Measurement of Serum Tenascin-X in Joint Hypermobility Syndrome Patients.

abstract：:4-Acetyltropolone, a minor component of Thujopsis dolabrata SIEB. et Zucc. hondai MAKINO, showed antimicrobial activity against various microorganisms including wood-rotting fungi, a phytogrowth-inhibitory effect with chlorophyll biosynthesis inhibition, cytotoxic effect and inhibitory activity on metalloproteases. Th...

journal_title：Biological & pharmaceutical bulletin

authors： Morita Y,Matsumura E,Tsujibo H,Yasuda M,Okabe T,Sakagami Y,Kumeda Y,Ishida N,Inamor Y

更新日期：2002-08-01 00:00:00

abstract：:Lysosomal trapping was investigated in the retinal capillary endothelial cells that are responsible for the inner blood-retinal barrier (BRB) using LysoTracker(®) Red (LTR). Using confocal microscopy on TR-iBRB2 cells, an in vitro model of the inner BRB, the presence of lysosomal trapping in retinal capillary endothel...

journal_title：Biological & pharmaceutical bulletin

authors： Kubo Y,Seko N,Usui T,Akanuma S,Hosoya K

更新日期：2016-01-01 00:00:00

abstract：:Mume fruit, the Japanese apricot (Prunus mume SIEB. et ZUCC.), is popular in Japan and is mostly consumed in the pickled form called umeboshi. This fruit is known to have anti-microbial properties, but the principal constituents responsible for the antimicrobial properties have not yet been elucidated. We investigated...

journal_title：Biological & pharmaceutical bulletin

authors： Mitani T,Ota K,Inaba N,Kishida K,Koyama HA

更新日期：2018-01-01 00:00:00

abstract：:We previously prepared 2-hydroxypropyl-beta-cyclodextrin (HPbetaCD) solutions containing disulfiram (DSF) and hydroxypropylmethylcellulose (HPMC, DSF solutions), and found the instillation of this DSF solutions delayed lens opacification in ICR/f rats, a recessive-type hereditary cataractous strain. In this study, we ...

journal_title：Biological & pharmaceutical bulletin

authors： Nagai N,Inomata M,Ito Y

更新日期：2008-07-01 00:00:00

abstract：:The binding and internalization of fractionated [3H]heparin (FH) was kinetically analyzed in rat liver parenchymal cells to clarify its cellular uptake mechanism. The binding of FH to the cell surface was saturable with the dissociation constant (Kd) of 53.5 nM and a maximum binding capacity (Bmax) of 19.9 pmol/mg pro...

journal_title：Biological & pharmaceutical bulletin

authors： Urano K,Haba M,Yuasa H,Watanabe J

更新日期：1997-06-01 00:00:00

abstract：:Preparation of the fatty alcohol propylene glycol (FAPG) ointment base plays an important role in controlling the physicochemical properties of ointments. These essay investigates the effects of preparative conditions such as cooling rate and stirring rate on the percutaneous absorption of norfloxacin from FAPG ointme...

journal_title：Biological & pharmaceutical bulletin

authors： Lin HH,Hsu LR,Wu PC,Tsai YH

更新日期：1995-11-01 00:00:00

abstract：:To clarify the pathogenicity and the pathogenic factors of Candida tropicalis strains, five strains, IFO 0199, IFO 0587, IFO 0589, IFO 1400, and IFO 1647, of C. tropicalis were tested for their lethality to mice, adherence to Hela cells, hydrophobicity, cell growth under acidic conditions (pH 2.0-5.9), and sucrose ass...

journal_title：Biological & pharmaceutical bulletin

authors： Okawa Y,Miyauchi M,Kobayashi H

更新日期：2008-08-01 00:00:00

abstract：:Cationic lipid-mediated transfer of DNA is promising in gene therapy. However, one disadvantage with this approach is the induction of an inflammatory response, which may decrease transgene expression. Recently, we found that plasmid DNA containing N6-methyladenine (N6-MeA), a bacterium-specific modified base, induced...

