Adjuvant effect of grifolan on antibody production in mice.

abstract：:We recently isolated a novel lignan, 4-hydroxykobusin from Geranium thunbergii (Liu et al., Arch. Pharm. Res., 29, 1109-1113, 2006). Here, we studied its effect on the expression of inducible nitric oxide synthase (iNOS) gene in RAW264.7 cells. 4-Hydroxykobusin inhibited nitric oxide (NO) production in a concentration...

journal_title：Biological & pharmaceutical bulletin

authors： Pokharel YR,Liu QH,Oh JW,Woo ER,Kang KW

更新日期：2007-06-01 00:00:00

abstract：:Bis(indole) alkaloids, of the topsentin class (1-4) and hamacanthin class (5-9), isolated from the marine sponge Spongosorites sp. were investigated using several biological assays. In the evaluation of antimicrobial activity against various strains of bacteria and fungi, compounds of the hamacanthin class exhibited m...

journal_title：Biological & pharmaceutical bulletin

authors： Oh KB,Mar W,Kim S,Kim JY,Lee TH,Kim JG,Shin D,Sim CJ,Shin J

更新日期：2006-03-01 00:00:00

abstract：:Vesicular glutamate transporter (VGLUT) is responsible for the active transport of L-glutamate into synaptic vesicles and, thus, plays an essential role in the glutamatergic chemical transmission in the central and peripheral nervous systems. Recent studies indicated that VGLUT is also expressed and localized in vario...

journal_title：Biological & pharmaceutical bulletin

authors： Moriyama Y,Omote H

更新日期：2008-10-01 00:00:00

abstract：:The effects of nefiracetam on the cerebral adenylyl cyclase (AC) activity of animals with microsphere embolism-induced memory dysfunction were examined. Sustained cerebral ischemia in the right cerebral hemisphere was induced by an injection of microspheres into the right internal carotid artery of rats. To examine le...

journal_title：Biological & pharmaceutical bulletin

authors： Takeo S,Miyake-Takagi K,Kikuchi K,Ando T,Ichikawa T,Omino K,Kajihara H,Takagi N,Tanonaka K

更新日期：2003-03-01 00:00:00

abstract：:The role of leukotriene B4 (LTB4) in leukocyte infiltration in zymosan-induced rat pleurisy was investigated by studying the effects of 5-lipoxygenase inhibitors, T-0757 and AA-861, and a cyclooxygenase inhibitor, indomethacin, on leukocyte infiltration and LTB4 levels in the inflammatory exudate of rat pleurisy induc...

journal_title：Biological & pharmaceutical bulletin

authors： Kikuchi M,Tsuzurahara K,Naito K

更新日期：1995-09-01 00:00:00

abstract：:We have isolated insulin resistant mice (ddY-H mice) which are spontaneously induced even if fed with the standard chow pellets. Since marked accumulation of triglycerides (TG) in liver was observed, the present study investigated causes of hepatic TG accumulation in ddY-H mice fed with the standard chow pellets. In d...

journal_title：Biological & pharmaceutical bulletin

authors： Satoh H,Ide N,Kagawa Y,Maeda T

更新日期：2013-01-01 00:00:00

abstract：:This article has been retracted by the Editorial Committee of The Pharmaceutical Society of Japan because it contains scientific misconduct. Although the data published in this article were generated in part by the first author, the authors violated authorship and sponsorship protocol. ...

journal_title：Biological & pharmaceutical bulletin

authors： Kim JH,Lee JH,Kim YJ

更新日期：2015-11-06 00:00:00

abstract：:The present study was designed to examine whether the methanol extract of Sorbus commixta cortex (MSC) could prevent the development of atherosclerosis through regulating the vascular nitric oxide (NO) and endothelin-1 (ET-1) systems in atherogenic-diet rats. Our findings show that aortic NO production as well as endo...

journal_title：Biological & pharmaceutical bulletin

authors： Sohn EJ,Kang DG,Mun YJ,Woo WH,Lee HS

更新日期：2005-08-01 00:00:00

abstract：:Hypertension is one of the most prevalent diseases worldwide and can cause harmful complications within the vascular system. Further research on vascular responsiveness to different ligands and diverse receptors in various arteries is required to understand the mechanisms underlying the development of these vascular c...

journal_title：Biological & pharmaceutical bulletin

authors： Ando M,Matsumoto T,Kobayashi S,Iguchi M,Taguchi K,Kobayashi T

更新日期：2018-01-01 00:00:00

abstract：:Two conjugates of marine polysaccharide (MPS) and bovine serum albumin (BSA) were prepared using two methods, periodate oxidation and reductive amination, with the intent of enhancing its immunogenicity. Sera samples from Balb/c mice immunized with the products named MPS-BSAp and MPS-BSAr respectively were evaluated b...

