Abstract:
:The present study has been designed to investigate the modulatory role of dichlorobenzamil a Na(+)/Ca(2+) exchanger inhibitor in ischemic post-conditioning-induced neuroprotection in mice. Bilateral carotid artery occlusion followed by reperfusion, produced a significant rise in cerebral infarct size along with impairment of memory and motor coordination. Ischemic post-conditioning involving three episodes of 10 s carotid artery occlusion with intermittent reperfusion of 10 s proceeding prolonged ischemic insult of 12 min, produced a significant decrease in cerebral infarct size along with reversal of ischemia-reperfusion-induced impairment of memory and motor coordination. Ischemic post-conditioning-induced neuroprotective effects were significantly abolished by pretreatment with dichlorobenzamil (DBZ 0.5, 1 mg/kg, intraperitoneal) a Na(+)/Ca(2+) exchange inhibitor. It may be concluded that Na(+)/Ca(2+) exchanger possibly plays an important role in ischemic post-conditioning-induced neuroprotection.
journal_name
Biol Pharm Bulljournal_title
Biological & pharmaceutical bulletinauthors
Kaur H,Jaggi AS,Singh Ndoi
10.1248/bpb.33.585subject
Has Abstractpub_date
2010-01-01 00:00:00pages
585-91issue
4eissn
0918-6158issn
1347-5215pii
JST.JSTAGE/bpb/33.585journal_volume
33pub_type
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