Inhibitory effects of pentamidine on N-methyl-D-aspartate (NMDA) receptor/channels in the rat brain.

abstract：:Aromatase is a cytochrome P-450 enzyme complex that catalyzes the conversion of androst-4-ene-3,17-dione (AD) to estrone through three sequential oxygenations of the 19-methyl group. To gain insight into the ability of AD isomers, 4-en-6-one 1a, 5-en-4-one 2a, and 5-en-7-one 3a, competitive inhibitors of aromatase wit...

journal_title：Biological & pharmaceutical bulletin

authors： Numazawa M,Yamada K,Nagaoka M

更新日期：2001-04-01 00:00:00

abstract：:Epidermis is one of the well-known estrogen target tissues. Information regarding estrogen metabolism in epidermis is still very limited compared to that of estrogen action. In the breast cancer tissue, 17β-estradiol (E(2)) is inactivated by sulfation and the expression level of estrogen sulfotransferase (SULT1E1) is ...

journal_title：Biological & pharmaceutical bulletin

authors： Kushida A,Hattori K,Yamaguchi N,Kobayashi T,Date A,Tamura H

更新日期：2011-01-01 00:00:00

abstract：:Sentinel lymph nodes (SLN) are the first lymph nodes (LN) where cancer cells metastasize from the primary tumor. We designed fluorophore-quencher-based activatable nanoparticles for SLN imaging. We selected TAMRA as a fluorophore and BHQ2 or QSY7 as a quencher. Ternary anionic complexes were constructed with generatio...

journal_title：Biological & pharmaceutical bulletin

authors： Hagimori M,Hatabe E,Sano K,Miyazaki H,Sasaki H,Saji H,Mukai T

更新日期：2017-01-01 00:00:00

abstract：:This study aimed to investigate the mechanism by which the human lung cancer drug resistance-related gene BC006151 regulates chemosensitivity by down-regulating BC006151 expression via antisense gene transfer in H446/(C)DDP cells. A retroviral vector containing the antisense BC006151 sequence was constructed and trans...

journal_title：Biological & pharmaceutical bulletin

authors： Li S,Shi H,Ji F,Wang B,Feng Q,Feng X,Jia Z,Zhao Q,Qian G

更新日期：2010-01-01 00:00:00

abstract：:By means of successive heparin-affinity and glycyrrhizin (GL)-affinity column chromatographies (HPLC), a 55 kDa GL-binding protein (gp55) was purified to apparent homogeneity from the Superdex P-I fraction of Habu snake venom. This gp55 was identified as an apoxin I-like protein, because (i) its 20 N-terminal amino ac...

journal_title：Biological & pharmaceutical bulletin

authors： Abe Y,Shimoyama Y,Munakata H,Ito J,Nagata N,Ohtsuki K

更新日期：1998-09-01 00:00:00

abstract：:Uridine diphosphate (UDP)-glucuronosyltransferase 1A1 (UGT1A1) plays important roles in the glucuronidation of various drugs and endogenous substances. Minipigs have been used as experimental animals in pharmacological and toxicological studies, because many of their physiological characteristics are similar to those ...

journal_title：Biological & pharmaceutical bulletin

authors： Miyake Y,Mayumi K,Jinno H,Tanaka-Kagawa T,Narimatsu S,Hanioka N

更新日期：2013-01-01 00:00:00

abstract：:Methylmercury (MeHg) is a causative agent of Minamata disease and an environmental pollutant that comprises a large portion of organically occurring mercury. Many aspects of the biological defense mechanisms against MeHg toxicity remain unclear. Recently, nuclear factor-E2-related factor 2 (Nrf2), heat shock factor pr...

journal_title：Biological & pharmaceutical bulletin

authors： Hwang GW

更新日期：2012-01-01 00:00:00

abstract：:The objective of this study was to evaluate the interactions between various drugs and aojiru (green juice), a popular health food in Japan, using a simple centrifugation method. The mixture of drug solution and aojiru suspension was gently shaken and centrifuged. The drug concentration in the supernatant fluid was th...

