The physicochemical and biopharmaceutical properties of fragmented keratin as a new drug carrier.

abstract：:The role of leukotriene B4 (LTB4) in leukocyte infiltration in zymosan-induced rat pleurisy was investigated by studying the effects of 5-lipoxygenase inhibitors, T-0757 and AA-861, and a cyclooxygenase inhibitor, indomethacin, on leukocyte infiltration and LTB4 levels in the inflammatory exudate of rat pleurisy induc...

journal_title：Biological & pharmaceutical bulletin

authors： Kikuchi M,Tsuzurahara K,Naito K

更新日期：1995-09-01 00:00:00

abstract：:Several Pt(IV) and Pt(II) complexes containing 1R,2R-cyclohexanediamine (1R,2R-dach) as a carrier ligand were synthesized. The cytotoxicities and the uptake of the platinum complexes by leukemia L1210 cells were compared in order to study the correlation between their structures and cytotoxicities. [Pt(II)Cl2(1R,2R-da...

journal_title：Biological & pharmaceutical bulletin

authors： Yamashita T,Hirose J,Noji M,Saito R,Tomida H,Kidani Y

更新日期：1993-10-01 00:00:00

abstract：:In this study, the quantitative analysis of saikosaponins from Radix Bupleuri in China was performed by high performance liquid chromatography. Saikosaponin-a and -d were converted completely into saikosaponin-b1 and -b2 by mild acid treatment. Distinctive measuring of these converted diene-saponins provided a rapid a...

journal_title：Biological & pharmaceutical bulletin

authors： Li XQ,Gao QT,Chen XH,Bi KS

更新日期：2005-09-01 00:00:00

abstract：:Vonoprazan fumarate (vonoprazan) is a new kind of acid suppressant with potent acid inhibitory effects. Therefore, it has been administered to kidney transplant recipients for treatment or prophylaxis of steroid ulcers, refractory peptic ulcers, and gastroesophageal reflux disease. Because tacrolimus, which is a well-...

journal_title：Biological & pharmaceutical bulletin

authors： Mei T,Noguchi H,Suetsugu K,Hisadome Y,Kaku K,Okabe Y,Masuda S,Nakamura M

更新日期：2020-01-01 00:00:00

abstract：:We examined the effects of purified tannins and related compounds (33 species) on NADH-ubiquinone-1 oxidoreductase activity in four kinds of organism (Paracoccus denitrificans, Bacillus subtilis, Photobacterium phosphoreum, and Thermus thermophilus HB-8) and rat liver mitochondria. In addition to pentagalloylglucose, ...

journal_title：Biological & pharmaceutical bulletin

authors： Konishi K,Adachi H,Ishigaki N,Kanamura Y,Adachi I,Tanaka T,Nishioka I,Nonaka G,Horikoshi I

更新日期：1993-07-01 00:00:00

abstract：:This study was conducted to determine the beneficial effects of treating digestive disorders of (6E,12E)-tetradecadiene-8,10-diyne-1,3-diol diacetate (TDEYA) detected in the plasma in hydrolyzed form: (6E,12E)-tetradecadiene-8,10-diyne-1,3-diol (TDEY), following the oral administration of a decoction of Atractylodes r...

journal_title：Biological & pharmaceutical bulletin

authors： Sakurai T,Sugawara H,Saito K,Kano Y

更新日期：1994-10-01 00:00:00

abstract：:We examined the inhibitory effects of N-beta-alanyl-5-S-glutathionyl-3,4-dihydroxyphenylalanine (5-S-GAD), a novel antibacterial substance from the immunized adult Sarcophaga peregrina (flesh fly), on protein phosphorylation using immune complexes of protein tyrosine kinases (PTKs) with anti-PTKs monoclonal antibody. ...

journal_title：Biological & pharmaceutical bulletin

authors： Leem JY,Park HY,Fukazawa H,Uehara Y,Natori S

更新日期：1998-07-01 00:00:00

abstract：:Shikonin, a major ingredient in the Chinese traditional herb Lithospermum erythrorhixon, exhibits multiple biological functions including antimicrobial, anti-inflammatory, and antitumor effects. In this study, we delineated the molecular mechanisms of shikonin in the apoptosis of 143B osteosarcoma cells. Shikonin redu...

