Protective Effects of Curcumin on Manganese-Induced BV-2 Microglial Cell Death.

abstract：:The effect of extracellular calcium on the intracellular calcium level of newborn rat skin basal cells was examined. The intracellular calcium level of basal cells was affected by the extracellular calcium concentration on culture of the cells on a collagen-coated filter, but not on a plate. The intracellular calcium ...

journal_title：Biological & pharmaceutical bulletin

authors： Ohkura K,Hori H,Terada H

更新日期：1998-01-01 00:00:00

abstract：:Hyphal growth of Candida albicans was observed at neutral condition, whereas the yeast growth was increased below pH 5. Eight out of 12 strains of C. albicans grow in hyphal form at pH 7, and hyphal formation was inhibited in all strains at pH 4. The addition of GMP, an alternative oxidase (AOX) activator, induced the...

journal_title：Biological & pharmaceutical bulletin

authors： Konno N,Ishii M,Nagai A,Watanabe T,Ogasawara A,Mikami T,Matsumoto T

更新日期：2006-05-01 00:00:00

abstract：:The purpose of this review is to summarize the recent studies examining the expression of leukotrienes (LTs) and their receptors in nociceptive pathways, and their crucial roles in pathological pain conditions. LTs belong to a large family of lipid mediators, termed eicosanoids, which are derived from arachidonic acid...

journal_title：Biological & pharmaceutical bulletin

authors： Noguchi K,Okubo M

更新日期：2011-01-01 00:00:00

abstract：:Hydroxylysylpyridinoline (HP), an intermolecular cross-linking amino acid, is present only in bone and cartilage collagen. We examined urinary HP levels in order to assess bone collagen metabolism using HPLC. Urinary HP excretion levels (nmol/mmol creatinine) of healthy control groups gradually increased with aging. U...

journal_title：Biological & pharmaceutical bulletin

authors： Yoshihara K,Nemoto S,Nagata M

更新日期：1994-06-01 00:00:00

abstract：:Tryptanthrin originally isolated from Isatis tinctoria L. has been characterized to have anti-inflammatory activities through the dual inhibition of cyclooxygenase-2 and 5-lipoxygenase mediated prostaglandin and leukotriene syntheses. To characterize phase I metabolite(s), tryptanthrin was incubated with rat liver mic...

journal_title：Biological & pharmaceutical bulletin

authors： Lee SK,Kim GH,Kim DH,Kim DH,Jahng Y,Jeong TC

更新日期：2007-10-01 00:00:00

abstract：:Spontaneous transfer of protein from either influenza virus-infected or uninfected cells to dimyristoylphosphatidylcholine (DMPC) liposomes was examined. The amount of transferred protein of liposomes incubated with influenza virus-infected cells (I-lipo) was more than that of liposomes incubated with uninfected cells...

journal_title：Biological & pharmaceutical bulletin

authors： Kogure K,Itoh M,Hayashi K,Ueno M

更新日期：1995-08-01 00:00:00

abstract：:The effects of the plant isoflavones, daidzin and genistin, on bone loss in ovariectomized (ovx) rats fed a calcium-deficient diet were investigated. Daidzin and genistin were orally administered to ovx rats for 4 weeks. The femurs of these rats showed significantly lower density, strength (breaking forces), ash weigh...

journal_title：Biological & pharmaceutical bulletin

authors： Ishida H,Uesugi T,Hirai K,Toda T,Nukaya H,Yokotsuka K,Tsuji K

更新日期：1998-01-01 00:00:00

abstract：:When kalopanaxsaponin K (KPK) from Kalopanax pictus was incubated for 24 h at 37 degrees C with human intestinal microflora, KPK was mainly metabolized to kalopanaxsaponin I (KPI) via kalopanaxsaponin H (KPH) rather than via kalopanaxsaponin J (KPJ), and then transformed to kalopanaxsaponin A (KPA) and hederagenin. Ba...

journal_title：Biological & pharmaceutical bulletin

authors： Kim DH,Bae EA,Han MJ,Park HJ,Choi JW

更新日期：2002-01-01 00:00:00

abstract：:A new HPLC method has been developed for measuring clonazepam (CZP) in plasma, using a reversed-phase non-porous silica column packed with 2 microm particles. CZP in plasma was first purified with a column extraction technique and injected onto a non-porous silica column. The calibration curve was linear from 5-200 ng...

journal_title：Biological & pharmaceutical bulletin

authors： Nakamura M,Fukawa K,Sugiyama T,Katagiri Y

更新日期：2004-06-01 00:00:00

abstract：:Postprandial hypertriglyceridemia, as well as postprandial hyperglycemia, are important factors contributing to the development of cardiovascular disease in patients with type 2 diabetes. Nateglinide is a recently approved antidiabetic that suppresses postprandial hyperglycemia by stimulating the early phase of insuli...

