10-Hydroxydecanoic Acid Potentially Elicits Antigen-Specific IgA Responses.

abstract：:The mitochondrial ADP/ATP carrier (AAC) has 6 transmembrane regions and 3 matrix loops. Our previous mutational study on the Cys residue in the LM1s of chimeric bovine type 1 AAC (yN-bAAC1), in which the N-terminal 11 amino acids of bovine type 1 AAC are substituted with the corresponding 26 amino acids of yeast type ...

journal_title：Biological & pharmaceutical bulletin

authors： Kihira Y,Ueno M,Terada H

更新日期：2007-05-01 00:00:00

abstract：:Controlling axon and dendrite elongation is critical in developing precise neural circuits. Using isolated cultures of dentate granule neurons, we succeeded in simultaneously monitoring the behaviors of axonal and dendritic outgrowth. Our previous study shows that cAMP contributes differentially to Sema3F-induced resp...

journal_title：Biological & pharmaceutical bulletin

authors： Yamada RX,Matsuki N,Ikegaya Y

更新日期：2006-04-01 00:00:00

abstract：:HL-60 cells differentiate into granulocyte-like cells by all-trans retinoic acid (ATRA) treatment, and the cellular proliferation is markedly reduced during the differentiation. To elucidate the molecular mechanisms of the growth arrest during the cellular differentiation, we examined the regulated expression of the t...

journal_title：Biological & pharmaceutical bulletin

authors： Horie N,Komada Y,Ueta Y,Suzuki T,Nozawa R,Takeishi K

更新日期：2001-12-01 00:00:00

abstract：:UDP-N-acetylglucosaminyl transferase (OGT) resides in both cytosolic and nuclear compartments and catalyzes O-linked glycosylation of various proteins. In the current study, we have extracted protein from nuclear DNA (chromatin protein) using 0.2% NP-40 detergent. Addition of chromatin protein to either cytosolic or n...

journal_title：Biological & pharmaceutical bulletin

authors： Okuyama R,Marshall S

更新日期：2004-08-01 00:00:00

abstract：:Behavioral and psychological symptoms of dementia (BPSD) are commonly seen in patients with Alzheimer's disease (AD) and other forms of senile dementia. BPSD have a serious impact on the quality of life of dementia patients, as well as on that of their caregivers. However, effective drug therapy for BPSD has not been ...

journal_title：Biological & pharmaceutical bulletin

authors： Uchida N,Egashira N,Iwasaki K,Ishibashi A,Tashiro R,Nogami A,Manome N,Abe M,Takasaki K,Mishima K,Takata J,Oishi R,Nishimura R,Fujiwara M

更新日期：2009-03-01 00:00:00

abstract：:The complete amino acid sequences of [2Fe-2S] ferredoxin from Atropa belladonna and Hyoscyamus niger have been determined by automated Edman degradation of the entire S-carboxymethylcysteinyl proteins and of the peptides obtained by enzymatic digestion. These two ferredoxins exhibited 1-8 differences in their amino ac...

journal_title：Biological & pharmaceutical bulletin

authors： Mino Y,Yukita M,Hiratsuka N,Wariishi H

更新日期：2005-08-01 00:00:00

abstract：:Cry j 1 is one of the major allergens in Japanese cedar pollen. We attempt high throughput analysis and comprehensive identification of the linear IgE epitopes of Cry j 1. A series of overlapping synthetic Cry j 1 peptides chemically spotted on cellulose membrane was probed with sera from patients in Japan and United ...

journal_title：Biological & pharmaceutical bulletin

authors： Takagi K,Teshima R,Sawada J

更新日期：2005-08-01 00:00:00

abstract：:Accumulation of β-amyloid peptide (Aβ) in the brain plays an important role in the pathogenesis of Alzheimer’s disease (AD). Previous studies have demonstrated the neuroprotective role of osthole against oxygen and glucose deprivation in cortical neurons. However, the effects of osthole on Aβ-induced neurotoxicity in ...

