Abstract:
:We attempted to produce a model mouse with a liver injury resulting from an immunological mechanism in C57BL/6J mice, and the effect of hepatitis on the hepatic microsomal mixed-function oxidase system was studied. An experimental immunological liver injury model was caused by the intravenous injection of an anti-basic liver protein (BLP) antibody in mice which had been previously immunized with normal rabbit IgG (RGG) and complete Freund's adjuvant. C57BL/6J strain mice showed the highest susceptibility to the immunological liver injury. Typical histopathological changes in the liver included submassive hepatocellular necrosis and infiltration of lymphocytes into the portal tract and sinusoid area in a necrotic lesion. The liver injury in this model was markedly inhibited by the administration of prednisolone (20 mg/kg, p.o.), cyclophosphamide (15 mg/kg, i.p.), levamisole (10 mg/kg, p.o.), glycyrrhizin (50 mg/kg, i.p.) and cepharanthine (10 mg/kg, i.p.), which act on the immune system. Twenty-four hours after the injection of anti-BLP antibody, the activities of aminopyrine N-demethylase, aniline hydroxylase and NADPH-cytochrome c reductase and the content of cytochrome P-450 were mostly reduced, whereas cytochrome b5 and NADH-ferricyanide reductase were not. These results suggest that the experimental liver injury model in C57BL/6J mice is useful as a model of liver injury model, and its hepatitis was shown to inhibit the cytochrome P-450-dependent biotransformation of drugs in the mouse.
journal_name
Biol Pharm Bulljournal_title
Biological & pharmaceutical bulletinauthors
Ishikawa M,Takayanagi Y,Sasaki Kdoi
10.1248/bpb.16.982subject
Has Abstractpub_date
1993-10-01 00:00:00pages
982-8issue
10eissn
0918-6158issn
1347-5215journal_volume
16pub_type
杂志文章abstract::The effect of gel-forming (1-->3)-beta-D-glucan on the immunological activities of murine kupffer cells was examined. A branched type gel-forming (1-->3)-beta-D-glucan, GRN, was administered intravenously to mice. GRN associating to kupffer cells was detected by an immunohistochemical technique using anti-GRN antibody...
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pub_type: 杂志文章
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更新日期:1993-09-01 00:00:00
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pub_type: 临床试验,杂志文章
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abstract::Infection of human cell with human immunodeficiency virus type-1 (HIV-1) was suppressed by cellular genetic factor(s) at reverse transcription step. Although same amount of virus adsorbed on both cells, small amount of HIV-1 (IIIB strain) infected HeLa (MAGI/CCR5) cell, while large amount of HIV-1 infected HOS (GHOST/...
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pub_type: 杂志文章,评审
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更新日期:2001-10-01 00:00:00
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更新日期:2005-07-01 00:00:00
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更新日期:2007-02-01 00:00:00
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journal_title:Biological & pharmaceutical bulletin
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更新日期:1994-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2002-08-01 00:00:00
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更新日期:2009-12-01 00:00:00
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journal_title:Biological & pharmaceutical bulletin
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更新日期:2004-07-01 00:00:00
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更新日期:2000-02-01 00:00:00
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更新日期:2007-01-01 00:00:00
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journal_title:Biological & pharmaceutical bulletin
pub_type: 杂志文章
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更新日期:2015-01-01 00:00:00
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journal_title:Biological & pharmaceutical bulletin
pub_type: 杂志文章
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更新日期:2009-07-01 00:00:00
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journal_title:Biological & pharmaceutical bulletin
pub_type: 杂志文章
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更新日期:1995-06-01 00:00:00
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journal_title:Biological & pharmaceutical bulletin
pub_type: 杂志文章
doi:10.1248/bpb.18.1467
更新日期:1995-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:1999-09-01 00:00:00