journal_title：Biological & pharmaceutical bulletin

authors： Iwao K,Kawai RT,Oda M,Saitoh H

更新日期：2017-01-01 00:00:00

abstract：:To investigate the mechanism responsible for the increased bioavailability of propranolol in bilateral ureter-ligated (BUL) rats, the intestinal absorption and hepatic extraction of propranolol and metoprolol were evaluated. The initial absorption rate of these drugs after intra-intestinal administration was only slig...

journal_title：Biological & pharmaceutical bulletin

authors： Okabe H,Higashi T,Ohta T,Hashimoto Y

更新日期：2004-09-01 00:00:00

abstract：:Granisetron (GRN) is widely used for patients with various cancers who suffer from chemotherapy-induced vomiting and nausea. The, pharmacokinetics of GRN has not been fully evaluated in such patients, however, and its dosage regimen is still controversial. In this study, we determined GRN levels in serum and urine fro...

journal_title：Biological & pharmaceutical bulletin

authors： Wada I,Takeda T,Sato M,Saitoh H,Nakabayashi T,Mino K,Honma T,Takada M,Hirano K

更新日期：2001-04-01 00:00:00

abstract：:The complete amino acid sequences of [2Fe-2S] ferredoxin from Atropa belladonna and Hyoscyamus niger have been determined by automated Edman degradation of the entire S-carboxymethylcysteinyl proteins and of the peptides obtained by enzymatic digestion. These two ferredoxins exhibited 1-8 differences in their amino ac...

journal_title：Biological & pharmaceutical bulletin

authors： Mino Y,Yukita M,Hiratsuka N,Wariishi H

更新日期：2005-08-01 00:00:00

abstract：:Irsogladine maleate (2,4-diamino-6-[2,5-dichlorophenyl]-s-triazine maleate; IM), an anti-peptic ulcer drug, may have a protective effect on the gastrointestinal mucosa. This study investigated the effects of IM on spontaneous colitis in interleukin-10 gene-deficient (IL-10(-/-)) mice. Five-week-old IL-10(-/-) mice wer...

journal_title：Biological & pharmaceutical bulletin

authors： Nakagawa T,Katsuno T,Noguchi Y,Mandai Y,Yoshihama S,Saito K,Maruoka D,Matsumura T,Arai M,Yokosuka O

更新日期：2015-01-01 00:00:00

abstract：:The purpose of this research is improvement of therapeutic treatment for periodontitis by using lipophilic and/or hydrophilic zinc materials. The sample suspension injections were prepared from zinc octanate (C8Zn), zinc stearate (C18Zn), zinc sulfate hepta-hydrate (ZnSO4) and tricalcium phosphate (ZnTCP) containing 6...

journal_title：Biological & pharmaceutical bulletin

authors： Tokudome Y,Otsuka M

更新日期：2012-01-01 00:00:00

abstract：:A plasmid-cured strain of the marine Vibrio alginolyticus 138-2 retains a respiration-driven Na+ pump. Examinations of several strains of V. alginolyticus and V. parahaemolyticus revealed that these murine Vibrio always possessed the respiration-driven Na+ pump irrespective of the presence or absence of plasmids. Thes...

journal_title：Biological & pharmaceutical bulletin

authors： Nakamura T,Hayashi S,Yamanaka R,Hamashima H,Arai T,Unemoto T

更新日期：1993-08-01 00:00:00

abstract：:Proteinase-activated receptor-2 (PAR2) may be an important regulator of skin mast cell function during cutaneous inflammation and hypersensitivity. However, little is known of the role of PAR2 in allergic pruritus, because mast cells, which are thought to be responsible for this symptom, can release a number of differ...

