Improving the stability of short hairpin RNA against fetal bovine serum using the third double-stranded RNA-binding domain from Staufen protein.

abstract：:The adsorption characteristics of eight adsorbents, cholestyramine, colestimide, aluminum silicate, sucralfate, aluminum hydroxide, calcium polystyrene sulfonate, carbon sphere and medicinal carbon, on the drugs such as methotrexate, antidepressants, mizoribine and ciprofloxacin hydrochloride were investigated in vitr...

journal_title：Biological & pharmaceutical bulletin

authors： Toyoguchi T,Ebihara M,Ojima F,Hosoya J,Nakagawa Y

更新日期：2005-05-01 00:00:00

abstract：:Phenolic compounds, in general, exhibit antioxidant and antibacterial activities. We studied antimicrobial activity of the phenolic antioxidants, propofol (2,6-diisopropylphenol), tocopherol, eugenol, butylated hydroxyanisole (BHA), and several of their dimer compounds. Dipropofol (dimer of 2,6-diisopropylphenol) show...

journal_title：Biological & pharmaceutical bulletin

authors： Ogata M,Tutumimoto Sato K,Kunikane T,Oka K,Seki M,Urano S,Hiramatsu K,Endo T

更新日期：2005-06-01 00:00:00

abstract：:To find new antipruritic herbal medicines for pruritus, we screened the methanol extracts of seven herbal medicines which have been used to treat dermatologic diseases, testing them on mouse models of acute and chronic itch. When administrated perorally (p.o.) at a dose of 200 mg/kg, methanol extracts of Sophora flave...

journal_title：Biological & pharmaceutical bulletin

authors： Yamaguchi-Miyamoto T,Kawasuji T,Kuraishi Y,Suzuki H

更新日期：2003-05-01 00:00:00

abstract：:In Japan, an increasing number of people suffer from pollenosis, a typical atopic disease. Japanese cedar (Cryptomeria japonica) pollen is the most common allergen that causes pollenosis. Although Cry j 1 and Cry j 2 are the common allergenic proteins contained in the pollen, there is a small population of patients wh...

journal_title：Biological & pharmaceutical bulletin

authors： Matsumura D,Nabe T,Mizutani N,Fujii M,Kohno S

更新日期：2006-06-01 00:00:00

abstract：:A series of anthracene derivatives have been synthesized, and their potential individual cytotoxicity was evaluated using Jurkat T cells and peripheral blood mononuclear cells (PBMCs) in vitro. These compounds, except for 2l, showed less cytotoxicity in PBMCs than mitoxantrone. We also analyzed the antiproliferative a...

journal_title：Biological & pharmaceutical bulletin

authors： Chen RF,Chou CL,Wang MR,Chen CF,Liao JF,Ho LK,Tao CW,Huang HS

更新日期：2004-06-01 00:00:00

abstract：:Bee pollen consists of floral pollen mixed with bee secretions and nectar. It has been considered as a functional food and has different kinds of biologically active ingredients, such as flavonoids, polyphenols, phytosterols and minerals. However, its function in cognition has yet been investigated. In the present stu...

journal_title：Biological & pharmaceutical bulletin

authors： Liao Y,Bae HJ,Zhang J,Kwon Y,Koo B,Jung IH,Kim HM,Park JH,Lew JH,Ryu JH

更新日期：2019-01-01 00:00:00

abstract：:We investigated the efficacy of clonazepam as an antiemetic in cisplatin-based chemotherapy for lung cancer. Seven patients experienced cisplatin-induced vomiting despite antiemetic therapy including 5-hydroxytryptamine(3) (5-HT(3)) antagonist and dexamethasone. Therefore, the antiemetic therapy including clonazepam, ...