journal_title：Biological & pharmaceutical bulletin

authors： Ochiai H,Harashima H,Kamiya H

更新日期：2005-10-01 00:00:00

abstract：:The present study examined the anti-obesity effects of pine needle extract (PNE) in 3T3-L1 preadipocytes and in vivo studies. PNE treatment suppressed both glycerol-3-phosphate dehydrogenase activity and expression of peroxisome proliferator-activated receptor (PPAR) gamma in cultured 3T3-L1 adipocytes. To investigate...

journal_title：Biological & pharmaceutical bulletin

authors： Jeon JR,Kim JY

更新日期：2006-10-01 00:00:00

abstract：:Schizophyllan (SPG) is used to treat cervical cancer in combination with irradiation to enhance the immunological surveillance system. Dectin-1 is a cell surface receptor for 1,3-beta-glucan. In this study, we prepared two anti-Dectin-1 monoclonal antibodies, 4B2 and SC30 having a K(D) of 7.04 x 10(-8) M and 1.55 x 10...

journal_title：Biological & pharmaceutical bulletin

authors： Ikeda Y,Adachi Y,Ishii T,Tamura H,Aketagawa J,Tanaka S,Ohno N

更新日期：2007-08-01 00:00:00

abstract：:The genetic similarities of four species of Glycyrrhiza plants were determined by DNA analyses of random amplified polymorphic DNA (RAPD) and restriction fragment length polymorphism (RFLP). The phylogenic trees were constructed from the genetic similarities estimated from RAPD and RFLP profiles. These results indicat...

journal_title：Biological & pharmaceutical bulletin

authors： Yamazaki M,Sato A,Shimomura K,Saito K,Murakoshi I

更新日期：1994-11-01 00:00:00

abstract：:Metallothioneins (MTs) occur throughout the animal kingdom and they are induced in vivo by metals, hormones, cytotoxic agents, and some kind of stress. It is well known that various stresses such as starvation and immobilization can induce MT synthesis in animal tissues, but the influence of dietary restriction is unk...

journal_title：Biological & pharmaceutical bulletin

authors： Shinogi M,Sakaridani M,Yokoyama I

更新日期：1999-02-01 00:00:00

abstract：:Middle East Respiratory Syndrome Coronavirus (MERS CoV) is a new emerging viral disease characterized by high fatality rate. Understanding MERS CoV genetic aspects and codon usage pattern is important to understand MERS CoV survival, adaptation, evolution, resistance to innate immunity, and help in finding the unique ...

journal_title：Biological & pharmaceutical bulletin

authors： Alnazawi M,Altaher A,Kandeel M

更新日期：2017-01-01 00:00:00

abstract：:We examined region-dependent differences and alterations in the levels of protective thiol compounds, glutathione (GSH) and metallothionein (MT)-I and -II, in cultured rat astrocytes under several culture conditions and in brain tissues of rats at postnatal and weaning periods. Regardless of culture conditions, both p...

journal_title：Biological & pharmaceutical bulletin

authors： Adachi T,Satoh M,Pramanik R,Kuroda S,Ishido M,Kunimoto M

更新日期：2006-07-01 00:00:00

abstract：:The inhibitory effects of various sulfated compounds on the activities of sialidases purified from porcine liver and human placenta were investigated. Among the sulfated compounds tested, heparin, dextran sulfate, condroitin sulfates and sulfatide significantly inhibited the 4-methylumbelliferyl-alpha-N-acetylneuramin...

journal_title：Biological & pharmaceutical bulletin

authors： Nagaoka M,Shiraishi T,Furuhata K,Uda Y

更新日期：1998-11-01 00:00:00

abstract：:Permeation enhancement of ketoprofen (KP) from supersaturated systems and the effects of antinucleant polymers on both stability and permeation of supersaturated KP were investigated using silicone membrane as a skin model. The supersaturation was prepared by the cosolvent technique with water and propylene glycol (PG...