journal_title：Biological & pharmaceutical bulletin

authors： Gan L,Xin X,Geng M,Ding J

更新日期：2004-10-01 00:00:00

abstract：:Lymphocyte homing is mediated by a specific interaction between the lymphocyte homing receptor L-selectin and its sulfated glycoprotein ligands, which are expressed on high endothelial venules (HEV) in the lymph nodes. To examine the significance of the sulfation of L-selectin ligands, our group has generated gene-tar...

journal_title：Biological & pharmaceutical bulletin

authors： Kawashima H

更新日期：2006-12-01 00:00:00

abstract：:We investigated the psychostimulant, rewarding, and anxiolytic-like effects of pulegone. Possible interactions between pulegone and menthol concerning their psychostimulant effect were also analyzed. General mouse activity after pulegone treatment, and the interacitons between pulegone and menthol, were determined in ...

journal_title：Biological & pharmaceutical bulletin

authors： da Silveira NS,de Oliveira-Silva GL,Lamanes Bde F,Prado LC,Bispo-da-Silva LB

更新日期：2014-01-01 00:00:00

abstract：:Schizophyllan (SPG) is used to treat cervical cancer in combination with irradiation to enhance the immunological surveillance system. Dectin-1 is a cell surface receptor for 1,3-beta-glucan. In this study, we prepared two anti-Dectin-1 monoclonal antibodies, 4B2 and SC30 having a K(D) of 7.04 x 10(-8) M and 1.55 x 10...

journal_title：Biological & pharmaceutical bulletin

authors： Ikeda Y,Adachi Y,Ishii T,Tamura H,Aketagawa J,Tanaka S,Ohno N

更新日期：2007-08-01 00:00:00

abstract：:As a study to assess the potential application of milk fat-globule membrane (MFGM), which is of natural origin and expected to be a safer alternative to synthetic emulsifiers, to pharmaceutical dosage forms, the oral absorption of alpha-linolenic acid was evaluated by the analysis of gastrointestinal disposition after...

journal_title：Biological & pharmaceutical bulletin

authors： Yuasa H,Sekiya M,Ozeki S,Watanabe J

更新日期：1994-09-01 00:00:00

abstract：:Irsogladine maleate (2,4-diamino-6-[2,5-dichlorophenyl]-s-triazine maleate; IM), an anti-peptic ulcer drug, may have a protective effect on the gastrointestinal mucosa. This study investigated the effects of IM on spontaneous colitis in interleukin-10 gene-deficient (IL-10(-/-)) mice. Five-week-old IL-10(-/-) mice wer...

journal_title：Biological & pharmaceutical bulletin

authors： Nakagawa T,Katsuno T,Noguchi Y,Mandai Y,Yoshihama S,Saito K,Maruoka D,Matsumura T,Arai M,Yokosuka O

更新日期：2015-01-01 00:00:00

abstract：:We investigated acute cytotoxic effects and Hg accumulation after exposure to methylmercury (MeHg) or Hg(2+) in the presence or absence of serum in cultured astrocytes prepared from the cerebral hemisphere or cerebellum of newborn rats. Dose-related changes in viable cell numbers after exposure to mercuric compounds w...

journal_title：Biological & pharmaceutical bulletin

authors： Adachi T,Kunimoto M

更新日期：2005-12-01 00:00:00

abstract：:Previous reports have indicated that isosteviol sodium (STVNa) has neuroprotective effects against acute focal cerebral ischemia in rats; however, the exact underlying mechanisms and ideal treatment paradigm are not known. To find a reasonable method for STVNa administration and to determine its possible therapeutic m...

journal_title：Biological & pharmaceutical bulletin

authors： Zhang H,Sun X,Xie Y,Tian F,Hu H,Tan W

更新日期：2018-01-01 00:00:00

abstract：:Alkyl viologens showed cytotoxicity when incubated with cultured murine leukemia L1210 cells for 48 h, whereas they were not cytotoxic when briefly incubated for 10 min. Under the permeabilizing conditions achieved by vortex-stirring with a high molecular weight polyacrylic acid (A-119), appreciable cytotoxicity was s...

journal_title：Biological & pharmaceutical bulletin

authors： Shimizu N,Wu W,Kohara A,Kohda K,Suzuki T,Kawazoe Y

更新日期：1997-02-01 00:00:00

abstract：:We examined the inhibitory effects of N-beta-alanyl-5-S-glutathionyl-3,4-dihydroxyphenylalanine (5-S-GAD), a novel antibacterial substance from the immunized adult Sarcophaga peregrina (flesh fly), on protein phosphorylation using immune complexes of protein tyrosine kinases (PTKs) with anti-PTKs monoclonal antibody. ...

journal_title：Biological & pharmaceutical bulletin

authors： Leem JY,Park HY,Fukazawa H,Uehara Y,Natori S

更新日期：1998-07-01 00:00:00

abstract：:Melatonin has been suggested to play important roles in lipid metabolism as well as circadian rhythm; however, very few studies explored the effects of ramelteon, a selective melatonin receptor agonist, on serum lipid profiles. In this study effects of ramelteon on serum lipid profiles were explored, comparing to thos...

