Suppression of formalin-induced nociception by cilnidipine, a voltage-dependent calcium channel blocker.

abstract：:To investigate the protective effect of ginsenoside Re (Re) against cerebral ischemia-reperfusion injury, adult male Wistar rats weighing 250-300 g were subjected to either sham surgery or middle cerebral artery occlusion (MCAO) for 2 h of brain ischemia and 2 h reperfusion. A fluorescence polarization assay was carri...

journal_title：Biological & pharmaceutical bulletin

authors： Zhou XM,Cao YL,Dou DQ

更新日期：2006-12-01 00:00:00

abstract：:We investigated the changes (increase or decrease in peak intensity) in the expression of plasma proteins in spontaneously diabetic WBN/Kob rats that were with complicated diabetic nephropathy, to determine multiple biomarkers in the plasma of diabetic rats. The present study using surface enhanced laser desorption/io...

journal_title：Biological & pharmaceutical bulletin

authors： Kiga C,Nakagawa T,Koizumi K,Sakurai H,Shibagaki Y,Ogawa K,Goto H,Saiki I

更新日期：2005-06-01 00:00:00

abstract：:To elucidate drug interaction between human immunodeficiency virus (HIV) protease inhibitors (PIs), the effect of indinavir (IDV) on the intestinal exsorption of other HIV PIs, amprenavir (APV), saquinavir (SQV) and nelfinavir (NFV) was investigated in rats using an in situ single perfusion method. IDV in the intestin...

journal_title：Biological & pharmaceutical bulletin

authors： Gao W,Kageyama M,Inoue Y,Tadano J,Fukumoto K,Fukushima K,Yamasaki D,Nishimura A,Yoshikawa Y,Shibata N,Takada K

更新日期：2003-02-01 00:00:00

abstract：:Eight new diterpenoids (1-8) have been isolated from the wood of Excoecaria agallocha (Euphorbiaceae) and their inhibitory effects on the induction of Epstein-Barr virus early antigen (EBV-EA) in Raji cells were examined to search for potent anti-tumor-promoters from natural resources. Of these compounds, the secolabd...

journal_title：Biological & pharmaceutical bulletin

authors： Konoshima T,Konishi T,Takasaki M,Yamazoe K,Tokuda H

更新日期：2001-12-01 00:00:00

abstract：:Apoptosis is the main form of β-cell death in diabetes. Ginseng has been used as an anti-diabetic herb for several thousand years in Asia with ginsenoside Rg1 and ginsenoside Rb1 as important active ingredients. In this study, we demonstrated ginsenoside Rg1 and Rb1 protect β-cells from high glucose/cytokine-induced p...

journal_title：Biological & pharmaceutical bulletin

authors： Chen F,Chen Y,Kang X,Zhou Z,Zhang Z,Liu D

更新日期：2012-01-01 00:00:00

abstract：:Potent ligands of peroxisome proliferator-activated receptor γ (PPARγ) such as thiazolidinediones (pioglitazone, troglitazone, etc.) improve insulin sensitivity by increasing the levels of adiponectin, an important adipocytokine associated with insulin sensitivity in adipose tissue. Several constituents from medicinal...

journal_title：Biological & pharmaceutical bulletin

authors： Matsuda H,Nakamura S,Yoshikawa M

更新日期：2014-01-01 00:00:00

abstract：:The effect of pH on the microenvironment surrounding 34Cys in human serum albumin (HSA) has been studied using acrylodan, a Cys-specific fluorescence probe. The reactivity of 34Cys with 5,5'-dithiobis(2-nitro benzoic acid) (DTNB) followed a pseudo-first-order reaction, and the increase in reactivity was dependent on p...