journal_title：Biological & pharmaceutical bulletin

authors： Hayashi M,Takao Y,Hata C,Teramachi H,Tsuchiya T

更新日期：2010-01-01 00:00:00

abstract：:Beta-D-Xylosidase (EC 3.2.1.37) has been purified from ginsenoside Ra-metabolizing Bifidobacterium breve K-110, which was isolated from human intestinal microflora. beta-D-Xylosidase was purified to apparent homogeneity by a combination of ammonium sulfate precipitation, QAE-cellulose, butyl-toyopearl, hydroxyapatit a...

journal_title：Biological & pharmaceutical bulletin

authors： Shin HY,Lee JH,Lee JY,Han YO,Han MJ,Kim DH

更新日期：2003-08-01 00:00:00

abstract：:Since grape extract (GE) contains oligomeric proanthocyanidins and numerous polyphenols, dietary GE supplements may exert protective effects against various diseases. The present study investigated the pharmacological effects of GE derived from Chardonnay in vitro and in vivo. GE (100 µg/mL) completely inhibited tumor...

journal_title：Biological & pharmaceutical bulletin

authors： Ohkita M,Hayashi H,Ito K,Shigematsu N,Tanaka R,Tsutsui H,Matsumura Y

更新日期：2019-01-01 00:00:00

abstract：:Spermatogenesis associated 4 (SPATA4) is a testis-specific gene first cloned by our laboratory, and plays an important role in maintaining the physiological function of germ cells. Accumulated evidence suggests that SPATA4 might be associated with apoptosis. Here we established HeLa cells that stably expressed SPATA4 ...

journal_title：Biological & pharmaceutical bulletin

authors： Jiang J,Li L,Xie M,Fuji R,Liu S,Yin X,Li G,Wang Z

更新日期：2015-01-01 00:00:00

abstract：:We reported previously that monkey embryonic stem cells (ESCs) were differentiated into hepatocytes by formation of embryoid bodies (EBs). However, this EB formation method is not always efficient for assays using a large number of samples simultaneously. A dispersion culture system, one of the differentiation methods...

journal_title：Biological & pharmaceutical bulletin

authors： Maruyama J,Matsunaga T,Yamaori S,Sakamoto S,Kamada N,Nakamura K,Kikuchi S,Ohmori S

更新日期：2013-01-01 00:00:00

abstract：:Di-n-butyl phthalate (DBP), a phthalate ester, has been shown to have an adjuvant effect on fluorescein isothiocyanate (FITC)-induced contact hypersensitivity (CHS) mouse models. Di-n-butyl maleate (DBM), widely used as a plasticizer for industrial application, has been reported to cause dermatitis in humans. DBM is a...

journal_title：Biological & pharmaceutical bulletin

authors： Matsuoka T,Kurohane K,Suzuki W,Ogawa E,Kobayashi K,Imai Y

更新日期：2016-01-01 00:00:00

abstract：:Early diagnosis of Niemann-Pick diseases (NPDs) is important for better prognosis of such diseases. N-Palmitoyl-O-phosphocholine-serine (PPCS) is a new NPD biomarker possessing high sensitivity, and with its combination with sphingosylphosphocholine (SPC) it may be possible to distinguish NPD-C from NPD-A/B. In this s...

journal_title：Biological & pharmaceutical bulletin

authors： Iwahori A,Maekawa M,Narita A,Kato A,Sato T,Ogura J,Sato Y,Kikuchi M,Noguchi A,Higaki K,Okuyama T,Takahashi T,Eto Y,Mano N

更新日期：2020-09-01 00:00:00

abstract：:Behavioral and psychological symptoms of dementia (BPSD) are commonly seen in patients with Alzheimer's disease (AD) and other forms of senile dementia. BPSD have a serious impact on the quality of life of dementia patients, as well as on that of their caregivers. However, effective drug therapy for BPSD has not been ...

journal_title：Biological & pharmaceutical bulletin

authors： Uchida N,Egashira N,Iwasaki K,Ishibashi A,Tashiro R,Nogami A,Manome N,Abe M,Takasaki K,Mishima K,Takata J,Oishi R,Nishimura R,Fujiwara M

