The Anti-hyperlipidemia Effects of Raw Polygonum multiflorum Extract in Vivo.

abstract：:The objective of this study was to evaluate the interactions between various drugs and aojiru (green juice), a popular health food in Japan, using a simple centrifugation method. The mixture of drug solution and aojiru suspension was gently shaken and centrifuged. The drug concentration in the supernatant fluid was th...

journal_title：Biological & pharmaceutical bulletin

authors： Iwao K,Kawai RT,Oda M,Saitoh H

更新日期：2017-01-01 00:00:00

abstract：:Although distigmine is known to sometimes cause severe adverse drug reactions (ADRs), such as cholinergic crisis, there are limited data on the risk factors for these ADRs. In this study, we defined a serum cholinesterase (sChE) cutoff level for early detection of ADRs to distigmine and sought to identify risk factors...

journal_title：Biological & pharmaceutical bulletin

authors： Mitsuboshi S,Nagai K,Okajima H

更新日期：2020-01-01 00:00:00

abstract：:To develop potent paclitaxel (PTX) formulations for cancer chemotherapy, we formulated PTX into polymeric nanoparticles composed of polyethylene glycol (PEG) and polylactic acid (PLA) block copolymer (PN-PTX). First, the physicochemical properties of PN-PTX prepared were assessed; the mean particle size was around 80 ...

journal_title：Biological & pharmaceutical bulletin

authors： Araki T,Kono Y,Ogawara K,Watanabe T,Ono T,Kimura T,Higaki K

更新日期：2012-01-01 00:00:00

abstract：:Numerous people die of paraquat (PQ) poisoning every year in the world. Although several studies regarding paraquat (PQ) poisoning have been conducted, the metabolic changes in plasma remain unknown. In this study, the metabolomics of 15 PQ poisoned patients with plasma PQ concentrations in excess of 0.1 µg/mL and 16 ...

journal_title：Biological & pharmaceutical bulletin

authors： Wang X,Zhang M,Ma J,Zhang Y,Hong G,Sun F,Lin G,Hu L

更新日期：2015-01-01 00:00:00

abstract：:Previous studies show that the combined method using thrombolytic drugs and ultrasonic irradiation enhances the effect of thrombolysis in in vitro and in vivo experiments. However, the mechanism of the clot lysis was unclear. In previous studies the evaluation of the clot lysis effect was determined by the rate of dec...

journal_title：Biological & pharmaceutical bulletin

authors： Kimura M,Iijima S,Kobayashi K,Furuhata H

更新日期：1994-01-01 00:00:00

abstract：:The inducibility of chromosomal aberration was studied using five mammalian topoisomerase inhibitors in Chinese hamster lung fibroblastic cells (CHL) in two protocols involving 6 and 24 h treatment, with respect to the mechanism of chromosomal aberration. In the 6 h treatment plus 18 h recovery culture (6 h treatment)...

journal_title：Biological & pharmaceutical bulletin

authors： Suzuki H,Nakane S

更新日期：1994-02-01 00:00:00

abstract：:Two angiotensin-I-converting enzyme (ACE) inhibitory peptides were isolated from a tryptic hydrolysate of human serum albumin (HSA). The peptides were identified by sequencing and other analyses as Ala-Trp and the nonapeptide Ala-Phe-Lys-Ala-Trp-Ala-Val-Ala-Arg (human albutensin A), corresponding to f(213-214) and f(2...

journal_title：Biological & pharmaceutical bulletin

authors： Nakagomi K,Ebisu H,Sadakane Y,Fujii N,Akizawa T,Tanimura T

更新日期：2000-07-01 00:00:00

abstract：:Indole-3-carbinol (I3C) is a natural compound found in a wide variety of plant food substances including members of the family Cruciferae with antioxidant and potential chemopreventive properties. In a previous study, I3C exhibited broad spectrum antibacterial activities. Particularly, it showed a more potent antibact...

journal_title：Biological & pharmaceutical bulletin

authors： Sung WS,Lee DG

更新日期：2008-09-01 00:00:00

abstract：:Possible involvement of the peripheral-type benzodiazepine receptor (PBR) in hemin/protoporphyrin-induced erythroid differentiation of human leukemia K562 cells was investigated by the use of the ligands, diazepam and PK11195. Diazepam itself exhibited differentiation-inducing activity on K562 cells. The PBR-specific ...

journal_title：Biological & pharmaceutical bulletin

authors： Nakajima O,Hashimoto Y,Iwasaki S

更新日期：1995-06-01 00:00:00

abstract：:The uric acid concentration in blood has been widely accepted as a diagnostic indicator of hyperuricemia and gout, and its assay method is well established. In the present study, we developed a simple and rapid method for the determination of uric acid in hair, which can be obtained non-invasively. The concentration (...

journal_title：Biological & pharmaceutical bulletin

authors： Kobayashi K,Morioka Y,Isaka Y,Tozawa T

更新日期：1998-04-01 00:00:00

abstract：:UDP-N-acetylglucosaminyl transferase (OGT) resides in both cytosolic and nuclear compartments and catalyzes O-linked glycosylation of various proteins. In the current study, we have extracted protein from nuclear DNA (chromatin protein) using 0.2% NP-40 detergent. Addition of chromatin protein to either cytosolic or n...

