Properties and human origin of two angiotensin-I-converting enzyme inhibitory peptides isolated from a tryptic hydrolysate of human serum albumin.

abstract：:Liquid intraurethral prostaglandin E1 (PGE1) delivery system was developed using self-microemulsifying drug delivery system (SMEDDS). For this, pseudo-ternary phase diagrams were constructed and characterized. The viscosity of optimized formulation was increased gradually upon the addition of water and it was decrease...

journal_title：Biological & pharmaceutical bulletin

authors： Lee S,Lee J,Choi YW

更新日期：2008-04-01 00:00:00

abstract：:Mitogenicity and the production of tumor necrosis factor (TNF) by a chemically synthesized lipotetrapeptide analog (KAB-8), S-[2,3-bis(palmitoyloxy)-2R-propyl]-N-[(2,2,2)-trichloro- ethoxycarbonyl: Troc group]-(R)-cysteinyl-(S)-seryl-(S)-seryl-(S)-asparagine, the amino acid sequence of which corresponds to that of the...

journal_title：Biological & pharmaceutical bulletin

authors： Shimizu T,Iwamoto Y,Yanagihara Y,Kurimura M,Achiwa K

更新日期：1994-07-01 00:00:00

abstract：:Essential elements (Ca, Mg, Zn, Cu, Fe, Cr, Mn and V) and non-essential elements (As, Cd, Hg and Pb) were measured in scalp hair samples of 45 diabetic subjects and 59 control subjects in Japan using inductively coupled plasma mass spectrometry. All diabetic subjects took insulin and/or antidiabetic agents, with glyca...

journal_title：Biological & pharmaceutical bulletin

authors： Hotta Y,Fujino R,Kimura O,Endo T

更新日期：2018-01-01 00:00:00

abstract：:Cry j 1 is one of the major allergens in Japanese cedar pollen. We attempt high throughput analysis and comprehensive identification of the linear IgE epitopes of Cry j 1. A series of overlapping synthetic Cry j 1 peptides chemically spotted on cellulose membrane was probed with sera from patients in Japan and United ...

journal_title：Biological & pharmaceutical bulletin

authors： Takagi K,Teshima R,Sawada J

更新日期：2005-08-01 00:00:00

abstract：:We investigated the possible protective effects of benidipine (Coniel), a calcium antagonist, on mechanical dysfunction, metabolic damage and changes in vascular reactivity during ischemia and reperfusion in the Langendorff-perfused rat heart. The responses of perfusion pressure to U-46619, a vasoconstrictor, and acet...

journal_title：Biological & pharmaceutical bulletin

authors： Yao K,Karasawa A

更新日期：1994-04-01 00:00:00

abstract：:We have previously proposed a novel deconvolution method, which can estimate first-pass metabolism of orally administered drugs. In the present study, we examined whether this deconvolution method is useful for evaluating oral dosage forms. The absorption and first-pass metabolism of orally administered aspirin formul...

journal_title：Biological & pharmaceutical bulletin

authors： Wu X,Yamashita F,Hashida M

更新日期：1999-11-01 00:00:00

abstract：:Since grape extract (GE) contains oligomeric proanthocyanidins and numerous polyphenols, dietary GE supplements may exert protective effects against various diseases. The present study investigated the pharmacological effects of GE derived from Chardonnay in vitro and in vivo. GE (100 µg/mL) completely inhibited tumor...

journal_title：Biological & pharmaceutical bulletin

authors： Ohkita M,Hayashi H,Ito K,Shigematsu N,Tanaka R,Tsutsui H,Matsumura Y

更新日期：2019-01-01 00:00:00

abstract：:When kalopanaxsaponin K (KPK) from Kalopanax pictus was incubated for 24 h at 37 degrees C with human intestinal microflora, KPK was mainly metabolized to kalopanaxsaponin I (KPI) via kalopanaxsaponin H (KPH) rather than via kalopanaxsaponin J (KPJ), and then transformed to kalopanaxsaponin A (KPA) and hederagenin. Ba...

