F1 hybrid mice (BALB/c x DBA/1) are resistant to collagen-induced arthritis with beta-glucan as an adjuvant.

abstract：:Permeation enhancement of ketoprofen (KP) from supersaturated systems and the effects of antinucleant polymers on both stability and permeation of supersaturated KP were investigated using silicone membrane as a skin model. The supersaturation was prepared by the cosolvent technique with water and propylene glycol (PG...

journal_title：Biological & pharmaceutical bulletin

authors： Kumprakob U,Kawakami J,Adachi I

更新日期：2005-09-01 00:00:00

abstract：:The pulmonary vein contains a myocardial layer extending from the left atrium, which is receiving attention as the source of ectopic electrical activity underlying atrial fibrillation. Electrophysiological and pharmacological analysis of the pulmonary vein myocardium performed in various experimental animal species ha...

journal_title：Biological & pharmaceutical bulletin

authors： Namekata I,Tsuneoka Y,Tanaka H

更新日期：2013-01-01 00:00:00

abstract：:The induction of lymphangiogenesis is an important process to promote cancer growth and cancer metastasis via the lymphatic system. Identifying the compounds that can prevent lymphangiogenesis for cancer therapy is urgently required. Chrysin, 5,7-dihydroxyflavone, a natural flavone extracted from Thai propolis, was us...

journal_title：Biological & pharmaceutical bulletin

authors： Prangsaengtong O,Athikomkulchai S,Xu J,Koizumi K,Inujima A,Shibahara N,Shimada Y,Tadtong S,Awale S

更新日期：2016-01-01 00:00:00

abstract：:Hypertension is one of the most prevalent diseases worldwide and can cause harmful complications within the vascular system. Further research on vascular responsiveness to different ligands and diverse receptors in various arteries is required to understand the mechanisms underlying the development of these vascular c...

journal_title：Biological & pharmaceutical bulletin

authors： Ando M,Matsumoto T,Kobayashi S,Iguchi M,Taguchi K,Kobayashi T

更新日期：2018-01-01 00:00:00

abstract：:The major physiologic effect of thyroid hormone is thought to be initiated by the binding of T3 to the DNA binding thyroid hormone receptor (TR). The aim of this study has been to characterize the organ specific expression of thyroid hormone receptor mRNA, as well as its protein distribution and molecular weight in ma...

journal_title：Biological & pharmaceutical bulletin

authors： Shahrara S,Drvota V,Sylvén C

更新日期：1999-10-01 00:00:00

abstract：:A significant sex-related difference was observed for the pharmacokinetics of acetohexamide in Wistar-Imamichi (Wistar-IM) rats. However, there was no sex difference of the in vitro reductive metabolism of acetohexamide in the liver or kidney of these rats. Testectomy was found to decrease the plasma clearance (CLp) o...

journal_title：Biological & pharmaceutical bulletin

authors： Imamura Y,Kaneko M,Mori Y,Otagiri M

更新日期：1999-04-01 00:00:00

abstract：:Apocynum venetum LINN. is an important Chinese crude drug, and its sibling species A. pictum SCHRENK is a confusable herb which is similar to it. The purpose of this study is to develop DNA molecular markers to distinguish A. venetum from A. pictum through the combinative technologies of bulked segregate analysis (BSA...

journal_title：Biological & pharmaceutical bulletin

authors： Lu C,Zhang W,Peng X,Gu G,Chen M,Tang Z

更新日期：2010-01-01 00:00:00

abstract：:The overproduction of nitric oxide (NO) by inducible nitric oxide synthase (iNOS) switches the function of NO from a physiological neuromodulator to a neurotoxic effector in central nervous system (CNS) after brain injury. From the methanol extracts of Psoralea corylifolia, we purified two inhibitors of NO production ...

journal_title：Biological & pharmaceutical bulletin

authors： Lee MH,Kim JY,Ryu JH

更新日期：2005-12-01 00:00:00

abstract：:6-(10-Hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone (idebenone) has been found to have a membrane-stabilizing activity in studies using lysosomes. Using dimyristoyl L-alpha-phosphatidylcholine (DMPC) as a substrate, the effects of idebenone and related benzoquinones on phospholipid digestion by phospholipase A...

journal_title：Biological & pharmaceutical bulletin

authors： Amano T,Terao S,Imada I

更新日期：1995-05-01 00:00:00

abstract：:As a study to assess the potential application of milk fat-globule membrane (MFGM), which is of natural origin and expected to be a safer alternative to synthetic emulsifiers, to pharmaceutical dosage forms, the oral absorption of alpha-linolenic acid was evaluated by the analysis of gastrointestinal disposition after...

journal_title：Biological & pharmaceutical bulletin

authors： Yuasa H,Sekiya M,Ozeki S,Watanabe J

更新日期：1994-09-01 00:00:00

abstract：:Doxorubicin (DOX) is a potent antitumor agent, but the cardiotoxicity mediated by the formation of reactive oxygen species limit its clinical use. The present study aims to explore electrocardiographic and biochemical evidence for the cardioprotective effect of two antioxidants, Lycium barbarum polysaccharides (LBP, t...

