Enhancement of norepinephrine and angiotensin II-induced renal effects by NG-nitro-L-arginine, a nitric oxide synthase inhibitor.

abstract：:Pneumolysin (PLY) is a devastating bacterial protein toxin of Streptococcus pneumoniae that punctures the cytomembrane, leading to pathological reactions, such as cell disruption and inflammation. Drugs capable of closely impacting the toxin are considered advantageous in the treatment of bacterial infections. Amentof...

journal_title：Biological & pharmaceutical bulletin

authors： Zhao X,Liu B,Liu S,Wang L,Wang J

更新日期：2017-01-01 00:00:00

abstract：:Oligodeoxyribonucleotides containing 8-hydroxyguanine and 2-hydroxyadenine, purine lesions produced in cells by reactive oxygen species, were synthesized and inserted into vector DNAs to introduce each lesion at a predetermined site. The manipulated DNAs were transfected into living cells, and the mutants induced by e...

journal_title：Biological & pharmaceutical bulletin

authors： Kamiya H

更新日期：2004-04-01 00:00:00

abstract：:Compound C is a widely used chemical inhibitor that down-regulates AMP-activated protein kinase (AMPK) activity. However, it has been suggested that compound C exerts AMPK-independent effects in various cells. Here, we investigated whether compound C induces Sestrin2 (SESN2), an antioxidant enzyme induced by diverse s...

journal_title：Biological & pharmaceutical bulletin

authors： Seo K,Seo S,Ki SH,Shin SM

更新日期：2016-01-01 00:00:00

abstract：:This study investigated most suitable transforming factor related to the daily Phenobarbital dose (D) providing a steady-state serum concentration (Ct) and analyzed the influences of concomitant antiepileptic drugs on Ct quantitatively. Data obtained by routine therapeutic drug monitoring from a total of 326 epileptic...

journal_title：Biological & pharmaceutical bulletin

authors： Fukuoka N,Tsukamoto T,Uno J,Kimura M,Morita S

更新日期：2004-12-01 00:00:00

abstract：:Distigmine bromide (distigmine) is a reversible carbamate cholinesterase (ChE) inhibitor. Its principle clinical application is in the treatment of myasthenia gravis. Distigmine is also used as a remedy for dysuria and glaucoma. Its effectiveness in the management of dysuria has been demonstrated in several clinical r...

journal_title：Biological & pharmaceutical bulletin

authors： Obara K,Tanaka Y

更新日期：2019-01-01 00:00:00

abstract：:We have previously proposed a novel deconvolution method, which can estimate first-pass metabolism of orally administered drugs. In the present study, we examined whether this deconvolution method is useful for evaluating oral dosage forms. The absorption and first-pass metabolism of orally administered aspirin formul...

journal_title：Biological & pharmaceutical bulletin

authors： Wu X,Yamashita F,Hashida M

更新日期：1999-11-01 00:00:00

abstract：:The effects of aged garlic extract (AGE) on longevity and learning and memory performances were studied in the senescence accelerated mouse (SAM). A solid diet containing 2% (w/w) AGE was given to SAM from 2 months of age. The survival ratio of SAM P8, senescence accelerated animals, treated with AGE was significantly...

journal_title：Biological & pharmaceutical bulletin

authors： Moriguchi T,Takashina K,Chu PJ,Saito H,Nishiyama N

更新日期：1994-12-01 00:00:00

abstract：:This study was conducted to determine the beneficial effects of treating digestive disorders of (6E,12E)-tetradecadiene-8,10-diyne-1,3-diol diacetate (TDEYA) detected in the plasma in hydrolyzed form: (6E,12E)-tetradecadiene-8,10-diyne-1,3-diol (TDEY), following the oral administration of a decoction of Atractylodes r...

journal_title：Biological & pharmaceutical bulletin

authors： Sakurai T,Sugawara H,Saito K,Kano Y

更新日期：1994-10-01 00:00:00

abstract：:A biologically active quinone that exhibits a growth-inhibitory effect on rat liver cancer cells was isolated from the nest of a social wasp, Vespa simillima (Vespinae, Vespidae). The structure was unambiguously determined by NMR and synthetic experiments and identified as being 7,8-seco-para-ferruginone. The syntheti...

journal_title：Biological & pharmaceutical bulletin

authors： Fujiwara Y,Mangetsu M,Yang P,Kofujita H,Suzuki K,Ohfune Y,Shinada T

更新日期：2008-04-01 00:00:00

abstract：:The lactose transport system of Citrobacter freundii was characterized. Both the lactose transport system and beta-galactosidase were induced with either lactose or isopropyl-beta-D-thiogalactopyranoside (IPTG), the latter being the better inducer. The Km values for methyl-beta-D-thiogalactopyranoside (TMG) transport ...

journal_title：Biological & pharmaceutical bulletin

authors： Okazaki N,Tsuda M,Wilson TH,Tsuchiya T

更新日期：1994-06-01 00:00:00

abstract：:The total alkaloid fractions of the methanolic extracts of the leaves, ripe fruits, roots, seeds and stem of Solanum pseudocapsicum were subjected to in-vitro cytotoxicity, short-term toxicity and long-term survival studies. All the five fractions exhibited potent activity. The total alkaloid fraction of leaves was fo...