journal_title：Biological & pharmaceutical bulletin

authors： Kim DH,Bae EA,Han MJ,Park HJ,Choi JW

更新日期：2002-01-01 00:00:00

abstract：:Three sialoglycoprotein fractions having reactivities against influenza A and B viruses (IV-A and IV-B) and influenza virus-hemagglutinin (IV-HA), were obtained by gel filtration using a Sephacryl S-300 column and an Asahipak GS-710 HPLC column from water-soluble fraction prepared from human meconium (ME-WSF). Molecul...

journal_title：Biological & pharmaceutical bulletin

authors： Ohyama K,Shinozuka T,Yanagida J,Yamakawa T

更新日期：1997-11-01 00:00:00

abstract：:To analyze the renal handling of therapeutic compounds observed as a non-linear process with a diffusion phenomenon, we employed a non-linear dispersion model described with a partial differential equation and solved it by using the finite difference method with an implicit scheme in a model dependent analysis. In thi...

journal_title：Biological & pharmaceutical bulletin

authors： Aiba T,Kubota S,Koizumi T

更新日期：1999-06-01 00:00:00

abstract：:Exosomes are tiny extracellular vesicles that are usually harvested in small quantities. Such small yield has been an obstacle for the expansion of the basic research regarding exosome analysis and applications in drug delivery. To increase exosome yield, we attempted to stimulate tumor cells via the addition of lipos...

journal_title：Biological & pharmaceutical bulletin

authors： Emam SE,Ando H,Abu Lila AS,Shimizu T,Ukawa M,Okuhira K,Ishima Y,Mahdy MA,Ghazy FS,Ishida T

更新日期：2018-01-01 00:00:00

abstract：:The present study investigated whether Astragalus polysaccharide (APS) possessed immunotherapeutic effects on type 1 diabetes mellitus. Diabetic mice induced by multiple low dose streptozotocin (MLD-STZ) were administered either APS (100, 200, 400 mg/kg body weight) or saline intraperitoneally daily, and sacrificed af...

journal_title：Biological & pharmaceutical bulletin

authors： Li RJ,Qiu SD,Chen HX,Tian H,Wang HX

更新日期：2007-03-01 00:00:00

abstract：:Plant phenolic compounds isolated from a 70% aqueous acetone extract of the leaves of Malus doumeri A. CHEV. var. formosana (KAWAK. & KOIDZ.) S. S. YING, a type of Taiwanese indigenous plant, were evaluated for potential application in the field of skin care. A phytochemical investigation of the active fractions resul...

journal_title：Biological & pharmaceutical bulletin

authors： Leu SJ,Lin YP,Lin RD,Wen CL,Cheng KT,Hsu FL,Lee MH

更新日期：2006-04-01 00:00:00

abstract：:Transient receptor potential vanilloid 1 (TRPV1) is primarily expressed in central and peripheral terminals of non-myelinated primary afferent neurons. We previously showed that AS1928370, a novel TRPV1 antagonist that can prevent ligand-induced activation but not proton-induced activation, ameliorates neuropathic pai...

journal_title：Biological & pharmaceutical bulletin

authors： Watabiki T,Kiso T,Tsukamoto M,Aoki T,Matsuoka N

更新日期：2011-01-01 00:00:00

abstract：:The absorption of glycerol was examined using the closed loop of the rat small intestine in situ to clarify the transport mechanism. The absorption of glycerol, evaluated by its disappearance from the intestinal lumen, was saturable and reduced under the Na(+)-free conditions, suggesting the involvement of an Na(+)-de...

journal_title：Biological & pharmaceutical bulletin

authors： Kato T,Hayashi Y,Inoue K,Yuasa H

更新日期：2005-03-01 00:00:00

abstract：:The present study was designed to evaluate skin permeation enhancement effect of essential oils from Ligusticum chuanxiong Hort (chuanxiong oil) in rabbits and to compare the in vivo absorption and in vitro permeation using flurbiprofen as a model drug. In vivo results demonstrated that chuanxiong oil showed a rapid a...

