Inhibitory effects of tannins on NADH dehydrogenases of various organisms.

abstract：:We investigated the effect of components in grapefruit juice (GFJ) on the transport of vinblastine, a substrate of P-glycoprotein (P-gp), across Caco-2 cells. The apical to basolateral flux of [3H]vinblastine was increased in the presence of GFJ extracts. The steady-state uptake of [3H]vinblastine from the apical side...

journal_title：Biological & pharmaceutical bulletin

authors： Takanaga H,Ohnishi A,Matsuo H,Sawada Y

更新日期：1998-10-01 00:00:00

abstract：:Resveratrol, which is found in grapes, red wine, and berries, has many beneficial health effects, such as anti-cancer, neuro-protective, anti-inflammatory, and life-prolonging effects. However, the cellular mechanisms by which resveratrol acts are relatively unknown, especially in terms of possible regulation of recep...

journal_title：Biological & pharmaceutical bulletin

authors： Lee BH,Hwang SH,Choi SH,Shin TJ,Kang J,Lee SM,Nah SY

更新日期：2011-01-01 00:00:00

abstract：:Endogenously produced reactive oxygen species reportedly stimulate insulin secretion from islet β-cells. However, the molecular machinery that governs the oxidant-induced insulin secretion has yet to be determined. The present study demonstrates, using rat islet β-cell-derived RINm5F cells, the involvement of the tran...

journal_title：Biological & pharmaceutical bulletin

authors： Numazawa S,Takase M,Ahiko T,Ishii M,Shimizu S,Yoshida T

更新日期：2012-01-01 00:00:00

abstract：:Alpha1-adrenoceptor antagonists are clinically useful for the improvement of urinary obstruction due to benign prostatic hyperplasia (BPH), and their therapeutic effects are mediated through the blockade of prostatic alpha(1)-adrenoceptors. The present study was undertaken to predict the magnitude and duration of alph...

journal_title：Biological & pharmaceutical bulletin

authors： Yamada S,Kato Y,Okura T,Kagawa Y,Kawabe K

更新日期：2007-07-01 00:00:00

abstract：:Liquid intraurethral prostaglandin E1 (PGE1) delivery system was developed using self-microemulsifying drug delivery system (SMEDDS). For this, pseudo-ternary phase diagrams were constructed and characterized. The viscosity of optimized formulation was increased gradually upon the addition of water and it was decrease...

journal_title：Biological & pharmaceutical bulletin

authors： Lee S,Lee J,Choi YW

更新日期：2008-04-01 00:00:00

abstract：:Methylmercury (MeHg) is a causative agent of Minamata disease and an environmental pollutant that comprises a large portion of organically occurring mercury. Many aspects of the biological defense mechanisms against MeHg toxicity remain unclear. Recently, nuclear factor-E2-related factor 2 (Nrf2), heat shock factor pr...

journal_title：Biological & pharmaceutical bulletin

authors： Hwang GW

更新日期：2012-01-01 00:00:00

abstract：:Cationic lipid-mediated transfer of DNA is promising in gene therapy. However, one disadvantage with this approach is the induction of an inflammatory response, which may decrease transgene expression. Recently, we found that plasmid DNA containing N6-methyladenine (N6-MeA), a bacterium-specific modified base, induced...

journal_title：Biological & pharmaceutical bulletin

authors： Ochiai H,Harashima H,Kamiya H

更新日期：2005-10-01 00:00:00

abstract：:Effects of certain antiallergic drugs on experimental conjunctivitis were studied with guinea pigs. Chlorpheniramine, ketotifen and levocabastine were effective in inhibiting histamine- and antigen-induced conjunctivitis in guinea pigs. By contrast, amlexanox was only effective in inhibiting antigen-induced conjunctiv...

journal_title：Biological & pharmaceutical bulletin

authors： Kamei C,Izushi K,Nakamura S

更新日期：1995-11-01 00:00:00

abstract：:The objective of this study was to determine pharmacokinetic differences of acetyl salicylic acid (ASA) and its metabolites: gentisic acid (GA), salicylic acid (SA) and salicyluric acid (SUA) between Otomies and Mesticians healthy subjects. Design. Ten Otomies and 10 Mesticians were included. After a single dose of as...

journal_title：Biological & pharmaceutical bulletin

authors： Lares-Asseff I,Juárez-Olguín H,Flores-Pérez J,Guillé-Pérez A,Vargas A

更新日期：2004-05-01 00:00:00

abstract：:Checkpoint kinase 1 (Chk1) plays important roles in genotoxic stress-induced cell cycle checkpoint and in normal cell cycle progression. Here, we show that Chk1 is cleaved in the treatment of apoptotic dose of etoposide (ETP) or cisplatin (CIS) but not of viable dose in HeLa S3 cells. The cleavage of Chk1 was complete...

