Urinary excretion level of hydroxylysylpyridinoline as an index of bone resorption.

abstract：:The effects of grifolan (GRN), a gel-forming (1-->6)-branched (1-->3)-beta-D-glucan, on antibody production were examined. Sera from mice that were injected with GRN and trinitrophenyl ovalbumin (TNP-OVA) intraperitoneally showed a significantly increased level of anti-TNP IgG. However, injection of TNP-OVA alone show...

journal_title：Biological & pharmaceutical bulletin

authors： Adachi Y,Suzuki Y,Ohno N,Yadomae T

更新日期：1998-09-01 00:00:00

abstract：:OK205 is a traditional Korean prescription containing water-soluble chitosan, glucosamine HCl, chondroitin sulfate, and extract of herbal medicine, and has been used commercially to treat rheumatoid arthritis (RA). Because infiltrated mast cells and their mediators may contribute to the initiation and progression of t...

journal_title：Biological & pharmaceutical bulletin

authors： Choi IY,Jung HS,Kim HR,Lee EJ,Lee EH,Shin TY,Kim HM,Hong SH

更新日期：2004-11-01 00:00:00

abstract：:Mangiferin, a natural glucosyl xanthone from the leaves of Mangifera indica L., was previously shown to exert potent hypouricemic effects associated with inhibition of the activity of xanthine dehydrogenase/oxidase. The present study aimed to evaluate its uricosuric effect and possible molecular mechanisms underlying ...

journal_title：Biological & pharmaceutical bulletin

authors： Yang H,Gao L,Niu Y,Zhou Y,Lin H,Jiang J,Kong X,Liu X,Li L

更新日期：2015-01-01 00:00:00

abstract：:The effect of sesamol and 20 related compounds on the lipid peroxidation of liposomes induced by Fe(2)+, on the lipid peroxidation of rat liver microsomes induced by CCl(4) or NADPH and on the lipid peroxidation of mitochondria induced by ascorbate/Fe(2)+ were demonstrated. Consequently, sesamol and related compounds,...

journal_title：Biological & pharmaceutical bulletin

authors： Uchida M,Nakajin S,Toyoshima S,Shinoda M

更新日期：1996-04-01 00:00:00

abstract：:Markedly inhibitory effects of Ca(2+) on the growth of human tumor cells were attained through the induction of apoptosis in vitro. On the other hand, a good correlation between the growth inhibition effects of Ca(2+) and the amounts of phosphatidylserines (PS) in the cell membranes (plasma membranes) was obtained. Fu...

journal_title：Biological & pharmaceutical bulletin

authors： Goto K,Tatsumi K,Nagata T,Komizu Y,Ueoka R

更新日期：2011-01-01 00:00:00

abstract：:The objective of this study was to determine pharmacokinetic differences of acetyl salicylic acid (ASA) and its metabolites: gentisic acid (GA), salicylic acid (SA) and salicyluric acid (SUA) between Otomies and Mesticians healthy subjects. Design. Ten Otomies and 10 Mesticians were included. After a single dose of as...

journal_title：Biological & pharmaceutical bulletin

authors： Lares-Asseff I,Juárez-Olguín H,Flores-Pérez J,Guillé-Pérez A,Vargas A

更新日期：2004-05-01 00:00:00

abstract：:The effect of pH on the microenvironment surrounding 34Cys in human serum albumin (HSA) has been studied using acrylodan, a Cys-specific fluorescence probe. The reactivity of 34Cys with 5,5'-dithiobis(2-nitro benzoic acid) (DTNB) followed a pseudo-first-order reaction, and the increase in reactivity was dependent on p...

journal_title：Biological & pharmaceutical bulletin

authors： Narazaki R,Maruyama T,Otagiri M

更新日期：1997-04-01 00:00:00

abstract：:Stressors with a physical factor such as immobilization, electric foot shock, cold swim, etc., have been shown to produce oxidative damage to membrane lipids in the brain. In this study, we investigated the effect of protracted social isolation stress on lipid peroxidation activity in the mouse brain and elucidated th...