journal_title：Biological & pharmaceutical bulletin

authors： Mine T,Miura K,Kitahara Y,Okano A,Kawamori R

更新日期：2002-11-01 00:00:00

abstract：:Onset of cancer and neurodegenerative disease occurs by abnormal cell growth and neuronal cell death, respectively, and the number of patients with both diseases has been increasing in parallel with an increase in mean lifetime, especially in developed countries. Although both diseases are sporadic, about 10% of the d...

journal_title：Biological & pharmaceutical bulletin

authors： Ariga H

更新日期：2015-01-01 00:00:00

abstract：:We aimed to identify a novel flavonoid from the in-house natural products to suppress matrix metalloproteases (MMPs), which is responsible for degradation of collagen and other extracellular matrix proteins. Total eight natural products were screened for identification of a novel MMP-9 suppressor using MMP-9 reporter ...

journal_title：Biological & pharmaceutical bulletin

authors： Kim JJ,Korm S,Kim WS,Kim OS,Lee JS,Min HG,Chin YW,Cha HJ

更新日期：2014-01-01 00:00:00

abstract：:(1-->3)-beta-D-Glucans exhibit a variety of biological and immunopharmacological activities, and the degree of these activities depends on the nature of the individual glucans e.q. molecular weight, degree of branching and conformation. Based on the generally accepted evidence that the conformation of Sonifilan (SPG) ...

journal_title：Biological & pharmaceutical bulletin

authors： Miura NN,Ohno N,Adachi Y,Aketagawa J,Tamura H,Tanaka S,Yadomae T

更新日期：1995-01-01 00:00:00

abstract：:A protein was purified from rabbit seminal plasma using preparative acrylamide disc electrophoresis, ammonium sulfate precipitation and gel filtration. The protein inhibited the in vitro fertilization of mouse ova inseminated with epididymal sperm and with capacitated sperm. The inhibition was not observed, however, w...

journal_title：Biological & pharmaceutical bulletin

authors： Okabe M,Kishi Y,Ying X,Kohama Y,Mimura T,Li SS

更新日期：1993-05-01 00:00:00

abstract：:Endothelin-1 (ET-1) has been reported to be expressed in human epidermis at both the gene and protein levels. ET-1 plays a pivotal role in ultraviolet B (UVB)-induced pigmentation due to its accentuated secretion after UVB irradiation and its function as a mitogen and as a melanogen for human melanocytes. We have rece...

journal_title：Biological & pharmaceutical bulletin

authors： Hachiya A,Kobayashi A,Ohuchi A,Kitahara T,Takema Y

更新日期：2001-06-01 00:00:00

abstract：:We have previously proposed a novel deconvolution method, which can estimate first-pass metabolism of orally administered drugs. In the present study, we examined whether this deconvolution method is useful for evaluating oral dosage forms. The absorption and first-pass metabolism of orally administered aspirin formul...

journal_title：Biological & pharmaceutical bulletin

authors： Wu X,Yamashita F,Hashida M

更新日期：1999-11-01 00:00:00

abstract：:The inhibitory effects of various sulfated compounds on the activities of sialidases purified from porcine liver and human placenta were investigated. Among the sulfated compounds tested, heparin, dextran sulfate, condroitin sulfates and sulfatide significantly inhibited the 4-methylumbelliferyl-alpha-N-acetylneuramin...

journal_title：Biological & pharmaceutical bulletin

authors： Nagaoka M,Shiraishi T,Furuhata K,Uda Y

更新日期：1998-11-01 00:00:00

abstract：:Continuous oral administration of the acidic polysaccharide (TAP) solution (0.5 g/l) and the TAP-H (degradation products of TAP) solution (1.5 g/l) instead of water for 10 weeks were found to depress plasma glucose increases in diabetes using genetically non-insulin-dependent diabetic model (KK-Ay) mice. TAP and TAP-H...

journal_title：Biological & pharmaceutical bulletin

authors： Kiho T,Kochi M,Usui S,Hirano K,Aizawa K,Inakuma T

更新日期：2001-12-01 00:00:00

abstract：:The role of leukotriene B4 (LTB4) in leukocyte infiltration in zymosan-induced rat pleurisy was investigated by studying the effects of 5-lipoxygenase inhibitors, T-0757 and AA-861, and a cyclooxygenase inhibitor, indomethacin, on leukocyte infiltration and LTB4 levels in the inflammatory exudate of rat pleurisy induc...

journal_title：Biological & pharmaceutical bulletin

authors： Kikuchi M,Tsuzurahara K,Naito K

更新日期：1995-09-01 00:00:00

abstract：:Calreticulin (CRT) and calnexin (CNX), homologous major chaperones in the endoplasmic reticulum (ER), are known to translocate to the cell surface in response to chemotherapeutic agents, such as mitoxantrone (MIT), and cellular stresses, including apoptosis. Cell surface CRT (ecto-CRT) is relevant to the phagocytic up...