journal_title：Biological & pharmaceutical bulletin

authors： Kumprakob U,Kawakami J,Adachi I

更新日期：2005-09-01 00:00:00

abstract：:We have previously reported the expression of CYP genes in human myeloblastic and lymphoid cell lines, and the induction of the CYP3A4 and GSTP1 genes by oxidative stress in the human erythroleukemia cell line, K562. To further elucidate the role of drug metabolizing enzymes in hematogenesis, we have characterized the...

journal_title：Biological & pharmaceutical bulletin

authors： Nagai F,Shimizu M,Sakamoto T,Kobayashi T,Tamura H

更新日期：2007-10-01 00:00:00

abstract：:A highly sensitive ELISA for the determination of polymyxin B sulfate (PMB) was developed which is capable of measuring as low as 32 pg/ml. Anti-PMB antibody was obtained by immunizing rabbits with PMB conjugated with mercaptosuccinyl bovine serum albumin (MS. BSA) using N-(gamma-maleimidobutyryloxy) succinimide (GMBS...

journal_title：Biological & pharmaceutical bulletin

authors： Saita T,Yoshida M,Nakashima M,Matsunaga H,Fujito H,Mori M

更新日期：1999-12-01 00:00:00

abstract：:Cerebral ischemia causes the depletion of oxygen and nutrition from brain tissues, and when persistent, results in irreversible damage to the cell function and survival. The cellular response to ischemic conditions and its mechanisms have been investigated widely in in vivo and in vitro experimental models, yet no stu...

journal_title：Biological & pharmaceutical bulletin

authors： Ujita S,Mizunuma M,Matsuki N,Ikegaya Y

更新日期：2011-01-01 00:00:00

abstract：:The effect of methylcarbonylmethyl 2(S)-14-(4-guanidino-benzoyloxy) phenyl] propionate methanesulfonate (TT-S24) on experimental pancreatitis in rats was examined in comparison with that of camostat. TT-S24 showed a preventive effect on increases in plasma amylase activity and pancreatic weight induced by cerulein inj...

journal_title：Biological & pharmaceutical bulletin

authors： Tagami H,Abe S,Yoshida Y,Tanaka I,Kamei C

更新日期：1998-03-01 00:00:00

abstract：:It has been well known that 3-O-methyldopa (3-OMD) is a metabolite of L-3,4-dihydroxyphenylalanine (L-DOPA) formed by catechol O-methyltransferase (COMT), and 3-OMD blood level often reaches higher than physiological level in Parkinson's disease (PD) patients receiving long term L-DOPA therapy. However, the physiologi...

journal_title：Biological & pharmaceutical bulletin

authors： Onzawa Y,Kimura Y,Uzuhashi K,Shirasuna M,Hirosawa T,Taogoshi T,Kihira K

更新日期：2012-01-01 00:00:00

abstract：:We determined the effects of psychotropic drugs on the cytochrome P450 2D (CYP2D)-mediated 21-hydroxylation of progesterone (PROG) and allopregnanolone (ALLO) with the goal of clarifying whether neurosteroid levels are affected by psychotropic drugs in the brain. PROG or ALLO was incubated with rat CYP2D4 or human CYP...

journal_title：Biological & pharmaceutical bulletin

authors： Niwa T,Okada K,Hiroi T,Imaoka S,Narimatsu S,Funae Y

更新日期：2008-03-01 00:00:00

abstract：:It is widely accepted that selective serotonin reuptake inhibitors (SSRIs) require 2 to 4 weeks of administration before improvements in emotional symptoms of depression are seen. We evaluated whether early monitoring of Hamilton Rating Scale for Depression (HAMD) scores in patients treated with the SSRI fluvoxamine c...