journal_title：Biological & pharmaceutical bulletin

authors： Narazaki R,Maruyama T,Otagiri M

更新日期：1997-04-01 00:00:00

abstract：:The effect of sesamol and 20 related compounds on the lipid peroxidation of liposomes induced by Fe(2)+, on the lipid peroxidation of rat liver microsomes induced by CCl(4) or NADPH and on the lipid peroxidation of mitochondria induced by ascorbate/Fe(2)+ were demonstrated. Consequently, sesamol and related compounds,...

journal_title：Biological & pharmaceutical bulletin

authors： Uchida M,Nakajin S,Toyoshima S,Shinoda M

更新日期：1996-04-01 00:00:00

abstract：:R(-)-Apomorphine is a dopamine agonist used for rescue management of motor function impairment associated with levodopa therapy in Parkinson's disease patients. The aim of this study was to examine the role of proton-coupled organic cation antiporter in uptake of R(-)-apomorphine and its S-enantiomer in human brain, u...

journal_title：Biological & pharmaceutical bulletin

authors： Okura T,Higuchi K,Kitamura A,Deguchi Y

更新日期：2014-01-01 00:00:00

abstract：:Radiation induces an important inflammatory response in the irradiated organs, characterized by leukocyte infiltration and vascular changes. Since adhesion molecules play an important role in facilitating the immune response at the inflammation sites, interfering with the expression of these molecules may be an import...

journal_title：Biological & pharmaceutical bulletin

authors： Ma ZC,Hong Q,Wang YG,Tan HL,Xiao CR,Liang QD,Cai SH,Gao Y

更新日期：2010-01-01 00:00:00

abstract：:In a previous study we found that 50% ethanol extracts of immature fruits of Citrus unshiu (satsuma mandarin) have anti-allergic effects against the Type I, II and IV allergic reactions. However, many adverse interactions between citrus fruit, especially grapefruit juice, and drugs have been reported due to the inhibi...

journal_title：Biological & pharmaceutical bulletin

authors： Fujita T,Kawase A,Niwa T,Tomohiro N,Masuda M,Matsuda H,Iwaki M

更新日期：2008-05-01 00:00:00

abstract：:Curcumin, a bioactive component in tumeric, has been shown to exert antioxidant, anti-inflammatory, anticarcinogenic, hepatoprotective, and neuroprotective effects, but the effects of curcumin against manganese (Mn)-mediated neurotoxicity have not been studied. This study examined the protective effects of curcumin on...

journal_title：Biological & pharmaceutical bulletin

authors： Park E,Chun HS

更新日期：2017-08-01 00:00:00

abstract：:Novel delivery technology using cell-penetrating peptides (CPPs) have recently shown their potential and are emerging as promising candidates for an oral protein and peptide delivery systems. As with for the development of any absorption enhancer that is meant to function across an epithelial layer covering a surface ...

journal_title：Biological & pharmaceutical bulletin

authors： Nielsen EJ,Kamei N,Takeda-Morishita M

更新日期：2015-01-01 00:00:00

abstract：:Restraint stressed rats were used as a model of Shanghuo and a global metabolic investigation of the effects of cantonese herbal tea (CHT) on the model rats was then performed by gas chromatography-mass spectrometry (GC/MS) metabonomics in an attempt to characterize the metabolic changes underlying such stress and any...

journal_title：Biological & pharmaceutical bulletin

authors： You R,Pang Q,Li L

更新日期：2014-01-01 00:00:00

abstract：:The purpose of this study was to determine the high-density lipoprotein (HDL)-associated alpha-tocopherol (alpha-tocopherol-HDL) transport and clarify the contribution of scavenger receptor class B, type I (SR-BI) to the uptake in the human retinal pigment epithelial cell line (ARPE-19 cells). [(3)H]alpha-Tocopherol-H...

journal_title：Biological & pharmaceutical bulletin

authors： Akanuma S,Yamamoto A,Okayasu S,Tachikawa M,Hosoya K

更新日期：2009-06-01 00:00:00

abstract：:The present study was designed to investigate the modulatory effects of rottlerin on ischemia reperfusion induced myocardial injury. Isolated rat hearts were exposed to 30 min of global ischemia followed by 120 min of reperfusion using Langendorff apparatus. Myocardial injury was assessed in the terms of infarct size,...