journal_title：Biological & pharmaceutical bulletin

authors： Okuyama R,Marshall S

更新日期：2004-08-01 00:00:00

abstract：:PhiC31 integrase has the potential to achieve long-term transgene expression because of site-specific and unidirectional recombination. In this study, plasmid DNA (pDNA) encoding Gaussia luciferase (Gluc) cDNA was constructed and the optimal condition for long-term gene expression using phiC31 integrase in mouse liver...

journal_title：Biological & pharmaceutical bulletin

authors： Umemoto Y,Kawakami S,Otani Y,Higuchi Y,Yamashita F,Hashida M

更新日期：2012-01-01 00:00:00

abstract：:The purpose of this study was to investigate the absorption behavior of an ophthalmic drug injected in rabbit periocular tissues. After intracapsular, retrobulbar and palpebral conjunctival injections of 150 microl and 50 microl fluorescein isothiocyanate dextran (FITC-dextran, average molecular weight 11000), leakage...

journal_title：Biological & pharmaceutical bulletin

authors： Sasaki H,Kashiwagi S,Mukai T,Nishida K,Nakamura J,Nakashima M,Ichikawa M

更新日期：1999-09-01 00:00:00

abstract：:Apocynum venetum LINN. is an important Chinese crude drug, and its sibling species A. pictum SCHRENK is a confusable herb which is similar to it. The purpose of this study is to develop DNA molecular markers to distinguish A. venetum from A. pictum through the combinative technologies of bulked segregate analysis (BSA...

journal_title：Biological & pharmaceutical bulletin

authors： Lu C,Zhang W,Peng X,Gu G,Chen M,Tang Z

更新日期：2010-01-01 00:00:00

abstract：:Treatment of Xenopus blastula with activin converts undifferentiated presumptive ectoderm (animal cap) into mesoderm and endoderm in a dose-dependent manner. At low concentrations, activin induces ventral mesoderm such as blood cells. Here we show that activin-treated aggregates of animal cap cells prepared from undif...

journal_title：Biological & pharmaceutical bulletin

authors： Nagamine K,Furue M,Fukui A,Matsuda A,Hori T,Asashima M

更新日期：2007-10-01 00:00:00

abstract：:Alzheimer's beta-amyloid protein (A beta) is the main component of senile plaques, which are characteristic hallmarks of the Alzheimer's disease brain. Recently, there have been several reports that A beta has toxic effects on both cultured neurons and in the brain. We confirmed the neurotoxicity of A beta in vitro an...

journal_title：Biological & pharmaceutical bulletin

authors： Hasegawa Y,Sugimoto E,Endo T,Ogawa K,Aratake H,Morikawa A,Kitaguchi N

更新日期：1995-12-01 00:00:00

abstract：:Berberine has a wide range of biochemical and pharmacologic effects, including antitumor activity, but the mechanisms involved in berberine-induced apoptosis remain unclear. The purpose of the present study was to investigate the changes in oxidative stress and endoplasmic reticulum (ER)-related molecules, which are c...

journal_title：Biological & pharmaceutical bulletin

authors： Eom KS,Kim HJ,So HS,Park R,Kim TY

更新日期：2010-01-01 00:00:00

abstract：:The aim of the present study was to clarify the mechanism underlying the inhibition of cell proliferation in human lung cancer A549 cells by selenium (Se) compounds. Methylseleninic acid (CH3SeO2H, abbreviated as MSA), a synthetic Se compound, is a direct precursor of active methylselenol (CH3SeH) and is considered to...

journal_title：Biological & pharmaceutical bulletin

authors： Okuno T,Honda E,Arakawa T,Ogino H,Ueno H

更新日期：2014-01-01 00:00:00

abstract：:The relation between degranulation and rapid metabolic responses (acidification rate changes) in RBL-2H3 cells was studied using a cytosensor microphysiometer, a silicon-based biosensor system. The metabolic responses in RBL-2H3 cells by antigen stimulation were compared with those by inhibitors of Ca2+ -ATPase. The f...

journal_title：Biological & pharmaceutical bulletin

authors： Furuno T,Ohyama N,Nakanishi M

更新日期：1999-03-01 00:00:00

abstract：:Purslane (Portulaca oleracea L.) is popular as a potherb in many areas of Europe, Asia, and the Mediterranean region and is widely distributed around the globe. It has a wide range of pharmacological effects, such as antibacterial, anti-aging, anti-inflammatory, and anti-oxidative properties. Although the extract of p...

journal_title：Biological & pharmaceutical bulletin

authors： Kim JY,Oh HM,Kwak SC,Cheon YH,Lee MS,Rho MC,Oh J

更新日期：2015-01-01 00:00:00

abstract：:Bee pollen consists of floral pollen mixed with bee secretions and nectar. It has been considered as a functional food and has different kinds of biologically active ingredients, such as flavonoids, polyphenols, phytosterols and minerals. However, its function in cognition has yet been investigated. In the present stu...

