The inhibitory effect of an extract of Sanguisorba officinalis L. on ultraviolet B-induced pigmentation via the suppression of endothelin-converting enzyme-1alpha.

abstract：:To elucidate insecticidal activity of spider toxins, metal ions in venoms and in the bodies were determined by thin layer chromatography, spark source mass spectrometry, ion chromatography, inductively coupled plasma emission spectrometry and atomic absorption spectrometry. Two kinds of spiders were used, Nephila clav...

journal_title：Biological & pharmaceutical bulletin

authors： Yoshioka M,Narai N,Shinkai A,Tokuda T,Saito K,Shioya M,Tokoro N,Kono Y

更新日期：1994-04-01 00:00:00

abstract：:Studies were performed to characterize the opioid receptors in guinea pig brain using the radiolabeled opioid antagonists, [3H]naloxone and [3H]diprenorphine and the kappa-agonist [3H]U-69593. The binding of [3H]U-69593 to guinea pig cerebellar membranes was reduced by NaCl, guanyl-5'yl-imidodiphosphate (GppNHp) and N...

journal_title：Biological & pharmaceutical bulletin

authors： Ishige K,Makimura M,Ito Y,Murakoshi Y

更新日期：1993-09-01 00:00:00

abstract：:Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is characterized by disabling fatigue of at least 6 months, in addition to symptoms such as muscle pain and muscle weakness. There is no treatment provides long-term benefits to most patients. Recently, clinical research suggested the involvement of pyruvate ...

journal_title：Biological & pharmaceutical bulletin

authors： Ohba T,Domoto S,Tanaka M,Nakamura S,Shimazawa M,Hara H

更新日期：2019-01-01 00:00:00

abstract：:The purpose of this study was to evaluate the essential oils from sweet basil (Ocimum basilicum, OB) as skin permeation enhancers to promote the percutaneous absorption of drugs. The in vitro and in vivo irritancy of the essential oils was also examined. Terpenes with various carbon numbers (mono-, sesqui-, di-, and t...

journal_title：Biological & pharmaceutical bulletin

authors： Fang JY,Leu YL,Hwang TL,Cheng HC

更新日期：2004-11-01 00:00:00

abstract：:The present study describes the activity of Ca(2+)-ATPase in liver plasma membrane and cytosolic-free Ca2+ concentration ([Ca2+]i) in an individual vital cell in mouse liver 18 h after endotoxin administration. Ca(2+)-ATPase activity in liver plasma membrane in the poisoned mice was markedly decreased to 28% of that i...

journal_title：Biological & pharmaceutical bulletin

authors： Sakaguchi S,Tsutsumi E,Yokota K

更新日期：1993-08-01 00:00:00

abstract：:To study the role of asarinin on collagen-induced arthritis (CIA) and its treatment mechanism on dendritic cells (DCs) and T cells. Before the onset of arthritis, asarinin were given orally to CIA mouse. Macroscopic scoring and micrometer caliper measurement were used to assess arthritis. The occurrence of cartilage d...

journal_title：Biological & pharmaceutical bulletin

authors： Dai Q,Wang M,Li Y,Li J

更新日期：2019-07-01 00:00:00

abstract：:The extracellular signal-regulated kinase (ERK) pathway is a major determinant in the control of diverse cellular processes such as proliferation, survival, and motility. This pathway is often upregulated in human cancers and as such represents an attractive target for mechanism-based approaches to cancer treatment. H...

journal_title：Biological & pharmaceutical bulletin

authors： Kohno M,Tanimura S,Ozaki K

更新日期：2011-01-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is an inflammatory disease with joint dysfunction following cartilage degradation. The level of lysophosphatidic acid (LPA) has been reported to be augmented in human synovial fluid from patients with RA. However, it remains to be elucidated whether LPA participates in cartilage destruction. ...

journal_title：Biological & pharmaceutical bulletin

authors： Mizuno K,Komiya M,Okuyama K,Imada K,Sato T

更新日期：2021-01-01 00:00:00

abstract：:We investigated the gene expression of GAPDH, cytochrome P450 isoforms (CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2E1, CYP3A4, CYP3A5, and CYP3A7), UGT-dependent glucuronosyl transferase isoforms (UGT1A6 and UGT1A9), and ABC transporter (ABCB1) after exposure to 0.1, 0.5, and 2.5% dimethyl sulfoxide (DMSO). GAPDH mRNA levels...

journal_title：Biological & pharmaceutical bulletin

authors： Nishimura M,Ueda N,Naito S

更新日期：2003-07-01 00:00:00

abstract：:This study examined the osteoblast-like MC3T3-E1 cell responses to poly(DL-lactide) (PDLLA) and poly(L-lactide) (PLLA) with different weight average molecular weight (M.W.). Colony formation of MC3T3-E1 cells on the PLLA with M.W. 270000 or 1370000 was slightly lower than that on glass. The protein, DNA and hydroxypro...