journal_title：Biological & pharmaceutical bulletin

authors： Chang IC,Huang YJ,Chiang TI,Yeh CW,Hsu LS

更新日期：2010-01-01 00:00:00

abstract：:Epoxyeicosatrienoic acids (EETs) are produced primarily by CYPs from arachidonic acid (AA) and then further metabolized to the corresponding dihydroxyeicosatrienoic acids (DHETs). EETs play important roles in physiological processes such as regulating vasodilation and inflammation. Thus, the drug inhibition of CYP-med...

journal_title：Biological & pharmaceutical bulletin

authors： Mukai Y,Toda T,Takeuchi S,Senda A,Yamashita M,Eliasson E,Rane A,Inotsume N

更新日期：2015-01-01 00:00:00

abstract：:Compound C is a widely used chemical inhibitor that down-regulates AMP-activated protein kinase (AMPK) activity. However, it has been suggested that compound C exerts AMPK-independent effects in various cells. Here, we investigated whether compound C induces Sestrin2 (SESN2), an antioxidant enzyme induced by diverse s...

journal_title：Biological & pharmaceutical bulletin

authors： Seo K,Seo S,Ki SH,Shin SM

更新日期：2016-01-01 00:00:00

abstract：:The MeOH and water extracts of the Netherlands propolis were tested for their inhibitory activity toward nitric oxide (NO) production in lipopolysaccharide (LPS)-activated murine macrophage-like J774.1 cells. Both of the extract possessed significant NO inhibitory activity with IC(50) values of 23.8 and 51.5 microg/ml...

journal_title：Biological & pharmaceutical bulletin

authors： Nagaoka T,Banskota AH,Tezuka Y,Midorikawa K,Matsushige K,Kadota S

更新日期：2003-04-01 00:00:00

abstract：:Alzheimer's disease (AD) is pathologically characterized by accumulation of amyloid β (Aβ) and hyperphosphorylated tau, and thereby induction of neuronal cell death. The Aβ-induced neuronal cell death has been shown to occur by several modes, such as apoptosis, necrosis, and necroptosis. Interestingly, in AD patients,...

journal_title：Biological & pharmaceutical bulletin

authors： Tagai N,Tanaka A,Sato A,Uchiumi F,Tanuma SI

更新日期：2020-01-01 00:00:00

abstract：:Information on the comparative digestibility of food allergens and non-allergenic proteins is crucial when stability to digestion is to be used as a criterion to assess the allergenic potential of novel proteins. Preheating effect on in vitro digestibility has not been fully examined. In this study we investigated the...

journal_title：Biological & pharmaceutical bulletin

authors： Takagi K,Teshima R,Okunuki H,Sawada J

更新日期：2003-07-01 00:00:00

abstract：:Ras, a small G-protein, physiologically directs cell proliferation and cell cycle via regulation of mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) signaling cascade. Dysregulation of Ras/MEK/ERK signaling has been reported to cause tumorigenesis and gliomas. Nobiletin, a citr...

journal_title：Biological & pharmaceutical bulletin

authors： Aoki K,Yokosuka A,Mimaki Y,Fukunaga K,Yamakuni T

更新日期：2013-01-01 00:00:00

abstract：:Bone marrow mesenchymal stem cells (MSCs) have the potential to be used in the cellular therapy of solid organs. However, tissue regeneration is limited by the death of transplanted cells. One of the main mechanisms of stem cell death in transplanted organs is through ischemia. In the present study, we sought to inves...

journal_title：Biological & pharmaceutical bulletin

authors： Zhang W,Su X,Gao Y,Sun B,Yu Y,Wang X,Zhang F

更新日期：2009-08-01 00:00:00

abstract：:The object of this study was to investigate the binding affinity of a newly synthesized 5-HT2 antagonist, (N-[2-[4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-piperidino]ethyl]-1-formyl-4-piperidinecarboxamide monohydrochloride monohydrate) (AT-1015), in the rabbit platelet membrane using [3H]-ketanserin by radioligand bin...