journal_title：Biological & pharmaceutical bulletin

authors： Liao Y,Bae HJ,Zhang J,Kwon Y,Koo B,Jung IH,Kim HM,Park JH,Lew JH,Ryu JH

更新日期：2019-01-01 00:00:00

abstract：:The estimation of metallothionein (MT) levels in a biological sample is required to study the physiological role or the induction of MT, which is a multifunctional protein. MT contains 61 amino acids with 20 homologous cysteines. The high selectivity, sensitivity and stability of N-[4-(dimethylamino-2-benzofuranyl)phe...

journal_title：Biological & pharmaceutical bulletin

authors： Shinogi M,Nishinaga K,Yokoyama I

更新日期：1996-07-01 00:00:00

abstract：:Microvessels are composed of endothelial cells that cover the luminal surface and pericytes that wrap around and along endothelial cells. In the present study, we investigated the regulation of fibrinolysis in cultured human brain microvascular pericytes and endothelial cells after exposure to thrombin. It was found t...

journal_title：Biological & pharmaceutical bulletin

authors： Yamamoto C,Sugato M,Fujiwara Y,Kaji T

更新日期：2005-02-01 00:00:00

abstract：:Apoptosis is the main form of β-cell death in diabetes. Ginseng has been used as an anti-diabetic herb for several thousand years in Asia with ginsenoside Rg1 and ginsenoside Rb1 as important active ingredients. In this study, we demonstrated ginsenoside Rg1 and Rb1 protect β-cells from high glucose/cytokine-induced p...

journal_title：Biological & pharmaceutical bulletin

authors： Chen F,Chen Y,Kang X,Zhou Z,Zhang Z,Liu D

更新日期：2012-01-01 00:00:00

abstract：:The aim of this work is to investigate the therapeutic efficacy of VP-343 ((N-[4-[[(2S,3aR)-2-hydroxy-2,3,3a,4-tetrahydropyrrolo[1,2-a]qunoxalin-5(1H)-yl]phenyl]-4'-methyl[1,1'-biphenyl]-2-carboxamide), a selective vasopressin V2 receptor antagonist, using the experimental SIADH (syndrome of inappropriate secretion of...

journal_title：Biological & pharmaceutical bulletin

authors： Naito A,Hasegawa H,Kurasawa T,Ohtake Y,Matsukawa H,Ezure Y,Tsuriya Y,Koike K,Shigenobu K

更新日期：2000-11-01 00:00:00

abstract：:The radioprotective effects of propolis and polyphenolic compounds from propolis on the radiation-induced mortality of mice exposed to 9 Gy of gamma-irradiation were studied. Intraperitoneal (i.p.) treatment of mice at doses of 100 mg kg(-1) body weight of propolis (water or ethanolic extract; WSDP or EEP) or its poly...

journal_title：Biological & pharmaceutical bulletin

authors： Orsolić N,Benković V,Horvat-Knezević A,Kopjar N,Kosalec I,Bakmaz M,Mihaljević Z,Bendelja K,Basić I

更新日期：2007-05-01 00:00:00

abstract：:Hypericum perforatum extract (St. John's wort, SJW), Harpagophytum procumbens extract (HPE) and Grape seed proanthocyanidin extract (GSPE) have a broad spectrum of biological activities including antidepressant, anti-inflammatory or anti-oxidant effects. The aim of this study was to clarify antinociceptive properties ...

journal_title：Biological & pharmaceutical bulletin

authors： Uchida S,Hirai K,Hatanaka J,Hanato J,Umegaki K,Yamada S

更新日期：2008-02-01 00:00:00

abstract：:HL-60 cells differentiate into granulocyte-like cells by all-trans retinoic acid (ATRA) treatment, and the cellular proliferation is markedly reduced during the differentiation. To elucidate the molecular mechanisms of the growth arrest during the cellular differentiation, we examined the regulated expression of the t...

journal_title：Biological & pharmaceutical bulletin

authors： Horie N,Komada Y,Ueta Y,Suzuki T,Nozawa R,Takeishi K

更新日期：2001-12-01 00:00:00

abstract：:For the accurate identification of medicinal licorice species, nucleotide sequences of four types of DNA regions were researched for 205 specimens, including three species used as licorice: Glycyrrhiza uralensis, Glycyrrhiza glabra, and Glycyrrhiza inflata. The four DNA regions were the internal transcribed spacer (IT...

journal_title：Biological & pharmaceutical bulletin

authors： Kondo K,Shiba M,Yamaji H,Morota T,Zhengmin C,Huixia P,Shoyama Y

更新日期：2007-08-01 00:00:00

abstract：:The phylogenetic relationship of Cistanche deserticola, C. salsa and C. tubulosa was analyzed by comparing the nucleotide sequences of the plastid rps2 gene and the intergenic spacer region between rpl16 and rpl14. By comparison of sequence data, the Cistanche samples were distinguishable from each other. The results ...

journal_title：Biological & pharmaceutical bulletin

authors： Tomari N,Ishizuka Y,Moriya A,Kojima S,Deyama T,Mizukami H,Tu P

更新日期：2002-02-01 00:00:00