journal_title：Biological & pharmaceutical bulletin

authors： Xin Y,Zhang S,Gu L,Liu S,Gao H,You Z,Zhou G,Wen L,Yu J,Xuan Y

更新日期：2011-01-01 00:00:00

abstract：:Imbalance between oxidative stress and antioxidative defence system is generally known as one of mechanisms causing an oxidative stress-medieated neuropathogenesis. Peroxiredoxins (Prxs), a family of antioxidative enzymes neutralizing cellular hydroperoxides, was characterized recently, but their distributions and rol...

journal_title：Biological & pharmaceutical bulletin

authors： Kim SU,Hwang CN,Sun HN,Jin MH,Han YH,Lee H,Kim JM,Kim SK,Yu DY,Lee DS,Lee SH

更新日期：2008-05-01 00:00:00

abstract：:Small extracellular vesicles (sEVs), including exosomes as typical example, are cell-derived vesicles comprising lipid bilayer with a diameter approximately 100 nm. sEVs are endogenous delivery vehicles that deliver their contents such as nucleic acids and proteins to recipient cells. Because of their potential nature...

journal_title：Biological & pharmaceutical bulletin

authors： Takakura Y,Matsumoto A,Takahashi Y

更新日期：2020-01-01 00:00:00

abstract：:The purpose of this study was to investigate the absorption behavior of an ophthalmic drug injected in rabbit periocular tissues. After intracapsular, retrobulbar and palpebral conjunctival injections of 150 microl and 50 microl fluorescein isothiocyanate dextran (FITC-dextran, average molecular weight 11000), leakage...

journal_title：Biological & pharmaceutical bulletin

authors： Sasaki H,Kashiwagi S,Mukai T,Nishida K,Nakamura J,Nakashima M,Ichikawa M

更新日期：1999-09-01 00:00:00

abstract：:Bryonolic acid was isolated in high yield from transformed hairy root cultures of Trichosanthes kirilowii var. Japonica. Bryonolic acid exhibited cytotoxic activity to various tumor cells in vitro, independent of cell type. Normal cells such as rat hepatocytes are less sensitive to bryonolic acid. The appearance of a ...

journal_title：Biological & pharmaceutical bulletin

authors： Kondo T,Inoue M,Mizukami H,Ogihara Y

更新日期：1995-05-01 00:00:00

abstract：:Cephradine-containing ethylcellulose microparticles (MPC) were prepared by the solvent evaporation method. Chitosan-coated MPC (Chi-MPC) were prepared by doping MPC with viscous chitosan solution and subsequently drying. When fluorescein isothiocyanate (FITC)-labeled chitosan-coated ethylcellulose microparticles witho...

journal_title：Biological & pharmaceutical bulletin

authors： Takishima J,Onishi H,Machida Y

更新日期：2002-11-01 00:00:00

abstract：:Endometriosis, a disease affecting 5-15% of women of reproductive age, is characterized by the ectopic growth of endometrial tissue. Costunolide, a sesquiterpene lactone, has anti-proliferative and pro-apoptotic activities that may be efficacious in therapy for endometriosis. In the present study, we investigated the ...

journal_title：Biological & pharmaceutical bulletin

authors： Kim JH,Yang YI,Lee KT,Park HJ,Choi JH

更新日期：2011-01-01 00:00:00

abstract：:The mechanistic/mammalian target of rapamycin complex-1 (mTORC1) integrates multiple signaling pathways and regulates various cellular processes. Tuberous sclerosis complex 1 (Tsc1) and complex 2 (Tsc2) are critical negative regulators of mTORC1. Mouse genetic studies, including ours, have revealed that inactivation o...

journal_title：Biological & pharmaceutical bulletin

authors： Iwahashi S,Tokumura K,Park G,Ochiai S,Okayama Y,Fusawa H,Ohta K,Fukasawa K,Iezaki T,Hinoi E

更新日期：2020-01-01 00:00:00

abstract：:Chemoprevention has emerged as a very effective preventive measure against carcinogenesis. Several bioactive compounds present in fruits and vegetables have revealed their cancer curative potential on benzo(a)pyrene (B(a)P) induced carcinogenesis. In the present study, the efficacy of quercetin on the level of lipid p...

journal_title：Biological & pharmaceutical bulletin

authors： Kamaraj S,Vinodhkumar R,Anandakumar P,Jagan S,Ramakrishnan G,Devaki T

更新日期：2007-12-01 00:00:00

abstract：:We investigated whether peripherally administered aconitine increases spontaneous acetylcholine (ACh) release from the frontal cerebral cortex in freely moving rats using in vivo microdialysis, as it relates to aconitine-induced bradycardia estimated by a tail-artery cuff technique in unilateral anterior hypothalamus ...

