ichikawa T

更新日期：2020-01-01 00:00:00

abstract：:The relation between degranulation and rapid metabolic responses (acidification rate changes) in RBL-2H3 cells was studied using a cytosensor microphysiometer, a silicon-based biosensor system. The metabolic responses in RBL-2H3 cells by antigen stimulation were compared with those by inhibitors of Ca2+ -ATPase. The f...

journal_title：Biological & pharmaceutical bulletin

authors： Furuno T,Ohyama N,Nakanishi M

更新日期：1999-03-01 00:00:00

abstract：:Skeletal muscle is a major site for glucose metabolism and its injury by cytokines can induce insulin resistance leading to type 2 diabetes. It has been suggested that quercetin may act as an anti-diabetic agent, however, the effects of quercetin on insulin resistance in skeletal muscle remain unknown. We aimed to inv...

journal_title：Biological & pharmaceutical bulletin

authors： Dai X,Ding Y,Zhang Z,Cai X,Bao L,Li Y

更新日期：2013-01-01 00:00:00

abstract：:DJ-1 was first identified as a novel candidate of an oncogene product in cooperation with an activated ras, and DJ-1 was later found to be a positive regulator of the androgen receptor (AR) transcription activity that was repressed by PIASxalpha. DJ-1 was also found to be an infertility-related protein that was reduce...

journal_title：Biological & pharmaceutical bulletin

authors： Taira T,Iguchi-Ariga SM,Ariga H

更新日期：2004-04-01 00:00:00

abstract：:The total iron-binding capacity (TIBC) and iron contents of diabetic rat serum, as well as the iron-binding capacity of glycated transferrin and oxygen radical production by the glycated proteins were examined. The TIBC and iron content of diabetic rat sera were found to be much lower than those of control rat sera. I...

journal_title：Biological & pharmaceutical bulletin

authors： Fujimoto S,Kawakami N,Ohara A

更新日期：1995-03-01 00:00:00

abstract：:Continuous oral administration of the acidic polysaccharide (TAP) solution (0.5 g/l) and the TAP-H (degradation products of TAP) solution (1.5 g/l) instead of water for 10 weeks were found to depress plasma glucose increases in diabetes using genetically non-insulin-dependent diabetic model (KK-Ay) mice. TAP and TAP-H...

journal_title：Biological & pharmaceutical bulletin

authors： Kiho T,Kochi M,Usui S,Hirano K,Aizawa K,Inakuma T

更新日期：2001-12-01 00:00:00

abstract：:Direct detection of nitric oxide (NO) is essential for understanding the precise mechanism of its production from endothelial cells. Previously, we developed an NO detection system based on the chemiluminescence reaction between NO and luminol-H2O2. Here, we have applied this system to cultured endothelial cells for t...

journal_title：Biological & pharmaceutical bulletin

authors： Kurumatani H,Kikuchi K,Nagano T,Hirobe M,Yamazaki J,Nagao T

更新日期：1998-12-01 00:00:00

abstract：:Previously, we reported that dibenzylbutyrolactone lignans (DBLLs) from the fruit of Forsythia koreana NAKAI (Oleaceae) has anti-inflammatory, antioxidant, and anti-asthmatic effects. In this study, to clarify the anti-inflammatory mechanisms of DBLL, we evaluated the effects of DBLLs on lipopolysaccharide-stimulated ...

journal_title：Biological & pharmaceutical bulletin

authors： Lee JY,Cho BJ,Park TW,Park BE,Kim SJ,Sim SS,Kim CJ

更新日期：2010-01-01 00:00:00

abstract：:We have previously reported that INHAT (inhibitor of acetyltransferases) complex subunits, TAF (template activating factor)-Ialpha, TAF-Ibeta and pp32 can inhibit histone acetylation and HAT (histone acetyltransferase)-dependent transcription by binding to histones. Evidences are accumulating that INHAT complex subuni...

journal_title：Biological & pharmaceutical bulletin

authors： Lee IS,Oh SM,Kim SM,Lee DS,Seo SB

更新日期：2006-12-01 00:00:00

abstract：:Indomethacin is used as an anti-inflammatory drug and a nonselective cyclooxygenase inhibitor. When indomethacin in methanol was photo-irradiated with an Hg lamp, methyl ester, ethyl ester, and gamma-lactone derivatives of indomethacin were produced. In the present study, we found that the methyl ester derivative of i...

journal_title：Biological & pharmaceutical bulletin

authors： Chao SH,Wu AB,Lee CJ,Chen FA,Wang CC

更新日期：2005-12-01 00:00:00

abstract：:Infection of human cell with human immunodeficiency virus type-1 (HIV-1) was suppressed by cellular genetic factor(s) at reverse transcription step. Although same amount of virus adsorbed on both cells, small amount of HIV-1 (IIIB strain) infected HeLa (MAGI/CCR5) cell, while large amount of HIV-1 infected HOS (GHOST/...

journal_title：Biological & pharmaceutical bulletin

authors： Tempaku A

更新日期：2005-05-01 00:00:00

abstract：:Effects of pentamidine, a therapeutic drug for Pneumocystis carinii pneumonia (PCP) in acquired immunodeficiency syndrome (AIDS), on specific bindings of [3H](+)-5-methyl-10,11-dihydro-5H- dibenzo[a,d]cyclohepten-5,11-imine maleate (MK-801) and [3H]nitrendipine were investigated in crude synaptic membranes (CSM) of ra...