journal_title：Biological & pharmaceutical bulletin

authors： Rashid M,Watanabe M,Nakazawa M,Nagatomo T

更新日期：2001-10-01 00:00:00

abstract：:Cannabinoids are the active ingredients in marijuana, which is among the most widely used addictive drugs despite the well-documented harmfulness related to its abuse. The mechanism underlying cannabinoid addiction remains unclear, which is attributed partially to the difficulty in behavioral testing of high-dose cann...

journal_title：Biological & pharmaceutical bulletin

authors： Liu T,Zheng Q,Qian Z,Wang H,Liu Z,Ren W,Zhang X,Han J

更新日期：2016-05-01 00:00:00

abstract：:To search for possible anti-tumor-promoters, we carried out a primary screening of 21 cucurbitane triterpenoids using an in vitro assay system. Of these triterpenoids, scandenoside R6 (6), 23,24-dihydrocucurbitacin F (14), 25-acetyl-23,24-dihydrocucurbitacin F (15), 2-O-beta-D-glucopyranosyl-23,24-dihydrocucurbitacin ...

journal_title：Biological & pharmaceutical bulletin

authors： Konoshima T,Takasaki M,Tatsumoto T,Kozuka M,Kasai R,Tanaka O,Nie RL,Tokuda H,Nishino H,Iwashima A

更新日期：1994-05-01 00:00:00

abstract：:ICR/f mutation in rat, an inherited disorder, is characterized by the development of cataracts. In this study, we analyzed and compared the crystallins in normal and cataractous rat lenses using gel filtration and two-dimensional gel electrophoresis, and determined the transglutaminase activities and Ca2+ content in t...

journal_title：Biological & pharmaceutical bulletin

authors： Takeuchi N,Kamei A

更新日期：2000-03-01 00:00:00

abstract：:Our previous studies reported that methanol extract of Sanguisorbae radix from Sanguisorba officinalis L. (Rosaceae) prevented neuronal cell damage induced by Abeta (25-35) in vitro. The present study was carried out to investigate the effect of gallic acid isolated from Sanguisorbae radix on Abeta (25-35)-induced neu...

journal_title：Biological & pharmaceutical bulletin

authors： Ban JY,Nguyen HT,Lee HJ,Cho SO,Ju HS,Kim JY,Bae K,Song KS,Seong YH

更新日期：2008-01-01 00:00:00

abstract：:Nicotine-withdrawal symptoms have been indicated as a possible risk factor for neuropsychiatric events, such as depression and suicide, during use of smoking-cessation drugs. We aimed to investigate whether the results of the metabolomic analysis of the rat brain reflect nicotine-withdrawal symptoms. We also aimed to ...

journal_title：Biological & pharmaceutical bulletin

authors： Akimoto H,Oshima S,Michiyama Y,Negishi A,Nemoto T,Kobayashi D

更新日期：2018-12-01 00:00:00

abstract：:Purslane (Portulaca oleracea L.) is popular as a potherb in many areas of Europe, Asia, and the Mediterranean region and is widely distributed around the globe. It has a wide range of pharmacological effects, such as antibacterial, anti-aging, anti-inflammatory, and anti-oxidative properties. Although the extract of p...

journal_title：Biological & pharmaceutical bulletin

authors： Kim JY,Oh HM,Kwak SC,Cheon YH,Lee MS,Rho MC,Oh J

更新日期：2015-01-01 00:00:00

abstract：:Hydroxyoctadecadienoic acids (HODEs) are generated by oxidation of linoleic acid in vivo and thought to mediate various pathophysiological responses. In this study, we examined the effects of HODEs on EL4 mouse lymphoma cell growth and found that 9-(E,Z)-HODE inhibited EL4 cell growth in a dose-dependent manner, where...