journal_title：Biological & pharmaceutical bulletin

authors： Zhu Y,Peng C,Xu JG,Liu YX,Zhu QG,Liu JY,Li FQ,Wu JH,Hu JH

更新日期：2009-07-01 00:00:00

abstract：:Immediate early genes (IEG) are rapidly but transiently induced directly by intracellular signaling cascades to alter patterns of gene expression. It has been proposed that histone modifications could be the key to the quick alteration of chromatin structure, as this spread occurs too rapidly to be the consequence of ...

journal_title：Biological & pharmaceutical bulletin

authors： Sng JC,Taniura H,Yoneda Y

更新日期：2004-05-01 00:00:00

abstract：:The onset of oral candidiasis is accompanied by inflammatory symptoms such as pain in the tongue, edema or tissue damage and lowers the quality of life (QOL) of the patient. In a murine oral candidiasis model, the effects were studied of terpinen-4-ol (T-4-ol), one of the main constituents of tea tree oil, Melaleuca a...

journal_title：Biological & pharmaceutical bulletin

authors： Ninomiya K,Hayama K,Ishijima SA,Maruyama N,Irie H,Kurihara J,Abe S

更新日期：2013-01-01 00:00:00

abstract：:Imbalance between oxidative stress and antioxidative defence system is generally known as one of mechanisms causing an oxidative stress-medieated neuropathogenesis. Peroxiredoxins (Prxs), a family of antioxidative enzymes neutralizing cellular hydroperoxides, was characterized recently, but their distributions and rol...

journal_title：Biological & pharmaceutical bulletin

authors： Kim SU,Hwang CN,Sun HN,Jin MH,Han YH,Lee H,Kim JM,Kim SK,Yu DY,Lee DS,Lee SH

更新日期：2008-05-01 00:00:00

abstract：:Cilnidipine is a 1,4-dihydropyridine-derived voltage-dependent calcium channel (VDCC) blocker and suppresses N-type VDCC currents in addition to L-type VDCC currents. An earlier investigation has suggested that intrathecally injected cilnidipine produces antinociception by blocking N-type VDCCs in mice. The present st...

journal_title：Biological & pharmaceutical bulletin

authors： Koganei H,Shoji M,Iwata S

更新日期：2009-10-01 00:00:00

abstract：:We investigated a method for the simultaneous screening, identification, and quantitative determination of salicylic acid, acetaminophen, theophylline, barbiturates, and bromvalerylurea, drugs that frequently cause acute poisoning in Japan and therefore require rapid analysis for effective treatment in the clinical se...

journal_title：Biological & pharmaceutical bulletin

authors： Hori Y,Fujisawa M,Shimada K,Hirose Y,Yoshioka T

更新日期：2006-01-01 00:00:00

abstract：:Essential elements (Ca, Mg, Zn, Cu, Fe, Cr, Mn and V) and non-essential elements (As, Cd, Hg and Pb) were measured in scalp hair samples of 45 diabetic subjects and 59 control subjects in Japan using inductively coupled plasma mass spectrometry. All diabetic subjects took insulin and/or antidiabetic agents, with glyca...

journal_title：Biological & pharmaceutical bulletin

authors： Hotta Y,Fujino R,Kimura O,Endo T

更新日期：2018-01-01 00:00:00

abstract：:Corneal transplantation has been used to treat severe eye disease for decades, but the therapeutic effect of the operation is highly compromised by immunological allograft rejection. To improve the success rate of corneal transplantation, we studied the protective effects of cyclosporine nanomicelle eye drops (CNED) o...

journal_title：Biological & pharmaceutical bulletin

authors： Zhang H,Wang L,Zhang L

更新日期：2015-01-01 00:00:00

abstract：:Hinokitiol (beta-thujaplicin), beta-dolabrin and gamma-thujaplicin isolated from Thujopsis dolabrata SIEB. et ZUCC var hondai MAKINO showed antifungal activities against all of the wood-rotting fungi examined. The antifungal activity of three compounds on Daedalea dickinsii IFO-4979 was especially strong, their minimu...