journal_title：Biological & pharmaceutical bulletin

authors： Huong NT,Murakami Y,Tohda M,Watanabe H,Matsumoto K

更新日期：2005-08-01 00:00:00

abstract：:The effect of fungichromin (FC) on the formation of Candida albicans biofilm was assessed using 2,3-bis(2-methoxy-4-nitro-5-sulfo-phenyl)-2H-tetrazolium-5-carboxanilide (XTT) reduction method, scanning electron microscopy (SEM) and confocal laser scanning microscopy (CLSM). Results showed that FC revealed an inhibitor...

journal_title：Biological & pharmaceutical bulletin

authors： An D,Wang X,Li J,Jiang S,Ma X,Zhang H,Shi H,Sun H,Ye L,Li J

更新日期：2016-12-01 00:00:00

abstract：:Salt-sensitive hypertension induces renal injury via decreased blood flow in the renal artery (RA), and ion channel dysfunction in RA myocytes (RAMs) may be involved in the higher renal vascular resistance. We examined the effects of several voltage-gated K+ (KV) channel blockers on the resting tension in endothelium-...

journal_title：Biological & pharmaceutical bulletin

authors： Ogiwara K,Ohya S,Suzuki Y,Yamamura H,Imaizumi Y

更新日期：2017-01-01 00:00:00

abstract：:Biomacromolecules (>40 kDa) have been developed as drug delivery system (DDS) carriers of low-molecular weight drugs to promote these drugs' uptake by cancer tissues via enhanced permeability and retention (EPR) effects. Human serum albumin (HSA) has been found to accumulate in cancer tissues via this EPR effect. HSA ...

journal_title：Biological & pharmaceutical bulletin

authors： Ishima Y

更新日期：2017-01-01 00:00:00

abstract：:Panaxydol, a polyacetylenic compound derived from Panax ginseng has been reported to suppress the growth of cancer cells. However, the molecular mechanisms underlying cell cycle arrest by this compound in non-small cell lung cancer (NSCLC) are unknown. Our study found that panaxydol treatment induced cell cycle arrest...

journal_title：Biological & pharmaceutical bulletin

authors： Lee JH,Leem DG,Chung KS,Kim KT,Choi SY,Lee KT

更新日期：2018-01-01 00:00:00

abstract：:The effects of 70% methanol extract (EA-ext) from Evodiae Fructus (EA) consisting of dried fruits of Evodia rutaecarpa var. bodinieri (Rutaceae) on nociceptive responses were investigated. Oral administration of 50 or 200 mg/kg EA-ext had the same antinociceptive effect on writhing responses as induced by acetic acid....

journal_title：Biological & pharmaceutical bulletin

authors： Matsuda H,Wu JX,Tanaka T,Iinuma M,Kubo M

更新日期：1997-03-01 00:00:00

abstract：:The absorption and distribution of ulinastatin following intra-articular administration of [125I]ulinastatin to rabbits were determined and kinetic analysis using a multi-compartment model was performed. At 4 h after administration, the content of radioactivity in the synovial fluid, which was comparable to that of th...

journal_title：Biological & pharmaceutical bulletin

authors： Ohzawa N,Takahashi Y,Ogihara T,Nakai Y,Ishiguro J

更新日期：1997-07-01 00:00:00

abstract：:Reprogramming differentiated cells toward stem cells may have long-term applications in stem-cell research and regenerative medicine. Here we report on the dedifferentiation of human epidermal keratinocytes into their precursor cells in vitro with basic fibroblast growth factor (bFGF) but not external gene interventio...

