Abstract:
:The absorption of glycerol was examined using the closed loop of the rat small intestine in situ to clarify the transport mechanism. The absorption of glycerol, evaluated by its disappearance from the intestinal lumen, was saturable and reduced under the Na(+)-free conditions, suggesting the involvement of an Na(+)-dependent carrier-mediated transport system. Furthermore, glycerol absorption was selectively inhibited by several alcohols, among which 1,3-propanediol caused the greatest inhibition, and also by glycerol-3-phosphate and voglibose, which are alcohol-related compounds analogous to glycerol. Several other compounds that did not inhibit glycerol absorption included D-glucose and L-ascorbate, which are known to be transported by specific carriers. Therefore, the carriers for these two compounds do not seem to be involved in glycerol absorption. It is likely that the carrier-mediated transport system involved in glycerol absorption is specific to glycerol and, possibly, some analogous compounds with hydroxyl groups. Thus, the present study has provided in situ evidence for the presence of an Na(+)-dependent carrier-mediated transport system for glycerol in the rat small intestine. It would be interesting to examine the possibility that the carrier-mediated glycerol transport system could be involved in drug absorption and also that it could be used for oral drug delivery.
journal_name
Biol Pharm Bulljournal_title
Biological & pharmaceutical bulletinauthors
Kato T,Hayashi Y,Inoue K,Yuasa Hdoi
10.1248/bpb.28.553subject
Has Abstractpub_date
2005-03-01 00:00:00pages
553-5issue
3eissn
0918-6158issn
1347-5215pii
JST.JSTAGE/bpb/28.553journal_volume
28pub_type
杂志文章abstract::In Japan, an increasing number of people suffer from pollenosis, a typical atopic disease. Japanese cedar (Cryptomeria japonica) pollen is the most common allergen that causes pollenosis. Although Cry j 1 and Cry j 2 are the common allergenic proteins contained in the pollen, there is a small population of patients wh...
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journal_title:Biological & pharmaceutical bulletin
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更新日期:1999-11-01 00:00:00
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journal_title:Biological & pharmaceutical bulletin
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更新日期:2010-01-01 00:00:00
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