journal_title：Biological & pharmaceutical bulletin

authors： Zhang LC,Hu JH,Li L,Gao LH,Zhu QG,Li Z,Wang ZZ,Su DF

更新日期：2006-06-01 00:00:00

abstract：:Regorafenib is a small molecule inhibitor of tyrosine kinases, and has been shown to improve the outcomes of patients with advanced colorectal cancer and advanced gastrointestinal stromal tumors. The transport profiles of regorafenib by various transporters were evaluated. HEK293/organic anion transporting polypeptide...

journal_title：Biological & pharmaceutical bulletin

authors： Ohya H,Shibayama Y,Ogura J,Narumi K,Kobayashi M,Iseki K

更新日期：2015-01-01 00:00:00

abstract：:Resveratrol, which is found in grapes, red wine, and berries, has many beneficial health effects, such as anti-cancer, neuro-protective, anti-inflammatory, and life-prolonging effects. However, the cellular mechanisms by which resveratrol acts are relatively unknown, especially in terms of possible regulation of recep...

journal_title：Biological & pharmaceutical bulletin

authors： Lee BH,Hwang SH,Choi SH,Shin TJ,Kang J,Lee SM,Nah SY

更新日期：2011-01-01 00:00:00

abstract：:Irsogladine maleate (2,4-diamino-6-[2,5-dichlorophenyl]-s-triazine maleate; IM), an anti-peptic ulcer drug, may have a protective effect on the gastrointestinal mucosa. This study investigated the effects of IM on spontaneous colitis in interleukin-10 gene-deficient (IL-10(-/-)) mice. Five-week-old IL-10(-/-) mice wer...

journal_title：Biological & pharmaceutical bulletin

authors： Nakagawa T,Katsuno T,Noguchi Y,Mandai Y,Yoshihama S,Saito K,Maruoka D,Matsumura T,Arai M,Yokosuka O

更新日期：2015-01-01 00:00:00

abstract：:Skeletal muscle is a major site for glucose metabolism and its injury by cytokines can induce insulin resistance leading to type 2 diabetes. It has been suggested that quercetin may act as an anti-diabetic agent, however, the effects of quercetin on insulin resistance in skeletal muscle remain unknown. We aimed to inv...

journal_title：Biological & pharmaceutical bulletin

authors： Dai X,Ding Y,Zhang Z,Cai X,Bao L,Li Y

更新日期：2013-01-01 00:00:00

abstract：:Berberine is one of the main alkaloids of Rhizoma coptidis which has been used as a folk medicine to treat diabetes mellitus for more than 1400 years in China. To investigate the chronic effect of berberine on diabetic hyperlipidemic rats, fasted rats were intraperitoneally injected 35 mg/kg streptozotocin. Diabetic r...

journal_title：Biological & pharmaceutical bulletin

authors： Zhou JY,Zhou SW,Zhang KB,Tang JL,Guang LX,Ying Y,Xu Y,Zhang L,Li DD

更新日期：2008-06-01 00:00:00

abstract：:Bupleuri Radix (Chai-hu in Chinese and Saiko in Japanese) is one of the most important traditional Chinese crude drugs for treating hepatitis malaria and intermittent fever. B. kaoi is one of the Bupleurum spp. families locally found in Taiwan. The effects of saponin-enriched fraction (SEF) from Bupleurum Kaoi in huma...

journal_title：Biological & pharmaceutical bulletin

authors： Hsu YL,Kuo PL,Weng TC,Yen MH,Chiang LC,Lin CC

更新日期：2004-07-01 00:00:00

abstract：:Tumor necrosis factor alpha (TNFalpha) generates a potent cytotoxic effect, however many cancer cells are resistant to TNFalpha-mediated killing and the cause of the differential sensitivity remains to be elucidated. In this study, we demonstrated that TNFalpha induced cell death in four different human colon cancer c...