journal_title：Biological & pharmaceutical bulletin

authors： Sun X,Fu X,Han W,Zhao Y,Liu H,Sheng Z

更新日期：2011-01-01 00:00:00

abstract：:The bioavailability of morphine after rectal administration using three types of suppositories containing morphine hydrochloride (10 mg) in different added forms was evaluated in rabbits. Three types of suppositories were constructed with a base material (Witepsol H-15): a conventional suppository containing morphine ...

journal_title：Biological & pharmaceutical bulletin

authors： Matsumoto Y,Watanabe Y,Yamamoto I,Matsumoto M

更新日期：1993-02-01 00:00:00

abstract：:Cationic lipid-mediated transfer of DNA is promising in gene therapy. However, one disadvantage with this approach is the induction of an inflammatory response, which may decrease transgene expression. Recently, we found that plasmid DNA containing N6-methyladenine (N6-MeA), a bacterium-specific modified base, induced...

journal_title：Biological & pharmaceutical bulletin

authors： Ochiai H,Harashima H,Kamiya H

更新日期：2005-10-01 00:00:00

abstract：:Studies have shown that angiotensin-converting enzyme 2 (ACE2) plays modulating roles in lung pathophysiology, including pulmonary fibrosis (PF) and acute lung injury. Pulmonary fibrosis is a common complication in these interstitial lung diseases, and PF always has a poor prognosis and short survival. To date, there ...

journal_title：Biological & pharmaceutical bulletin

authors： Hao Y,Liu Y

更新日期：2016-01-01 00:00:00

abstract：:When ginsenoside R(c) was anaerobically incubated with human fecal microflora, all specimens metabolized ginsenoside R(c) to compound K and protopanaxadiol. The main metabolite was compound K. Among the bacteria isolated from human fecal microflora, most bacteria, such as Bacteroides sp., Eubacterium sp., and Bifidoba...

journal_title：Biological & pharmaceutical bulletin

authors： Bae EA,Choo MK,Park EK,Park SY,Shin HY,Kim DH

更新日期：2002-06-01 00:00:00

abstract：:Sixteen flavonoids including flavonols, flavones, flavanonol and catechins, and five aromatic compounds were examined for their ability to scavenge superoxide radical (O2-*) generated enzymatically in a xanthin-xanthinoxidase system and non-enzymatically in a phenazine methosulfate-NADH system. Pyrogallol, gallic acid...

journal_title：Biological & pharmaceutical bulletin

authors： Furuno K,Akasako T,Sugihara N

更新日期：2002-01-01 00:00:00

abstract：:Microsomal enzyme inducers are known to influence the expression of many transporter proteins and mRNA. In this study, we examined the effects of microsomal enzyme inducers on the mRNA expression of Breast Cancer Resistance Protein (BCRP) and Multidrug Resistance Associated Protein 2 (MRP2) in BALB/c mice. mRNA expres...

journal_title：Biological & pharmaceutical bulletin

authors： Han Y,Sugiyama Y

更新日期：2006-05-01 00:00:00

abstract：:Effects of atorvastatin and pravastatin on glucose tolerance in mildly induced diabetic rats by streptozotocin at 24 mg/kg, i.v. were studied. Non-diabetic and diabetic rats were given orally 0.5% carboxymethylcellulose (control), 8 mg/kg atorvastatin or 8 mg/kg pravastatin once a day for 6 weeks. An oral glucose tole...

journal_title：Biological & pharmaceutical bulletin

authors： Kanda M,Satoh K,Ichihara K

更新日期：2003-12-01 00:00:00

abstract：:This study was conducted to demonstrate the inhibitory effect of saucerneol G (SG), a new lignan, isolated from the aerial part of Saururus chinensis (Saururaceae) on lipopolysaccharide (LPS)-stimulated matrix metalloproteinase-9 (MMP)-9 inductions in RAW 264.7 cells. Aimed at evaluating the mechanism of action by whi...

journal_title：Biological & pharmaceutical bulletin

authors： Lu Y,Hong TG,Jin M,Yang JH,Suh SJ,Piao DG,Ko HK,Seo CS,Chang YC,Kim CH,Son JK,Chang HW