journal_title：Biological & pharmaceutical bulletin

authors： Okita N,Kudo Y,Tanuma S

更新日期：2007-02-01 00:00:00

abstract：:Compound C is a widely used chemical inhibitor that down-regulates AMP-activated protein kinase (AMPK) activity. However, it has been suggested that compound C exerts AMPK-independent effects in various cells. Here, we investigated whether compound C induces Sestrin2 (SESN2), an antioxidant enzyme induced by diverse s...

journal_title：Biological & pharmaceutical bulletin

authors： Seo K,Seo S,Ki SH,Shin SM

更新日期：2016-01-01 00:00:00

abstract：:The present study was aimed at kinetically characterizing the carrier-mediated transport systems for D-glucose and taurocholate in the rat colon, compared with their respective counterparts in the small intestine. The transport of these compounds was evaluated by measuring the initial uptake into everted intestinal ti...

journal_title：Biological & pharmaceutical bulletin

authors： Tomei S,Torimoto M,Hayashi Y,Inoue K,Yuasa H,Watanabe J

更新日期：2003-06-01 00:00:00

abstract：:The present study investigated whether Astragalus polysaccharide (APS) possessed immunotherapeutic effects on type 1 diabetes mellitus. Diabetic mice induced by multiple low dose streptozotocin (MLD-STZ) were administered either APS (100, 200, 400 mg/kg body weight) or saline intraperitoneally daily, and sacrificed af...

journal_title：Biological & pharmaceutical bulletin

authors： Li RJ,Qiu SD,Chen HX,Tian H,Wang HX

更新日期：2007-03-01 00:00:00

abstract：:Berberine has a wide range of biochemical and pharmacologic effects, including antitumor activity, but the mechanisms involved in berberine-induced apoptosis remain unclear. The purpose of the present study was to investigate the changes in oxidative stress and endoplasmic reticulum (ER)-related molecules, which are c...

journal_title：Biological & pharmaceutical bulletin

authors： Eom KS,Kim HJ,So HS,Park R,Kim TY

更新日期：2010-01-01 00:00:00

abstract：:To explore the role of the abnormal expression of the bile salt export pump (BSEP) and multidrug resistance protein 2 (MRP2) in isoniazid (INH)-induced liver injury, we assessed the liver injury induced by INH in rats and HepG2 cells in vitro. The regulatory pathways via Sirtuin 1 (SIRT1) and farnesoid X receptor (FXR...

journal_title：Biological & pharmaceutical bulletin

authors： Qu X,Zhang Y,Zhang S,Zhai J,Gao H,Tao L,Song Y

更新日期：2018-01-01 00:00:00

abstract：:When carbohydrate metabolism is impaired, fatty acid metabolism is activated. Excess acetyl-coenzyme A (CoA) is generated from fatty acids by β-oxidation and is used for the formation of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) and subsequently for acetoacetate. High levels of secreted ketone bodies (acetoacetate and ...

journal_title：Biological & pharmaceutical bulletin

authors： Nakagawa S,Kojima Y,Sekino K,Yamato S

更新日期：2013-01-01 00:00:00

abstract：:The objective of this study was to study the effect of olmesartan medoxomil (OLM), an antihypertensive drug, on intra-articular inflammation induced by zymosan (Zy) in Wistar rats. Intra-articular inflammation was induced in the right knees of rats by 1 mg Zy dissolved in saline. The animals were divided into the foll...

journal_title：Biological & pharmaceutical bulletin

authors： Guerra GC,de Menezes MS,de Araújo AA,de Araújo Júnior RF,de Medeiros CA

更新日期：2016-01-01 00:00:00

abstract：:This study investigated most suitable transforming factor related to the daily Phenobarbital dose (D) providing a steady-state serum concentration (Ct) and analyzed the influences of concomitant antiepileptic drugs on Ct quantitatively. Data obtained by routine therapeutic drug monitoring from a total of 326 epileptic...

journal_title：Biological & pharmaceutical bulletin

authors： Fukuoka N,Tsukamoto T,Uno J,Kimura M,Morita S

更新日期：2004-12-01 00:00:00

abstract：:A current anti-inflammatory agent often targets the prevention of inflammatory disorder development. The standardized Centella asiatica ECa 233 extract has been previously reported for anti-inflammatory effect. This study aimed to investigate its anti-inflammatory effect and mechanisms of ECa 233 in lipopolysaccharide...

journal_title：Biological & pharmaceutical bulletin

authors： Sukketsiri W,Tanasawet S,Moolsap F,Tantisira MH,Hutamekalin P,Tipmanee V

更新日期：2019-01-01 00:00:00

abstract：:Pantethine and fursultiamine have been evaluated for their clinical usefulness in the treatment and prevention of uncomplicated postoperative adhesive intestinal obstruction. In recent years, the actions of drugs used to treat gastrointestinal diseases have been elucidated pharmacologically from the viewpoints of gast...