journal_title：Biological & pharmaceutical bulletin

authors： Kimura I,Takada M,Nojima H,Kimura M

更新日期：1996-11-01 00:00:00

abstract：:The aqueous extract of whole plant of Coronopus didymus LINN (CD) [Family: Bracicacea] was screened for antiallergic, antipyretic and hepatoprotective effects in rats and hypoglycemic activity in mice. The extract showed significant antiallergic, antipyretic, hypoglycemic and hepatoprotective activity at 200 and 400 m...

journal_title：Biological & pharmaceutical bulletin

authors： Mantena SK,Mutalik S,Srinivasa H,Subramanian GS,Prabhakar KR,Reddy KR,Srinivasan KK,Unnikrishnan MK

更新日期：2005-03-01 00:00:00

abstract：:DNA rich in non-methylated CG motifs (CpGs) enhances induction of immune responses against co-administered antigen encoding genes. CpGs are therefore among the promising adjuvants known to date. However, naked plasmid DNA, even which contains CpG motifs, are taken up by antigen presenting cells via the endocytosis pat...

journal_title：Biological & pharmaceutical bulletin

authors： Yoshikawa T,Imazu S,Gao JQ,Hayashi K,Tsuda Y,Okada N,Tsutsumi Y,Akashi M,Mayumi T,Nakagawa S

更新日期：2006-01-01 00:00:00

abstract：:It is known that female rats are resistant to ischemic acute renal failure (ARF), compared with male rats. To elucidate sex differences in ischemic ARF, we searched global protein expression in post-ischemic kidneys using proteomic techniques. Ischemic ARF was induced by 45-min ischemia followed by reperfusion. By pro...

journal_title：Biological & pharmaceutical bulletin

authors： Takayama J,Takaoka M,Sugino Y,Yamamoto Y,Ohkita M,Matsumura Y

更新日期：2007-10-01 00:00:00

abstract：:The purpose of this study was to evaluate the essential oils from sweet basil (Ocimum basilicum, OB) as skin permeation enhancers to promote the percutaneous absorption of drugs. The in vitro and in vivo irritancy of the essential oils was also examined. Terpenes with various carbon numbers (mono-, sesqui-, di-, and t...

journal_title：Biological & pharmaceutical bulletin

authors： Fang JY,Leu YL,Hwang TL,Cheng HC

更新日期：2004-11-01 00:00:00

abstract：:The effects of aged garlic extract (AGE) on longevity and learning and memory performances were studied in the senescence accelerated mouse (SAM). A solid diet containing 2% (w/w) AGE was given to SAM from 2 months of age. The survival ratio of SAM P8, senescence accelerated animals, treated with AGE was significantly...

journal_title：Biological & pharmaceutical bulletin

authors： Moriguchi T,Takashina K,Chu PJ,Saito H,Nishiyama N

更新日期：1994-12-01 00:00:00

abstract：:Thyroid hormone, thyroxine (T4) binding to glycosylated human serum albumin (G-HSA), and native human serum albumin (HSA) were studied as a function of pH using the fluorescence method. T4 binding affinity for G-HSA was remarkably reduced in an alkaline pH as compared with the native HSA. The thermodynamic parameters ...

journal_title：Biological & pharmaceutical bulletin

authors： Okabe N,Yoshida S

更新日期：1995-01-01 00:00:00

abstract：:The neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) has been employed to create a Parkinson's disease-like model in both rodents and primates based primarily on its ability to create a striatal dopamine deficit due to the loss of dopaminergic neurons in the substantia nigra compacta. The present study w...

journal_title：Biological & pharmaceutical bulletin

authors： Geng X,Song L,Pu X,Tu P

更新日期：2004-06-01 00:00:00

abstract：:The present study was aimed at kinetically characterizing the carrier-mediated transport systems for D-glucose and taurocholate in the rat colon, compared with their respective counterparts in the small intestine. The transport of these compounds was evaluated by measuring the initial uptake into everted intestinal ti...

journal_title：Biological & pharmaceutical bulletin

authors： Tomei S,Torimoto M,Hayashi Y,Inoue K,Yuasa H,Watanabe J

更新日期：2003-06-01 00:00:00

abstract：:The effects of hop extracts (Humulus lupulus L.) on histamine release from rat peritoneal mast cells and human basophilic KU812 cells were studied. Hop water extract (HWE) and XAD-4 50% methanol fraction of HWE (MFH) inhibited histamine release from rat mast cells induced by compound 48/80 at concentrations of 100 and...

journal_title：Biological & pharmaceutical bulletin

authors： Takubo M,Inoue T,Jiang S,Tsumuro T,Ueda Y,Yatsuzuka R,Segawa S,Watari J,Kamei C

更新日期：2006-04-01 00:00:00

abstract：:A liposomal formulation of UCN-01 was studied to prevent binding of drug to human alpha1-acid glycoprotein (hAGP). The release of drug from liposomes added to various media was investigated by monitoring the concentration of UCN-01 in different fractions. Protein bound UCN-01 was separated from liposomal UCN-01 and fr...

journal_title：Biological & pharmaceutical bulletin

authors： Yamauchi M,Kusano H,Nakakura M,Kato Y

更新日期：2005-07-01 00:00:00