更新日期：2010-01-01 00:00:00

abstract：:Irsogladine maleate (2,4-diamino-6-[2,5-dichlorophenyl]-s-triazine maleate; IM), an anti-peptic ulcer drug, may have a protective effect on the gastrointestinal mucosa. This study investigated the effects of IM on spontaneous colitis in interleukin-10 gene-deficient (IL-10(-/-)) mice. Five-week-old IL-10(-/-) mice wer...

journal_title：Biological & pharmaceutical bulletin

authors： Nakagawa T,Katsuno T,Noguchi Y,Mandai Y,Yoshihama S,Saito K,Maruoka D,Matsumura T,Arai M,Yokosuka O

更新日期：2015-01-01 00:00:00

abstract：:Previous reports have indicated that isosteviol sodium (STVNa) has neuroprotective effects against acute focal cerebral ischemia in rats; however, the exact underlying mechanisms and ideal treatment paradigm are not known. To find a reasonable method for STVNa administration and to determine its possible therapeutic m...

journal_title：Biological & pharmaceutical bulletin

authors： Zhang H,Sun X,Xie Y,Tian F,Hu H,Tan W

更新日期：2018-01-01 00:00:00

abstract：:Lutein is a carotenoid and it has antioxidant effects. Lutein may have a protective effect on ischemia reperfusion (I/R) injury induced by free radical species. However, little is known about the protective effect of lutein on I/R injury in vivo. The present study was undertaken to clarify the protective effects of lu...

journal_title：Biological & pharmaceutical bulletin

authors： Ogura W,Itagaki S,Kurokawa T,Noda T,Hirano T,Mizuno S,Iseki K

更新日期：2006-08-01 00:00:00

abstract：:Indomethacin is used as an anti-inflammatory drug and a nonselective cyclooxygenase inhibitor. When indomethacin in methanol was photo-irradiated with an Hg lamp, methyl ester, ethyl ester, and gamma-lactone derivatives of indomethacin were produced. In the present study, we found that the methyl ester derivative of i...

journal_title：Biological & pharmaceutical bulletin

authors： Chao SH,Wu AB,Lee CJ,Chen FA,Wang CC

更新日期：2005-12-01 00:00:00

abstract：:We have studied lysosomal proteases capable of degrading a major form of cytochrome P450 (CYP2B1) which was purified from the liver microsomes of phenobarbital-treated rats. After incubation of CYP2B1 with extracts of triton-filled lysosomes (tritosomes), its proteolysis was measured by a quantitative immunoblot proce...

journal_title：Biological & pharmaceutical bulletin

authors： Tsuji H,Akasaki K

更新日期：1994-05-01 00:00:00

abstract：:To search for possible anti-tumor-promoters (cancer chemopreventive agents), we carried out primary screening of 23 triterpenoid hydrocarbons (1-23) isolated from ferns using an in vitro synergistic assay system. Of these triterpenoids, hop-17(21)-ene (2), neohop-13(18)-ene (3), neohop-12-ene (4), taraxerane (17), mul...

journal_title：Biological & pharmaceutical bulletin

authors： Konoshima T,Takasaki M,Tokuda H,Masuda K,Arai Y,Shiojima K,Ageta H

更新日期：1996-07-01 00:00:00

abstract：:A fungus of Pestalotiopsis species produced an extracellular, water-soluble polysaccharide (PS-N). PS-N exhibited significant hypoglycemic activity in streptozotocin-induced diabetic mice following intraperitoneal administration and had an effect on oral glucose tolerance in normal mice following oral administration. ...

journal_title：Biological & pharmaceutical bulletin

authors： Kiho T,Itahashi S,Sakushima M,Matsunaga T,Usui S,Ukai S,Mori H,Sakamoto H,Ishiguro Y

更新日期：1997-02-01 00:00:00