journal_title：Biological & pharmaceutical bulletin

authors： Suzuki Y,Itoh H,Abe T,Nishimura F,Sato Y,Takeyama M

更新日期：2011-01-01 00:00:00

abstract：:We investigated whether endogenous nitric oxide (NO) has a role as an inhibitory modulator of norepinephrine (NE)- and angiotensin II (Ang II)-induced renal effects in anesthetized dogs. Intrarenal arterial infusion of NE (100 ng/kg/min) or Ang II (10 ng/kg/min) decreased renal blood flow (RBF), glomerular filtration ...

journal_title：Biological & pharmaceutical bulletin

authors： Matsumura Y,Egi Y,Maekawa H,Miura A,Murata S,Morimoto S

更新日期：1995-04-01 00:00:00

abstract：:Swallowing involves several motor processes such as bolus formation and intraoral transport of a food bolus (oral stage) and a series of visceral events that occur in a relatively fixed timed sequence but are to some degree modifiable (pharyngeal stage or swallow reflex). Reflecting the progressive aging of society, p...

journal_title：Biological & pharmaceutical bulletin

authors： Yamamura K,Kitagawa J,Kurose M,Sugino S,Takatsuji H,Mostafeezur RM,Zakir HM,Yamada Y

更新日期：2010-01-01 00:00:00

abstract：:A liposomal formulation of UCN-01 was studied to prevent binding of drug to human alpha1-acid glycoprotein (hAGP). The release of drug from liposomes added to various media was investigated by monitoring the concentration of UCN-01 in different fractions. Protein bound UCN-01 was separated from liposomal UCN-01 and fr...

journal_title：Biological & pharmaceutical bulletin

authors： Yamauchi M,Kusano H,Nakakura M,Kato Y

更新日期：2005-07-01 00:00:00

abstract：:In the present study, we investigated the neuroprotective effects of kaempferol in the mouse model of Parkinson's disease, which was induced by neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). We confirmed that MPTP led to behavioral deficits, depletion of dopamine and its metabolites, reduction in supe...

journal_title：Biological & pharmaceutical bulletin

authors： Li S,Pu XP

更新日期：2011-01-01 00:00:00

abstract：:The transdermal therapeutic systems (TTS) usually achieve constant plasma concentration for an extended period of time. This is because a sufficient drug stored in the device can keep the constant concentration on the surface of the stratum corneum during the system application. When the drug molecules are not enough ...

journal_title：Biological & pharmaceutical bulletin

authors： Kawamata H,Tojo K

更新日期：2002-03-01 00:00:00

abstract：:Spontaneous transfer of protein from either influenza virus-infected or uninfected cells to dimyristoylphosphatidylcholine (DMPC) liposomes was examined. The amount of transferred protein of liposomes incubated with influenza virus-infected cells (I-lipo) was more than that of liposomes incubated with uninfected cells...

journal_title：Biological & pharmaceutical bulletin

authors： Kogure K,Itoh M,Hayashi K,Ueno M

更新日期：1995-08-01 00:00:00

abstract：:The quantification of tenofovir, a nucleoside reverse transcriptase inhibitor prescribed once daily, in human plasma is important due to a recent increase in its use. HPLC, however, can not easily detect and quantify tenofovir because of interfering peaks. Therefore, we developed a rapid and conventional LC-MS method,...

journal_title：Biological & pharmaceutical bulletin

authors： Takahashi M,Kudaka Y,Okumura N,Hirano A,Banno K,Kaneda T

更新日期：2007-09-01 00:00:00

abstract：:We investigated the anti-allergic effect of tea-leaf saponin (TLS), which was a mixture of saponins separated from the leaves of Camellia sinensis var. sinensis, in guinea pigs and rats. TLS (20-100 mg/kg) dose-dependently inhibited experimentally-induced asthma, and ID50 was 61.7 mg/kg. TLS (20-100 mg/kg) dose-depend...

journal_title：Biological & pharmaceutical bulletin

authors： Akagi M,Fukuishi N,Kan T,Sagesaka YM,Akagi R

更新日期：1997-05-01 00:00:00

abstract：:The metabolism of bisphenol A (BPA) was determined for 11 forms of human hepatic cytochromes P450 (CYPs) expressed in the yeast Saccharomyces cerevisiae and for human steroidogenic CYP17 expressed in Escherichia coli. Additionally, the effect of BPA on the progesterone 17alpha-chydroxylase activity of CYP17 was invest...

journal_title：Biological & pharmaceutical bulletin

authors： Niwa T,Fujimoto M,Kishimoto K,Yabusaki Y,Ishibashi F,Katagiri M

更新日期：2001-09-01 00:00:00

abstract：:The fundamental role that receptor tyrosine kinases play in cancer and other proliferative diseases has provided the impetus for an extensive effort on the part of both academic and pharmaceutical laboratories to develop highly specific inhibitors. In this study, inhibitory activity of previously synthesized arylaceti...

journal_title：Biological & pharmaceutical bulletin

authors： Altuntas TG,Olgen S,Nebioglu D,Akaho E

更新日期：2004-01-01 00:00:00