journal_title：Biological & pharmaceutical bulletin

authors： Vijayan P,Vijayaraj P,Setty PH,Hariharpura RC,Godavarthi A,Badami S,Arumugam DS,Bhojraj S

更新日期：2004-04-01 00:00:00

abstract：:Coffee is a popular beverage worldwide with various nutritional benefits. Diterpene cafestol, one of the major components of coffee, contributes to its beneficial effects through various biological activities such as chemopreventive, antitumorigenic, hepatoprotective, antioxidative and antiinflammatory effects. In thi...

journal_title：Biological & pharmaceutical bulletin

authors： Shen T,Lee J,Lee E,Kim SH,Kim TW,Cho JY

更新日期：2010-01-01 00:00:00

abstract：:Sixteen flavonoids including flavonols, flavones, flavanonol and catechins, and five aromatic compounds were examined for their ability to scavenge superoxide radical (O2-*) generated enzymatically in a xanthin-xanthinoxidase system and non-enzymatically in a phenazine methosulfate-NADH system. Pyrogallol, gallic acid...

journal_title：Biological & pharmaceutical bulletin

authors： Furuno K,Akasako T,Sugihara N

更新日期：2002-01-01 00:00:00

abstract：:The protective effect of panduratin A, isolated from Kaempferia pandurata ROXB. (Zingiberaceae), against tert-butylhydroperoxide (t-BHP)-induced cytotoxicity was investigated in a human hepatoma cell line, HepG2. The tetrazolium dye colorimetric test (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) ...

journal_title：Biological & pharmaceutical bulletin

authors： Sohn JH,Han KL,Lee SH,Hwang JK

更新日期：2005-06-01 00:00:00

abstract：:CC chemokine receptor 4 (CCR4) is generally recognized as a preferential marker for T helper 2 cells, and we have previously reported morpholine-derivative CCR4 antagonists, RS-1154 and RS-1269. Here, we investigate the pharmacological profiles of a novel pyrimidine-derivative CCR4 antagonist, 2-{4-[2-(diethylamino)et...

journal_title：Biological & pharmaceutical bulletin

authors： Nakagami Y,Kawase Y,Yonekubo K,Nosaka E,Etori M,Takahashi S,Takagi N,Fukuda T,Kuribayashi T,Nara F,Yamashita M

更新日期：2010-01-01 00:00:00

abstract：:The pulmonary vein contains a myocardial layer extending from the left atrium, which is receiving attention as the source of ectopic electrical activity underlying atrial fibrillation. Electrophysiological and pharmacological analysis of the pulmonary vein myocardium performed in various experimental animal species ha...

journal_title：Biological & pharmaceutical bulletin

authors： Namekata I,Tsuneoka Y,Tanaka H

更新日期：2013-01-01 00:00:00

abstract：:4-Acetyltropolone, a minor component of Thujopsis dolabrata SIEB. et Zucc. hondai MAKINO, showed antimicrobial activity against various microorganisms including wood-rotting fungi, a phytogrowth-inhibitory effect with chlorophyll biosynthesis inhibition, cytotoxic effect and inhibitory activity on metalloproteases. Th...

journal_title：Biological & pharmaceutical bulletin

authors： Morita Y,Matsumura E,Tsujibo H,Yasuda M,Okabe T,Sakagami Y,Kumeda Y,Ishida N,Inamor Y

更新日期：2002-08-01 00:00:00

abstract：:CCAAT/enhancer-binding protein delta (C/EBPdelta) transcription factor is rapidly induced at an early stage of acute phase response. We previously reported that this induction was mainly mediated by acute phase response factor/signal transducers and activators of transcription 3 (APRF/STAT3). Furthermore, the high exp...

journal_title：Biological & pharmaceutical bulletin

authors： Tanabe A,Kumahara C,Osada S,Nishihara T,Imagawa M

更新日期：2000-12-01 00:00:00

abstract：:The effects of different combinations of ciprofloxacin (CIP) and norfloxacin (NOR) against Escherichia coli and Staphylococcus aureus were studied using checkerboard, fractional inhibitory concentration (FIC) and time-kill analysis methods. Results obtained by the checkerboard method showed that the more effectives co...

journal_title：Biological & pharmaceutical bulletin

authors： Vitorino GP,Becerra MC,Barrera GD,Caira MR,Mazzieri MR

更新日期：2017-01-01 00:00:00

abstract：:The genetic similarities of four species of Glycyrrhiza plants were determined by DNA analyses of random amplified polymorphic DNA (RAPD) and restriction fragment length polymorphism (RFLP). The phylogenic trees were constructed from the genetic similarities estimated from RAPD and RFLP profiles. These results indicat...

