Increased in vitro release of interferon-gamma from ampicillin-stimulated peripheral blood mononuclear cells in Stevens-Johnson syndrome.

abstract：:It is therapeutically important to elucidate the factors involved in the radiation resistance of tumors. We previously showed that ATP is released from mouse melanoma B16 cells in response to γ-irradiation, but the role of adenosine, a metabolite of ATP, is still unclear. Here, we show that the adenosine A2B receptor ...

journal_title：Biological & pharmaceutical bulletin

authors： Tanaka Y,Kitabatake K,Abe R,Tsukimoto M

更新日期：2020-03-01 00:00:00

abstract：:Methylripariochromene A (MRC) was isolated from the leaves of Orthosiphon aristatus (Lamiaceae) and subjected to the examination of several pharmacological actions related to antihypertensive activity. The following four findings were revealed from the present study: 1) MRC caused a continuous decrease in systolic blo...

journal_title：Biological & pharmaceutical bulletin

authors： Matsubara T,Bohgaki T,Watarai M,Suzuki H,Ohashi K,Shibuya H

更新日期：1999-10-01 00:00:00

abstract：:TRPV2, a member of the transient receptor potential family, has been isolated as a capsaicin-receptor homolog and is thought to respond to noxious heat. Here we show that TRPV2 mRNA is predominantly expressed in the subpopulation of olfactory sensory neurons (OSNs). We carried out histochemical analyses of TRPV2 and i...

journal_title：Biological & pharmaceutical bulletin

authors： Matsui H,Noguchi T,Takakusaki K,Kashiwayanagi M

更新日期：2014-01-01 00:00:00

abstract：:In our previous paper, mixed polyetheleneglycol (PEG) modification of liposomes by a mixture of 1-monomethoxypolyethyleneglycol-2,3-distearoylglycerol (PEG-DSG) with short polyoxyethylene chain and PEG-DSG with long one was shown to increase fixed aqueous layer thickness (FALT) around the liposomal membrane, and this ...

journal_title：Biological & pharmaceutical bulletin

authors： Sugiyama I,Sadzuka Y

更新日期：2007-01-01 00:00:00

abstract：:The effects of grifolan (GRN), a gel-forming (1-->6)-branched (1-->3)-beta-D-glucan, on antibody production were examined. Sera from mice that were injected with GRN and trinitrophenyl ovalbumin (TNP-OVA) intraperitoneally showed a significantly increased level of anti-TNP IgG. However, injection of TNP-OVA alone show...

journal_title：Biological & pharmaceutical bulletin

authors： Adachi Y,Suzuki Y,Ohno N,Yadomae T

更新日期：1998-09-01 00:00:00

abstract：:Di-n-butyl phthalate (DBP), a phthalate ester, has been shown to have an adjuvant effect on fluorescein isothiocyanate (FITC)-induced contact hypersensitivity (CHS) mouse models. Di-n-butyl maleate (DBM), widely used as a plasticizer for industrial application, has been reported to cause dermatitis in humans. DBM is a...

journal_title：Biological & pharmaceutical bulletin

authors： Matsuoka T,Kurohane K,Suzuki W,Ogawa E,Kobayashi K,Imai Y

更新日期：2016-01-01 00:00:00

abstract：:Metronidazole (MTZ) ointment has been used widely as a hospital preparation against cancerous malodor. Although cancerous tissue with ulcer-like symptoms is likely to have a higher capacity to absorb drugs than normal skin, the extent to which MTZ is absorbed when a topical preparation is applied to cancerous tissue r...

journal_title：Biological & pharmaceutical bulletin

authors： Iida J,Kudo T,Shimada K,Yatsuno Y,Yamagishi S,Hasegawa S,Ike H,Sato T,Kagaya H,Ito K

更新日期：2013-01-01 00:00:00

abstract：:To investigate the protective effect of ginsenoside Re (Re) against cerebral ischemia-reperfusion injury, adult male Wistar rats weighing 250-300 g were subjected to either sham surgery or middle cerebral artery occlusion (MCAO) for 2 h of brain ischemia and 2 h reperfusion. A fluorescence polarization assay was carri...