journal_title：Biological & pharmaceutical bulletin

authors： Hu Y,Wen Q,Liang W,Kang T,Ren L,Zhang N,Zhao D,Sun D,Yang J

更新日期：2013-01-01 00:00:00

abstract：:The accumulation of amyloid β(1-42) peptide (Aβ(1-42)) in retina is implicated in the development of retinal ganglion cell apoptosis and diabetic retinopathy. In this study we demonstrate that spontaneous diabetes mellitus Otsuka Long-Evans Tokushima Fatty (OLETF) rats can be used as an animal model in studies to iden...

journal_title：Biological & pharmaceutical bulletin

authors： Nagai N,Ito Y,Tanino T

更新日期：2015-01-01 00:00:00

abstract：:Astragali Radix (AR), is a popular herbal medicine used to treat allergic diseases in Korea, Japan and China. Our study examined the effect of an AR ethanol extract on both in vitro and in vivo murine CD4 T cells' differentiation into Th1 and Th2 subsets. CD4 T cells from Balb/c mice were activated with anti-CD3/anti-...

journal_title：Biological & pharmaceutical bulletin

authors： Kang H,Ahn KS,Cho C,Bae HS

更新日期：2004-12-01 00:00:00

abstract：:Nicotine-withdrawal symptoms have been indicated as a possible risk factor for neuropsychiatric events, such as depression and suicide, during use of smoking-cessation drugs. We aimed to investigate whether the results of the metabolomic analysis of the rat brain reflect nicotine-withdrawal symptoms. We also aimed to ...

journal_title：Biological & pharmaceutical bulletin

authors： Akimoto H,Oshima S,Michiyama Y,Negishi A,Nemoto T,Kobayashi D

更新日期：2018-12-01 00:00:00

abstract：:A significant sex-related difference was observed for the pharmacokinetics of acetohexamide in Wistar-Imamichi (Wistar-IM) rats. However, there was no sex difference of the in vitro reductive metabolism of acetohexamide in the liver or kidney of these rats. Testectomy was found to decrease the plasma clearance (CLp) o...

journal_title：Biological & pharmaceutical bulletin

authors： Imamura Y,Kaneko M,Mori Y,Otagiri M

更新日期：1999-04-01 00:00:00

abstract：:All living organisms on earth are composed of L-amino acids and D-sugars. Therefore the presence and function of D-amino acids in living organisms have not been studied. Recently, however, D-aspartic acid (D-Asp) which is a D-amino acid, has been detected in various proteins from human tissue samples such as eye lens,...

journal_title：Biological & pharmaceutical bulletin

authors： Fujii N

更新日期：2005-09-01 00:00:00

abstract：:The inhibitory effects of various sulfated compounds on the activities of sialidases purified from porcine liver and human placenta were investigated. Among the sulfated compounds tested, heparin, dextran sulfate, condroitin sulfates and sulfatide significantly inhibited the 4-methylumbelliferyl-alpha-N-acetylneuramin...

journal_title：Biological & pharmaceutical bulletin

authors： Nagaoka M,Shiraishi T,Furuhata K,Uda Y

更新日期：1998-11-01 00:00:00

abstract：:This paper deals with the effects of elenoside, (3-hidroxymethyl-1-methoxy-5,6-methylene-dioxy-4-(3,4-methylenedioxyphenyl)-2-naftoic acid lactone-beta-D-glucoside) an arylnaphthalene lignan with broad spectrum cytotoxicity in a human tumor cell line panel, isolated from Justicia hyssopifolia (Acanthaceae) grown in th...

journal_title：Biological & pharmaceutical bulletin

authors： Navarro E,Alonso SJ,Trujillo J,Jorge E,Pérez C,Hernández-Calzadilla C

更新日期：2002-08-01 00:00:00

abstract：:The extracellular matrix (ECM), which contributes to structural homeostasis as well as to the regulation of cellular function, is enzymatically cleaved by proteases, such as matrix metalloproteinases and cathepsins, in the normal and diseased heart. During the past two decades, matricryptins have been defined as fragm...