journal_title：Biological & pharmaceutical bulletin

authors： Inamori Y,Sakagami Y,Morita Y,Shibata M,Sugiura M,Kumeda Y,Okabe T,Tsujibo H,Ishida N

更新日期：2000-08-01 00:00:00

abstract：:Oral tolerance is thought to have a role in preventing allergic responses and immune-mediated diseases. Modulation of this tolerance by drugs and chemicals can cause or suppress them. An improved model of oral tolerance to ovalbumin (OVA) in mice was developed to detect modulators of the tolerance and to apply it to s...

journal_title：Biological & pharmaceutical bulletin

authors： Kim JH,Ohsawa M

更新日期：1995-06-01 00:00:00

abstract：:As one of the adverse effects of oxaliplatin, a key agent in colon cancer chemotherapy, a taste disorder is a severe issue in a clinical situation because it decreases the quality of life of patients. However, there is little information on the mechanism underlying the oxaliplatin-induced taste disorder. Here, we exam...

journal_title：Biological & pharmaceutical bulletin

authors： Ohishi A,Nishida K,Yamanaka Y,Miyata A,Ikukawa A,Yabu M,Miyamoto K,Bansho S,Nagasawa K

更新日期：2016-01-01 00:00:00

abstract：:The oral administration of the water extract of Ginseng Radix (GR) to normal and epinephrine-induced hyperglycemic mice caused a significant decrease in the blood glucose level 4 h after its administration. The hepatic content of facilitative glucose transporter isoform 2, liver type glucose transporter (GLUT2) protei...

journal_title：Biological & pharmaceutical bulletin

authors： Ohnishi Y,Takagi S,Miura T,Usami M,Kako M,Ishihara E,Yano H,Tanigawa K,Seino Y

更新日期：1996-09-01 00:00:00

abstract：:Extracellular nucleotides have multiple biological actions in processes such as proliferation, differentiation, chemotaxis, and cytokine secretion through P2X receptors on the cell surface. To determine the biological activity of adenosine triphosphate (ATP) and the expression of P2 nucleotide receptors in murine bone...

journal_title：Biological & pharmaceutical bulletin

authors： Yoon MJ,Lee HJ,Lee YS,Kim JH,Park JK,Chang WK,Shin HC,Kim DK

更新日期：2007-04-01 00:00:00

abstract：:Sec61β is the β subunit of the Sec61 translocon and is responsible for expression and delivery of basolateral membrane proteins, including claudins, major constituents of tight junction (TJ). In the present study, the effect of Sec61β overexpression on TJ barrier functions in Madin-Darby canine kidney (MDCK) cells wer...

journal_title：Biological & pharmaceutical bulletin

authors： Washiyama M,Koizumi N,Fujii M,Watanabe Y

更新日期：2014-01-01 00:00:00

abstract：:The effect of methylcarbonylmethyl 2(S)-14-(4-guanidino-benzoyloxy) phenyl] propionate methanesulfonate (TT-S24) on experimental pancreatitis in rats was examined in comparison with that of camostat. TT-S24 showed a preventive effect on increases in plasma amylase activity and pancreatic weight induced by cerulein inj...

journal_title：Biological & pharmaceutical bulletin

authors： Tagami H,Abe S,Yoshida Y,Tanaka I,Kamei C

更新日期：1998-03-01 00:00:00

abstract：:Neuroinflammation has recently been implicated as an important mechanism responsible for the progression of neurodegenerative diseases. Activated microglia produce various proinflammatory cytokines and nitric oxide (NO) that are toxic to neurons. Thus, inhibition of microglial activation may alleviate neuroinflammator...

journal_title：Biological & pharmaceutical bulletin

authors： Ock J,Hong SH,Suk K

更新日期：2010-01-01 00:00:00