journal_title：Biological & pharmaceutical bulletin

authors： Zhou XM,Cao YL,Dou DQ

更新日期：2006-12-01 00:00:00

abstract：:The hydrodynamic method by rapid intravenous injection of a large volume of plasmid DNA is known to be an efficient and liver-specific method of in vivo gene delivery and achieves high levels of foreign gene expression, particularly in hepatocytes. Low transgene activities have also been observed in other organs such ...

journal_title：Biological & pharmaceutical bulletin

authors： Hattori Y,Koga K,Izumisawa T,Yamasaki M,Narishima R,Yoshida S,Fukui T,Maitani Y

更新日期：2009-04-01 00:00:00

abstract：:Echinacoside is a major compound of Cistanche Herb and has glutamate release-inhibiting activity in the brain. Given the involvement of excitotoxicity caused by massive glutamate in the pathophysiology of epilepsy, we explored the antiepileptic effect of echinacoside on kainic acid-induced seizures in rats. The rats w...

journal_title：Biological & pharmaceutical bulletin

authors： Lu CW,Hsieh HL,Lin TY,Hsieh TY,Huang SK,Wang SJ

更新日期：2018-11-01 00:00:00

abstract：:The effective antigen (Ag) uptake by microfold cells (M-cells) is important for the induction of an efficient mucosal immune responses. Here, we show that 10-hydroxydecanoic acid (10-HDAA) from royal jelly (RJ) potentially supports M-cell differentiation and induces effective antigen-specific mucosal immune responses ...

journal_title：Biological & pharmaceutical bulletin

authors： Isayama T,Etoh H,Kishimoto N,Takasaki T,Kuratani A,Ikuta T,Tatefuji T,Takamune N,Muneoka A,Takahashi Y,Misumi S

更新日期：2020-01-01 00:00:00

abstract：:The present study has been designed to investigate the modulatory role of dichlorobenzamil a Na(+)/Ca(2+) exchanger inhibitor in ischemic post-conditioning-induced neuroprotection in mice. Bilateral carotid artery occlusion followed by reperfusion, produced a significant rise in cerebral infarct size along with impair...

journal_title：Biological & pharmaceutical bulletin

authors： Kaur H,Jaggi AS,Singh N

更新日期：2010-01-01 00:00:00

abstract：:Bupleuri Radix (Chai-hu in Chinese and Saiko in Japanese) is one of the most important traditional Chinese crude drugs for treating hepatitis malaria and intermittent fever. B. kaoi is one of the Bupleurum spp. families locally found in Taiwan. The effects of saponin-enriched fraction (SEF) from Bupleurum Kaoi in huma...

journal_title：Biological & pharmaceutical bulletin

authors： Hsu YL,Kuo PL,Weng TC,Yen MH,Chiang LC,Lin CC

更新日期：2004-07-01 00:00:00

abstract：:The medial prefrontal cortex (mPFC) plays critical roles in the development of cocaine addiction. Numerous studies have reported about the effects of cocaine on neuronal and synaptic activities in the nucleus accumbens and ventral tegmental area, which are brain regions associated with cocaine addiction; however, a li...

journal_title：Biological & pharmaceutical bulletin

authors： Sasase H,Izumi S,Deyama S,Hinoi E,Kaneda K

更新日期：2019-01-01 00:00:00

abstract：:Hypertension is one of the most prevalent diseases worldwide and can cause harmful complications within the vascular system. Further research on vascular responsiveness to different ligands and diverse receptors in various arteries is required to understand the mechanisms underlying the development of these vascular c...

journal_title：Biological & pharmaceutical bulletin

authors： Ando M,Matsumoto T,Kobayashi S,Iguchi M,Taguchi K,Kobayashi T

更新日期：2018-01-01 00:00:00

abstract：:Splenic marginal zone macrophages expressing macrophage receptor with collagenous structure (MARCO) contribute to the clearance of blood-borne pathogens. We determined a splenic adherent cell fraction abundantly containing cells expressing a higher level of MARCO by flow cytometry, and examined the effects of daily ad...