journal_title：Biological & pharmaceutical bulletin

authors： Kaur K,Singh M,Singh N,Jaggi AS

更新日期：2008-09-01 00:00:00

abstract：:The effects of Ginkgo biloba leaf extract (GBE), one of the most widely used herbal dietary supplements in Japan and the United States, on the pharmacokinetics of nifedipine (NFP), a typical probe of P450 (CYP) 3A, but not a substrate of the multidrug transporter P-glycoprotein (P-gp), were studied using rats. Simulta...

journal_title：Biological & pharmaceutical bulletin

authors： Yoshioka M,Ohnishi N,Sone N,Egami S,Takara K,Yokoyama T,Kuroda K

更新日期：2004-12-01 00:00:00

abstract：:Proteinase-activated receptor-2 (PAR2) may be an important regulator of skin mast cell function during cutaneous inflammation and hypersensitivity. However, little is known of the role of PAR2 in allergic pruritus, because mast cells, which are thought to be responsible for this symptom, can release a number of differ...

journal_title：Biological & pharmaceutical bulletin

authors： Zhu Y,Peng C,Xu JG,Liu YX,Zhu QG,Liu JY,Li FQ,Wu JH,Hu JH

更新日期：2009-07-01 00:00:00

abstract：:Turnera ulmifolia is a plant belonging to the family Turneraceae, popularly known in Brazil as chanana. This species is distributed from Guyana to southern Brazil where it is considered a weed. The plant occurs in tropical rain forest, fields, and gardens. Chanana tea is used in Brazilian folk medicine for the treatme...

journal_title：Biological & pharmaceutical bulletin

authors： Gracioso Jde S,Vilegas W,Hiruma-Lima CA,Souza Brito AR

更新日期：2002-04-01 00:00:00

abstract：:To search for possible anti-tumor-promoters, we carried out a primary screening of 21 cucurbitane triterpenoids using an in vitro assay system. Of these triterpenoids, scandenoside R6 (6), 23,24-dihydrocucurbitacin F (14), 25-acetyl-23,24-dihydrocucurbitacin F (15), 2-O-beta-D-glucopyranosyl-23,24-dihydrocucurbitacin ...

journal_title：Biological & pharmaceutical bulletin

authors： Konoshima T,Takasaki M,Tatsumoto T,Kozuka M,Kasai R,Tanaka O,Nie RL,Tokuda H,Nishino H,Iwashima A

更新日期：1994-05-01 00:00:00

abstract：:A previous study showed that macelignan extracted from Myristica fragrans has anti-inflammatory properties using hippocampal neuronal and primary microglial cells. Subsequently, a study using animals with chronic lipopolysaccharide (LPS) infusion into the brain showed that oral treatments of macelignan reduced the hip...

journal_title：Biological & pharmaceutical bulletin

authors： Ma J,Hwang YK,Cho WH,Han SH,Hwang JK,Han JS

更新日期：2009-06-01 00:00:00

abstract：:Tryptanthrin originally isolated from Isatis tinctoria L. has been characterized to have anti-inflammatory activities through the dual inhibition of cyclooxygenase-2 and 5-lipoxygenase mediated prostaglandin and leukotriene syntheses. To characterize phase I metabolite(s), tryptanthrin was incubated with rat liver mic...

journal_title：Biological & pharmaceutical bulletin

authors： Lee SK,Kim GH,Kim DH,Kim DH,Jahng Y,Jeong TC

更新日期：2007-10-01 00:00:00

abstract：:All living organisms on earth are composed of L-amino acids and D-sugars. Therefore the presence and function of D-amino acids in living organisms have not been studied. Recently, however, D-aspartic acid (D-Asp) which is a D-amino acid, has been detected in various proteins from human tissue samples such as eye lens,...