journal_title：Biological & pharmaceutical bulletin

authors： Ikarashi Y,Tsuchiya T,Kaniwa M,Nakamura A

更新日期：2000-12-01 00:00:00

abstract：:The inhibitory effects of some flavonoids on the infectivity of rotavirus, which predominantly causes sporadic diarrhea in infants and young children, were investigated. Among tested flavonoids, diosmin and hesperidin had the most potent inhibitory activity on rotavirus infection. The fifty percent inhibitory concentr...

journal_title：Biological & pharmaceutical bulletin

authors： Bae EA,Han MJ,Lee M,Kim DH

更新日期：2000-09-01 00:00:00

abstract：:Uridine diphosphate (UDP)-glucuronosyltransferase 1A1 (UGT1A1) plays important roles in the glucuronidation of various drugs and endogenous substances. Minipigs have been used as experimental animals in pharmacological and toxicological studies, because many of their physiological characteristics are similar to those ...

journal_title：Biological & pharmaceutical bulletin

authors： Miyake Y,Mayumi K,Jinno H,Tanaka-Kagawa T,Narimatsu S,Hanioka N

更新日期：2013-01-01 00:00:00

abstract：:We recently isolated a novel lignan, 4-hydroxykobusin from Geranium thunbergii (Liu et al., Arch. Pharm. Res., 29, 1109-1113, 2006). Here, we studied its effect on the expression of inducible nitric oxide synthase (iNOS) gene in RAW264.7 cells. 4-Hydroxykobusin inhibited nitric oxide (NO) production in a concentration...

journal_title：Biological & pharmaceutical bulletin

authors： Pokharel YR,Liu QH,Oh JW,Woo ER,Kang KW

更新日期：2007-06-01 00:00:00

abstract：:The in vitro antimalarial activity against human malaria parasite (Plasmodium falciparum, FCR-3 strain) was examined using 59 triterpenoids obtained during studies on the triterpenic constituents of Cimicifuga spp. The 50% effective concentration values (EC50) of 25 active triterpenoids were 1.0-3.0 microM, and 19 of ...

journal_title：Biological & pharmaceutical bulletin

authors： Takahira M,Kusano A,Shibano M,Kusano G,Koizumi K,Suzuki R,Kim HS,Wataya Y

更新日期：1998-08-01 00:00:00

abstract：:Cinobufagin isolated from traditional Chinese herbs has antitumour, anaesthetic, analgesic and anti-inflammatory effects. Recently, the antitumour activity of cinobufagin has attracted increasing attention from researchers. However, the anticancer activity of this drug on esophageal cancer cells and the precise mechan...

journal_title：Biological & pharmaceutical bulletin

authors： Deng X,Sheng J,Liu H,Wang N,Dai C,Wang Z,Zhang J,Zhao J,Dai E

更新日期：2019-01-01 00:00:00

abstract：:Osthole, a main active constituent from Cnidium monnieri (L.) CUSSON, has been considered therapeutic agent in the treatment of ischemic stroke. This study was designed to investigate the effect of osthole on permanent middle cerebral artery occlusion (MCAO) in rats. Osthole was administrated by gavage to the normal a...

journal_title：Biological & pharmaceutical bulletin

authors： Li F,Gong Q,Wang L,Shi J

更新日期：2012-01-01 00:00:00

abstract：:The improvement of diabetic complications such as lipid lowering and anti-oxidative potential of Hydrangea Dulcis Folium (HDF) was studied in streptozotocin-induced diabetic rats. Male Sprague-Dawley rats were divided into 3 groups after induction of streptozotocin (STZ)-diabetes: normal control; diabetic control; dia...

journal_title：Biological & pharmaceutical bulletin

authors： Kim HK,Kim MJ,Lyu ES,Shin DH

更新日期：2009-01-01 00:00:00

abstract：:We studied the effects of twelve 5,7-dihydroxyflavone analogs on adipogenesis in 3T3-L1 cells. Among the compounds, luteolin, diosmetin, and chrysoeriol partly inhibited adipogenesis by blocking the accumulation of triacylglycerol in the cells. Conversely, tricetin facilitated triacylglycerol accumulation in the cells...

journal_title：Biological & pharmaceutical bulletin

authors： Nishina A,Ukiya M,Fukatsu M,Koketsu M,Ninomiya M,Sato D,Yamamoto J,Kobayashi-Hattori K,Okubo T,Tokuoka H,Kimura H

更新日期：2015-01-01 00:00:00

abstract：:Fat specific protein 27 (FSP27) was originally isolated by screen for genes specifically expressed in fully differentiated mouse adipocytes. FSP27 and cell death-inducing DFF45-like effector C (CIDEC), the human homologue of FSP27, belong to the CIDE family. The FSP27 in adipocytes was recently reported to be a lipid ...

journal_title：Biological & pharmaceutical bulletin

authors： Matsusue K

更新日期：2010-01-01 00:00:00

abstract：:Cisplatin chemotherapy is the standard treatment for metastatic urothelial carcinoma. Although there are second-line chemotherapeutic agents approved by the U.S. Food and Drug Administration (FDA) such as those targeting programmed death-ligand 1 (PD-L1), more effective pharmacotherapy is required for cisplatin-resist...

