Anti-tumor-promoting activities of triterpenoids from ferns. I.

Abstract:

:To search for possible anti-tumor-promoters (cancer chemopreventive agents), we carried out primary screening of 23 triterpenoid hydrocarbons (1-23) isolated from ferns using an in vitro synergistic assay system. Of these triterpenoids, hop-17(21)-ene (2), neohop-13(18)-ene (3), neohop-12-ene (4), taraxerane (17), multiflor-9(11)-ene (18), multiflor-8-ene (19), glutin-5(10)-ene (21) and taraxastane (23) exhibited remarkable inhibitory effects on Epstein-Barr virus (EBV) activation induced by the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA). Further, compounds 2 and 3 exhibited remarkable anti-tumorpromoting effects on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test using 7,12-dimethybenz[a]anthracene (DMBA) as an initiator and TPA as a promoter.

journal_name

Biol Pharm Bull

authors

Konoshima T,Takasaki M,Tokuda H,Masuda K,Arai Y,Shiojima K,Ageta H

doi

10.1248/bpb.19.962

subject

Has Abstract

pub_date

1996-07-01 00:00:00

pages

962-5

issue

7

eissn

0918-6158

issn

1347-5215

journal_volume

19

pub_type

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