journal_title：Biological & pharmaceutical bulletin

authors： Okada M,Imoto K,Sugiyama A,Yasuda J,Yamawaki H

更新日期：2017-01-01 00:00:00

abstract：:Pantethine and fursultiamine have been evaluated for their clinical usefulness in the treatment and prevention of uncomplicated postoperative adhesive intestinal obstruction. In recent years, the actions of drugs used to treat gastrointestinal diseases have been elucidated pharmacologically from the viewpoints of gast...

journal_title：Biological & pharmaceutical bulletin

authors： Suzuki Y,Itoh H,Abe T,Nishimura F,Sato Y,Takeyama M

更新日期：2011-01-01 00:00:00

abstract：:Neuroprotective effects of estrogen and estrogen-like chemicals on neurodegenerative diseases, especially Parkinson's disease, have been well established. In the present study, we compared the effects of Bak Foong Pill (BFP), a well-known gynaecological tonic in China, and 17beta-estradiol, on dopamine transporter (DA...

journal_title：Biological & pharmaceutical bulletin

authors： Liu B,Xie JX,Rowlands DK,Gou YL,Leung CC,Chung YW,Chan HC

更新日期：2004-08-01 00:00:00

abstract：:The immunoreactivity (specific binding) of three Gly(A1)-sulfobenzoxadiazole-labeled insulins which have different spacer groups, Gly(A1)-[3-(4-sulfobenzoxadiazol-7-ylthio)propanoyl]-insulin , Gly(A1)-[2-(4-sulfobenzoxadiazol-7-ylthio)acetyl]-insulin, Gly(A1)-[3-carboxy-2(or 3)-(4-sulfobenzoxadiazol-7-ylthio)propanoyl...

journal_title：Biological & pharmaceutical bulletin

authors： Nanami M,Zaitsu K,Ohkura Y

更新日期：1993-05-01 00:00:00

abstract：:The pharmacological characteristics of Ryokan-kyomi-shinge-nin-to (RKS), a traditional oriental herbal (Kampo) medicine which has been used for the treatment of allergic asthma and rhinitis, were investigated. The number of sneezes by actively sensitized mice after a topical antigen challenge was significantly reduced...

journal_title：Biological & pharmaceutical bulletin

authors： Sakaguchi M,Ikeda Y,Kido T,Yuzurihara M,Kase Y,Yamamoto M,Ishige A,Sasaki H

更新日期：2002-12-01 00:00:00

abstract：:Skeletal muscle is a major site for glucose metabolism and its injury by cytokines can induce insulin resistance leading to type 2 diabetes. It has been suggested that quercetin may act as an anti-diabetic agent, however, the effects of quercetin on insulin resistance in skeletal muscle remain unknown. We aimed to inv...

journal_title：Biological & pharmaceutical bulletin

authors： Dai X,Ding Y,Zhang Z,Cai X,Bao L,Li Y

更新日期：2013-01-01 00:00:00

abstract：:We established a highly sensitive method for evaluating P-glycoprotein activity in Caco-2 cells. Using time-lapse confocal laser-scanning microscopy, we measured the change in fluorescence of residual rhodamine 123 in Caco-2 cells. Horizontal fluorescence images of rhodamine 123 in the apical and central parts of thes...

journal_title：Biological & pharmaceutical bulletin

authors： Wakuda H,Nejime N,Tada Y,Kagota S,Umegaki K,Yamada S,Shinozuka K

更新日期：2010-01-01 00:00:00

abstract：:In this study the anti-proliferative effect of curcumin (curcuma longa) that is the active ingredient of ground dried rhizome has been studied against three local and three reference leishmanial strains, Leishmania major, Leishmania tropica and Leishmania infantum (Pakistani isolate). Curcumin has shown an average IC5...