journal_title：Biological & pharmaceutical bulletin

authors： Han SY,Choung SY,Paik IS,Kang HJ,Choi YH,Kim SJ,Lee MO

更新日期：2000-04-01 00:00:00

abstract：:Protein purification is a key technique for the identification of novel sensory nerve-specific proteins. A 35 kDa protein, the sensory neuronal specific protein, was isolated and purified from rabbit spinal ganglia and sensory fibers by homogenizing and deriving soluble extracts, followed by ion exchange chromatograph...

journal_title：Biological & pharmaceutical bulletin

authors： Ping XP,Wang JZ

更新日期：2000-05-01 00:00:00

abstract：:The accumulation of amyloid β(1-42) peptide (Aβ(1-42)) in retina is implicated in the development of retinal ganglion cell apoptosis and diabetic retinopathy. In this study we demonstrate that spontaneous diabetes mellitus Otsuka Long-Evans Tokushima Fatty (OLETF) rats can be used as an animal model in studies to iden...

journal_title：Biological & pharmaceutical bulletin

authors： Nagai N,Ito Y,Tanino T

更新日期：2015-01-01 00:00:00

abstract：:The total alkaloid fractions of the methanolic extracts of the leaves, ripe fruits, roots, seeds and stem of Solanum pseudocapsicum were subjected to in-vitro cytotoxicity, short-term toxicity and long-term survival studies. All the five fractions exhibited potent activity. The total alkaloid fraction of leaves was fo...

journal_title：Biological & pharmaceutical bulletin

authors： Vijayan P,Vijayaraj P,Setty PH,Hariharpura RC,Godavarthi A,Badami S,Arumugam DS,Bhojraj S

更新日期：2004-04-01 00:00:00

abstract：:The effect of extracellular calcium on the intracellular calcium level of newborn rat skin basal cells was examined. The intracellular calcium level of basal cells was affected by the extracellular calcium concentration on culture of the cells on a collagen-coated filter, but not on a plate. The intracellular calcium ...

journal_title：Biological & pharmaceutical bulletin

authors： Ohkura K,Hori H,Terada H

更新日期：1998-01-01 00:00:00

abstract：:The present study assessed the safety/toxicity of Senecio scandens, a well-known Chinese herb that is used as an anti-inflammatory, antibiosis, and antipyretic drug. A 90-d subchronic oral toxicity study of S. scandens was performed in Wistar rats. The extract of S. scandens was administered orally to male and female ...

journal_title：Biological & pharmaceutical bulletin

authors： Wang XK,Zhao Y,Liu T,Yi Y,Li CY,Wang HJ,Wang CH,Wang ZT,Ye ZG,Liang AH

更新日期：2015-01-01 00:00:00

abstract：:The fat-specific protein 27 (Fsp27) gene belongs to the cell death-inducing DNA fragmentation factor 45-like effector family. Fsp27 is highly expressed in adipose tissue as well as the fatty liver of ob/ob mice. Fsp27 is directly regulated by the peroxisome proliferator-activated receptor γ (PPARγ) in livers of geneti...

journal_title：Biological & pharmaceutical bulletin

authors： Matsuo K,Matsusue K,Aibara D,Takiguchi S,Gonzalez FJ,Yamano S

更新日期：2017-01-01 00:00:00

abstract：:Hepatoprotective effect of celosian, an acidic polysaccharide isolated from the water extract of the seed of Celosia argentea, was investigated using chemical and immunological liver injury models. Celosian inhibited the elevation of serum enzyme (GPT, GOT, LDH) and bilirubin levels on carbon tetrachloride (CC1(4))-in...

journal_title：Biological & pharmaceutical bulletin

authors： Hase K,Kadota S,Basnet P,Takahashi T,Namba T

更新日期：1996-04-01 00:00:00