Abstract:
:Restraint stressed rats were used as a model of Shanghuo and a global metabolic investigation of the effects of cantonese herbal tea (CHT) on the model rats was then performed by gas chromatography-mass spectrometry (GC/MS) metabonomics in an attempt to characterize the metabolic changes underlying such stress and any protective effects of CHT. Serum and urinary GC/MS profiling of rats exposed to 14 d of successive restraint stress for 6 h every day revealed dramatic changes as evidenced by downregulation of tryptophan metabolism, amino acid metabolism, energy metabolism and perturbation of gut microbiota composition. The administration of CHT to restraint-stressed rats ameliorated the symptoms by upregulation of energy metabolism, amino acid metabolism and modulation of the gut microbiota composition. In addition, CHT-treated rats exhibited a higher level of antioxidant production and a reduction in cholesterol level. The lower level of tryptophan metabolism caused by restraint stress, however, was not completely restored after CHT intake, indicating that the tea did not substantially improve this element. This research indicated that CHT intervention modeled Shanghuo symptoms of restraint stress through partial regulation of the perturbed metabolic pathways.
journal_name
Biol Pharm Bulljournal_title
Biological & pharmaceutical bulletinauthors
You R,Pang Q,Li Ldoi
10.1248/bpb.b14-00203subject
Has Abstractpub_date
2014-01-01 00:00:00pages
1466-74issue
9eissn
0918-6158issn
1347-5215pii
DN/JST.JSTAGE/bpb/b14-00203journal_volume
37pub_type
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