Abstract:
:The effect of sesamol and 20 related compounds on the lipid peroxidation of liposomes induced by Fe(2)+, on the lipid peroxidation of rat liver microsomes induced by CCl(4) or NADPH and on the lipid peroxidation of mitochondria induced by ascorbate/Fe(2)+ were demonstrated. Consequently, sesamol and related compounds, such as 3-methoxy-4-hydroxyquinone, isosafrol, isoeugenol, eugenol, 3,4-methylenedioxyaniline, catechol, hydroxy-hydroquinone, 3,4-dimethoxyaniline and caffeic acid, exhibited powerful inhibitory effects on the lipid peroxidation system investigated. In particular, isoeugenol was the most powerful inhibitor among all the sesamol-related compounds tested on the lipid peroxidation system. In addition, 1,2-methylenedioxybenzene, ferulic acid, and 3,4-methylenedioxynitrobenzene were also effective on the lipid peroxidation system of liposomes induced by Fe(2)+. The correlation between the structures of sesamol-related compounds and their inhibitory effect is discussed.
journal_name
Biol Pharm Bulljournal_title
Biological & pharmaceutical bulletinauthors
Uchida M,Nakajin S,Toyoshima S,Shinoda Mdoi
10.1248/bpb.19.623subject
Has Abstractpub_date
1996-04-01 00:00:00pages
623-26issue
4eissn
0918-6158issn
1347-5215journal_volume
19pub_type
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journal_title:Biological & pharmaceutical bulletin
pub_type: 杂志文章
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journal_title:Biological & pharmaceutical bulletin
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更新日期:2003-04-01 00:00:00
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journal_title:Biological & pharmaceutical bulletin
pub_type: 杂志文章
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pub_type: 杂志文章
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