journal_title：Biological & pharmaceutical bulletin

authors： Shirato K,Sato S,Sato M,Hashizume Y,Tachiyashiki K,Imaizumi K

更新日期：2013-01-01 00:00:00

abstract：:To develop potent paclitaxel (PTX) formulations for cancer chemotherapy, we formulated PTX into polymeric nanoparticles composed of polyethylene glycol (PEG) and polylactic acid (PLA) block copolymer (PN-PTX). First, the physicochemical properties of PN-PTX prepared were assessed; the mean particle size was around 80 ...

journal_title：Biological & pharmaceutical bulletin

authors： Araki T,Kono Y,Ogawara K,Watanabe T,Ono T,Kimura T,Higaki K

更新日期：2012-01-01 00:00:00

abstract：:The effects of hop extracts (Humulus lupulus L.) on histamine release from rat peritoneal mast cells and human basophilic KU812 cells were studied. Hop water extract (HWE) and XAD-4 50% methanol fraction of HWE (MFH) inhibited histamine release from rat mast cells induced by compound 48/80 at concentrations of 100 and...

journal_title：Biological & pharmaceutical bulletin

authors： Takubo M,Inoue T,Jiang S,Tsumuro T,Ueda Y,Yatsuzuka R,Segawa S,Watari J,Kamei C

更新日期：2006-04-01 00:00:00

abstract：:Accumulation of β-amyloid peptide (Aβ) in the brain plays an important role in the pathogenesis of Alzheimer’s disease (AD). Previous studies have demonstrated the neuroprotective role of osthole against oxygen and glucose deprivation in cortical neurons. However, the effects of osthole on Aβ-induced neurotoxicity in ...

journal_title：Biological & pharmaceutical bulletin

authors： Hu Y,Wen Q,Liang W,Kang T,Ren L,Zhang N,Zhao D,Sun D,Yang J

更新日期：2013-01-01 00:00:00

abstract：:We investigated the changes (increase or decrease in peak intensity) in the expression of plasma proteins in spontaneously diabetic WBN/Kob rats that were with complicated diabetic nephropathy, to determine multiple biomarkers in the plasma of diabetic rats. The present study using surface enhanced laser desorption/io...

journal_title：Biological & pharmaceutical bulletin

authors： Kiga C,Nakagawa T,Koizumi K,Sakurai H,Shibagaki Y,Ogawa K,Goto H,Saiki I

更新日期：2005-06-01 00:00:00

abstract：:CC chemokine receptor 4 (CCR4) is generally recognized as a preferential marker for T helper 2 cells, and we have previously reported morpholine-derivative CCR4 antagonists, RS-1154 and RS-1269. Here, we investigate the pharmacological profiles of a novel pyrimidine-derivative CCR4 antagonist, 2-{4-[2-(diethylamino)et...

journal_title：Biological & pharmaceutical bulletin

authors： Nakagami Y,Kawase Y,Yonekubo K,Nosaka E,Etori M,Takahashi S,Takagi N,Fukuda T,Kuribayashi T,Nara F,Yamashita M

更新日期：2010-01-01 00:00:00

abstract：:Uridine diphosphate (UDP)-glucuronosyltransferase 1A1 (UGT1A1) plays important roles in the glucuronidation of various drugs and endogenous substances. Minipigs have been used as experimental animals in pharmacological and toxicological studies, because many of their physiological characteristics are similar to those ...

journal_title：Biological & pharmaceutical bulletin

authors： Miyake Y,Mayumi K,Jinno H,Tanaka-Kagawa T,Narimatsu S,Hanioka N

更新日期：2013-01-01 00:00:00

abstract：:Preparation of the fatty alcohol propylene glycol (FAPG) ointment base plays an important role in controlling the physicochemical properties of ointments. These essay investigates the effects of preparative conditions such as cooling rate and stirring rate on the percutaneous absorption of norfloxacin from FAPG ointme...