journal_title：Biological & pharmaceutical bulletin

authors： Katoh Y,Uchida S,Kawai M,Takei N,Mori N,Kawakami J,Kagawa Y,Yamada S,Namiki N,Hashimoto H

更新日期：2010-01-01 00:00:00

abstract：:Orally disintegrating tablets (ODTs) are formulated to disintegrate upon contact with saliva, allowing administration without water. Olopatadine hydrochloride, a second-generation antihistamine, is widely used for treating allergic rhinitis. However, it has a bitter taste; therefore, the development of taste-masked ol...

journal_title：Biological & pharmaceutical bulletin

authors： Sotoyama M,Uchida S,Tanaka S,Hakamata A,Odagiri K,Inui N,Watanabe H,Namiki N

更新日期：2017-01-01 00:00:00

abstract：:The purpose of the present study was to investigate the efficacy of a liquid culture filtrates of the entomogenous fungus Paecilomyces tenuipes (PTCF) and its main active glycoprotein-enriched (PGF) fraction against hematotoxicity in mice treated with 5-fluorouracil (5-FU). Oral administration of PTCF (100 mg/kg/d) fo...

journal_title：Biological & pharmaceutical bulletin

authors： Takata T,Tanaka T,Yahagi N,Yahagi R,Tsuchida H,Ishigaki Y,Tomosugi N,Fushiya S,Takano F,Ohta T

更新日期：2008-08-01 00:00:00

abstract：:The present study was performed to investigate the effects of histamine H(1)-antagonists on the sleep-awake state in rats placed on a grid suspended over water in comparison with rats placed on sawdust. When rats were placed on the grid suspended over water, significant increases in the awake time and decreases in non...

journal_title：Biological & pharmaceutical bulletin

authors： Tokunaga S,Tsutsui R,Obara Y,Ishida T,Kamei C

更新日期：2009-01-01 00:00:00

abstract：:This study sought to investigate the ameliorating effects of soy 11S protein on the impacts of alcohol consumption in rat hepatocytes and in reducing total cholesterol levels and total lipid levels in the serum. Liver histology and the clinically important enzyme markers (Aspartate Aminotransferase: AST and Alanine Am...

journal_title：Biological & pharmaceutical bulletin

authors： Park KJ,Kim HY,Chang BJ,Lee HH

更新日期：2004-10-01 00:00:00

abstract：:The complete molecule or the ligand-binding domain-containing region of each of the three subtypes of human retinoic acid receptors (hRAR alpha, hRAR beta and hRAR gamma) was expressed in Escherichia coli. The expressed recombinant RARs (rRARs: rRAR alpha/E, rRAR beta/E and rRAR gamma) showed nearly the same magnitude...

journal_title：Biological & pharmaceutical bulletin

authors： Fukasawa H,Iijima T,Kagechika H,Hashimoto Y,Shudo K

更新日期：1993-04-01 00:00:00

abstract：:Coagulase-negative Staphylococcus (CNS) strains are frequently associated with bacteremia and hospital-acquired infections. 293 CNS strains were isolated from 744 samples from a dialysis center in S. M. de Tucumán, Argentina, from hemocultures, catheters and urine and identified as S. epidermidis, S. haemolyticus, S. ...

journal_title：Biological & pharmaceutical bulletin

authors： de Allori MC,Jure MA,Romero C,de Castillo ME

更新日期：2006-08-01 00:00:00

abstract：:We examined the biological activities present in Streptomyces strains preserved at the National Institute of Technology and Evaluation Biological Resource Center, and found a metabolite of Streptomyces roseolilacinus NBRC 12815 that showed a potent anti-tyrosinase activity. The compounds with anti-tyrosinase activity ...

journal_title：Biological & pharmaceutical bulletin

authors： Nakashima T,Anzai K,Kuwahara N,Komaki H,Miyadoh S,Harayama S,Tianero MD,Tanaka J,Kanamoto A,Ando K

更新日期：2009-05-01 00:00:00