Abstract:
:The dopamine reuptake inhibitor bupropion and dopamine D2/3 receptor agonist pramipexole have been clinically proven to improve both depression and treatment-resistant depression. We examined its influence on the duration of immobility during the forced swim test in adrenocorticotropic hormone (ACTH)-treated rats and further analyzed the possible role of the dopamine nerve system in this effect. Bupropion and pramipexole significantly decreased the duration of immobility in normal and ACTH-treated rats. We previously demonstrated that the chronic administration of ACTH caused a significant decrease in hippocampal cell proliferation and neurogenesis. In this study, we used the mitotic marker 5-bromo-2'-deoxyridine to investigate the effects of bupropion and pramipexole on cell proliferation in the subgranular zone of the hippocampal dentate gyrus following chronic treatment with ACTH. The ACTH treatment for 14 d decreased adult hippocampal cell proliferation. The chronic administration of bupropion for 14 d blocked the loss of cell proliferation resulting from the chronic treatment with ACTH, whereas pramipexole did not. The administration of bupropion may have treatment-resistant antidepressive properties, which may be partly attributed to the normalization of hippocampal cell proliferation.
journal_name
Biol Pharm Bulljournal_title
Biological & pharmaceutical bulletinauthors
Onoue Y,Kuwatsuka K,Miyazaki I,Asanuma M,Kitamura Y,Sendo Tdoi
10.1248/bpb.b13-00749subject
Has Abstractpub_date
2014-01-01 00:00:00pages
327-30issue
2eissn
0918-6158issn
1347-5215pii
DN/JST.JSTAGE/bpb/b13-00749journal_volume
37pub_type
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