journal_title：Biological & pharmaceutical bulletin

authors： Lin HH,Hsu LR,Wu PC,Tsai YH

更新日期：1995-11-01 00:00:00

abstract：:Using the par to rep region of the 24653 bp plasmid pN315, which is present in Staphylococcus aureus strain N315, we constructed three vectors that can be shuttled between Escherichia coli and S. aureus and maintained stably in S. aureus. Due to plasmid incompatibility, the resident plasmid in S. aureus cells can be r...

journal_title：Biological & pharmaceutical bulletin

authors： Matsuo M,Kurokawa K,Lee BL,Sekimizu K

更新日期：2010-01-01 00:00:00

abstract：:Solifenacin succinate is a novel muscarinic receptor antagonist used for the treatment of overactive bladder (OAB). We investigated the effects of solifenacin by oral and intravenous administration on carbachol (CCh)-induced intravesical pressure (IVP) elevation and compared its efficacy with that on CCh-induced saliv...

journal_title：Biological & pharmaceutical bulletin

authors： Okutsu H,Noguchi Y,Ohtake A,Suzuki M,Sato S,Sasamata M

更新日期：2007-12-01 00:00:00

abstract：:Direct detection of nitric oxide (NO) is essential for understanding the precise mechanism of its production from endothelial cells. Previously, we developed an NO detection system based on the chemiluminescence reaction between NO and luminol-H2O2. Here, we have applied this system to cultured endothelial cells for t...

journal_title：Biological & pharmaceutical bulletin

authors： Kurumatani H,Kikuchi K,Nagano T,Hirobe M,Yamazaki J,Nagao T

更新日期：1998-12-01 00:00:00

abstract：:We investigated the genotypic status of thiopurine methyltransferase (TPMT) polymorphism to evaluate the possible risk of the toxicity of azathioprine (AZA) in 68 patients with systemic lupus erythematosus (SLE). The allele frequency of TPMT mutation in the SLE group (2.9%) was higher than that in 174 Japanese healthy...

journal_title：Biological & pharmaceutical bulletin

authors： Okada Y,Nakamura K,Kodama T,Ueki K,Tsukada Y,Maezawa A,Tsukamoto N,Nojima Y,Ishizaki T,Horiuchi R,Yamamoto K

更新日期：2005-11-01 00:00:00

abstract：:A DNA fragment responsible for resistance to antimicrobial agents was cloned from chromosomal DNA of Enterococcus faecium FN-1, a clinically isolated strain. Escherichia coli KAM32, a drug-hypersusceptible mutant, was used as a host for gene cloning. Cells of E. coli KAM32 harboring a recombinant plasmid (pTFM8) carry...

journal_title：Biological & pharmaceutical bulletin

authors： Nishioka T,Ogawa W,Kuroda T,Katsu T,Tsuchiya T

更新日期：2009-03-01 00:00:00

abstract：:Exosomes are tiny extracellular vesicles that are usually harvested in small quantities. Such small yield has been an obstacle for the expansion of the basic research regarding exosome analysis and applications in drug delivery. To increase exosome yield, we attempted to stimulate tumor cells via the addition of lipos...

journal_title：Biological & pharmaceutical bulletin

authors： Emam SE,Ando H,Abu Lila AS,Shimizu T,Ukawa M,Okuhira K,Ishima Y,Mahdy MA,Ghazy FS,Ishida T

更新日期：2018-01-01 00:00:00

abstract：:Liposomes were prepared from hydrogenated lecithin (H-PC) by sonication (S) or injection (I) of H-PC dissolved in ethanol containing dl-tocopherol acetate (VEA). The effects of liposomes on the dermal absorption of VEA were studied. The particle diameter of S-liposomes was smaller than that of I-liposomes. The penetra...

journal_title：Biological & pharmaceutical bulletin

authors： Natsuki R,Morita Y,Osawa S,Takeda Y

更新日期：1996-05-01 00:00:00