更新日期：2009-03-01 00:00:00

abstract：:Previous reports have indicated that isosteviol sodium (STVNa) has neuroprotective effects against acute focal cerebral ischemia in rats; however, the exact underlying mechanisms and ideal treatment paradigm are not known. To find a reasonable method for STVNa administration and to determine its possible therapeutic m...

journal_title：Biological & pharmaceutical bulletin

authors： Zhang H,Sun X,Xie Y,Tian F,Hu H,Tan W

更新日期：2018-01-01 00:00:00

abstract：:Oral tolerance is thought to have a role in preventing allergic responses and immune-mediated diseases. Modulation of this tolerance by drugs and chemicals can cause or suppress them. An improved model of oral tolerance to ovalbumin (OVA) in mice was developed to detect modulators of the tolerance and to apply it to s...

journal_title：Biological & pharmaceutical bulletin

authors： Kim JH,Ohsawa M

更新日期：1995-06-01 00:00:00

abstract：:Bepridil hydrochloride is used for treatment of atrial fibrillation (AF) in Japan. We investigated the relationship between plasma concentrations of bepridil just before dosing (Cbep) and its clinical efficacy in Japanese patients (n=36) with AF. Patients were treated orally with 100, 150 or 200 mg/d bepridil. Cbep we...

journal_title：Biological & pharmaceutical bulletin

authors： Noda K,Gotoh Y,Tanioka S,Narayama Y,Kobayashi M,Iwai S,Katoh N,Tadano K

更新日期：2012-01-01 00:00:00

abstract：:We investigated whether endogenous nitric oxide (NO) has a role as an inhibitory modulator of norepinephrine (NE)- and angiotensin II (Ang II)-induced renal effects in anesthetized dogs. Intrarenal arterial infusion of NE (100 ng/kg/min) or Ang II (10 ng/kg/min) decreased renal blood flow (RBF), glomerular filtration ...

journal_title：Biological & pharmaceutical bulletin

authors： Matsumura Y,Egi Y,Maekawa H,Miura A,Murata S,Morimoto S

更新日期：1995-04-01 00:00:00

abstract：:The aim of this study was to determine the stimulatory effects of Maillard reaction, a non-enzymatic browning reaction on the expression of pro-inflammatory cytokines and phagocytic activity induced by whey protein concentrate (WPC). Glycated WPC (G-WPC) was prepared by a reaction between WPC and the lactose it contai...

journal_title：Biological & pharmaceutical bulletin

authors： Chun SH,Lee HA,Lee KB,Kim SH,Park KY,Lee KW

更新日期：2016-01-01 00:00:00

abstract：:Baculovirus vectors (BVs) enable safe and efficient gene delivery to mammalian cells and are useful in a wide range of applications, including gene therapy and in vivo analysis of gene functions. We previously developed BVs expressing malaria sporozoite surface proteins for targeting liver cells or hepatocytes. Howeve...

journal_title：Biological & pharmaceutical bulletin

authors： Kawai Y,Kawabata C,Sakaguchi M,Tamura T

更新日期：2018-01-01 00:00:00

abstract：:To enhance tumor magnetic resonance imaging (MRI) signals via the selective accumulation of contrast agents, we prepared folate-modified gadolinium-lipid-based nanoparticles as MRI contrast agents. Folate-modified nanoparticles were comprised of polyethylene glycol (PEG)-lipid, gadolinium diethylenetriamine pentaaceti...

journal_title：Biological & pharmaceutical bulletin

authors： Nakamura T,Kawano K,Shiraishi K,Yokoyama M,Maitani Y

更新日期：2014-01-01 00:00:00

abstract：:The present study was aimed at kinetically characterizing the carrier-mediated transport systems for D-glucose and taurocholate in the rat colon, compared with their respective counterparts in the small intestine. The transport of these compounds was evaluated by measuring the initial uptake into everted intestinal ti...