journal_title：Biological & pharmaceutical bulletin

authors： Ryu H,Jin H,Ho JN,Bae J,Lee E,Lee SE,Lee S

更新日期：2019-01-01 00:00:00

abstract：:Inhibition of Rho kinase (ROCK) ameliorates many cardiovascular dysfunctions. The aim of the current study is to investigate the anti-inflammatory effects of fasudil, a selective ROCK inhibitor, on high cholesterol diet-induced hypercholesterolemic rats and its possible mechanisms. In hypercholesterolemic rats, we fou...

journal_title：Biological & pharmaceutical bulletin

authors： Ma Z,Zhang J,Du R,Ji E,Chu L

更新日期：2011-01-01 00:00:00

abstract：:Tetrandrine (TET), a bis-benzylisoquinoline alkaloid isolated from the dried root of hang-fang-chi (Stephania tetrandra S. Moore), is traditionally used in China for treating inflammation, hypertension and silicosis. In this study, our aim was to examine the anti-inflammatory mechanism of TET through measuring the ind...

journal_title：Biological & pharmaceutical bulletin

authors： Wu SJ,Ng LT

更新日期：2007-01-01 00:00:00

abstract：:Site-directed mutagenesis was used to investigate the molecular interactions involved in sarpogrelate binding to the human 5-Hydroxytryptamine(5-HT)2C receptor. Based on molecular modeling studies, Aspartic acid (Asp)155[3.32] in transmembrane region III and Serine(Ser)361[7.46] in transmembrane region VII of the 5-HT...

journal_title：Biological & pharmaceutical bulletin

authors： Muntasir HA,Takahashi J,Rashid M,Ahmed M,Komiyama T,Hossain M,Kawakami J,Nashimoto M,Nagatomo T

更新日期：2006-08-01 00:00:00

abstract：:The constituents of the leaves of Garcinia intermedia and heartwood of Calophyllum brasiliense were investigated based on their trypanocidal activity against epimastigotes of Trypanosoma cruzi, the etiologic agent of Chagas' disease. As the active components, the polyisoprenylated benzophenone derivative guttiferone A...

journal_title：Biological & pharmaceutical bulletin

authors： Abe F,Nagafuji S,Okabe H,Akahane H,Estrada-Muñiz E,Huerta-Reyes M,Reyes-Chilpa R

更新日期：2004-01-01 00:00:00

abstract：:Direct detection of nitric oxide (NO) is essential for understanding the precise mechanism of its production from endothelial cells. Previously, we developed an NO detection system based on the chemiluminescence reaction between NO and luminol-H2O2. Here, we have applied this system to cultured endothelial cells for t...

journal_title：Biological & pharmaceutical bulletin

authors： Kurumatani H,Kikuchi K,Nagano T,Hirobe M,Yamazaki J,Nagao T

更新日期：1998-12-01 00:00:00

abstract：:Fossilia Mastodi OSSIS, which is a skeletal fossil of a Mastodon, an ancient mammal, has been found to have anxiolytic, sedative and anticonvulsant activities in Oriental medicine. In this study, in vivo characterization of the sedative activities of Fossilia Mastodi OSSIS was performed in order to obtain basic inform...

journal_title：Biological & pharmaceutical bulletin

authors： Ha JH,Lee MG,Chang SM,Lee JT

更新日期：2006-07-01 00:00:00

abstract：:It has been suggested that imbalances in gut microbiota are related to diseases associated with metabolism, the central nervous system, etc. Therefore, analysis of short-chain fatty acids (SCFAs) produced by gut microbiota is very important as an indicator of causation, demonstrating the effects on the host due to cha...

journal_title：Biological & pharmaceutical bulletin

authors： Inoue H,Takayama K,Takahara C,Tabuchi N,Okamura N,Narahara N,Kojima E,Date Y,Tsuruta Y

更新日期：2019-01-01 00:00:00

abstract：:The effect of pH on the microenvironment surrounding 34Cys in human serum albumin (HSA) has been studied using acrylodan, a Cys-specific fluorescence probe. The reactivity of 34Cys with 5,5'-dithiobis(2-nitro benzoic acid) (DTNB) followed a pseudo-first-order reaction, and the increase in reactivity was dependent on p...

journal_title：Biological & pharmaceutical bulletin

authors： Narazaki R,Maruyama T,Otagiri M

更新日期：1997-04-01 00:00:00

abstract：:Rats stressed by specific alternation of rhythm in temperature (SART) show various symptoms of disautonomia, increased pulse rates, continuous hypotension, and severe orthostatic hypotension (OH) when they are subjected to postural change. The OH symptoms are improved by muscarinic M2-receptor blockers. In the present...

journal_title：Biological & pharmaceutical bulletin

authors： Funakami Y,Hata T,Itoh E,Itano S

更新日期：2007-02-01 00:00:00

abstract：:The absorption of glycerol was examined using the closed loop of the rat small intestine in situ to clarify the transport mechanism. The absorption of glycerol, evaluated by its disappearance from the intestinal lumen, was saturable and reduced under the Na(+)-free conditions, suggesting the involvement of an Na(+)-de...

journal_title：Biological & pharmaceutical bulletin

authors： Kato T,Hayashi Y,Inoue K,Yuasa H

更新日期：2005-03-01 00:00:00