Abstract:
:Metallothioneins (MTs) occur throughout the animal kingdom and they are induced in vivo by metals, hormones, cytotoxic agents, and some kind of stress. It is well known that various stresses such as starvation and immobilization can induce MT synthesis in animal tissues, but the influence of dietary restriction is unknown. The MT levels in the liver increased by food-deprivation and then decreased by refeeding, and a long period of starvation down-alters hepatic MT levels. When the stress is intensified, the induced quantity of hepatic MT is reduced. It became clear that hepatic MT concentrations are controlled within a two fold limit when stressed by dietary restriction. MT was also induced in rat liver at recovery stage following an exhaustive running exercise, and thionein was synthesized first and then zinc bound to the protein. The half-life of hepatic MT induced by exercise (which is a nonmetallic inducer) was estimated at 5.2 h. Preinduced MT markedly suppressed exercise-induced lipid peroxidation in rat liver.
journal_name
Biol Pharm Bulljournal_title
Biological & pharmaceutical bulletinauthors
Shinogi M,Sakaridani M,Yokoyama Idoi
10.1248/bpb.22.132subject
Has Abstractpub_date
1999-02-01 00:00:00pages
132-6issue
2eissn
0918-6158issn
1347-5215journal_volume
22pub_type
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