journal_title：Biological & pharmaceutical bulletin

authors： Tomei S,Torimoto M,Hayashi Y,Inoue K,Yuasa H,Watanabe J

更新日期：2003-06-01 00:00:00

abstract：:The effect of Laennec, a hydrolyte of human placenta, on immune-mediated liver injury was investigated in vivo and in vitro in murine. Vena caudalis administration of concanavalin A (Con A) was employed to establish an in vivo liver-injury model, and in vitro hepatotoxicity was induced by 8 h interaction between Con A...

journal_title：Biological & pharmaceutical bulletin

authors： Wu J,Yang T,Wang C,Liu Q,Yao J,Sun H,Kaku T,Liu KX

更新日期：2008-11-01 00:00:00

abstract：:It has been suggested that the activities of type IV collagenase and/or ectopeptidases possessed by malignant cells are related to their metastatic potentials. In the present study, we examined the activities of three aminopeptidases, two serine proteases, as well as type IV collagenase, in three kinds of cell lines o...

journal_title：Biological & pharmaceutical bulletin

authors： Funahashi T,Shimamura M,Kocha T,Fukuda T,Aoyagi T

更新日期：1994-08-01 00:00:00

abstract：:Many plant-derived flavonoids including quercetin exhibit antioxidant and antiinflammatory properties. Proinflammatory cytokines and oxidative stress play an important role in acute pancreatitis. This study aimed to evaluate the effect of quercetin on cerulein-induced acute pancreatitis in mice. Animal groups were pre...

journal_title：Biological & pharmaceutical bulletin

authors： Carvalho KM,Morais TC,de Melo TS,de Castro Brito GA,de Andrade GM,Rao VS,Santos FA

更新日期：2010-01-01 00:00:00

abstract：:Morinda citrifolia L., known as noni, originated from Indonesia exhibits various pharmacological activities including anti-inflammatory properties. However, the validity of noni fruit juice as a treatment for rheumatoid arthritis (RA), an autoimmune disorder, has not been confirmed yet. Therefore, the main purpose of ...

journal_title：Biological & pharmaceutical bulletin

authors： Kustiarini DA,Nishigaki T,Kanno H,To H

更新日期：2019-01-01 00:00:00

abstract：:In addition to regulation of normal cell functions, hepatocyte growth factor (HGF) has also been shown to be involved in malignant cell transformation and in growth, invasion and metastasis in cancer cells. Inhibitors of HGF production have a potential for interfering with malignant cell transformation and progression...

journal_title：Biological & pharmaceutical bulletin

authors： Motoki T,Takami Y,Yagi Y,Tai A,Yamamoto I,Gohda E

更新日期：2005-02-01 00:00:00

abstract：:Previous studies show that the combined method using thrombolytic drugs and ultrasonic irradiation enhances the effect of thrombolysis in in vitro and in vivo experiments. However, the mechanism of the clot lysis was unclear. In previous studies the evaluation of the clot lysis effect was determined by the rate of dec...

journal_title：Biological & pharmaceutical bulletin

authors： Kimura M,Iijima S,Kobayashi K,Furuhata H

更新日期：1994-01-01 00:00:00

abstract：:Oligodeoxyribonucleotides containing 8-hydroxyguanine and 2-hydroxyadenine, purine lesions produced in cells by reactive oxygen species, were synthesized and inserted into vector DNAs to introduce each lesion at a predetermined site. The manipulated DNAs were transfected into living cells, and the mutants induced by e...

journal_title：Biological & pharmaceutical bulletin

authors： Kamiya H

更新日期：2004-04-01 00:00:00

abstract：:Nanoparticles are used in many fields and in everyday products. Silver nanoparticles are the most frequently used nanoparticles; for example, in food-related products, owing to their antibacterial activity. However, it has been pointed out that they might have unexpected biological effects, and evaluation of their eff...

journal_title：Biological & pharmaceutical bulletin

authors： Maki A,Lin Y,Aoyama M,Sato K,Gao JQ,Tsujino H,Nagano K,Higashisaka K,Tsutsumi Y

更新日期：2020-01-01 00:00:00