journal_title：Biological & pharmaceutical bulletin

authors： Kodaka A,Hayakawa Y,AlSayegh RJ,Yasuhara T,Tomoda H,Oku T,Dan S,Tsuiji M,Tsuji T

更新日期：2019-01-01 00:00:00

abstract：:The inhibitory effect of suramin on the phosphorylation of GST-HBV core fusion protein (GST-Hcore) and two GST-Hcore fusion polypeptides (Hcore157B and Hcore164B) by two alpha-type cAMP-dependent protein kinases (PKAIalpha and PKAIIalpha) was biochemically investigated in vitro. It was found that (i) this phosphorylat...

journal_title：Biological & pharmaceutical bulletin

authors： Okabe M,Enomoto M,Maeda H,Kuroki K,Ohtsuki K

更新日期：2006-09-01 00:00:00

abstract：:In the present study, we evaluated the effect of the novel acid pump antagonist 7-(4-fluorobenzyloxy)-2,3-dimethyl-1-{[(1S,2S)-2-methylcyclopropyl]methyl}-1H-pyrrolo[2,3-d]pyridazine (CS-526) on the intragastric acidity of cynomolgus monkeys. The study was performed in a crossover manner with five male animals. CS-526...

journal_title：Biological & pharmaceutical bulletin

authors： Ito K,Kinoshita K,Yamamura N,Tomizawa A,Inaba F,Morikawa-Inomata Y,Tabata K,Shibakawa N

更新日期：2009-12-01 00:00:00

abstract：:Effects of pentamidine, a therapeutic drug for Pneumocystis carinii pneumonia (PCP) in acquired immunodeficiency syndrome (AIDS), on specific bindings of [3H](+)-5-methyl-10,11-dihydro-5H- dibenzo[a,d]cyclohepten-5,11-imine maleate (MK-801) and [3H]nitrendipine were investigated in crude synaptic membranes (CSM) of ra...

journal_title：Biological & pharmaceutical bulletin

authors： Kitamura Y,Arima T,Sato T,Nakamura J,Nomura Y

更新日期：1995-02-01 00:00:00

abstract：:Coagulase-negative Staphylococcus (CNS) strains are frequently associated with bacteremia and hospital-acquired infections. 293 CNS strains were isolated from 744 samples from a dialysis center in S. M. de Tucumán, Argentina, from hemocultures, catheters and urine and identified as S. epidermidis, S. haemolyticus, S. ...

journal_title：Biological & pharmaceutical bulletin

authors： de Allori MC,Jure MA,Romero C,de Castillo ME

更新日期：2006-08-01 00:00:00

abstract：:Echinacoside is a major compound of Cistanche Herb and has glutamate release-inhibiting activity in the brain. Given the involvement of excitotoxicity caused by massive glutamate in the pathophysiology of epilepsy, we explored the antiepileptic effect of echinacoside on kainic acid-induced seizures in rats. The rats w...

journal_title：Biological & pharmaceutical bulletin

authors： Lu CW,Hsieh HL,Lin TY,Hsieh TY,Huang SK,Wang SJ

更新日期：2018-11-01 00:00:00

abstract：:Mouth washing after inhalation of corticosteroids is effective for prevention of local adverse effects such as hoarseness and oropharyngeal candidiasis. To establish an optimal procedure for such mouth washing, we investigated the removal rates of drug residues remaining on the oropharyngeal mucosa using various mouth...

journal_title：Biological & pharmaceutical bulletin

authors： Yokoyama H,Yamamura Y,Ozeki T,Iga T,Yamada Y

更新日期：2006-09-01 00:00:00

abstract：:Calprotectin is a calcium- and zinc-binding protein complex that is abundant in cytosol of neutrophils. The concentration of calprotectin in extracellular fluids is greatly increased under various inflammatory conditions in vivo. We recently demonstrated that calprotectin inhibited cell growth and induced apoptosis of...

journal_title：Biological & pharmaceutical bulletin

authors： Mikami M,Kitahara M,Kitano M,Ariki Y,Mimaki Y,Sashida Y,Yamazaki M,Yui S

更新日期：1999-07-01 00:00:00