journal_title：Biological & pharmaceutical bulletin

authors： Yamazaki M,Sato A,Shimomura K,Saito K,Murakoshi I

更新日期：1994-11-01 00:00:00

abstract：:We established a highly sensitive method for evaluating P-glycoprotein activity in Caco-2 cells. Using time-lapse confocal laser-scanning microscopy, we measured the change in fluorescence of residual rhodamine 123 in Caco-2 cells. Horizontal fluorescence images of rhodamine 123 in the apical and central parts of thes...

journal_title：Biological & pharmaceutical bulletin

authors： Wakuda H,Nejime N,Tada Y,Kagota S,Umegaki K,Yamada S,Shinozuka K

更新日期：2010-01-01 00:00:00

abstract：:Cynanchi Wilfordii Radix (CWR) is used in Korea as a substitute for Polygoni Multiflori Radix (PMR), which is a crude drug traditionally used in East Asian countries. Recently, the use of Cynanchi Auriculati Radix (CAR) in place of PMR and CWR has emerged a major concern in the Korean market. In Japan, PMR is permitte...

journal_title：Biological & pharmaceutical bulletin

authors： Sato-Masumoto N,Uchikura T,Sugiwaki H,Yoshimura M,Masada S,Atsumi T,Watanabe M,Tanaka N,Uchiyama N,Amakura Y,Hakamatsuka T

更新日期：2017-01-01 00:00:00

abstract：:In the present study, we investigated the neuroprotective effects of kaempferol in the mouse model of Parkinson's disease, which was induced by neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). We confirmed that MPTP led to behavioral deficits, depletion of dopamine and its metabolites, reduction in supe...

journal_title：Biological & pharmaceutical bulletin

authors： Li S,Pu XP

更新日期：2011-01-01 00:00:00

abstract：:Joint hypermobility syndrome (JHS) (also termed hypermobility type Ehlers-Danlos syndrome, hEDS) is a heritable connective tissue disorder that is characterized by generalized joint hypermobility, chronic pain, fatigue, and minor skin changes. Initially, it was reported that there is a small subset of patients with JH...

journal_title：Biological & pharmaceutical bulletin

authors： Yamada K,Watanabe A,Takeshita H,Fujita A,Miyake N,Matsumoto N,Matsumoto KI

更新日期：2019-01-01 00:00:00

abstract：:The in vitro skin permeability of 16 drugs with a wide range of lipophilicity (log P; -0.95-4.40) was evaluated by the use of an ethanol/water (60/40) binary vehicle with or without lauric acid as a permeation enhancer. The enhancing effect by the addition of lauric acid to the ethanol/water (60/40) binary vehicle cou...

journal_title：Biological & pharmaceutical bulletin

authors： Lee CK,Uchida T,Kitagawa K,Yagi A,Kim NS,Goto S

更新日期：1994-10-01 00:00:00

abstract：:The uptake of low molecular weight fractionated [3H]heparin (LMWFH: 7000 Da) was examined, for comparison with that of high molecular weight fractionated [3H]heparin (HMWFH:20000 Da), in a primary culture of rat hepatocytes. The uptake of LMWFH increased almost linearly with time up to 60 min (extended uptake), althou...

journal_title：Biological & pharmaceutical bulletin

authors： Watanabe J,Urano K,Muranishi H,Haba M,Yuasa H

更新日期：1995-03-01 00:00:00

abstract：:Effects of epidermal growth factor (EGF) on the expression of alpha(2)-adrenergic responses were examined in primary cultures of adult rat hepatocytes. The alpha(2)-responses were assessed by the inhibition of the rate of forskolin-stimulated cAMP formation by the selective alpha(2)-adrenergic agonists, oxymetazoline ...

journal_title：Biological & pharmaceutical bulletin

authors： Ogihara M

更新日期：1996-04-01 00:00:00

abstract：:DJ-1 was first identified as a novel candidate of an oncogene product in cooperation with an activated ras, and DJ-1 was later found to be a positive regulator of the androgen receptor (AR) transcription activity that was repressed by PIASxalpha. DJ-1 was also found to be an infertility-related protein that was reduce...

journal_title：Biological & pharmaceutical bulletin

authors： Taira T,Iguchi-Ariga SM,Ariga H

更新日期：2004-04-01 00:00:00

abstract：:Two types of fragmented keratin were prepared from buffalo horn and hoof using savinase and Na2S, and their physicochemical and biopharmaceutical properties were examined in mice. The number-average molecular weight of enzymatically fragmented keratin (E-FK), chemically fragmented keratin (C-FK), and fragmented gelati...

journal_title：Biological & pharmaceutical bulletin

authors： Noda J,Imai T,Kida K,Otagiri M

更新日期：1996-03-01 00:00:00

abstract：:We investigated the relationship between noradrenaline (NAd)-induced contractions, endothelial function, and hypertension in femoral arteries isolated from spontaneously hypertensive rats (SHR). In the femoral arteries of SHR, vs. age-matched control Wistar Kyoto (WKY) rats, contractions induced by NAd were increased....

journal_title：Biological & pharmaceutical bulletin

authors： Matsumoto T,Watanabe S,Iguchi M,Ando M,Oda M,Nagata M,Yamada K,Taguchi K,Kobayashi T

更新日期：2016-01-01 00:00:00