journal_title：Biological & pharmaceutical bulletin

authors： Fujii N

更新日期：2005-09-01 00:00:00

abstract：:The promoting effect of d-limonene and l-menthol on the percutaneous absorption of nonionized and ionized diclofenac (DF) was investigated employing a pretreatment method. After the pretreatment of hairless rat skin with an ethanol buffer solution containing terpenes, the permeation study was performed in vitro. The p...

journal_title：Biological & pharmaceutical bulletin

authors： Obata Y,Takayama K,Maitani Y,Machida Y,Nagai T

更新日期：1993-03-01 00:00:00

abstract：:Reprogramming differentiated cells toward stem cells may have long-term applications in stem-cell research and regenerative medicine. Here we report on the dedifferentiation of human epidermal keratinocytes into their precursor cells in vitro with basic fibroblast growth factor (bFGF) but not external gene interventio...

journal_title：Biological & pharmaceutical bulletin

authors： Sun X,Fu X,Han W,Zhao Y,Liu H,Sheng Z

更新日期：2011-01-01 00:00:00

abstract：:Doxorubicin, a very potent and often used anti-cancer drug, is largely limited due to the dose-related toxic effects. The present study investigated whether berberine, a natural product alkaloid, can reduce the liver injury induced by doxorubicin. Mice of either gender were randomly divided into four groups: the contr...

journal_title：Biological & pharmaceutical bulletin

authors： Zhao X,Zhang J,Tong N,Chen Y,Luo Y

更新日期：2012-01-01 00:00:00

abstract：:The effects of the angiotensin II type 1 receptor antagonist YM358 on blood pressure were compared to those of the angiotensin converting enzyme inhibitor enalapril in one-kidney, one-clip renal hypertensive rats (1K1C RHR), two-kidney, one-clip renal hypertensive rats (2K1C RHR) and normotensive rats (NTR). Additiona...

journal_title：Biological & pharmaceutical bulletin

authors： Tokioka T,Shibasaki M,Fujimori A,Matsuda-Satoh Y,Uchida W,Inagaki O,Yanagisawa I

更新日期：2000-02-01 00:00:00

abstract：:The effects of the plant isoflavones, daidzin and genistin, on bone loss in ovariectomized (ovx) rats fed a calcium-deficient diet were investigated. Daidzin and genistin were orally administered to ovx rats for 4 weeks. The femurs of these rats showed significantly lower density, strength (breaking forces), ash weigh...

journal_title：Biological & pharmaceutical bulletin

authors： Ishida H,Uesugi T,Hirai K,Toda T,Nukaya H,Yokotsuka K,Tsuji K

更新日期：1998-01-01 00:00:00

abstract：:Effects of certain antiallergic drugs on experimental conjunctivitis were studied with guinea pigs. Chlorpheniramine, ketotifen and levocabastine were effective in inhibiting histamine- and antigen-induced conjunctivitis in guinea pigs. By contrast, amlexanox was only effective in inhibiting antigen-induced conjunctiv...

journal_title：Biological & pharmaceutical bulletin

authors： Kamei C,Izushi K,Nakamura S

更新日期：1995-11-01 00:00:00

abstract：:Two known diarylheptanoids, oregonin (1), (5S)-1,7-bis-(3,4-dihydroxyphenyl)-heptane-3-one-5-O-beta-D-xylopyranosi de and hirsutanonol (2), (5S)-1,7-bis-(3,4-dihydroxyphenyl)-5-hydroxyheptane-3-one isolated from the bark of Alnus hirsuta var. sibirica, showed significant inhibitory effects on 12-O-tetradecanoylphorbol...

journal_title：Biological & pharmaceutical bulletin

authors： Lee MW,Kim JH,Jeong DW,Ahn KH,Toh SH,Surh YJ

更新日期：2000-04-01 00:00:00