journal_title：Biological & pharmaceutical bulletin

authors： Torii H,Shimizu R,Tanizaki Y,Omiya Y,Yamamoto M,Kamiike S,Yasuda D,Hiraoka Y,Hashida T,Kume N

更新日期：2018-01-01 00:00:00

abstract：:We examined region-dependent differences and alterations in the levels of protective thiol compounds, glutathione (GSH) and metallothionein (MT)-I and -II, in cultured rat astrocytes under several culture conditions and in brain tissues of rats at postnatal and weaning periods. Regardless of culture conditions, both p...

journal_title：Biological & pharmaceutical bulletin

authors： Adachi T,Satoh M,Pramanik R,Kuroda S,Ishido M,Kunimoto M

更新日期：2006-07-01 00:00:00

abstract：:The performance of milk fat-globule membrane (MFGM) emulsion as an oral dosage form was evaluated in rats using [14C]alpha-linolenic acid as a lipophilic model solute. For emulsions prepared by homogenization alone, the area under the plasma concentration versus time curve (AUC) after oral administration tended to be ...

journal_title：Biological & pharmaceutical bulletin

authors： Yuasa H,Sekiya M,Ozeki S,Watanabe J

更新日期：1994-05-01 00:00:00

abstract：:The effects of gamma-oryzanol, a drug mainly used for the treatment of hyperlipidaemia, on several cytochrome P450 (CYP) specific reactions in human liver microsomes were investigated to predict drug interactions with gamma-oryzanol in vivo from in vitro data. The following eight CYP catalytic reactions were used in t...

journal_title：Biological & pharmaceutical bulletin

authors： Umehara K,Shimokawa Y,Miyamoto G

更新日期：2004-07-01 00:00:00

abstract：:Coenzyme Q10 (Co-Q10) is a vitamin-like supplement which appears to be safe, with minimal side effects and low drug interaction potential. Co-Q10 is used in the treatment of a variety of disorders related primarily to suboptimal cellular energy metabolism and oxidative injury. Studies supporting the efficacy of Co-Q10...

journal_title：Biological & pharmaceutical bulletin

authors： Ewees MG,Messiha BA,Abo-Saif AA,Abd El-Latif HA

更新日期：2016-01-01 00:00:00

abstract：:The extracellular signal-regulated kinase (ERK) pathway is a major determinant in the control of diverse cellular processes such as proliferation, survival, and motility. This pathway is often upregulated in human cancers and as such represents an attractive target for mechanism-based approaches to cancer treatment. H...

journal_title：Biological & pharmaceutical bulletin

authors： Kohno M,Tanimura S,Ozaki K

更新日期：2011-01-01 00:00:00

abstract：:We investigated the possible protective effects of benidipine (Coniel), a calcium antagonist, on mechanical dysfunction, metabolic damage and changes in vascular reactivity during ischemia and reperfusion in the Langendorff-perfused rat heart. The responses of perfusion pressure to U-46619, a vasoconstrictor, and acet...

journal_title：Biological & pharmaceutical bulletin

authors： Yao K,Karasawa A

更新日期：1994-04-01 00:00:00

abstract：:Ointments of the skin depigmentation agent hydroquinone (HQ) have been prepared by extemporaneous nonsterile compounding in our hospital. The HQ ointments were highly effective in the treatment of various types of skin pigmentations; however, various problems have emerged including chromatic aberration of the ointment...

journal_title：Biological & pharmaceutical bulletin

authors： Matsubayashi T,Sakaeda T,Kita T,Kurimoto Y,Nakamura T,Nishiguchi K,Fujita T,Kamiyama F,Yamamoto A,Okumura K

更新日期：2003-09-01 00:00:00

abstract：:Cataractous lenses have an altered distribution of the intracellular ionic environment, and the lens ionic imbalance with increased levels of calcium (Ca2+) and sodium (Na+), coupled with decreased levels of magnesium (Mg2+) and potassium (K+), is related to cataract development in human senile cataracts. We previousl...

journal_title：Biological & pharmaceutical bulletin

authors： Nagai N,Fukuhata T,Ito Y

更新日期：2007-01-01 00:00:00

abstract：:The effect of extracellular calcium on the intracellular calcium level of newborn rat skin basal cells was examined. The intracellular calcium level of basal cells was affected by the extracellular calcium concentration on culture of the cells on a collagen-coated filter, but not on a plate. The intracellular calcium ...

journal_title：Biological & pharmaceutical bulletin

authors： Ohkura K,Hori H,Terada H

更新日期：1998-01-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the most common type of liver cancer with high mortality worldwide. Traditional chemotherapy for HCC is not widely accepted by clinical practitioners because of its toxic side effects. Thus, there is a need to identify chemotherapeutic drugs against HCC. AMP-activated protein kinase (...

journal_title：Biological & pharmaceutical bulletin

authors： Sul YH,Lee MS,Cha EY,Thuong PT,Khoi NM,Song IS

更新日期：2013-01-01 00:00:00