journal_title：Biological & pharmaceutical bulletin

authors： Kitamura Y,Arima T,Sato T,Nakamura J,Nomura Y

更新日期：1995-02-01 00:00:00

abstract：:We attempted to produce a model mouse with a liver injury resulting from an immunological mechanism in C57BL/6J mice, and the effect of hepatitis on the hepatic microsomal mixed-function oxidase system was studied. An experimental immunological liver injury model was caused by the intravenous injection of an anti-basi...

journal_title：Biological & pharmaceutical bulletin

authors： Ishikawa M,Takayanagi Y,Sasaki K

更新日期：1993-10-01 00:00:00

abstract：:Recent studies have shown that antibodies with low fucose content in their oligosaccharides exhibit highly potent antibody-dependent cellular cytotoxicity (ADCC). However, composites of therapeutic antibodies produced by conventional production systems using cell lines such as Chinese hamster ovary (CHO) and SP2/0 do ...

journal_title：Biological & pharmaceutical bulletin

authors： Tojo S,Okazaki A,Wakitani M,Shinkawa T,Uchida K,Suzawa T

更新日期：2009-09-01 00:00:00

abstract：:We have isolated insulin resistant mice (ddY-H mice) which are spontaneously induced even if fed with the standard chow pellets. Since marked accumulation of triglycerides (TG) in liver was observed, the present study investigated causes of hepatic TG accumulation in ddY-H mice fed with the standard chow pellets. In d...

journal_title：Biological & pharmaceutical bulletin

authors： Satoh H,Ide N,Kagawa Y,Maeda T

更新日期：2013-01-01 00:00:00

abstract：:Hemorrhoids are a common anorectal disease. Epidemiological studies on medication trends and risk factors using information from real-world databases are rare. Our objective was to analyze the relationship between hemorrhoid treatment prescription trends and several risk factors using the National Database of Health I...

journal_title：Biological & pharmaceutical bulletin

authors： Mukai R,Shimada K,Suzuki T,Nakao S,Tanaka M,Matsumoto K,Yoshida Y,Goto F,Inoue M,Satake R,Nishibata Y,Sugihara H,Nakamura M

更新日期：2020-01-01 00:00:00

abstract：:The therapeutic value of an antirheumatic alkaloid, sinomenine (SIN), was investigated in the acute experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis (MS). SIN is a bioactive alkaloid derived from the Chinese medicinal plant, Sinomenium acutum REHDER & E. H. WILSON (Family Menispermaceae). Ch...

journal_title：Biological & pharmaceutical bulletin

authors： Zeng Y,Gu B,Ji X,Ding X,Song C,Wu F

更新日期：2007-08-01 00:00:00

abstract：:The constituents of the stem bark of Garcinia subelliptica (Guttiferae) were investigated based on its trypanocidal activity against epimastigotes of Trypanosoma cruzi, the etiologic agent for Chagas' disease. As the active components, nine xanthones were isolated including two new ones, 4-hydroxybrasilixanthone B and...

journal_title：Biological & pharmaceutical bulletin

authors： Abe F,Nagafuji S,Okabe H,Higo H,Akahane H

更新日期：2003-12-01 00:00:00

abstract：:3',4'-Diisovalerylkhellactone diester (PJ-1) is a coumarin derivative purified from the medicinal herb Peucedanum japonicum Thunb. We examined its in vitro effects on various aspects of platelet reactivity. PJ-1 inhibited the aggregation and ATP release of rabbit platelets induced by PAF (platelet-activating factor) a...

journal_title：Biological & pharmaceutical bulletin

authors： Hsiao G,Ko FN,Jong TT,Teng CM

更新日期：1998-07-01 00:00:00

abstract：:Oxidation of low density lipoprotein (LDL) is strongly implicated as a key process in the onset of atherosclerosis. In this study, nine alkylated (C10-C5) flavonoids from Sophora flavescens were examined for their inhibitory effects on copper-induced LDL oxidation. Of the flavonoids tested, sophoraflavanone G (1), kur...

journal_title：Biological & pharmaceutical bulletin

authors： Jeong TS,Ryu YB,Kim HY,Curtis-Long MJ,An S,Lee JH,Lee WS,Park KH

更新日期：2008-11-01 00:00:00

abstract：:An accumulating body of evidence indicates that inflammation plays a crucial role in the pathophysiology of myocardial infarction (MI). Nucleotide-binding oligomerization domain-like receptor (NLR) family pyrin domain containing 3 (NLRP3) inflammasome is an intracellular multiprotein complex that regulates caspase-1 a...

journal_title：Biological & pharmaceutical bulletin

authors： Takahashi M

更新日期：2019-01-01 00:00:00

abstract：:Inhibition of Rho kinase (ROCK) ameliorates many cardiovascular dysfunctions. The aim of the current study is to investigate the anti-inflammatory effects of fasudil, a selective ROCK inhibitor, on high cholesterol diet-induced hypercholesterolemic rats and its possible mechanisms. In hypercholesterolemic rats, we fou...

journal_title：Biological & pharmaceutical bulletin

authors： Ma Z,Zhang J,Du R,Ji E,Chu L

更新日期：2011-01-01 00:00:00

abstract：:A pharmacokinetic analysis program based on a tank-in-series model, MULTI(TIS), was developed for the evaluation of dose-dependency in the local disposition of a drug. The program written in FORTRAN was constructed by expanding MULTI(RUNGE). The reliability of MULTI(TIS) was verified by analyzing the experimental data...

journal_title：Biological & pharmaceutical bulletin

authors： Fukumura K,Yamaoka K,Higashimori M,Nakagawa T

更新日期：1998-12-01 00:00:00