journal_title：Biological & pharmaceutical bulletin

authors： Saleheen D,Ali SA,Ashfaq K,Siddiqui AA,Agha A,Yasinzai MM

更新日期：2002-03-01 00:00:00

abstract：:To explore the role of the abnormal expression of the bile salt export pump (BSEP) and multidrug resistance protein 2 (MRP2) in isoniazid (INH)-induced liver injury, we assessed the liver injury induced by INH in rats and HepG2 cells in vitro. The regulatory pathways via Sirtuin 1 (SIRT1) and farnesoid X receptor (FXR...

journal_title：Biological & pharmaceutical bulletin

authors： Qu X,Zhang Y,Zhang S,Zhai J,Gao H,Tao L,Song Y

更新日期：2018-01-01 00:00:00

abstract：:Plasma hyaluronan biding protein (PHBP) is a novel serine protease, which has an amino acid sequence homology to that of hepatocyte growth factor activator (HGFA), and has a similar domain structure to that of urinary plasminogen activator (u-PA), found in human plasma. We searched the PHBP substrate in human plasma b...

journal_title：Biological & pharmaceutical bulletin

authors： Choi-Miura NH,Yoda M,Saito K,Takahashi K,Tomita M

更新日期：2001-02-01 00:00:00

abstract：:We recently isolated a novel lignan, 4-hydroxykobusin from Geranium thunbergii (Liu et al., Arch. Pharm. Res., 29, 1109-1113, 2006). Here, we studied its effect on the expression of inducible nitric oxide synthase (iNOS) gene in RAW264.7 cells. 4-Hydroxykobusin inhibited nitric oxide (NO) production in a concentration...

journal_title：Biological & pharmaceutical bulletin

authors： Pokharel YR,Liu QH,Oh JW,Woo ER,Kang KW

更新日期：2007-06-01 00:00:00

abstract：:We studied the effects of twelve 5,7-dihydroxyflavone analogs on adipogenesis in 3T3-L1 cells. Among the compounds, luteolin, diosmetin, and chrysoeriol partly inhibited adipogenesis by blocking the accumulation of triacylglycerol in the cells. Conversely, tricetin facilitated triacylglycerol accumulation in the cells...

journal_title：Biological & pharmaceutical bulletin

authors： Nishina A,Ukiya M,Fukatsu M,Koketsu M,Ninomiya M,Sato D,Yamamoto J,Kobayashi-Hattori K,Okubo T,Tokuoka H,Kimura H

更新日期：2015-01-01 00:00:00

abstract：:Apoptosis is the main form of β-cell death in diabetes. Ginseng has been used as an anti-diabetic herb for several thousand years in Asia with ginsenoside Rg1 and ginsenoside Rb1 as important active ingredients. In this study, we demonstrated ginsenoside Rg1 and Rb1 protect β-cells from high glucose/cytokine-induced p...

journal_title：Biological & pharmaceutical bulletin

authors： Chen F,Chen Y,Kang X,Zhou Z,Zhang Z,Liu D

更新日期：2012-01-01 00:00:00

abstract：:We examined the transport mechanisms of daunorubicin (DNR) and doxorubicin (ADR) in HL60 and HL60/THP cells which were the non-P-glycoprotein-mediated resistant clone of the parent HL60 cells and showed a low degree of resistance, and compared them with those of pirarubicin (THP). In both lines, it appeared that the u...

journal_title：Biological & pharmaceutical bulletin

authors： Nagasawa K,Natazuka T,Nomiyama M,Ohnishi N,Yokoyama T

更新日期：1996-01-01 00:00:00

abstract：:Two fractions of neutral alpha-glucosidase were partially purified from the insoluble fraction of bovine lens. This is the first report of such an event to the best of our knowledge. The apparent native molecular weights of these fractions were 121 kDa (fraction-I) and 254 kDa (fraction-II). Both fractions contained t...

journal_title：Biological & pharmaceutical bulletin

authors： Kamei A,Fujiyama O

更新日期：1995-08-01 00:00:00