journal_title：Biological & pharmaceutical bulletin

authors： Azuma Y,Suzuki K,Higai K,Matsumoto K,Tada S

更新日期：2020-10-01 00:00:00

abstract：:Formation of DNA breaking hydroxyfuranone and hydroxypyranone derivatives in the Maillard reaction of glucose and bovine serum albumin (BSA) under physiological conditions was investigated. A mixture of glucose and BSA was incubated at 37 degrees C in water or in 1 M phosphate buffer (pH 7.4). The ethyl acetate/2-prop...

journal_title：Biological & pharmaceutical bulletin

authors： Hiramoto K,Ishihara A,Sakui N,Daishima S,Kikugawa K

更新日期：1998-02-01 00:00:00

abstract：:Berberine is an isoquinoline plant alkaloid with a long history of being used for the treatment of many diseases in Chinese herbal medicine. Berberine has a wide range of biochemical and pharmacological effects, including antitumor activities, but its mechanism of action is not clearly understood. In this study, we in...

journal_title：Biological & pharmaceutical bulletin

authors： Eom KS,Hong JM,Youn MJ,So HS,Park R,Kim JM,Kim TY

更新日期：2008-04-01 00:00:00

abstract：:Formulations consisting of egg albumin, indomethacin (IND), and olive oil or fatty acids, were prepared by vigorous stirring using a high-speed homogenizer and subsequent freeze-drying. To confirm the anti-inflammatory properties and ulcerogenic effects of the formulations, we examined the action of the formulations o...

journal_title：Biological & pharmaceutical bulletin

authors： Tsuji Y,Kakegawa H,Miyataka H,Matsumoto H,Satoh T

更新日期：1993-07-01 00:00:00

abstract：:Joint hypermobility syndrome (JHS) (also termed hypermobility type Ehlers-Danlos syndrome, hEDS) is a heritable connective tissue disorder that is characterized by generalized joint hypermobility, chronic pain, fatigue, and minor skin changes. Initially, it was reported that there is a small subset of patients with JH...

journal_title：Biological & pharmaceutical bulletin

authors： Yamada K,Watanabe A,Takeshita H,Fujita A,Miyake N,Matsumoto N,Matsumoto KI

更新日期：2019-01-01 00:00:00

abstract：:The MeOH and water extracts of the Netherlands propolis were tested for their inhibitory activity toward nitric oxide (NO) production in lipopolysaccharide (LPS)-activated murine macrophage-like J774.1 cells. Both of the extract possessed significant NO inhibitory activity with IC(50) values of 23.8 and 51.5 microg/ml...

journal_title：Biological & pharmaceutical bulletin

authors： Nagaoka T,Banskota AH,Tezuka Y,Midorikawa K,Matsushige K,Kadota S

更新日期：2003-04-01 00:00:00

abstract：:Eight new diterpenoids (1-8) have been isolated from the wood of Excoecaria agallocha (Euphorbiaceae) and their inhibitory effects on the induction of Epstein-Barr virus early antigen (EBV-EA) in Raji cells were examined to search for potent anti-tumor-promoters from natural resources. Of these compounds, the secolabd...

journal_title：Biological & pharmaceutical bulletin

authors： Konoshima T,Konishi T,Takasaki M,Yamazoe K,Tokuda H

更新日期：2001-12-01 00:00:00

abstract：:The effects of nefiracetam on the cerebral adenylyl cyclase (AC) activity of animals with microsphere embolism-induced memory dysfunction were examined. Sustained cerebral ischemia in the right cerebral hemisphere was induced by an injection of microspheres into the right internal carotid artery of rats. To examine le...

journal_title：Biological & pharmaceutical bulletin

authors： Takeo S,Miyake-Takagi K,Kikuchi K,Ando T,Ichikawa T,Omino K,Kajihara H,Takagi N,Tanonaka K

更新日期：2003-03-01 00:00:00

abstract：:The present study has been designed to investigate the modulatory role of dichlorobenzamil a Na(+)/Ca(2+) exchanger inhibitor in ischemic post-conditioning-induced neuroprotection in mice. Bilateral carotid artery occlusion followed by reperfusion, produced a significant rise in cerebral infarct size along with impair...

journal_title：Biological & pharmaceutical bulletin

authors： Kaur H,Jaggi AS,Singh N

更新日期：2010-01-01 00:00:00

abstract：:DJ-1 was first identified as a novel candidate of an oncogene product in cooperation with an activated ras, and DJ-1 was later found to be a positive regulator of the androgen receptor (AR) transcription activity that was repressed by PIASxalpha. DJ-1 was also found to be an infertility-related protein that was reduce...

journal_title：Biological & pharmaceutical bulletin

authors： Taira T,Iguchi-Ariga SM,Ariga H

更新日期：2004-04-01 00:00:00

abstract：:Calcium channel blockers have become important tools in the treatment of cardiovascular disorders and other diseases. Hybridization of well established calcium antagonist subclasses was an attempt to optimize their pharmacological profile. The intension of this study was to investigate the electrophysiological propert...

journal_title：Biological & pharmaceutical bulletin

authors： Schade B,Erker T,Weber M,Studenik C

更新日期：2004-09-01 00:00:00