Abstract:
:Ginsenosides, the unique constituents and secondary metabolites of the Panax species, have been known to be the pharmacologically active ingredients of ginseng. Recently, our research group has developed a new processed ginseng, called Sun ginseng (SG), which has an increased amount of the red ginseng unique ginsenosides (RGUG). In our previous studies, this new processed ginseng reduced cisplatin-induced nephrotoxicity more than white ginseng in both in vitro and in vivo systems. In this study, we isolated and characterized active principles through activity-guided fractionation. Ginsenosides Rh4 and Rk3 significantly reduced the cisplatin-induced nephrotoxicity in LLC-PK1 cells in a dose-dependent manner. The mechanisms of function and structure-activity relationships with other ginsenosides remain for further investigation.
journal_name
Biol Pharm Bulljournal_title
Biological & pharmaceutical bulletinauthors
Baek SH,Piao XL,Lee UJ,Kim HY,Park JHdoi
10.1248/bpb.29.2051subject
Has Abstractpub_date
2006-10-01 00:00:00pages
2051-5issue
10eissn
0918-6158issn
1347-5215pii
JST.JSTAGE/bpb/29.2051journal_volume
29pub_type
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